|Grant Number:||1UM1CA176726-01 Interpret this number|
|Primary Investigator:||Willett, Walter|
|Organization:||Harvard School Of Public Health|
|Project Title:||Life Course Cancer Epidemiology Cohort in Women|
DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Nurses' Health Study II, a cancer epidemiology cohort of 116,430 women enrolled at ages 25 to 42 years in 1989. The cohort is currently supported as an R0I. Consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The NHSII biorepository includes plasma, red blood cells, white blood cells, and first morning urine samples from 29,611 women; for two thirds of these women we have timed follicular and luteal premenopausal samples. Over 16,000 provided a 2nd blood/urine sample in 2008-11 when the majorities were postmenopausal, and we have cheek cell DNA from an additional 29,859 women. We have collected archival tissue blocks for incident breast and ovarian cancers and melanoma (approximately 70% of requested have been obtained). We have created tissue microarrays for breast cancers that are already being used extensively. Prediagnostic mammograms have been collected for breast cancer cases and controls, as well as pathology material from previous biopsies of benign lesions. The follow-up of the NHSII cohort, conducted every two years, has been high and accounts for 93% of potential person-time. We have nearly complete ascertainment of deaths using the National Death Index and other methods. The NHSII cohort is unique in many ways, as the only large cohort of women enrolled before menopause, with information on smoking, weight, medication use, and medical diagnoses updated every 2 years and information on diet and physical activity updated every four years. Further, we have collected detailed on in utero and infant exposures (from participants' mothers), diet during high school, and other valuable exposure information. This cohort has been highly productive; over 150 papers have been published during the last five years, and the rate of publication is increasingly rapidly. This cohort is a member of the NCI Cohort Consortium, has participated in many collaborative studies, and has an active resource-sharing component. Enhancements of the cohort infrastructure involve assessment of breast tumor DNA methylation and RNA expression and the gut microbiome, and development of software to account for measurement error.
Dense and Non-dense Mammographic Area and Risk of Breast Cancer by Age and Tumor Characteristics.
Authors: Bertrand KA, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Norman AD, Visscher DW, Couch FJ, Shepherd J, Chen YY, Fan B, Wu FF, Ma L, Beck AH, Cummings SR, Kerlikowske K, Vachon CM
Source: Cancer Epidemiol Biomarkers Prev, 2015 Feb 25;null, p. null.
EPub date: 2015 Feb 25.
Antihypertensive medication use and incident breast cancer in women.
Authors: Devore EE, Kim S, Ramin CA, Wegrzyn LR, Massa J, Holmes MD, Michels KB, Tamimi RM, Forman JP, Schernhammer ES
Source: Breast Cancer Res Treat, 2015 Feb;150(1), p. 219-29.
EPub date: 2015 Feb 21.
Investigation of Dietary Factors and Endometrial Cancer Risk Using a Nutrient-wide Association Study Approach in the EPIC and Nurses' Health Study (NHS) and NHSII.
Authors: Merritt MA, Tzoulaki I, Tworoger SS, De Vivo I, Hankinson SE, Fernandes J, Tsilidis KK, Weiderpass E, Tjønneland A, Petersen KE, Dahm CC, Overvad K, Dossus L, Boutron-Ruault MC, Fagherazzi G, Fortner RT, Kaaks R, Aleksandrova K, Boeing H, Trichopoulou A, Bamia C, Trichopoulos D, Palli D, Grioni S, Tumino R, Sacerdote C, Mattiello A, Bueno-de-Mesquita HB, Onland-Moret NC, Peeters PH, Gram IT, Skeie G, Quirós JR, Duell EJ, Sánchez MJ, Salmerón D, Barricarte A, Chamosa S, Ericson U, Sonestedt E, Nilsson LM, Idahl A, Khaw KT, Wareham N, Travis RC, Rinaldi S, Romieu I, Patel CJ, Riboli E, Gunter MJ
Source: Cancer Epidemiol Biomarkers Prev, 2015 Feb;24(2), p. 466-71.
Healthy lifestyle in the primordial prevention of cardiovascular disease among young women.
Authors: Chomistek AK, Chiuve SE, Eliassen AH, Mukamal KJ, Willett WC, Rimm EB
Source: J Am Coll Cardiol, 2015 Jan 6;65(1), p. 43-51.
Premenopausal plasma 25-hydroxyvitamin D, mammographic density, and risk of breast cancer.
Authors: Bertrand KA, Rosner B, Eliassen AH, Hankinson SE, Rexrode KM, Willett W, Tamimi RM
Source: Breast Cancer Res Treat, 2015 Jan;149(2), p. 479-87.
EPub date: 2014 Dec 28.
Weight training, aerobic physical activities, and long-term waist circumference change in men.
Authors: Mekary RA, Grøntved A, Despres JP, De Moura LP, Asgarzadeh M, Willett WC, Rimm EB, Giovannucci E, Hu FB
Source: Obesity (Silver Spring), 2015 Feb;23(2), p. 461-7.
EPub date: 2014 Dec 19.
Rice consumption and risk of cardiovascular disease: results from a pooled analysis of 3 U.S. cohorts.
Authors: Muraki I, Wu H, Imamura F, Laden F, Rimm EB, Hu FB, Willett WC, Sun Q
Source: Am J Clin Nutr, 2015 Jan;101(1), p. 164-72.
EPub date: 2014 Nov 12.
Migraine and breast cancer risk: a prospective cohort study and meta-analysis.
Authors: Winter AC, Rice MS, Fortner RT, Eliassen AH, Kurth T, Tamimi RM
Source: J Natl Cancer Inst, 2015 Jan;107(1), p. 381.
EPub date: 2014 Dec 12.
Prospective study of alcohol consumption and self-reported hearing loss in women.
Authors: Curhan SG, Eavey R, Wang M, Stampfer MJ, Curhan GC
Source: Alcohol, 2015 Feb;49(1), p. 71-7.
EPub date: 2014 Oct 31.
Intakes of fat and micronutrients between ages 13 and 18 years and the incidence of proliferative benign breast disease.
Authors: Su X, Boeke CE, Collins LC, Baer HJ, Willett WC, Schnitt SJ, Connolly JL, Rosner B, Colditz GA, Tamimi RM
Source: Cancer Causes Control, 2015 Jan;26(1), p. 79-90.
EPub date: 2014 Nov 7.
The interaction between early-life body size and physical activity on risk of breast cancer.
Authors: Oh H, Boeke CE, Tamimi RM, Smith-Warner SA, Wang M, Willett WC, Eliassen AH
Source: Int J Cancer, 2014 Oct 21;null, p. null.
EPub date: 2014 Oct 21.
Fish and fatty acid consumption and the risk of hearing loss in women.
Authors: Curhan SG, Eavey RD, Wang M, Rimm EB, Curhan GC
Source: Am J Clin Nutr, 2014 Nov;100(5), p. 1371-7.
EPub date: 2014 Sep 10.
Intake of dietary flavonoids and risk of epithelial ovarian cancer.
Authors: Cassidy A, Huang T, Rice MS, Rimm EB, Tworoger SS
Source: Am J Clin Nutr, 2014 Nov;100(5), p. 1344-51.
EPub date: 2014 Aug 20.
The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease.
Authors: Fu YP, Kohaar I, Moore LE, Lenz P, Figueroa JD, Tang W, Porter-Gill P, Chatterjee N, Scott-Johnson A, Garcia-Closas M, Muchmore B, Baris D, Paquin A, Ylaya K, Schwenn M, Apolo AB, Karagas MR, Tarway M, Johnson A, Mumy A, Schned A, Guedez L, Jones MA, Kida M, Hosain GM, Malats N, Kogevinas M, Tardon A, Serra C, Carrato A, Garcia-Closas R, Lloreta J, Wu X, Purdue M, Andriole GL Jr, Grubb RL 3rd, Black A, Landi MT, Caporaso NE, Vineis P, Siddiq A, Bueno-de-Mesquita HB, Trichopoulos D, Ljungberg B, Severi G, Weiderpass E, Krogh V, Dorronsoro M, Travis RC, Tjønneland A, Brennan P, Chang-Claude J, Riboli E, Prescott J, Chen C, De Vivo I, Govannucci E, Hunter D, Kraft P, Lindstrom S, Gapstur SM, Jacobs EJ, Diver WR, Albanes D, Weinstein SJ, Virtamo J, Kooperberg C, Hohensee C, Rodabough RJ, Cortessis VK, Conti DV, Gago-Dominguez M, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Haiman CA, Cussenot O, Cancel-Tassin G, Roupret M, Comperat E, Porru S, Carta A, Pavanello S, Arici C, Mastrangelo G, Grossman HB, Wang Z, Deng X, Chung CC, Hutchinson A, Burdette L, Wheeler W, Fraumeni J Jr, Chanock SJ, Hewitt SM, Silverman DT, Rothman N, Prokunina-Olsson L
Source: Cancer Res, 2014 Oct 15;74(20), p. 5808-18.
Bioactive prolactin levels and risk of breast cancer: a nested case-control study.
Authors: Tworoger SS, Rice MS, Rosner BA, Feeney YB, Clevenger CV, Hankinson SE
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jan;24(1), p. 73-80.
EPub date: 2014 Oct 14.
Pre-pregnancy fried food consumption and the risk of gestational diabetes mellitus: a prospective cohort study.
Authors: Bao W, Tobias DK, Olsen SF, Zhang C
Source: Diabetologia, 2014 Dec;57(12), p. 2485-91.
EPub date: 2014 Oct 11.
Alcohol consumption in relation to plasma sex hormones, prolactin, and sex hormone-binding globulin in premenopausal women.
Authors: Hirko KA, Spiegelman D, Willett WC, Hankinson SE, Eliassen AH
Source: Cancer Epidemiol Biomarkers Prev, 2014 Dec;23(12), p. 2943-53.
EPub date: 2014 Oct 3.
Adherence to healthy lifestyle and risk of gestational diabetes mellitus: prospective cohort study.
Authors: Zhang C, Tobias DK, Chavarro JE, Bao W, Wang D, Ley SH, Hu FB
Source: BMJ, 2014 Sep 30;349, p. g5450.
EPub date: 2014 Sep 30.
Night shift work at specific age ranges and chronic disease risk factors.
Authors: Ramin C, Devore EE, Wang W, Pierre-Paul J, Wegrzyn LR, Schernhammer ES
Source: Occup Environ Med, 2015 Feb;72(2), p. 100-7.
EPub date: 2014 Sep 26.
Prepregnancy dietary patterns and risk of pregnancy loss.
Authors: Gaskins AJ, Rich-Edwards JW, Hauser R, Williams PL, Gillman MW, Penzias A, Missmer SA, Chavarro JE
Source: Am J Clin Nutr, 2014 Oct;100(4), p. 1166-72.
EPub date: 2014 Aug 13.
Adolescent meat intake and breast cancer risk.
Authors: Farvid MS, Cho E, Chen WY, Eliassen AH, Willett WC
Source: Int J Cancer, 2015 Apr 15;136(8), p. 1909-20.
EPub date: 2014 Oct 3.
Prepregnancy and early adulthood body mass index and adult weight change in relation to fetal loss.
Authors: Gaskins AJ, Rich-Edwards JW, Colaci DS, Afeiche MC, Toth TL, Gillman MW, Missmer SA, Chavarro JE
Source: Obstet Gynecol, 2014 Oct;124(4), p. 662-9.
Severe teenage acne and risk of endometriosis.
Authors: Xie J, Kvaskoff M, Li Y, Zhang M, Qureshi AA, Missmer SA, Han J
Source: Hum Reprod, 2014 Nov;29(11), p. 2592-9.
EPub date: 2014 Aug 19.
Duration of obesity and overweight and risk of type 2 diabetes among US women.
Authors: Hu Y, Bhupathiraju SN, de Koning L, Hu FB
Source: Obesity (Silver Spring), 2014 Oct;22(10), p. 2267-73.
EPub date: 2014 Jul 31.
Early life emotional, physical, and sexual abuse and the development of premenstrual syndrome: a longitudinal study.
Authors: Bertone-Johnson ER, Whitcomb BW, Missmer SA, Manson JE, Hankinson SE, Rich-Edwards JW
Source: J Womens Health (Larchmt), 2014 Sep;23(9), p. 729-39.
EPub date: 2014 Aug 6.
Circulating 25-hydroxyvitamin D level and risk of developing rheumatoid arthritis.
Authors: Hiraki LT, Arkema EV, Cui J, Malspeis S, Costenbader KH, Karlson EW
Source: Rheumatology (Oxford), 2014 Dec;53(12), p. 2243-8.
EPub date: 2014 Jul 26.