|Grant Number:||5UM1CA167552-02 Interpret this number|
|Primary Investigator:||Willett, Walter|
|Organization:||Harvard School Of Public Health|
|Project Title:||Cancer Epidemiology Cohort in Male Health Professionals|
DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Health Professional's Follow-up Study, a cancer epidemiology cohort of 51,529 men enrolled in 1986 when they were 40 to 75 years of age. The cohort is currently supported as part of a Program Project; consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The cohort includes a biorespository with DNA samples from 35,000 participants, plasma from 18,000, nails from 33,000, and tumor tissue from approximately 70% of incident colon, prostate, and other important cancers. In this cohort, smoking, weight, medication use, and medical diagnoses have been updated every 2 years and information on diet and physical activity has been updated every four years. Much other valuable exposure information is collected. Follow-up of the cohort has been approximately 94% complete at each of the 2-year follow-up cycles and ascertainment of deaths is at least 98% complete. This cohort has been highly productive; 341 papers have been published during the current funding cycle or are in press. Novel findings include the identification of modifiable risk factors that account for one third of aggressive prostate cancer; strong evidence based on plasma levels, germ line DNA, and gene expression in tumor tissue that vitamin D is importantly involved in risk of death from prostate cancer; and roles of specific diet factors and physical activity after the diagnosis f colorectal and prostate cancer in survival. This cohort has also contributed to 19 cancer-related consortia during this funding period and has an active data sharing component. The HPFS is unique as the largest cancer cohort in men with many repeated measures of exposure over more than two decades, which provides a powerful view of realistic latent periods for carcinogenesis and the opportunity to examine both pre-and post-diagnosis determinants of survival from cancer. Because of the massive, detailed data and biological samples already in hand, the nearly complete ascertainment of incident cancers with high rates of tissue acquisition, and the entry of the younger members of the cohort into the age of maximal cancer incidence, this cohort will be even more fruitful scientifically during the next five years.
Lower Urinary Tract Symptoms and Risk of Bladder Cancer in Men: Results From the Health Professionals Follow-up Study.
Authors: Zhou J, Kelsey KT, Smith S, Giovannucci E, Michaud DS
Source: Urology, 2015 Apr 8;null, p. null.
EPub date: 2015 Apr 8.
Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: Results from five cohort studies.
Authors: Fondell E, O'Reilly ÉJ, Fitzgerald KC, Falcone GJ, Kolonel LN, Park Y, Gapstur SM, Ascherio A
Source: Amyotroph Lateral Scler Frontotemporal Degener, 2015 Mar 30;null, p. 1-6.
EPub date: 2015 Mar 30.
Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.
Authors: Nan H, Hutter CM, Lin Y, Jacobs EJ, Ulrich CM, White E, Baron JA, Berndt SI, Brenner H, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Casey G, Chang-Claude J, Chanock SJ, Cotterchio M, Duggan D, Figueiredo JC, Fuchs CS, Giovannucci EL, Gong J, Haile RW, Harrison TA, Hayes RB, Hoffmeister M, Hopper JL, Hudson TJ, Jenkins MA, Jiao S, Lindor NM, Lemire M, Le Marchand L, Newcomb PA, Ogino S, Pflugeisen BM, Potter JD, Qu C, Rosse SA, Rudolph A, Schoen RE, Schumacher FR, Seminara D, Slattery ML, Thibodeau SN, Thomas F, Thornquist M, Warnick GS, Zanke BW, Gauderman WJ, Peters U, Hsu L, Chan AT, CCFR, GECCO
Source: JAMA, 2015 Mar 17;313(11), p. 1133-42.
The TMPRSS2:ERG fusion and response to androgen deprivation therapy for prostate cancer.
Authors: Graff RE, Pettersson A, Lis RT, DuPre N, Jordahl KM, Nuttall E, Rider JR, Fiorentino M, Sesso HD, Kenfield SA, Loda M, Giovannucci EL, Rosner B, Nguyen PL, Sweeney CJ, Mucci LA, on behalf of the Transdisciplinary Prostate Cancer Partnership ToPCaP
Source: Prostate, 2015 Mar 1;null, p. null.
EPub date: 2015 Mar 1.
Alternate Healthy Eating Index 2010 and risk of chronic obstructive pulmonary disease among US women and men: prospective study.
Authors: Varraso R, Chiuve SE, Fung TT, Barr RG, Hu FB, Willett WC, Camargo CA
Source: BMJ, 2015 Feb 3;350, p. h286.
EPub date: 2015 Feb 3.
Fish intake and risk of chronic obstructive pulmonary disease in 2 large US cohorts.
Authors: Varraso R, Barr RG, Willett WC, Speizer FE, Camargo CA Jr
Source: Am J Clin Nutr, 2015 Feb;101(2), p. 354-61.
EPub date: 2014 Nov 26.
Dietary phosphatidylcholine intake and type 2 diabetes in men and women.
Authors: Li Y, Wang DD, Chiuve SE, Manson JE, Willett WC, Hu FB, Qi L
Source: Diabetes Care, 2015 Feb;38(2), p. e13-4.
Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
Authors: Song M, Nishihara R, Wang M, Chan AT, Qian ZR, Inamura K, Zhang X, Ng K, Kim SA, Mima K, Sukawa Y, Nosho K, Fuchs CS, Giovannucci EL, Wu K, Ogino S
Source: Gut, 2015 Jan 15;null, p. null.
EPub date: 2015 Jan 15.
Television watching and risk of colorectal adenoma.
Authors: Cao Y, Keum NN, Chan AT, Fuchs CS, Wu K, Giovannucci EL
Source: Br J Cancer, 2015 Mar 3;112(5), p. 934-42.
EPub date: 2015 Jan 15.
A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
Authors: Vijai J, Wang Z, Berndt SI, Skibola CF, Slager SL, de Sanjose S, Melbye M, Glimelius B, Bracci PM, Conde L, Birmann BM, Wang SS, Brooks-Wilson AR, Lan Q, de Bakker PI, Vermeulen RC, Portlock C, Ansell SM, Link BK, Riby J, North KE, Gu J, Hjalgrim H, Cozen W, Becker N, Teras LR, Spinelli JJ, Turner J, Zhang Y, Purdue MP, Giles GG, Kelly RS, Zeleniuch-Jacquotte A, Ennas MG, Monnereau A, Bertrand KA, Albanes D, Lightfoot T, Yeager M, Chung CC, Burdett L, Hutchinson A, Lawrence C, Montalvan R, Liang L, Huang J, Ma B, Villano DJ, Maria A, Corines M, Thomas T, Novak AJ, Dogan A, Liebow M, Thompson CA, Witzig TE, Habermann TM, Weiner GJ, Smith MT, Holly EA, Jackson RD, Tinker LF, Ye Y, Adami HO, Smedby KE, De Roos AJ, Hartge P, Morton LM, Severson RK, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Diver WR, Vajdic CM, Armstrong BK, Kricker A, Zheng T, Holford TR, Severi G, Vineis P, Ferri GM, Ricco R, Miligi L, Clavel J, Giovannucci E, Kraft P, Virtamo J, Smith A, Kane E, Roman E, Chiu BC, Fraumeni JF, Wu X, Cerhan JR, Offit K, Chanock SJ, Rothman N, Nieters A
Source: Nat Commun, 2015 Jan 8;6, p. 5751.
EPub date: 2015 Jan 8.
Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer.
Authors: Julin B, Shui I, Heaphy CM, Joshu CE, Meeker AK, Giovannucci E, De Vivo I, Platz EA
Source: Br J Cancer, 2015 Feb 17;112(4), p. 769-76.
EPub date: 2015 Jan 6.
Association between dietary whole grain intake and risk of mortality: two large prospective studies in US men and women.
Authors: Wu H, Flint AJ, Qi Q, van Dam RM, Sampson LA, Rimm EB, Holmes MD, Willett WC, Hu FB, Sun Q
Source: JAMA Intern Med, 2015 Mar;175(3), p. 373-84.
The high prevalence of undiagnosed prostate cancer at autopsy: implications for epidemiology and treatment of prostate cancer in the Prostate-specific Antigen-era.
Authors: Jahn JL, Giovannucci EL, Stampfer MJ
Source: Int J Cancer, 2014 Dec 29;null, p. null.
EPub date: 2014 Dec 29.
Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy.
Authors: Li TT, Ogino S, Qian ZR
Source: World J Gastroenterol, 2014 Dec 21;20(47), p. 17699-708.