|Grant Number:||5UM1CA167552-02 Interpret this number|
|Primary Investigator:||Willett, Walter|
|Organization:||Harvard School Of Public Health|
|Project Title:||Cancer Epidemiology Cohort in Male Health Professionals|
DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Health Professional's Follow-up Study, a cancer epidemiology cohort of 51,529 men enrolled in 1986 when they were 40 to 75 years of age. The cohort is currently supported as part of a Program Project; consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The cohort includes a biorespository with DNA samples from 35,000 participants, plasma from 18,000, nails from 33,000, and tumor tissue from approximately 70% of incident colon, prostate, and other important cancers. In this cohort, smoking, weight, medication use, and medical diagnoses have been updated every 2 years and information on diet and physical activity has been updated every four years. Much other valuable exposure information is collected. Follow-up of the cohort has been approximately 94% complete at each of the 2-year follow-up cycles and ascertainment of deaths is at least 98% complete. This cohort has been highly productive; 341 papers have been published during the current funding cycle or are in press. Novel findings include the identification of modifiable risk factors that account for one third of aggressive prostate cancer; strong evidence based on plasma levels, germ line DNA, and gene expression in tumor tissue that vitamin D is importantly involved in risk of death from prostate cancer; and roles of specific diet factors and physical activity after the diagnosis f colorectal and prostate cancer in survival. This cohort has also contributed to 19 cancer-related consortia during this funding period and has an active data sharing component. The HPFS is unique as the largest cancer cohort in men with many repeated measures of exposure over more than two decades, which provides a powerful view of realistic latent periods for carcinogenesis and the opportunity to examine both pre-and post-diagnosis determinants of survival from cancer. Because of the massive, detailed data and biological samples already in hand, the nearly complete ascertainment of incident cancers with high rates of tissue acquisition, and the entry of the younger members of the cohort into the age of maximal cancer incidence, this cohort will be even more fruitful scientifically during the next five years.
Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
Authors: Song M, Nishihara R, Wang M, Chan AT, Qian ZR, Inamura K, Zhang X, Ng K, Kim SA, Mima K, Sukawa Y, Nosho K, Fuchs CS, Giovannucci EL, Wu K, Ogino S
Source: Gut, 2015 Jan 15;null, p. null.
EPub date: 2015 Jan 15.
A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
Authors: Vijai J, Wang Z, Berndt SI, Skibola CF, Slager SL, de Sanjose S, Melbye M, Glimelius B, Bracci PM, Conde L, Birmann BM, Wang SS, Brooks-Wilson AR, Lan Q, de Bakker PI, Vermeulen RC, Portlock C, Ansell SM, Link BK, Riby J, North KE, Gu J, Hjalgrim H, Cozen W, Becker N, Teras LR, Spinelli JJ, Turner J, Zhang Y, Purdue MP, Giles GG, Kelly RS, Zeleniuch-Jacquotte A, Ennas MG, Monnereau A, Bertrand KA, Albanes D, Lightfoot T, Yeager M, Chung CC, Burdett L, Hutchinson A, Lawrence C, Montalvan R, Liang L, Huang J, Ma B, Villano DJ, Maria A, Corines M, Thomas T, Novak AJ, Dogan A, Liebow M, Thompson CA, Witzig TE, Habermann TM, Weiner GJ, Smith MT, Holly EA, Jackson RD, Tinker LF, Ye Y, Adami HO, Smedby KE, De Roos AJ, Hartge P, Morton LM, Severson RK, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Diver WR, Vajdic CM, Armstrong BK, Kricker A, Zheng T, Holford TR, Severi G, Vineis P, Ferri GM, Ricco R, Miligi L, Clavel J, Giovannucci E, Kraft P, Virtamo J, Smith A, Kane E, Roman E, Chiu BC, Fraumeni JF, Wu X, Cerhan JR, Offit K, Chanock SJ, Rothman N, Nieters A
Source: Nat Commun, 2015 Jan 8;6, p. 5751.
EPub date: 2015 Jan 8.
The high prevalence of undiagnosed prostate cancer at autopsy: implications for epidemiology and treatment of prostate cancer in the Prostate-specific Antigen-era.
Authors: Jahn JL, Giovannucci EL, Stampfer MJ
Source: Int J Cancer, 2014 Dec 29;null, p. null.
EPub date: 2014 Dec 29.
Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy.
Authors: Li TT, Ogino S, Qian ZR
Source: World J Gastroenterol, 2014 Dec 21;20(47), p. 17699-708.
Weight training, aerobic physical activities, and long-term waist circumference change in men.
Authors: Mekary RA, Grøntved A, Despres JP, De Moura LP, Asgarzadeh M, Willett WC, Rimm EB, Giovannucci E, Hu FB
Source: Obesity (Silver Spring), 2015 Feb;23(2), p. 461-7.
EPub date: 2014 Dec 19.
Calcium and phosphorus intake and prostate cancer risk: a 24-y follow-up study.
Authors: Wilson KM, Shui IM, Mucci LA, Giovannucci E
Source: Am J Clin Nutr, 2015 Jan;101(1), p. 173-83.
EPub date: 2014 Nov 19.
Rice consumption and risk of cardiovascular disease: results from a pooled analysis of 3 U.S. cohorts.
Authors: Muraki I, Wu H, Imamura F, Laden F, Rimm EB, Hu FB, Willett WC, Sun Q
Source: Am J Clin Nutr, 2015 Jan;101(1), p. 164-72.
EPub date: 2014 Nov 12.
Derivation and validation of homocysteine score in u.s. Men and women.
Authors: Jung S, Je Y, Giovannucci EL, Rosner B, Ogino S, Cho E
Source: J Nutr, 2015 Jan;145(1), p. 96-104.
EPub date: 2014 Nov 12.
Post diagnosis diet quality and colorectal cancer survival in women.
Authors: Fung TT, Kashambwa R, Sato K, Chiuve SE, Fuchs CS, Wu K, Giovannucci E, Ogino S, Hu FB, Meyerhardt JA
Source: PLoS One, 2014;9(12), p. e115377.
EPub date: 2014 Dec 15.
Selenium supplementation and prostate cancer mortality.
Authors: Kenfield SA, Van Blarigan EL, DuPre N, Stampfer MJ, L Giovannucci E, Chan JM
Source: J Natl Cancer Inst, 2015 Jan;107(1), p. 360.
EPub date: 2014 Dec 12.
Genetic variants of adiponectin and risk of colorectal cancer.
Authors: Song M, Gong J, Giovannucci EL, Berndt SI, Brenner H, Chang-Claude J, Curtis KR, Harrison TA, Hoffmeister M, Hsu L, Jiao S, Le Marchand L, Potter JD, Schoen RE, Seminara D, Slattery ML, White E, Wu K, Ogino S, Fuchs CS, Hunter DJ, Tworoger SS, Hu FB, Rimm E, Jensen M, Peters U, Chan AT
Source: Int J Cancer, 2014 Nov 27;null, p. null.
EPub date: 2014 Nov 27.
DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma.
Authors: Liu Y, Garrett ME, Yaspan BL, Bailey JC, Loomis SJ, Brilliant M, Budenz DL, Christen WG, Fingert JH, Gaasterland D, Gaasterland T, Kang JH, Lee RK, Lichter P, Moroi SE, Realini A, Richards JE, Schuman JS, Scott WK, Singh K, Sit AJ, Vollrath D, Weinreb R, Wollstein G, Zack DJ, Zhang K, Pericak-Vance MA, Haines JL, Pasquale LR, Wiggs JL, Allingham RR, Ashley-Koch AE, Hauser MA
Source: Invest Ophthalmol Vis Sci, 2014 Nov 20;55(12), p. 8251-8.
EPub date: 2014 Nov 20.
Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region.
Authors: Nishihara R, Wang M, Qian ZR, Baba Y, Yamauchi M, Mima K, Sukawa Y, Kim SA, Inamura K, Zhang X, Wu K, Giovannucci EL, Chan AT, Fuchs CS, Ogino S, Schernhammer ES
Source: Am J Clin Nutr, 2014 Dec;100(6), p. 1479-88.
EPub date: 2014 Oct 8.
Circulating biomarkers of dairy fat and risk of incident stroke in U.S. men and women in 2 large prospective cohorts.
Authors: Yakoob MY, Shi P, Hu FB, Campos H, Rexrode KM, Orav EJ, Willett WC, Mozaffarian D
Source: Am J Clin Nutr, 2014 Dec;100(6), p. 1437-47.
EPub date: 2014 Sep 24.
Survival among patients with pancreatic cancer and long-standing or recent-onset diabetes mellitus.
Authors: Yuan C, Rubinson DA, Qian ZR, Wu C, Kraft P, Bao Y, Ogino S, Ng K, Clancy TE, Swanson RS, Gorman MJ, Brais LK, Li T, Stampfer MJ, Hu FB, Giovannucci EL, Kulke MH, Fuchs CS, Wolpin BM
Source: J Clin Oncol, 2015 Jan 1;33(1), p. 29-35.
EPub date: 2014 Nov 17.
Lifestyle-based prediction model for the prevention of CVD: the Healthy Heart Score.
Authors: Chiuve SE, Cook NR, Shay CM, Rexrode KM, Albert CM, Manson JE, Willett WC, Rimm EB
Source: J Am Heart Assoc, 2014 Nov 14;3(6), p. e000954.
EPub date: 2014 Nov 14.
RNF43 is frequently mutated in colorectal and endometrial cancers.
Authors: Giannakis M, Hodis E, Jasmine Mu X, Yamauchi M, Rosenbluh J, Cibulskis K, Saksena G, Lawrence MS, Qian ZR, Nishihara R, Van Allen EM, Hahn WC, Gabriel SB, Lander ES, Getz G, Ogino S, Fuchs CS, Garraway LA
Source: Nat Genet, 2014 Dec;46(12), p. 1264-6.
EPub date: 2014 Oct 26.