|Grant Number:||5UM1CA164974-02 Interpret this number|
|Primary Investigator:||Rosenberg, Lynn|
|Organization:||Boston University Medical Campus|
|Project Title:||A Follow-Up Study for Causes of Cancer in Black Women|
DESCRIPTION (provided by applicant): The Black Women's Health Study (BWHS), the largest follow-up study for cancer in African American (AA) women, began in 1995 when 59,000 women (median age, 38) from across the U.S. enrolled. The BWHS has successfully followed participants with biennial questionnaires for data on incident disease and medical, reproductive, behavioral, psychosocial, and socioeconomic factors, linked addresses to U.S. census data, and are currently linking to air pollution data. Cancer diagnoses are validated by pathology data from hospitals and cancer registries. A DNA bio repository was established through collection of cheek cell samples from 26,800 participants. Despite initial slow accrual of cancers due to the young age of participants at entry, the BWHS has published extensively on risk factors for breast cancer; sufficient cases of lung cancer, colorectal cancer, and colon adenomas are now available. We propose to (1) continue follow-up/data collection; (2) establish a repository of 17,800 blood samples; (3) share data/samples in consortia projects. Continuation of the BWHS is highly desirable: 90% of participants are still cancer-free; follow-up has been successful and unbiased; the cohort has reached ages at which cancer incidence increases markedly; effects of exposures (e.g., severe obesity, racism) that are less common in other populations can be studied; the DNA has made valuable contributions to genetic cancer studies and is a major replication source for studies of breast cancer and related phenotypes in AA and other groups; the BWHS is a key contributor to consortia projects of rarer cancers in /\As; and the BWHS has been highly productive. Because levels of many blood markers are unfavorable among AAs and few studies of blood biomarkers in relation to cancer incidence have been carried out specifically in /\As, we propose to establish a repository of blood samples in the BWHS. A successful pilot study demonstrated the feasibility of our methods and participation was unbiased and similar to that in other large follow-up studies. The repository will increase by 60% the limited number of AA women with available blood samples being followed in U.S. cancer cohort studies. AA women continue to be disproportionately affected by many cancers. Continuation of the BWHS will permit continuation of its valuable contributions to understanding cancer etiology in this understudied group. A blood repository will greatly increase the value of the BWHS resource by permitting studies that help to fill the knowledge gap about the relation of biomarkers to cancer incidence and survival in AAs. The assessment of serious nonmalignant illnesses in the BWHS enhances the value of this resource at no cost to the study of cancer.
Important Role of Menarche in Development of Estrogen Receptor-Negative Breast Cancer in African American Women.
Authors: Ambrosone CB, Zirpoli G, Hong CC, Yao S, Troester MA, Bandera EV, Schedin P, Bethea TN, Borges V, Park SY, Chandra D, Rosenberg L, Kolonel LN, Olshan AF, Palmer JR
Source: J Natl Cancer Inst, 2015 Sep;107(9), p. null.
EPub date: 2015 Jun 17.
Lactation in Relation to Long-Term Maternal Weight Gain in African-American Women.
Authors: Palmer JR, Kipping-Ruane K, Wise LA, Yu J, Rosenberg L
Source: Am J Epidemiol, 2015 Jun 15;181(12), p. 932-9.
EPub date: 2015 May 5.
A case-control analysis of oral contraceptive use and breast cancer subtypes in the African American Breast Cancer Epidemiology and Risk Consortium.
Authors: Bethea TN, Rosenberg L, Hong CC, Troester MA, Lunetta KL, Bandera EV, Schedin P, Kolonel LN, Olshan AF, Ambrosone CB, Palmer JR
Source: Breast Cancer Res, 2015 Feb 21;17, p. 22.
EPub date: 2015 Feb 21.
Obesity, body fat distribution, and risk of breast cancer subtypes in African American women participating in the AMBER Consortium.
Authors: Bandera EV, Chandran U, Hong CC, Troester MA, Bethea TN, Adams-Campbell LL, Haiman CA, Park SY, Olshan AF, Ambrosone CB, Palmer JR, Rosenberg L
Source: Breast Cancer Res Treat, 2015 Apr;150(3), p. 655-66.
EPub date: 2015 Mar 26.
Higher diet quality is inversely associated with mortality in African-American women.
Authors: Boggs DA, Ban Y, Palmer JR, Rosenberg L
Source: J Nutr, 2015 Mar;145(3), p. 547-54.
EPub date: 2014 Dec 31.
Prospective approach to breast cancer risk prediction in African American women: the black women's health study model.
Authors: Boggs DA, Rosenberg L, Adams-Campbell LL, Palmer JR
Source: J Clin Oncol, 2015 Mar 20;33(9), p. 1038-44.
EPub date: 2015 Jan 26.
Night-shift work and incident diabetes among African-American women.
Authors: Vimalananda VG, Palmer JR, Gerlovin H, Wise LA, Rosenzweig JL, Rosenberg L, Ruiz NarvŠez EA
Source: Diabetologia, 2015 Apr;58(4), p. 699-706.
EPub date: 2015 Jan 14.
Depressive symptoms and risk of uterine leiomyomata.
Authors: Wise LA, Li S, Palmer JR, Rosenberg L
Source: Am J Obstet Gynecol, 2015 May;212(5), p. 617.e1-10.
EPub date: 2014 Dec 13.
Obesity and weight gain in relation to incidence of sarcoidosis in US black women: data from the Black Women's Health Study.
Authors: Cozier YC, Coogan PF, Govender P, Berman JS, Palmer JR, Rosenberg L
Source: Chest, 2015 Apr;147(4), p. 1086-93.
Active and passive smoking and the incidence of asthma in the Black Women's Health Study.
Authors: Coogan PF, Castro-Webb N, Yu J, O'Connor GT, Palmer JR, Rosenberg L
Source: Am J Respir Crit Care Med, 2015 Jan 15;191(2), p. 168-76.
Intrauterine devices and endometrial cancer risk: a pooled analysis of the Epidemiology of Endometrial Cancer Consortium.
Authors: Felix AS, Gaudet MM, La Vecchia C, Nagle CM, Shu XO, Weiderpass E, Adami HO, Beresford S, Bernstein L, Chen C, Cook LS, De Vivo I, Doherty JA, Friedenreich CM, Gapstur SM, Hill D, Horn-Ross PL, Lacey JV, Levi F, Liang X, Lu L, Magliocco A, McCann SE, Negri E, Olson SH, Palmer JR, Patel AV, Petruzella S, Prescott J, Risch HA, Rosenberg L, Sherman ME, Spurdle AB, Webb PM, Wise LA, Xiang YB, Xu W, Yang HP, Yu H, Zeleniuch-Jacquotte A, Brinton LA
Source: Int J Cancer, 2015 Mar 1;136(5), p. E410-22.
EPub date: 2014 Sep 30.
Parity, lactation, and breast cancer subtypes in African American women: results from the AMBER Consortium.
Authors: Palmer JR, Viscidi E, Troester MA, Hong CC, Schedin P, Bethea TN, Bandera EV, Borges V, McKinnon C, Haiman CA, Lunetta K, Kolonel LN, Rosenberg L, Olshan AF, Ambrosone CB
Source: J Natl Cancer Inst, 2014 Oct;106(10), p. null.
EPub date: 2014 Sep 15.
Hypothesis about alternative use of redundant regulatory elements was validated by recent results.
Authors: Ruiz-NarvŠez EA
Source: Med Hypotheses, 2014 Oct;83(4), p. 513-4.
EPub date: 2014 Aug 20.
Preterm birth and subsequent risk of type 2 diabetes in black women.
Authors: James-Todd T, Wise L, Boggs D, Rich-Edwards J, Rosenberg L, Palmer J
Source: Epidemiology, 2014 Nov;25(6), p. 805-10.
Birth weight and risk of type 2 diabetes in the black women's health study: does adult BMI play a mediating role?
Authors: Ruiz-NarvŠez EA, Palmer JR, Gerlovin H, Wise LA, Vimalananda VG, Rosenzweig JL, Rosenberg L
Source: Diabetes Care, 2014 Sep;37(9), p. 2572-8.
A prospective study of physical activity and breast cancer incidence in African-American women.
Authors: Rosenberg L, Palmer JR, Bethea TN, Ban Y, Kipping-Ruane K, Adams-Campbell LL
Source: Cancer Epidemiol Biomarkers Prev, 2014 Nov;23(11), p. 2522-31.
EPub date: 2014 Aug 7.
A pooled analysis of body mass index and pancreatic cancer mortality in african americans.
Authors: Bethea TN, Kitahara CM, Sonderman J, Patel AV, Harvey C, Knutsen SF, Park Y, Park SY, Fraser GE, Jacobs EJ, Purdue MP, Stolzenberg-Solomon RZ, Gillanders EM, Blot WJ, Palmer JR, Kolonel LN
Source: Cancer Epidemiol Biomarkers Prev, 2014 Oct;23(10), p. 2119-25.
EPub date: 2014 Jul 13.
Polymorphisms in vitamin D-related genes and risk of uterine leiomyomata.
Authors: Wise LA, Ruiz-NarvŠez EA, Haddad SA, Rosenberg L, Palmer JR
Source: Fertil Steril, 2014 Aug;102(2), p. 503-510.e1.
EPub date: 2014 Jun 2.
Depressive symptoms, antidepressant use, and the incidence of diabetes in the Black Women's Health Study.
Authors: Vimalananda VG, Palmer JR, Gerlovin H, Wise LA, Rosenzweig JL, Rosenberg L, Ruiz-NarvŠez EA
Source: Diabetes Care, 2014 Aug;37(8), p. 2211-7.
EPub date: 2014 May 1.
Prospective study of dietary fat and risk of uterine leiomyomata.
Authors: Wise LA, Radin RG, Kumanyika SK, Ruiz-NarvŠez EA, Palmer JR, Rosenberg L
Source: Am J Clin Nutr, 2014 May;99(5), p. 1105-16.
EPub date: 2014 Mar 5.
Racism, segregation, and risk of obesity in the Black Women's Health Study.
Authors: Cozier YC, Yu J, Coogan PF, Bethea TN, Rosenberg L, Palmer JR
Source: Am J Epidemiol, 2014 Apr 1;179(7), p. 875-83.
EPub date: 2014 Feb 27.
Bilateral oophorectomy and risk of cancer in African American women.
Authors: Boggs DA, Palmer JR, Rosenberg L
Source: Cancer Causes Control, 2014 Apr;25(4), p. 507-13.
EPub date: 2014 Feb 1.
Depressive symptoms and the incidence of adult-onset asthma in African American women.
Authors: Coogan PF, Yu J, O'Connor GT, Brown TA, Palmer JR, Rosenberg L
Source: Ann Allergy Asthma Immunol, 2014 Apr;112(4), p. 333-8.e1.
EPub date: 2014 Jan 17.