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Grant Details

Grant Number: 5UM1CA164974-02 Interpret this number
Primary Investigator: Rosenberg, Lynn
Organization: Boston University Medical Campus
Project Title: A Follow-Up Study for Causes of Cancer in Black Women
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): The Black Women's Health Study (BWHS), the largest follow-up study for cancer in African American (AA) women, began in 1995 when 59,000 women (median age, 38) from across the U.S. enrolled. The BWHS has successfully followed participants with biennial questionnaires for data on incident disease and medical, reproductive, behavioral, psychosocial, and socioeconomic factors, linked addresses to U.S. census data, and are currently linking to air pollution data. Cancer diagnoses are validated by pathology data from hospitals and cancer registries. A DNA bio repository was established through collection of cheek cell samples from 26,800 participants. Despite initial slow accrual of cancers due to the young age of participants at entry, the BWHS has published extensively on risk factors for breast cancer; sufficient cases of lung cancer, colorectal cancer, and colon adenomas are now available. We propose to (1) continue follow-up/data collection; (2) establish a repository of 17,800 blood samples; (3) share data/samples in consortia projects. Continuation of the BWHS is highly desirable: 90% of participants are still cancer-free; follow-up has been successful and unbiased; the cohort has reached ages at which cancer incidence increases markedly; effects of exposures (e.g., severe obesity, racism) that are less common in other populations can be studied; the DNA has made valuable contributions to genetic cancer studies and is a major replication source for studies of breast cancer and related phenotypes in AA and other groups; the BWHS is a key contributor to consortia projects of rarer cancers in /\As; and the BWHS has been highly productive. Because levels of many blood markers are unfavorable among AAs and few studies of blood biomarkers in relation to cancer incidence have been carried out specifically in /\As, we propose to establish a repository of blood samples in the BWHS. A successful pilot study demonstrated the feasibility of our methods and participation was unbiased and similar to that in other large follow-up studies. The repository will increase by 60% the limited number of AA women with available blood samples being followed in U.S. cancer cohort studies. AA women continue to be disproportionately affected by many cancers. Continuation of the BWHS will permit continuation of its valuable contributions to understanding cancer etiology in this understudied group. A blood repository will greatly increase the value of the BWHS resource by permitting studies that help to fill the knowledge gap about the relation of biomarkers to cancer incidence and survival in AAs. The assessment of serious nonmalignant illnesses in the BWHS enhances the value of this resource at no cost to the study of cancer.

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Publications

Prospective study of dietary fat and risk of uterine leiomyomata.
Authors: Wise LA, Radin RG, Kumanyika SK, Ruiz-Narváez EA, Palmer JR, Rosenberg L
Source: Am J Clin Nutr, 2014 May;99(5), p. 1105-16.
EPub date: 2014 Mar 5.
PMID: 24598152
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Racism, segregation, and risk of obesity in the Black Women's Health Study.
Authors: Cozier YC, Yu J, Coogan PF, Bethea TN, Rosenberg L, Palmer JR
Source: Am J Epidemiol, 2014 Apr 1;179(7), p. 875-83.
EPub date: 2014 Feb 27.
PMID: 24585257
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Depressive symptoms and the incidence of adult-onset asthma in African American women.
Authors: Coogan PF, Yu J, O'Connor GT, Brown TA, Palmer JR, Rosenberg L
Source: Ann Allergy Asthma Immunol, 2014 Apr;112(4), p. 333-8.e1.
EPub date: 2014 Jan 17.
PMID: 24440322
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Restaurant foods, sugar-sweetened soft drinks, and obesity risk among young African American women.
Authors: Boggs DA, Rosenberg L, Coogan PF, Makambi KH, Adams-Campbell LL, Palmer JR
Source: Ethn Dis, 2013 Autumn;23(4), p. 445-51.
PMID: 24392607
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A collaborative study of the etiology of breast cancer subtypes in African American women: the AMBER consortium.
Authors: Palmer JR, Ambrosone CB, Olshan AF
Source: Cancer Causes Control, 2014 Mar;25(3), p. 309-19.
EPub date: 2013 Dec 17.
PMID: 24343304
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Type 2 diabetes and the risk of colorectal adenomas: Black Women's Health Study.
Authors: Dash C, Palmer JR, Boggs DA, Rosenberg L, Adams-Campbell LL
Source: Am J Epidemiol, 2014 Jan 1;179(1), p. 112-9.
EPub date: 2013 Oct 2.
PMID: 24091887
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A prospective study of smoking and breast cancer risk among African-American women.
Authors: Rosenberg L, Boggs DA, Bethea TN, Wise LA, Adams-Campbell LL, Palmer JR
Source: Cancer Causes Control, 2013 Dec;24(12), p. 2207-15.
EPub date: 2013 Oct 2.
PMID: 24085586
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??Mortality among African American women with sarcoidosis: data from the Black Women's Health Study.
Authors: Tukey MH, Berman JS, Boggs Et Al DA
Source: Sarcoidosis Vasc Diffuse Lung Dis, 2013 Aug 1;30(2), p. 128-33.
EPub date: 2013 Aug 1.
PMID: 24071884
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Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
Authors: Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE, Fox CS
Source: PLoS Genet, 2013;9(8), p. e1003681.
EPub date: 2013 Aug 15.
PMID: 23966867
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Body size and time-to-pregnancy in black women.
Authors: Wise LA, Palmer JR, Rosenberg L
Source: Hum Reprod, 2013 Oct;28(10), p. 2856-64.
EPub date: 2013 Aug 19.
PMID: 23958939
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Physical activity and the incidence of obesity in young African-American women.
Authors: Rosenberg L, Kipping-Ruane KL, Boggs DA, Palmer JR
Source: Am J Prev Med, 2013 Sep;45(3), p. 262-8.
PMID: 23953351
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Long-term diet quality is associated with lower obesity risk in young African American women with normal BMI at baseline.
Authors: Boggs DA, Rosenberg L, Rodríguez-Bernal CL, Palmer JR
Source: J Nutr, 2013 Oct;143(10), p. 1636-41.
EPub date: 2013 Jul 31.
PMID: 23902954
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Experiences of racism and the incidence of adult-onset asthma in the Black Women's Health Study.
Authors: Coogan PF, Yu J, O'Connor GT, Brown TA, Cozier YC, Palmer JR, Rosenberg L
Source: Chest, 2014 Mar 1;145(3), p. 480-5.
PMID: 23887828
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Is the observed association between dairy intake and fibroids in African Americans explained by genetic ancestry?
Authors: Wise LA, Palmer JR, Ruiz-Narvaez E, Reich DE, Rosenberg L
Source: Am J Epidemiol, 2013 Oct 1;178(7), p. 1114-9.
EPub date: 2013 Jul 3.
PMID: 23825169
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Obesity in relation to lung cancer incidence in African American women.
Authors: Bethea TN, Rosenberg L, Charlot M, O'Connor GT, Adams-Campbell LL, Palmer JR
Source: Cancer Causes Control, 2013 Sep;24(9), p. 1695-703.
EPub date: 2013 Jun 7.
PMID: 23744044
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Age at natural menopause in relation to all-cause and cause-specific mortality in a follow-up study of US black women.
Authors: Li S, Rosenberg L, Wise LA, Boggs DA, LaValley M, Palmer JR
Source: Maturitas, 2013 Jul;75(3), p. 246-52.
EPub date: 2013 May 1.
PMID: 23642541
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Genome-wide association study of age at menarche in African-American women.
Authors: Demerath EW, Liu CT, Franceschini N, Chen G, Palmer JR, Smith EN, Chen CT, Ambrosone CB, Arnold AM, Bandera EV, Berenson GS, Bernstein L, Britton A, Cappola AR, Carlson CS, Chanock SJ, Chen W, Chen Z, Deming SL, Elks CE, Evans MK, Gajdos Z, Henderson BE, Hu JJ, Ingles S, John EM, Kerr KF, Kolonel LN, Le Marchand L, Lu X, Millikan RC, Musani SK, Nock NL, North K, Nyante S, Press MF, Rodriquez-Gil JL, Ruiz-Narvaez EA, Schork NJ, Srinivasan SR, Woods NF, Zheng W, Ziegler RG, Zonderman A, Heiss G, Gwen Windham B, Wellons M, Murray SS, Nalls M, Pastinen T, Rajkovic A, Hirschhorn J, Adrienne Cupples L, Kooperberg C, Murabito JM, Haiman CA
Source: Hum Mol Genet, 2013 Aug 15;22(16), p. 3329-46.
EPub date: 2013 Apr 17.
PMID: 23599027
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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Authors: Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls MA, Sun YV, Wojczynski MK, Yanek LR, Aldrich MC, Ademola A, Amos CI, Bandera EV, Bock CH, Britton A, Broeckel U, Cai Q, Caporaso NE, Carlson CS, Carpten J, Casey G, Chen WM, Chen F, Chen YD, Chiang CW, Coetzee GA, Demerath E, Deming-Halverson SL, Driver RW, Dubbert P, Feitosa MF, Feng Y, Freedman BI, Gillanders EM, Gottesman O, Guo X, Haritunians T, Harris T, Harris CC, Hennis AJ, Hernandez DG, McNeill LH, Howard TD, Howard BV, Howard VJ, Johnson KC, Kang SJ, Keating BJ, Kolb S, Kuller LH, Kutlar A, Langefeld CD, Lettre G, Lohman K, Lotay V, Lyon H, Manson JE, Maixner W, Meng YA, Monroe KR, Morhason-Bello I, Murphy AB, Mychaleckyj JC, Nadukuru R, Nathanson KL, Nayak U, N'diaye A, Nemesure B, Wu SY, Leske MC, Neslund-Dudas C, Neuhouser M, Nyante S, Ochs-Balcom H, Ogunniyi A, Ogundiran TO, Ojengbede O, Olopade OI, Palmer JR, Ruiz-Narvaez EA, Palmer ND, Press MF, Rampersaud E, Rasmussen-Torvik LJ, Rodriguez-Gil JL, Salako B, Schadt EE, Schwartz AG, Shriner DA, Siscovick D, Smith SB, Wassertheil-Smoller S, Speliotes EK, Spitz MR, Sucheston L, Taylor H, Tayo BO, Tucker MA, Van Den Berg DJ, Edwards DR, Wang Z, Wiencke JK, Winkler TW, Witte JS, Wrensch M, Wu X, Yang JJ, Levin AM, Young TR, Zakai NA, Cushman M, Zanetti KA, Zhao JH, Zhao W, Zheng Y, Zhou J, Ziegler RG, Zmuda JM, Fernandes JK, Gilkeson GS, Kamen DL, Hunt KJ, Spruill IJ, Ambrosone CB, Ambs S, Arnett DK, Atwood L, Becker DM, Berndt SI, Bernstein L, Blot WJ, Borecki IB, Bottinger EP, Bowden DW, Burke G, Chanock SJ, Cooper RS, Ding J, Duggan D, Evans MK, Fox C, Garvey WT, Bradfield JP, Hakonarson H, Grant SF, Hsing A, Chu L, Hu JJ, Huo D, Ingles SA, John EM, Jordan JM, Kabagambe EK, Kardia SL, Kittles RA, Goodman PJ, Klein EA, Kolonel LN, Le Marchand L, Liu S, McKnight B, Millikan RC, Mosley TH, Padhukasahasram B, Williams LK, Patel SR, Peters U, Pettaway CA, Peyser PA, Psaty BM, Redline S, Rotimi CN, Rybicki BA, Sale MM, Schreiner PJ, Signorello LB, Singleton AB, Stanford JL, Strom SS, Thun MJ, Vitolins M, Zheng W, Moore JH, Williams SM, Ketkar S, Zhu X, Zonderman AB, NABEC Consortium, UKBEC Consortium, BioBank Japan Project, AGEN Consortium, Kooperberg C, Papanicolaou GJ, Henderson BE, Reiner AP, Hirschhorn JN, Loos RJ, North KE, Haiman CA
Source: Nat Genet, 2013 Jun;45(6), p. 690-6.
EPub date: 2013 Apr 14.
PMID: 23583978
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Replication of genetic loci for sarcoidosis in US black women: data from the Black Women's Health Study.
Authors: Cozier Y, Ruiz-Narvaez E, McKinnon C, Berman J, Rosenberg L, Palmer J
Source: Hum Genet, 2013 Jul;132(7), p. 803-10.
EPub date: 2013 Mar 31.
PMID: 23543185
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Central adiposity and other anthropometric factors in relation to risk of macrosomia in an African American population.
Authors: Li S, Rosenberg L, Palmer JR, Phillips GS, Heffner LJ, Wise LA
Source: Obesity (Silver Spring), 2013 Jan;21(1), p. 178-84.
PMID: 23505184
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Validation of a breast cancer risk prediction model developed for Black women.
Authors: Boggs DA, Rosenberg L, Pencina MJ, Adams-Campbell LL, Palmer JR
Source: J Natl Cancer Inst, 2013 Mar 6;105(5), p. 361-7.
EPub date: 2013 Feb 14.
PMID: 23411594
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Estrogen receptor positive tumors: do reproductive factors explain differences in incidence between black and white women?
Authors: Warner ET, Tamimi RM, Boggs DA, Rosner B, Rosenberg L, Colditz GA, Palmer JR
Source: Cancer Causes Control, 2013 Apr;24(4), p. 731-9.
EPub date: 2013 Feb 5.
PMID: 23380944
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