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Grant Details

Grant Number: 1UM1CA176726-01 Interpret this number
Primary Investigator: Willett, Walter
Organization: Harvard School Of Public Health
Project Title: Life Course Cancer Epidemiology Cohort in Women
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Nurses' Health Study II, a cancer epidemiology cohort of 116,430 women enrolled at ages 25 to 42 years in 1989. The cohort is currently supported as an R0I. Consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The NHSII biorepository includes plasma, red blood cells, white blood cells, and first morning urine samples from 29,611 women; for two thirds of these women we have timed follicular and luteal premenopausal samples. Over 16,000 provided a 2nd blood/urine sample in 2008-11 when the majorities were postmenopausal, and we have cheek cell DNA from an additional 29,859 women. We have collected archival tissue blocks for incident breast and ovarian cancers and melanoma (approximately 70% of requested have been obtained). We have created tissue microarrays for breast cancers that are already being used extensively. Prediagnostic mammograms have been collected for breast cancer cases and controls, as well as pathology material from previous biopsies of benign lesions. The follow-up of the NHSII cohort, conducted every two years, has been high and accounts for 93% of potential person-time. We have nearly complete ascertainment of deaths using the National Death Index and other methods. The NHSII cohort is unique in many ways, as the only large cohort of women enrolled before menopause, with information on smoking, weight, medication use, and medical diagnoses updated every 2 years and information on diet and physical activity updated every four years. Further, we have collected detailed on in utero and infant exposures (from participants' mothers), diet during high school, and other valuable exposure information. This cohort has been highly productive; over 150 papers have been published during the last five years, and the rate of publication is increasingly rapidly. This cohort is a member of the NCI Cohort Consortium, has participated in many collaborative studies, and has an active resource-sharing component. Enhancements of the cohort infrastructure involve assessment of breast tumor DNA methylation and RNA expression and the gut microbiome, and development of software to account for measurement error.

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Publications

Personal history of rosacea and risk of incident cancer among women in the US.
Authors: Li WQ, Zhang M, Danby FW, Han J, Qureshi AA
Source: Br J Cancer, 2015 Jul 28;113(3), p. 520-3.
EPub date: 2015 Jun 23.
PMID: 26103573
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Adolescent dietary vitamin D and sun exposure in relation to benign breast disease.
Authors: Boeke CE, Tamimi RM, Berkey CS, Colditz GA, Giovannucci E, Malspeis S, Willett WC, Frazier AL
Source: Cancer Causes Control, 2015 Aug;26(8), p. 1181-7.
EPub date: 2015 Jun 18.
PMID: 26084210
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Genome-wide significant risk associations for mucinous ovarian carcinoma.
Authors: Ovarian Cancer Association Consortium, Australian Cancer Study, Australian Ovarian Cancer Study Group
Source: Nat Genet, 2015 Aug;47(8), p. 888-97.
EPub date: 2015 Jun 15.
PMID: 26075790
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Oral Contraceptive Use and Colorectal Cancer in the Nurses' Health Study I and II.
Authors: Charlton BM, Wu K, Zhang X, Giovannucci EL, Fuchs CS, Missmer SA, Rosner B, Hankinson SE, Willett WC, Michels KB
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jun 10;null, p. null.
EPub date: 2015 Jun 10.
PMID: 26063479
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Caffeine, Coffee, and Tea Intake and Urinary Estrogens and Estrogen Metabolites in Premenopausal Women.
Authors: Sisti JS, Hankinson SE, Caporaso NE, Gu F, Tamimi RM, Rosner B, Xu X, Ziegler R, Eliassen AH
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jun 10;null, p. null.
EPub date: 2015 Jun 10.
PMID: 26063478
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Infertility, fertility treatment, and risk of hypertension.
Authors: Farland LV, Grodstein F, Srouji SS, Forman JP, Rich-Edwards J, Chavarro JE, Missmer SA
Source: Fertil Steril, 2015 Jun 11;null, p. null.
EPub date: 2015 Jun 11.
PMID: 26049054
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Job strain and changes in the body mass index among working women: a prospective study.
Authors: Fujishiro K, Lawson CC, Hibert EL, Chavarro JE, Rich-Edwards JW
Source: Int J Obes (Lond), 2015 May 19;null, p. null.
EPub date: 2015 May 19.
PMID: 25986779
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Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses.
Authors: Adebamowo SN, Spiegelman D, Willett WC, Rexrode KM
Source: Am J Clin Nutr, 2015 Jun;101(6), p. 1269-77.
EPub date: 2015 May 6.
PMID: 25948665
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The association of body size in early to mid-life with adult urinary 6-sulfatoxymelatonin levels among night shift health care workers.
Authors: Ramin CA, Massa J, Wegrzyn LR, Brown SB, Pierre-Paul J, Devore EE, Hankinson SE, Schernhammer ES
Source: BMC Public Health, 2015 May 6;15, p. 467.
EPub date: 2015 May 6.
PMID: 25943349
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Premenopausal plasma carotenoids, fluorescent oxidation products, and subsequent breast cancer risk in the nurses' health studies.
Authors: Sisti JS, Lindström S, Kraft P, Tamimi RM, Rosner BA, Wu T, Willett WC, Eliassen AH
Source: Breast Cancer Res Treat, 2015 Jun;151(2), p. 415-25.
EPub date: 2015 Apr 28.
PMID: 25917867
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Changes in intake of protein foods, carbohydrate amount and quality, and long-term weight change: results from 3 prospective cohorts.
Authors: Smith JD, Hou T, Ludwig DS, Rimm EB, Willett W, Hu FB, Mozaffarian D
Source: Am J Clin Nutr, 2015 Jun;101(6), p. 1216-24.
EPub date: 2015 Apr 8.
PMID: 25854882
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Adolescent and Early Adulthood Dietary Carbohydrate Quantity and Quality in Relation to Breast Cancer Risk.
Authors: Farvid MS, Eliassen AH, Cho E, Chen WY, Willett WC
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jul;24(7), p. 1111-20.
EPub date: 2015 Mar 24.
PMID: 25805068
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Long-term risk of type 2 diabetes mellitus in relation to BMI and weight change among women with a history of gestational diabetes mellitus: a prospective cohort study.
Authors: Bao W, Yeung E, Tobias DK, Hu FB, Vaag AA, Chavarro JE, Mills JL, Grunnet LG, Bowers K, Ley SH, Kiely M, Olsen SF, Zhang C
Source: Diabetologia, 2015 Jun;58(6), p. 1212-9.
EPub date: 2015 Mar 22.
PMID: 25796371
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Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics.
Authors: Bertrand KA, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Norman AD, Visscher DW, Couch FJ, Shepherd J, Chen YY, Fan B, Wu FF, Ma L, Beck AH, Cummings SR, Kerlikowske K, Vachon CM
Source: Cancer Epidemiol Biomarkers Prev, 2015 May;24(5), p. 798-809.
EPub date: 2015 Feb 25.
PMID: 25716949
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Asthma history, job type and job changes among US nurses.
Authors: Dumas O, Varraso R, Zock JP, Henneberger PK, Speizer FE, Wiley AS, Le Moual N, Camargo CA Jr
Source: Occup Environ Med, 2015 Jul;72(7), p. 482-8.
EPub date: 2015 Feb 24.
PMID: 25713153
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Antihypertensive medication use and incident breast cancer in women.
Authors: Devore EE, Kim S, Ramin CA, Wegrzyn LR, Massa J, Holmes MD, Michels KB, Tamimi RM, Forman JP, Schernhammer ES
Source: Breast Cancer Res Treat, 2015 Feb;150(1), p. 219-29.
EPub date: 2015 Feb 21.
PMID: 25701121
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Investigation of dietary factors and endometrial cancer risk using a nutrient-wide association study approach in the EPIC and Nurses' Health Study (NHS) and NHSII.
Authors: Merritt MA, Tzoulaki I, Tworoger SS, De Vivo I, Hankinson SE, Fernandes J, Tsilidis KK, Weiderpass E, Tjønneland A, Petersen KE, Dahm CC, Overvad K, Dossus L, Boutron-Ruault MC, Fagherazzi G, Fortner RT, Kaaks R, Aleksandrova K, Boeing H, Trichopoulou A, Bamia C, Trichopoulos D, Palli D, Grioni S, Tumino R, Sacerdote C, Mattiello A, Bueno-de-Mesquita HB, Onland-Moret NC, Peeters PH, Gram IT, Skeie G, Quirós JR, Duell EJ, Sánchez MJ, Salmerón D, Barricarte A, Chamosa S, Ericson U, Sonestedt E, Nilsson LM, Idahl A, Khaw KT, Wareham N, Travis RC, Rinaldi S, Romieu I, Patel CJ, Riboli E, Gunter MJ
Source: Cancer Epidemiol Biomarkers Prev, 2015 Feb;24(2), p. 466-71.
PMID: 25662427
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Prospective study of body size throughout the life-course and the incidence of endometrial cancer among premenopausal and postmenopausal women.
Authors: Dougan MM, Hankinson SE, Vivo ID, Tworoger SS, Glynn RJ, Michels KB
Source: Int J Cancer, 2015 Aug 1;137(3), p. 625-37.
EPub date: 2015 Feb 5.
PMID: 25641700
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