|Grant Number:||1P50CA180890-01 Interpret this number|
|Primary Investigator:||Glantz, Stanton|
|Organization:||University Of California, San Francisco|
|Project Title:||Improved Models to Inform Tobacco Product Regulation|
DESCRIPTION (provided by applicant): The overarching theme of this Tobacco Center of Regulatory Science is the development of improved models to inform tobacco product regulatory strategies that integrate 1) economic impacts of tobacco use on health costs, 2) risk perceptions, perceived acceptability, consumer responses to pro-tobacco marketing and anti-tobacco messages and other social determinants of tobacco use, and 3) rapid changes in risk due to tobacco use and secondhand smoke exposure as manifested in cardiovascular and pulmonary dysfunction. This TCORS includes five full projects (one on economic models, two on behavioral models, and two on cardiovascular and pulmonary disease models), two developmental projects (one on behavioral models and one on cardiovascular and pulmonary disease models), three Cores (Administrative, Informatics and Analysis, and Biomarker), a postdoctoral training program and a process for selecting future developmental projects. The results will inform FDA regulation of the manufacture, distribution and marketing of tobacco products by providing an improved scientific framework in which to evaluate the likely effects of specific regulatory strategies by developing 1) improved economic models for analysis of proposed regulations that account for short-term as well as long-term effects of tobacco use, 2) better understanding of behavioral and social determinants of tobacco use (including perception of risk and decision making processes) to inform the economic models, regulation of marketing, and public education about risks of tobacco products, and 3) functional biomarkers of acute cardiopulmonary responses to tobacco use and secondhand smoke that may predict future disease and also support development of improved economic models. In particular, these improved economic models will integrate the rapid changes in risk due to reductions in cardiovascular and pulmonary diseases which would be expected to result from FDA regulatory decisions. This TCORS is built on the UCSF Center for Tobacco Control Research and Education's tradition of strong transdisciplinary and collaborative research, education and service. RELEVANCE: This TCORS will inform FDA regulation by developing new economic models that account for short-term and long-term effects of tobacco use, developing a better understanding of behavioral determinants of tobacco use, and identifying functional biomarkers of acute cardiopulmonary responses to tobacco use that could be used in premarket testing of tobacco products.
Polytobacco Use of Cigarettes, Cigars, Chewing Tobacco, and Snuff Among US Adults.
Authors: Sung HY, Wang Y, Yao T, Lightwood J, Max W
Source: Nicotine Tob Res, 2015 Jun 30;null, p. null.
EPub date: 2015 Jun 30.
Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.
Authors: Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB
Source: Crit Care Med, 2015 Sep;43(9), p. 1790-7.
Conditional risk assessment of adolescents' electronic cigarette perceptions.
Authors: Chaffee BW, Gansky SA, Halpern-Felsher B, Couch ET, Essex G, Walsh MM
Source: Am J Health Behav, 2015 May;39(3), p. 421-32.
E-cigarette marketing and older smokers: road to renormalization.
Authors: Cataldo JK, Petersen AB, Hunter M, Wang J, Sheon N
Source: Am J Health Behav, 2015 May;39(3), p. 361-71.
Positive and instructive anti-smoking messages speak to older smokers: a focus group study.
Authors: Cataldo JK, Hunter M, Petersen AB, Sheon N
Source: Tob Induc Dis, 2015;13(1), p. 2.
EPub date: 2015 Jan 24.
Clearing the air. Smoking and incident asthma in adults.
Authors: Moazed F, Calfee CS
Source: Am J Respir Crit Care Med, 2015 Jan 15;191(2), p. 123-4.
Assessing tobacco regulation: moving beyond economists.
Authors: Song AV, Glantz SA
Source: Tob Control, 2015 Mar;24(2), p. 123-4.
EPub date: 2015 Jan 6.
Secondhand smoke exposure and serum cotinine levels among current smokers in the USA.
Authors: Lindsay RP, Tsoh JY, Sung HY, Max W
Source: Tob Control, 2014 Nov 14;null, p. null.
EPub date: 2014 Nov 14.
High international electronic cigarette use among never smoker adolescents.
Authors: Dutra LM, Glantz SA
Source: J Adolesc Health, 2014 Nov;55(5), p. 595-7.
Childhood secondhand smoke exposure and ADHD-attributable costs to the health and education system.
Authors: Max W, Sung HY, Shi Y
Source: J Sch Health, 2014 Oct;84(10), p. 683-6.
Electronic cigarettes: review of use, content, safety, effects on smokers and potential for harm and benefit.
Authors: Hajek P, Etter JF, Benowitz N, Eissenberg T, McRobbie H
Source: Addiction, 2014 Nov;109(11), p. 1801-10.
EPub date: 2014 Jul 31.
Electronic cigarettes. Cardiology patient page.
Authors: Grana RA, Ling PM, Benowitz N, Glantz S
Source: Circulation, 2014 May 13;129(19), p. e490-2.
E-cigarettes: a scientific review.
Authors: Grana R, Benowitz N, Glantz SA
Source: Circulation, 2014 May 13;129(19), p. 1972-86.
Smoking: Tobacco trends.
Authors: Chaffee BW, Couch ET, Essex G, Walsh MM
Source: Br Dent J, 2014 Mar;216(6), p. 266.
The cost of secondhand smoke exposure at home in California.
Authors: Max W, Sung HY, Shi Y
Source: Tob Control, 2015 Mar;24(2), p. 205-10.
EPub date: 2014 Feb 5.
Impact of the 2009 Taiwan tobacco hazards prevention act on smoking cessation.
Authors: Chang FC, Sung HY, Zhu SH, Chiou ST
Source: Addiction, 2014 Jan;109(1), p. 140-6.
EPub date: 2013 Oct 22.
The impact of smoke-free legislation on reducing exposure to secondhand smoke: differences across gender and socioeconomic groups.
Authors: Tsai YW, Chang LC, Sung HY, Hu TW, Chiou ST
Source: Tob Control, 2015 Jan;24(1), p. 62-9.
EPub date: 2013 Sep 6.