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Grant Details

Grant Number: 5R01CA140002-06 Interpret this number
Primary Investigator: Slattery, Martha
Organization: University Of Utah
Project Title: Disparities in Breast Cancer: Development and Survival in Hispanic and Nhw Women
Fiscal Year: 2013
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Abstract

The incidence rates of breast cancer vary more than two-fold between Hispanic and non-Hispanic white (NHW) women; Hispanic women have worse survival after diagnosis than NHW women. We propose to evaluate these health disparities in breast cancer development and surival along the continuation of American Indian to NHW women utilizing existing resources from the 4 Corner's States, California, and Mexico City. Existing resources utilized will be behorial and social lifestyle exposure data along with DNA obtained at the time of interview. Survival data has been ongoing and will continue to be monitored via local SEER and CDC tumor registries. Genetic and lifestyle data are available from approximately 8039 Hispanic and NHW cases of breast cancer and population-based controls. By pooling resources from three studies, we will efficiently examine a biological pathway that we believe is important to breast cancer development and survival and that influences differences in breast cancer rates among Hispanic and NHW women. Evaluation of genetic factors will focus on a pathway that appears to work in conjunction with insulin-, estrogen-, and inflammation-related pathways and represents a point of convergence. This pathway, which we call the Convergence of Hormones, Inflammation, and Energy Functioning (CHIEF) Signaling Pathway has not been studied comprehensively in either Hispanic or non-Hispanic white women and will include enes to be studied include SOC1, SOC2, AKT, FRAP1(alias mTOR), P13K, STK11, AMP, PTEN, VEGF, & S6K1,S6K2, CRP, NFKB, IKB, IL10, IL8, IL6, TNFalpha using an Illumina platform. Breast cancer associations will be tested between genetic polymorphisms and haplotypes of these genes in Hispanic and NHW women and by proportion of American Indian ancestry. Interaction of signaling pathway genes with each other and with NSAIDs, aspirin, BMI, estrogen, and physical activity will be examined. These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women.

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Publications

Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study.
Authors: Slattery ML, Lundgreen A, Hines LM, Torres-Mejia G, Wolff RK, Stern MC, John EM
Source: Breast Cancer Res Treat, 2014 Aug;147(1), p. 145-58.
EPub date: 2014 Aug 8.
PMID: 25104439
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Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study.
Authors: Slattery ML, Hines LH, Lundgreen A, Baumgartner KB, Wolff RK, Stern MC, John EM
Source: Cancer Causes Control, 2014 Sep;25(9), p. 1211-25.
EPub date: 2014 Jul 4.
PMID: 24993294
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Genetic variants in interleukin genes are associated with breast cancer risk and survival in a genetically admixed population: the Breast Cancer Health Disparities Study.
Authors: Slattery ML, Herrick JS, Torres-Mejia G, John EM, Giuliano AR, Hines LM, Stern MC, Baumgartner KB, Presson AP, Wolff RK
Source: Carcinogenesis, 2014 Aug;35(8), p. 1750-9.
EPub date: 2014 Mar 26.
PMID: 24670917
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Genetic variants and non-genetic factors predict circulating vitamin D levels in Hispanic and non-Hispanic White women: the Breast Cancer Health Disparities Study.
Authors: Wang W, Ingles SA, Torres-Mejía G, Stern MC, Stanczyk FZ, Schwartz GG, Nelson DO, Fejerman L, Wolff RK, Slattery ML, John EM
Source: Int J Mol Epidemiol Genet, 2014;5(1), p. 31-46.
EPub date: 2014 Feb 17.
PMID: 24596595
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The influence of genetic ancestry and ethnicity on breast cancer survival associated with genetic variation in the TGF-?-signaling pathway: The Breast Cancer Health Disparities Study.
Authors: Slattery ML, Lundgreen A, Stern MC, Hines L, Wolff RK, Giuliano AR, Baumgartner KB, John EM
Source: Cancer Causes Control, 2014 Mar;25(3), p. 293-307.
EPub date: 2013 Dec 12.
PMID: 24337772
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Associations between genetic variants in the TGF-? signaling pathway and breast cancer risk among Hispanic and non-Hispanic white women.
Authors: Boone SD, Baumgartner KB, Baumgartner RN, Connor AE, Pinkston CM, John EM, Hines LM, Stern MC, Giuliano AR, Torres-Mejia G, Brock GN, Groves FD, Kerber RA, Wolff RK, Slattery ML
Source: Breast Cancer Res Treat, 2013 Sep;141(2), p. 287-97.
EPub date: 2013 Sep 14.
PMID: 24036662
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Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study.
Authors: Slattery ML, John EM, Stern MC, Herrick J, Lundgreen A, Giuliano AR, Hines L, Baumgartner KB, Torres-Mejia G, Wolff RK
Source: Breast Cancer Res Treat, 2013 Aug;140(3), p. 587-601.
EPub date: 2013 Aug 3.
PMID: 23912956
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Angiogenesis genes, dietary oxidative balance and breast cancer risk and progression: the Breast Cancer Health Disparities Study.
Authors: Slattery ML, John EM, Torres-Mejia G, Lundgreen A, Lewinger JP, Stern MC, Hines L, Baumgartner KB, Giuliano AR, Wolff RK
Source: Int J Cancer, 2014 Feb 1;134(3), p. 629-44.
EPub date: 2013 Aug 9.
PMID: 23832257
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Matrix metalloproteinase genes are associated with breast cancer risk and survival: the Breast Cancer Health Disparities Study.
Authors: Slattery ML, John E, Torres-Mejia G, Stern M, Lundgreen A, Hines L, Giuliano A, Baumgartner K, Herrick J, Wolff RK
Source: PLoS One, 2013;8(5), p. e63165.
EPub date: 2013 May 16.
PMID: 23696797
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Telomere length, telomere-related genes, and breast cancer risk: the breast cancer health disparities study.
Authors: Pellatt AJ, Wolff RK, Torres-Mejia G, John EM, Herrick JS, Lundgreen A, Baumgartner KB, Giuliano AR, Hines LM, Fejerman L, Cawthon R, Slattery ML
Source: Genes Chromosomes Cancer, 2013 Jul;52(7), p. 595-609.
EPub date: 2013 Apr 30.
PMID: 23629941
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Genetic ancestry modifies the association between genetic risk variants and breast cancer risk among Hispanic and non-Hispanic white women.
Authors: Fejerman L, Stern MC, Ziv E, John EM, Torres-Mejia G, Hines LM, Wolff R, Wang W, Baumgartner KB, Giuliano AR, Slattery ML
Source: Carcinogenesis, 2013 Aug;34(8), p. 1787-93.
EPub date: 2013 Apr 4.
PMID: 23563089
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Differences between Hispanic and non-Hispanic white women with breast cancer for clinical characteristics and their correlates.
Authors: Connor AE, Baumgartner RN, Yang D, Slattery ML, Giuliano AR, Risendal BC, Abdel-Maksoud MM, Baumgartner KB
Source: Ann Epidemiol, 2013 Apr;23(4), p. 227-32.
EPub date: 2013 Jan 28.
PMID: 23369848
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Genetic variation in bone morphogenetic proteins and breast cancer risk in hispanic and non-hispanic white women: The breast cancer health disparities study.
Authors: Slattery ML, John EM, Torres-Mejia G, Herrick JS, Giuliano AR, Baumgartner KB, Hines LM, Wolff RK
Source: Int J Cancer, 2013 Jun 15;132(12), p. 2928-39.
EPub date: 2012 Dec 13.
PMID: 23180569
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Associations between TCF7L2 polymorphisms and risk of breast cancer among Hispanic and non-Hispanic white women: the Breast Cancer Health Disparities Study.
Authors: Connor AE, Baumgartner RN, Baumgartner KB, Kerber RA, Pinkston C, John EM, Torres-Mejia G, Hines L, Giuliano A, Wolff RK, Slattery ML
Source: Breast Cancer Res Treat, 2012 Nov;136(2), p. 593-602.
EPub date: 2012 Oct 21.
PMID: 23085767
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ADRB2 G-G haplotype associated with breast cancer risk among Hispanic and non-Hispanic white women: interaction with type 2 diabetes and obesity.
Authors: Connor A, Baumgartner RN, Kerber RA, O'Brien E, Rai SN, Wolff RK, Slattery ML, Giuliano AR, Risendal BC, Byers TE, Baumgartner KB
Source: Cancer Causes Control, 2012 Oct;23(10), p. 1653-63.
EPub date: 2012 Aug 5.
PMID: 22864926
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Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population.
Authors: Slattery ML, John EM, Torres-Mejia G, Lundgreen A, Herrick JS, Baumgartner KB, Hines LM, Stern MC, Wolff RK
Source: Carcinogenesis, 2012 Aug;33(8), p. 1512-21.
EPub date: 2012 May 4.
PMID: 22562547
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Vitamin D intake, vitamin D receptor polymorphisms, and breast cancer risk among women living in the southwestern U.S.
Authors: Rollison DE, Cole AL, Tung KH, Slattery ML, Baumgartner KB, Byers T, Wolff RK, Giuliano AR
Source: Breast Cancer Res Treat, 2012 Apr;132(2), p. 683-91.
EPub date: 2011 Dec 1.
PMID: 22130867
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Behavioral risk factors and their relationship to tumor characteristics in Hispanic and non-Hispanic white long-term breast cancer survivors.
Authors: Abdel-Maksoud MF, Risendal BC, Slattery ML, Giuliano AR, Baumgartner KB, Byers TE
Source: Breast Cancer Res Treat, 2012 Jan;131(1), p. 169-76.
EPub date: 2011 Aug 6.
PMID: 21822637
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Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States.
Authors: Slattery ML, Baumgartner KB, Giuliano AR, Byers T, Herrick JS, Wolff RK
Source: Breast Cancer Res Treat, 2011 Sep;129(2), p. 531-9.
EPub date: 2011 Apr 8.
PMID: 21475998
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Comparative analysis of breast cancer risk factors among Hispanic and non-Hispanic white women.
Authors: Hines LM, Risendal B, Slattery ML, Baumgartner KB, Giuliano AR, Sweeney C, Rollison DE, Byers T
Source: Cancer, 2010 Jul 1;116(13), p. 3215-23.
PMID: 20564638
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