|Grant Number:||5P01CA154292-03 Interpret this number|
|Primary Investigator:||Miglioretti, Diana|
|Organization:||Group Health Cooperative|
|Project Title:||Risk-Based Breast Cancer Screening in Community Settings|
The program theme is to identify effective breast cancer screening strategies for women with diverse levels of breast cancer risk to maximize screening benefits while minimizing potential harms. Program aims follow the premise that breast cancer screening will be most effective when: guidelines are based on accurate risk estimates that are tied to the effectiveness and harms of screening tests; women and physicians are informed about screening test performance based on risk level; risk-based screening practices are equitable; and high-quality comparative effectiveness research results are disseminated into community practice. Program goals will be met through three complementary research projects and three shared resource cores. Project 1, Risk Assessment in Community Practice: Developing Better Models, will improve prediction of breast cancer and breast cancer subtypes among women of varying ages and race/ethnicity and evaluate whether predicted risk can be used to optimize screening outcomes. Project 2, Comparative Effectiveness of Imaging Strategies for Breast Cancer Screening in Community Practice, will characterize the performance of advanced imaging technologies and screening strategies according to age, race/ethnicity, breast density, and overall breast cancer risk. Project 3, Community-based Utilization of Breast Imaging Technologies, will assess risk-based screening in diverse populations and identify disparities in access and use of new technologies. The Administrative Core will support logistical requirements and facilitate communication and data sharing. The Biostatistics and Data Management Core will coordinate data collection, management, and analysis and will develop statistical methods. The Comparative Effectiveness Core will use simulation modeling to estimate long-term implications of different screening practices on population health. The program represents an integrated effort to improve screening with the overall aim of averting deaths from breast cancer while minimizing harms.
Patterns of breast magnetic resonance imaging use in community practice.
Authors: Wernli KJ, DeMartini WB, Ichikawa L, Lehman CD, Onega T, Kerlikowske K, Henderson LM, Geller BM, Hofmann M, Yankaskas BC, Breast Cancer Surveillance Consortium
Source: JAMA Intern Med, 2014 Jan;174(1), p. 125-32.
Mammographic screening interval in relation to tumor characteristics and false-positive risk by race/ethnicity and age.
Authors: O'Meara ES, Zhu W, Hubbard RA, Braithwaite D, Kerlikowske K, Dittus KL, Geller B, Wernli KJ, Miglioretti DL
Source: Cancer, 2013 Nov 15;119(22), p. 3959-67.
EPub date: 2013 Aug 26.
Impact of mammography screening interval on breast cancer diagnosis by menopausal status and BMI.
Authors: Dittus K, Geller B, Weaver DL, Kerlikowske K, Zhu W, Hubbard R, Braithwaite D, O'Meara ES, Miglioretti DL, Breast Cancer Surveillance Consortium
Source: J Gen Intern Med, 2013 Nov;28(11), p. 1454-62.
EPub date: 2013 Jun 13.
Benign breast disease, mammographic breast density, and the risk of breast cancer.
Authors: Tice JA, O'Meara ES, Weaver DL, Vachon C, Ballard-Barbash R, Kerlikowske K
Source: J Natl Cancer Inst, 2013 Jul 17;105(14), p. 1043-9.
EPub date: 2013 Jun 6.