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Grant Details

Grant Number: 5P01CA163233-02 Interpret this number
Primary Investigator: Katz, Steven
Organization: University Of Michigan
Project Title: The Challenge of Individualizing Treatments for Patients with Breast Cancer
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): Treatments for cancer impose substantial burden and morbidity but net survival benefit of different strategies is often small and virtually always uncertain. Thus, clinicians may do more harm than good if treatment is too aggressive. There are a number of management strategies for breast cancer aimed at reducing unnecessary morbidity and burden on patients with favorable disease. A key barrier to advancing these initiatives is the need for a better understanding of the challenges of individualizing cancer care The goal of this program is to improve population health by helping clinicians and their patients address the challenges of individualizing treatment of breast cancer for patients with favorable prognosis. Objective 1: To examine the challenges of individualizing treatment for women with breast cancer. Two projects will each undertake an observational study of patients newly diagnosed with breast cancer (including their attending clinicians) who were reported to the SEER registries of Georgia and New Jersey during an 18 month period to examine patient and clinician factors associated with key evaluative tests, treatments, and patient appraisal of decision quality. Project 1 will focus on challenges for surgeons and their patients with regard to locoregional therapy. Project 2 will focus on challenges for medical oncologists and their patients with regard to systemic therapy. Objective 2: To improve treatment decision quality. Project 3 will perform a randomized controlled trial of a practice based online decision tool for patients newly diagnosed with breast cancer in the Detroit and Atlanta SEER regions intended to improve decision quality. Objective 3: To accelerate the dissemination of SEER-based research findings by implementing and evaluating a tailored online portal aimed at all surgeons and medical oncologists who treated the patient samples in P1 and P2 to evaluate whether our research findings can more directly and promptly inform clinicians knowledge and attitudes about individualizing treatment. Objective 4: To advance methods in SEER population translational research focused on quality of cancer care. We propose four shared resource cores that will support program project activities, advance innovative methods in oncology population sciences, and advance team mission and long-term strategic planning.

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Publications

Concerns about cancer risk and experiences with genetic testing in a diverse population of patients with breast cancer.
Authors: Jagsi R, Griffith KA, Kurian AW, Morrow M, Hamilton AS, Graff JJ, Katz SJ, Hawley ST
Source: J Clin Oncol, 2015 May 10;33(14), p. 1584-91.
EPub date: 2015 Apr 6.
PMID: 25847940
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How can we best respect patient autonomy in breast cancer treatment decisions?
Authors: Martinez KA, Kurian AW, Hawley ST, Jagsi R
Source: Breast Cancer Manag, 2015;4(1), p. 53-64.
PMID: 25733982
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Patient-Reported Quality of Life and Satisfaction With Cosmetic Outcomes After Breast Conservation and Mastectomy With and Without Reconstruction: Results of a Survey of Breast Cancer Survivors.
Authors: Jagsi R, Li Y, Morrow M, Janz N, Alderman A, Graff J, Hamilton A, Katz S, Hawley S
Source: Ann Surg, 2015 Jan 23;null, p. null.
EPub date: 2015 Jan 23.
PMID: 25654742
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Development and psychometric properties of a brief measure of subjective decision quality for breast cancer treatment.
Authors: Resnicow K, Abrahamse P, Tocco RS, Hawley S, Griggs J, Janz N, Fagerlin A, Wilson A, Ward KC, Gabram SG, Katz S
Source: BMC Med Inform Decis Mak, 2014 Dec 5;14, p. 110.
EPub date: 2014 Dec 5.
PMID: 25476986
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Access to breast reconstruction after mastectomy and patient perspectives on reconstruction decision making.
Authors: Morrow M, Li Y, Alderman AK, Jagsi R, Hamilton AS, Graff JJ, Hawley ST, Katz SJ
Source: JAMA Surg, 2014 Oct;149(10), p. 1015-21.
PMID: 25141939
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Social and Clinical Determinants of Contralateral Prophylactic Mastectomy.
Authors: Hawley ST, Jagsi R, Morrow M, Janz NK, Hamilton A, Graff JJ, Katz SJ
Source: JAMA Surg, 2014 May 21;null, p. null.
EPub date: 2014 May 21.
PMID: 24849045
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Shared decision making for treatment of cancer: challenges and opportunities.
Authors: Katz SJ, Belkora J, Elwyn G
Source: J Oncol Pract, 2014 May;10(3), p. 206-8.
PMID: 24839284
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Impact of adjuvant chemotherapy on long-term employment of survivors of early-stage breast cancer.
Authors: Jagsi R, Hawley ST, Abrahamse P, Li Y, Janz NK, Griggs JJ, Bradley C, Graff JJ, Hamilton A, Katz SJ
Source: Cancer, 2014 Jun 15;120(12), p. 1854-62.
EPub date: 2014 Apr 28.
PMID: 24777606
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Long-term financial burden of breast cancer: experiences of a diverse cohort of survivors identified through population-based registries.
Authors: Jagsi R, Pottow JA, Griffith KA, Bradley C, Hamilton AS, Graff J, Katz SJ, Hawley ST
Source: J Clin Oncol, 2014 Apr 20;32(12), p. 1269-76.
EPub date: 2014 Mar 24.
PMID: 24663041
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Patient-physician shared decision making--reply.
Authors: Katz SJ, Hawley S
Source: JAMA, 2014 Feb 26;311(8), p. 864.
PMID: 24570256
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Treatment decision aids are unlikely to cut healthcare costs.
Authors: Katz SJ
Source: BMJ, 2014 Feb 5;348, p. g1172.
EPub date: 2014 Feb 5.
PMID: 24500345
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The value of sharing treatment decision making with patients: expecting too much?
Authors: Katz SJ, Hawley S
Source: JAMA, 2013 Oct 16;310(15), p. 1559-60.
PMID: 24061082
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Addressing overtreatment in breast cancer: The doctors' dilemma.
Authors: Katz SJ, Morrow M
Source: Cancer, 2013 Oct 15;119(20), p. 3584-8.
EPub date: 2013 Aug 2.
PMID: 23913512
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Contralateral prophylactic mastectomy for breast cancer: addressing peace of mind.
Authors: Katz SJ, Morrow M
Source: JAMA, 2013 Aug 28;310(8), p. 793-4.
PMID: 23907558
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Surgeon-level variation in patients' appraisals of their breast cancer treatment experiences.
Authors: Hawley ST, Lillie SE, Morris A, Graff JJ, Hamilton A, Katz SJ
Source: Ann Surg Oncol, 2013 Jan;20(1), p. 7-14.
EPub date: 2012 Oct 6.
PMID: 23054105
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