|Grant Number:||1UM1CA173640-01A1 Interpret this number|
|Primary Investigator:||Shu, Xiao-Ou|
|Project Title:||Shanghai Men's Health Study|
DESCRIPTION (provided by applicant): The Shanghai Men's Health Study (SMHS), funded by NCI since 2001 (R0I CA082729), is a population based cohort study of 61,491 men who were recruited between 2002 and 2006 and have been followed through multiple in-person follow-up surveys and record linkages. Over the years, data and biological samples collected in the SMHS have been used to evaluate many important etiologic hypotheses and support multiple studies, including over 25 consortium projects. To both sustain and expand its resources and success, we are applying for infrastructure funding with the following specific aims: 1) Continue the follow-up of this cohort for cancer incidence and cause-specific mortality and expand the cohort's resources by conducting in-person interviews to update information on exposures and selected disease outcomes; 2) Maintain the data bank and biorepository of the SMHS and implement quality control protocols to maximize the value of its resources for scientific research; 3) Collect blood and urine samples from 6,000 study participants to enhance our ability to study intermediate disease biomarkers as a consequence of exposures assessed at the baseline and subsequent follow-ups; 4) Collect information related to the diagnosis and treatment of common chronic diseases for cohort members by searching the database of an electronic Health Information System covering the study population; 5) Collect tumor tissue samples and detailed information on cancer treatment, recurrence, and survivorship for participants diagnosed with cancers of the lung, stomach, colon/rectum, liver, and prostate, the five most common cancers in the cohort, as well as collect post-diagnosis lifestyle factor and quality of life information for survivors of stomach, colon/rectum, and prostate cancer; 6).To build a website to promote and facilitate collaborations among the broader community of cancer researchers, to disseminate research findings, and to attract and cultivate new investigators. The SMHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in any other existing cohort study. Continuing follow-up of the cohort and expansion of its resources would further increase the value of the SMHS for a long-term epidemiologic study of cancer and other chronic diseases.
Higher dietary choline intake is associated with lower risk of nonalcoholic fatty liver in normal-weight Chinese women.
Authors: Yu D, Shu XO, Xiang YB, Li H, Yang G, Gao YT, Zheng W, Zhang X
Source: J Nutr, 2014 Dec;144(12), p. 2034-40.
EPub date: 2014 Oct 15.
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
Authors: Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang JY, Dorajoo R, Li H, Tsai FJ, Yang X, He J, Wu Y, He M, Zhang Y, Liang J, Guo X, Sheu WH, Delahanty R, Guo X, Kubo M, Yamamoto K, Ohkubo T, Go MJ, Liu JJ, Gan W, Chen CC, Gao Y, Li S, Lee NR, Wu C, Zhou X, Song H, Yao J, Lee IT, Long J, Tsunoda T, Akiyama K, Takashima N, Cho YS, Ong RT, Lu L, Chen CH, Tan A, Rice TK, Adair LS, Gui L, Allison M, Lee WJ, Cai Q, Isomura M, Umemura S, Kim YJ, Seielstad M, Hixson J, Xiang YB, Isono M, Kim BJ, Sim X, Lu W, Nabika T, Lee J, Lim WY, Gao YT, Takayanagi R, Kang DH, Wong TY, Hsiung CA, Wu IC, Juang JM, Shi J, Choi BY, Aung T, Hu F, Kim MK, Lim WY, Wang TD, Shin MH, Lee J, Ji BT, Lee YH, Young TL, Shin DH, Chun BY, Cho MC, Han BG, Hwu CM, Assimes TL, Absher D, Yan X, Kim E, Kuo JZ, Kwon S, Taylor KD, Chen YD, Rotter JI, Qi L, Zhu D, Wu T, Mohlke KL, Gu D, Mo Z, Wu JY, Lin X, Miki T, Tai ES, Lee JY, Kato N, Shu XO, Tanaka T
Source: Hum Mol Genet, 2014 Oct 15;23(20), p. 5492-504.
EPub date: 2014 May 26.
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Authors: Zhang B, Jia WH, Matsuda K, Kweon SS, Matsuo K, Xiang YB, Shin A, Jee SH, Kim DH, Cai Q, Long J, Shi J, Wen W, Yang G, Zhang Y, Li C, Li B, Guo Y, Ren Z, Ji BT, Pan ZZ, Takahashi A, Shin MH, Matsuda F, Gao YT, Oh JH, Kim S, Ahn YO, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Chan AT, Chang-Claude J, Slattery ML, Colorectal Transdisciplinary (CORECT) Study, Gruber SB, Schumacher FR, Stenzel SL, Colon Cancer Family Registry (CCFR), Casey G, Kim HR, Jeong JY, Park JW, Li HL, Hosono S, Cho SH, Kubo M, Shu XO, Zeng YX, Zheng W
Source: Nat Genet, 2014 Jun;46(6), p. 533-42.
EPub date: 2014 May 18.
Burden of total and cause-specific mortality related to tobacco smoking among adults aged ? 45 years in Asia: a pooled analysis of 21 cohorts.
Authors: Zheng W, McLerran DF, Rolland BA, Fu Z, Boffetta P, He J, Gupta PC, Ramadas K, Tsugane S, Irie F, Tamakoshi A, Gao YT, Koh WP, Shu XO, Ozasa K, Nishino Y, Tsuji I, Tanaka H, Chen CJ, Yuan JM, Ahn YO, Yoo KY, Ahsan H, Pan WH, Qiao YL, Gu D, Pednekar MS, Sauvaget C, Sawada N, Sairenchi T, Yang G, Wang R, Xiang YB, Ohishi W, Kakizaki M, Watanabe T, Oze I, You SL, Sugawara Y, Butler LM, Kim DH, Park SK, Parvez F, Chuang SY, Fan JH, Shen CY, Chen Y, Grant EJ, Lee JE, Sinha R, Matsuo K, Thornquist M, Inoue M, Feng Z, Kang D, Potter JD
Source: PLoS Med, 2014 Apr;11(4), p. e1001631.
EPub date: 2014 Apr 22.
Plasma folate concentrations and colorectal cancer risk: a case-control study nested within the Shanghai Men's Health Study.
Authors: Takata Y, Shrubsole MJ, Li H, Cai Q, Gao J, Wagner C, Wu J, Zheng W, Xiang YB, Shu XO
Source: Int J Cancer, 2014 Nov 1;135(9), p. 2191-8.
EPub date: 2014 Apr 11.
Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men.
Authors: Epplein M, Zheng W, Li H, Peek RM Jr, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Xiang YB, Shu XO
Source: Nutr Cancer, 2014;66(4), p. 550-7.
EPub date: 2014 Mar 25.
Cholelithiasis and the risk of liver cancer: results from cohort studies of 134,546 Chinese men and women.
Authors: Vogtmann E, Shu XO, Li HL, Chow WH, Yang G, Ji BT, Cai H, Yu C, Gao YT, Zheng W, Xiang YB
Source: J Epidemiol Community Health, 2014 Jun;68(6), p. 565-70.
EPub date: 2014 Feb 26.
Prospective cohort studies of association between family history of liver cancer and risk of liver cancer.
Authors: Yang Y, Wu QJ, Xie L, Chow WH, Rothman N, Li HL, Gao YT, Zheng W, Shu XO, Xiang YB
Source: Int J Cancer, 2014 Oct 1;135(7), p. 1605-14.
EPub date: 2014 Mar 7.
Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium.
Authors: Chen Y, Copeland WK, Vedanthan R, Grant E, Lee JE, Gu D, Gupta PC, Ramadas K, Inoue M, Tsugane S, Tamakoshi A, Gao YT, Yuan JM, Shu XO, Ozasa K, Tsuji I, Kakizaki M, Tanaka H, Nishino Y, Chen CJ, Wang R, Yoo KY, Ahn YO, Ahsan H, Pan WH, Chen CS, Pednekar MS, Sauvaget C, Sasazuki S, Yang G, Koh WP, Xiang YB, Ohishi W, Watanabe T, Sugawara Y, Matsuo K, You SL, Park SK, Kim DH, Parvez F, Chuang SY, Ge W, Rolland B, McLerran D, Sinha R, Thornquist M, Kang D, Feng Z, Boffetta P, Zheng W, He J, Potter JD
Source: BMJ, 2013 Oct 1;347, p. f5446.
EPub date: 2013 Oct 1.
Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.
Authors: Zhang B, Jia WH, Matsuo K, Shin A, Xiang YB, Matsuda K, Jee SH, Kim DH, Cheah PY, Ren Z, Cai Q, Long J, Shi J, Wen W, Yang G, Ji BT, Pan ZZ, Matsuda F, Gao YT, Oh JH, Ahn YO, Kubo M, Thean LF, Park EJ, Li HL, Park JW, Jo J, Jeong JY, Hosono S, Nakamura Y, Shu XO, Zeng YX, Zheng W
Source: Int J Cancer, 2014 Aug 15;135(4), p. 948-55.
EPub date: 2014 Jan 29.
Association of soy food intake with risk and biomarkers of coronary heart disease in Chinese men.
Authors: Yu D, Zhang X, Xiang YB, Yang G, Li H, Fazio S, Linton M, Cai Q, Zheng W, Gao YT, Shu XO
Source: Int J Cardiol, 2014 Mar 15;172(2), p. e285-7.
EPub date: 2014 Jan 8.
Cruciferous vegetables, glutathione S-transferase polymorphisms, and the risk of colorectal cancer among Chinese men.
Authors: Vogtmann E, Xiang YB, Li HL, Cai Q, Wu QJ, Xie L, Li GL, Yang G, Waterbor JW, Levitan EB, Zhang B, Zheng W, Shu XO
Source: Ann Epidemiol, 2014 Jan;24(1), p. 44-9.
EPub date: 2013 Oct 12.
Physical activity, smoking, and alcohol consumption in association with incidence of type 2 diabetes among middle-aged and elderly Chinese men.
Authors: Shi L, Shu XO, Li H, Cai H, Liu Q, Zheng W, Xiang YB, Villegas R
Source: PLoS One, 2013;8(11), p. e77919.
EPub date: 2013 Nov 4.
Personal history of diabetes, genetic susceptibility to diabetes, and risk of brain glioma: a pooled analysis of observational studies.
Authors: Kitahara CM, Linet MS, Brenner AV, Wang SS, Melin BS, Wang Z, Inskip PD, Freeman LE, Braganza MZ, Carreˇn T, Feychting M, Gaziano JM, Peters U, Purdue MP, Ruder AM, Sesso HD, Shu XO, Waters MA, White E, Zheng W, Hoover RN, Fraumeni JF Jr, Chatterjee N, Yeager M, Chanock SJ, Hartge P, Rajaraman P
Source: Cancer Epidemiol Biomarkers Prev, 2014 Jan;23(1), p. 47-54.
EPub date: 2013 Nov 12.
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
Authors: Wu Y, Gao H, Li H, Tabara Y, Nakatochi M, Chiu YF, Park EJ, Wen W, Adair LS, Borja JB, Cai Q, Chang YC, Chen P, Croteau-Chonka DC, Fogarty MP, Gan W, He CT, Hsiung CA, Hwu CM, Ichihara S, Igase M, Jo J, Kato N, Kawamoto R, Kuzawa CW, Lee JJ, Liu J, Lu L, McDade TW, Osawa H, Sheu WH, Teo Y, Vadlamudi S, Van Dam RM, Wang Y, Xiang YB, Yamamoto K, Ye X, Young TL, Zheng W, Zhu J, Shu XO, Shin C, Jee SH, Chuang LM, Miki T, Yokota M, Lin X, Mohlke KL, Tai ES
Source: Hum Mol Genet, 2014 Feb 15;23(4), p. 1108-19.
EPub date: 2013 Oct 8.
An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
Authors: Klein AP, Lindstr÷m S, Mendelsohn JB, Steplowski E, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Lacroix A, Li D, Mandelson MT, Olson SH, Petersen GM, Risch HA, Stolzenberg-Solomon RZ, Zheng W, Amundadottir L, Albanes D, Allen NE, Bamlet WR, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, Duell EJ, Elena J, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hassan M, Hutchinson A, Hunter DJ, Kooperberg C, Kurtz RC, Liu S, Overvad K, Palli D, Patel AV, Rabe KG, Shu XO, Slimani N, Tobias GS, Trichopoulos D, Van Den Eeden SK, Vineis P, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hoover RN, Hartge P, Kraft P
Source: PLoS One, 2013;8(9), p. e72311.
EPub date: 2013 Sep 13.
Circulating cytokines and gastric cancer risk.
Authors: Epplein M, Xiang YB, Cai Q, Peek RM Jr, Li H, Correa P, Gao J, Wu J, Michel A, Pawlita M, Zheng W, Shu XO
Source: Cancer Causes Control, 2013 Dec;24(12), p. 2245-50.
EPub date: 2013 Sep 20.
Effects of polymorphisms in translesion DNA synthesis genes on lung cancer risk and prognosis in Chinese men.
Authors: Xu HL, Gao XR, Zhang W, Cheng JR, Tan YT, Zheng W, Shu XO, Xiang YB
Source: Cancer Epidemiol, 2013 Dec;37(6), p. 917-22.
EPub date: 2013 Sep 5.
Dietary carbohydrates, refined grains, glycemic load, and risk of coronary heart disease in Chinese adults.
Authors: Yu D, Shu XO, Li H, Xiang YB, Yang G, Gao YT, Zheng W, Zhang X
Source: Am J Epidemiol, 2013 Nov 15;178(10), p. 1542-9.
EPub date: 2013 Sep 5.
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
Authors: Kelly TN, Takeuchi F, Tabara Y, Edwards TL, Kim YJ, Chen P, Li H, Wu Y, Yang CF, Zhang Y, Gu D, Katsuya T, Ohkubo T, Gao YT, Go MJ, Teo YY, Lu L, Lee NR, Chang LC, Peng H, Zhao Q, Nakashima E, Kita Y, Shu XO, Kim NH, Tai ES, Wang Y, Adair LS, Chen CH, Zhang S, Li C, Nabika T, Umemura S, Cai Q, Cho YS, Wong TY, Zhu J, Wu JY, Gao X, Hixson JE, Cai H, Lee J, Cheng CY, Rao DC, Xiang YB, Cho MC, Han BG, Wang A, Tsai FJ, Mohlke K, Lin X, Ikram MK, Lee JY, Zheng W, Tetsuro M, Kato N, He J
Source: Hypertension, 2013 Nov;62(5), p. 853-9.
EPub date: 2013 Sep 3.
Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population.
Authors: Kweon SS, Shu XO, Xiang Y, Cai H, Yang G, Ji BT, Li H, Gao YT, Zheng W, Epplein M
Source: J Nutr, 2013 Nov;143(11), p. 1736-42.
EPub date: 2013 Aug 28.
Circulating C-reactive protein and colorectal cancer risk: a report from the Shanghai Men's Health Study.
Authors: Wu J, Cai Q, Li H, Cai H, Gao J, Yang G, Zheng W, Xiang YB, Shu XO
Source: Carcinogenesis, 2013 Dec;34(12), p. 2799-803.
EPub date: 2013 Aug 28.
Fruit and vegetable intake and the risk of colorectal cancer: results from the Shanghai Men's Health Study.
Authors: Vogtmann E, Xiang YB, Li HL, Levitan EB, Yang G, Waterbor JW, Gao J, Cai H, Xie L, Wu QJ, Zhang B, Gao YT, Zheng W, Shu XO
Source: Cancer Causes Control, 2013 Nov;24(11), p. 1935-45.
EPub date: 2013 Aug 4.
Fruit and vegetable intake and risk of CHD: results from prospective cohort studies of Chinese adults in Shanghai.
Authors: Yu D, Zhang X, Gao YT, Li H, Yang G, Huang J, Zheng W, Xiang YB, Shu XO
Source: Br J Nutr, 2014 Jan 28;111(2), p. 353-62.
EPub date: 2013 Jul 19.
Vegetable-based dietary pattern and liver cancer risk: results from the Shanghai women's and men's health studies.
Authors: Zhang W, Xiang YB, Li HL, Yang G, Cai H, Ji BT, Gao YT, Zheng W, Shu XO
Source: Cancer Sci, 2013 Oct;104(10), p. 1353-61.
EPub date: 2013 Aug 5.
Associations of Tai Chi, walking, and jogging with mortality in Chinese men.
Authors: Wang N, Zhang X, Xiang YB, Li H, Yang G, Gao J, Zheng W, Shu XO
Source: Am J Epidemiol, 2013 Sep 1;178(5), p. 791-6.
EPub date: 2013 Jun 27.
Visceral adiposity and risk of coronary heart disease in relatively lean Chinese adults.
Authors: Zhang X, Shu XO, Li H, Yang G, Xiang YB, Cai Q, Ji BT, Gao YT, Zheng W
Source: Int J Cardiol, 2013 Oct 3;168(3), p. 2141-5.
EPub date: 2013 Mar 1.
Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
Authors: Wu C, Kraft P, Stolzenberg-Solomon R, Steplowski E, Brotzman M, Xu M, Mudgal P, Amundadottir L, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, Kooperberg C, Petersen GM, Zheng W, Albanes D, Boutron-Ruault MC, Buring JE, Canzian F, Cao G, Duell EJ, Elena JW, Gaziano JM, Giovannucci EL, Hallmans G, Hutchinson A, Hunter DJ, Jenab M, Jiang G, Khaw KT, LaCroix A, Li Z, Mendelsohn JB, Panico S, Patel AV, Qian ZR, Riboli E, Sesso H, Shen H, Shu XO, Tjonneland A, Tobias GS, Trichopoulos D, Virtamo J, Visvanathan K, Wactawski-Wende J, Wang C, Yu K, Zeleniuch-Jacquotte A, Chanock S, Hoover R, Hartge P, Fuchs CS, Lin D, Wolpin BM
Source: Gut, 2014 Jan;63(1), p. 152-60.
EPub date: 2012 Nov 24.