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Grant Details

Grant Number: 1UM1CA176726-01 Interpret this number
Primary Investigator: Willett, Walter
Organization: Harvard School Of Public Health
Project Title: Life Course Cancer Epidemiology Cohort in Women
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Nurses' Health Study II, a cancer epidemiology cohort of 116,430 women enrolled at ages 25 to 42 years in 1989. The cohort is currently supported as an R0I. Consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The NHSII biorepository includes plasma, red blood cells, white blood cells, and first morning urine samples from 29,611 women; for two thirds of these women we have timed follicular and luteal premenopausal samples. Over 16,000 provided a 2nd blood/urine sample in 2008-11 when the majorities were postmenopausal, and we have cheek cell DNA from an additional 29,859 women. We have collected archival tissue blocks for incident breast and ovarian cancers and melanoma (approximately 70% of requested have been obtained). We have created tissue microarrays for breast cancers that are already being used extensively. Prediagnostic mammograms have been collected for breast cancer cases and controls, as well as pathology material from previous biopsies of benign lesions. The follow-up of the NHSII cohort, conducted every two years, has been high and accounts for 93% of potential person-time. We have nearly complete ascertainment of deaths using the National Death Index and other methods. The NHSII cohort is unique in many ways, as the only large cohort of women enrolled before menopause, with information on smoking, weight, medication use, and medical diagnoses updated every 2 years and information on diet and physical activity updated every four years. Further, we have collected detailed on in utero and infant exposures (from participants' mothers), diet during high school, and other valuable exposure information. This cohort has been highly productive; over 150 papers have been published during the last five years, and the rate of publication is increasingly rapidly. This cohort is a member of the NCI Cohort Consortium, has participated in many collaborative studies, and has an active resource-sharing component. Enhancements of the cohort infrastructure involve assessment of breast tumor DNA methylation and RNA expression and the gut microbiome, and development of software to account for measurement error.

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Publications

The interaction between early-life body size and physical activity on risk of breast cancer.
Authors: Oh H, Boeke CE, Tamimi RM, Smith-Warner SA, Wang M, Willett WC, Eliassen AH
Source: Int J Cancer, 2014 Oct 21;null, p. null.
EPub date: 2014 Oct 21.
PMID: 25335465
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The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease.
Authors: Fu YP, Kohaar I, Moore LE, Lenz P, Figueroa JD, Tang W, Porter-Gill P, Chatterjee N, Scott-Johnson A, Garcia-Closas M, Muchmore B, Baris D, Paquin A, Ylaya K, Schwenn M, Apolo AB, Karagas MR, Tarway M, Johnson A, Mumy A, Schned A, Guedez L, Jones MA, Kida M, Hosain GM, Malats N, Kogevinas M, Tardon A, Serra C, Carrato A, Garcia-Closas R, Lloreta J, Wu X, Purdue M, Andriole GL Jr, Grubb RL 3rd, Black A, Landi MT, Caporaso NE, Vineis P, Siddiq A, Bueno-de-Mesquita HB, Trichopoulos D, Ljungberg B, Severi G, Weiderpass E, Krogh V, Dorronsoro M, Travis RC, Tjønneland A, Brennan P, Chang-Claude J, Riboli E, Prescott J, Chen C, De Vivo I, Govannucci E, Hunter D, Kraft P, Lindstrom S, Gapstur SM, Jacobs EJ, Diver WR, Albanes D, Weinstein SJ, Virtamo J, Kooperberg C, Hohensee C, Rodabough RJ, Cortessis VK, Conti DV, Gago-Dominguez M, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Haiman CA, Cussenot O, Cancel-Tassin G, Roupret M, Comperat E, Porru S, Carta A, Pavanello S, Arici C, Mastrangelo G, Grossman HB, Wang Z, Deng X, Chung CC, Hutchinson A, Burdette L, Wheeler W, Fraumeni J Jr, Chanock SJ, Hewitt SM, Silverman DT, Rothman N, Prokunina-Olsson L
Source: Cancer Res, 2014 Oct 15;74(20), p. 5808-18.
PMID: 25320178
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Bioactive prolactin levels and risk of breast cancer: a nested case-control study.
Authors: Tworoger SS, Rice MS, Rosner BA, Feeney YB, Clevenger CV, Hankinson SE
Source: Cancer Epidemiol Biomarkers Prev, 2014 Oct 14;null, p. null.
EPub date: 2014 Oct 14.
PMID: 25315962
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Alcohol consumption in relation to plasma sex hormones, prolactin and sex hormone-binding globulin in premenopausal women.
Authors: Hirko KA, Spiegelman D, Willett WC, Hankinson SE, Eliassen AH
Source: Cancer Epidemiol Biomarkers Prev, 2014 Oct 3;null, p. null.
EPub date: 2014 Oct 3.
PMID: 25281368
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Night shift work at specific age ranges and chronic disease risk factors.
Authors: Ramin C, Devore EE, Wang W, Pierre-Paul J, Wegrzyn LR, Schernhammer ES
Source: Occup Environ Med, 2014 Sep 26;null, p. null.
EPub date: 2014 Sep 26.
PMID: 25261528
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Prepregnancy and early adulthood body mass index and adult weight change in relation to fetal loss.
Authors: Gaskins AJ, Rich-Edwards JW, Colaci DS, Afeiche MC, Toth TL, Gillman MW, Missmer SA, Chavarro JE
Source: Obstet Gynecol, 2014 Oct;124(4), p. 662-9.
PMID: 25198273
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Severe teenage acne and risk of endometriosis.
Authors: Xie J, Kvaskoff M, Li Y, Zhang M, Qureshi AA, Missmer SA, Han J
Source: Hum Reprod, 2014 Nov;29(11), p. 2592-9.
EPub date: 2014 Aug 19.
PMID: 25139175
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Early life emotional, physical, and sexual abuse and the development of premenstrual syndrome: a longitudinal study.
Authors: Bertone-Johnson ER, Whitcomb BW, Missmer SA, Manson JE, Hankinson SE, Rich-Edwards JW
Source: J Womens Health (Larchmt), 2014 Sep;23(9), p. 729-39.
EPub date: 2014 Aug 6.
PMID: 25098348
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Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women.
Authors: Hu Y, Costenbader KH, Gao X, Al-Daabil M, Sparks JA, Solomon DH, Hu FB, Karlson EW, Lu B
Source: Am J Clin Nutr, 2014 Sep;100(3), p. 959-67.
EPub date: 2014 Jul 16.
PMID: 25030783
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Identification of a melanoma susceptibility locus and somatic mutation in TET2.
Authors: Song F, Amos CI, Lee JE, Lian CG, Fang S, Liu H, MacGregor S, Iles MM, Law MH, Lindeman NI, Montgomery GW, Duffy DL, Cust AE, Jenkins MA, Whiteman DC, Kefford RF, Giles GG, Armstrong BK, Aitken JF, Hopper JL, Brown KM, Martin NG, Mann GJ, Bishop DT, Bishop JA, GenoMEL consortium, Kraft P, Qureshi AA, Kanetsky PA, Hayward NK, Hunter DJ, Wei Q, Han J
Source: Carcinogenesis, 2014 Sep;35(9), p. 2097-101.
EPub date: 2014 Jun 30.
PMID: 24980573
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Changes in body weight and health-related quality of life: 2 cohorts of US women.
Authors: Pan A, Kawachi I, Luo N, Manson JE, Willett WC, Hu FB, Okereke OI
Source: Am J Epidemiol, 2014 Aug 1;180(3), p. 254-62.
EPub date: 2014 Jun 24.
PMID: 24966215
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Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth.
Authors: Gaskins AJ, Rich-Edwards JW, Hauser R, Williams PL, Gillman MW, Ginsburg ES, Missmer SA, Chavarro JE
Source: Obstet Gynecol, 2014 Jul;124(1), p. 23-31.
PMID: 24901281
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Dietary fat intake in relation to lethal breast cancer in two large prospective cohort studies.
Authors: Boeke CE, Eliassen AH, Chen WY, Cho E, Holmes MD, Rosner B, Willett WC, Tamimi RM
Source: Breast Cancer Res Treat, 2014 Jul;146(2), p. 383-92.
EPub date: 2014 Jun 4.
PMID: 24894342
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Physical activity and sedentary behaviors associated with risk of progression from gestational diabetes mellitus to type 2 diabetes mellitus: a prospective cohort study.
Authors: Bao W, Tobias DK, Bowers K, Chavarro J, Vaag A, Grunnet LG, Strøm M, Mills J, Liu A, Kiely M, Zhang C
Source: JAMA Intern Med, 2014 Jul;174(7), p. 1047-55.
PMID: 24841449
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Tubal ligation, hysterectomy, unilateral oophorectomy, and risk of ovarian cancer in the Nurses' Health Studies.
Authors: Rice MS, Hankinson SE, Tworoger SS
Source: Fertil Steril, 2014 Jul;102(1), p. 192-198.e3.
EPub date: 2014 May 10.
PMID: 24825424
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Air pollution and risk of uterine leiomyomata.
Authors: Mahalingaiah S, Hart JE, Laden F, Terry KL, Boynton-Jarrett R, Aschengrau A, Missmer SA
Source: Epidemiology, 2014 Sep;25(5), p. 682-8.
PMID: 24815304
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Use of fertility treatment modalities in a large United States cohort of professional women.
Authors: Farland LV, Missmer SA, Rich-Edwards J, Chavarro JE, Barbieri RL, Grodstein F
Source: Fertil Steril, 2014 Jun;101(6), p. 1705-10.
EPub date: 2014 Apr 18.
PMID: 24746739
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Alcohol consumption and risk of incident rheumatoid arthritis in women: a prospective study.
Authors: Lu B, Solomon DH, Costenbader KH, Karlson EW
Source: Arthritis Rheumatol, 2014 Aug;66(8), p. 1998-2005.
PMID: 24729427
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Plasma 25-hydroxyvitamin D and risk of premenstrual syndrome in a prospective cohort study.
Authors: Bertone-Johnson ER, Hankinson SE, Forger NG, Powers SI, Willett WC, Johnson SR, Manson JE
Source: BMC Womens Health, 2014 Apr 12;14, p. 56.
EPub date: 2014 Apr 12.
PMID: 24725979
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Adolescent physical activity in relation to breast cancer risk.
Authors: Boeke CE, Eliassen AH, Oh H, Spiegelman D, Willett WC, Tamimi RM
Source: Breast Cancer Res Treat, 2014 Jun;145(3), p. 715-24.
EPub date: 2014 Mar 30.
PMID: 24682675
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Genome-wide interaction study of smoking and bladder cancer risk.
Authors: Figueroa JD, Han SS, Garcia-Closas M, Baris D, Jacobs EJ, Kogevinas M, Schwenn M, Malats N, Johnson A, Purdue MP, Caporaso N, Landi MT, Prokunina-Olsson L, Wang Z, Hutchinson A, Burdette L, Wheeler W, Vineis P, Siddiq A, Cortessis VK, Kooperberg C, Cussenot O, Benhamou S, Prescott J, Porru S, Bueno-de-Mesquita HB, Trichopoulos D, Ljungberg B, Clavel-Chapelon F, Weiderpass E, Krogh V, Dorronsoro M, Travis R, Tjønneland A, Brenan P, Chang-Claude J, Riboli E, Conti D, Gago-Dominguez M, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Hohensee C, Rodabough R, Cancel-Tassin G, Roupret M, Comperat E, Chen C, De Vivo I, Giovannucci E, Hunter DJ, Kraft P, Lindstrom S, Carta A, Pavanello S, Arici C, Mastrangelo G, Karagas MR, Schned A, Armenti KR, Hosain GM, Haiman CA, Fraumeni JF Jr, Chanock SJ, Chatterjee N, Rothman N, Silverman DT
Source: Carcinogenesis, 2014 Aug;35(8), p. 1737-44.
EPub date: 2014 Mar 24.
PMID: 24662972
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A prospective study of caffeine intake and risk of incident tinnitus.
Authors: Glicksman JT, Curhan SG, Curhan GC
Source: Am J Med, 2014 Aug;127(8), p. 739-43.
EPub date: 2014 Mar 6.
PMID: 24608016
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Effects of buffer size and shape on associations between the built environment and energy balance.
Authors: James P, Berrigan D, Hart JE, Hipp JA, Hoehner CM, Kerr J, Major JM, Oka M, Laden F
Source: Health Place, 2014 May;27, p. 162-70.
EPub date: 2014 Mar 7.
PMID: 24607875
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Polymorphisms of MUC16 (CA125) and MUC1 (CA15.3) in relation to ovarian cancer risk and survival.
Authors: Williams KA, Terry KL, Tworoger SS, Vitonis AF, Titus LJ, Cramer DW
Source: PLoS One, 2014;9(2), p. e88334.
EPub date: 2014 Feb 13.
PMID: 24551091
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Fluid intake and risk of bladder cancer in the Nurses' Health Studies.
Authors: Zhou J, Kelsey KT, Giovannucci E, Michaud DS
Source: Int J Cancer, 2014 Sep 1;135(5), p. 1229-37.
EPub date: 2014 Feb 20.
PMID: 24500943
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Muscle-strengthening and conditioning activities and risk of type 2 diabetes: a prospective study in two cohorts of US women.
Authors: Grøntved A, Pan A, Mekary RA, Stampfer M, Willett WC, Manson JE, Hu FB
Source: PLoS Med, 2014 Jan;11(1), p. e1001587.
EPub date: 2014 Jan 14.
PMID: 24453948
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Premenopausal plasma ferritin levels, HFE polymorphisms, and risk of breast cancer in the nurses' health study II.
Authors: Graff RE, Cho E, Lindström S, Kraft P, Willett WC, Eliassen AH
Source: Cancer Epidemiol Biomarkers Prev, 2014 Mar;23(3), p. 516-24.
EPub date: 2014 Jan 17.
PMID: 24443403
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Body-mass index and mortality among adults with incident type 2 diabetes.
Authors: Tobias DK, Pan A, Jackson CL, O'Reilly EJ, Ding EL, Willett WC, Manson JE, Hu FB
Source: N Engl J Med, 2014 Jan 16;370(3), p. 233-44.
PMID: 24428469
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Analgesic use and patterns of estrogen metabolism in premenopausal women.
Authors: Fortner RT, Oh H, Daugherty SE, Xu X, Hankinson SE, Ziegler RG, Eliassen AH
Source: Horm Cancer, 2014 Apr;5(2), p. 104-12.
EPub date: 2014 Jan 10.
PMID: 24407556
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Air pollution exposures during adulthood and risk of endometriosis in the Nurses' Health Study II.
Authors: Mahalingaiah S, Hart JE, Laden F, Aschengrau A, Missmer SA
Source: Environ Health Perspect, 2014 Jan;122(1), p. 58-64.
EPub date: 2013 Nov 8.
PMID: 24225723
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Genome-wide association study identifies multiple loci associated with bladder cancer risk.
Authors: Figueroa JD, Ye Y, Siddiq A, Garcia-Closas M, Chatterjee N, Prokunina-Olsson L, Cortessis VK, Kooperberg C, Cussenot O, Benhamou S, Prescott J, Porru S, Dinney CP, Malats N, Baris D, Purdue M, Jacobs EJ, Albanes D, Wang Z, Deng X, Chung CC, Tang W, Bas Bueno-de-Mesquita H, Trichopoulos D, Ljungberg B, Clavel-Chapelon F, Weiderpass E, Krogh V, Dorronsoro M, Travis R, Tjønneland A, Brenan P, Chang-Claude J, Riboli E, Conti D, Gago-Dominguez M, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Hohensee C, Rodabough R, Cancel-Tassin G, Roupret M, Comperat E, Chen C, De Vivo I, Giovannucci E, Hunter DJ, Kraft P, Lindstrom S, Carta A, Pavanello S, Arici C, Mastrangelo G, Kamat AM, Lerner SP, Barton Grossman H, Lin J, Gu J, Pu X, Hutchinson A, Burdette L, Wheeler W, Kogevinas M, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Schwenn M, Karagas MR, Johnson A, Schned A, Armenti KR, Hosain GM, Andriole G Jr, Grubb R 3rd, Black A, Ryan Diver W, Gapstur SM, Weinstein SJ, Virtamo J, Haiman CA, Landi MT, Caporaso N, Fraumeni JF Jr, Vineis P, Wu X, Silverman DT, Chanock S, Rothman N
Source: Hum Mol Genet, 2014 Mar 1;23(5), p. 1387-98.
EPub date: 2013 Oct 24.
PMID: 24163127
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Prenatal diethylstilbestrol exposure and risk of uterine leiomyomata in the Nurses' Health Study II.
Authors: Mahalingaiah S, Hart JE, Wise LA, Terry KL, Boynton-Jarrett R, Missmer SA
Source: Am J Epidemiol, 2014 Jan 15;179(2), p. 186-91.
EPub date: 2013 Oct 18.
PMID: 24142917
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Reproductive factors and risk of premenopausal breast cancer by age at diagnosis: are there differences before and after age 40?
Authors: Warner ET, Colditz GA, Palmer JR, Partridge AH, Rosner BA, Tamimi RM
Source: Breast Cancer Res Treat, 2013 Nov;142(1), p. 165-75.
EPub date: 2013 Oct 18.
PMID: 24136668
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Tanning bed use is not associated with internal cancer risk: evidence from a large cohort study.
Authors: Zhang M, Song F, Hunter DJ, Qureshi AA, Han J
Source: Cancer Epidemiol Biomarkers Prev, 2013 Dec;22(12), p. 2425-9.
EPub date: 2013 Oct 15.
PMID: 24130225
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A genome-wide association study of severe teenage acne in European Americans.
Authors: Zhang M, Qureshi AA, Hunter DJ, Han J
Source: Hum Genet, 2014 Mar;133(3), p. 259-64.
EPub date: 2013 Oct 11.
PMID: 24114350
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Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies.
Authors: Muraki I, Imamura F, Manson JE, Hu FB, Willett WC, van Dam RM, Sun Q
Source: BMJ, 2013 Aug 28;347, p. f5001.
EPub date: 2013 Aug 28.
PMID: 23990623
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Associations between dietary acrylamide intake and plasma sex hormone levels.
Authors: Hogervorst JG, Fortner RT, Mucci LA, Tworoger SS, Eliassen AH, Hankinson SE, Wilson KM
Source: Cancer Epidemiol Biomarkers Prev, 2013 Nov;22(11), p. 2024-36.
EPub date: 2013 Aug 27.
PMID: 23983241
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Chronotype and breast cancer risk in a cohort of US nurses.
Authors: Ramin C, Devore EE, Pierre-Paul J, Duffy JF, Hankinson SE, Schernhammer ES
Source: Chronobiol Int, 2013 Nov;30(9), p. 1181-6.
EPub date: 2013 Aug 20.
PMID: 23961712
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Sexual orientation differences in teen pregnancy and hormonal contraceptive use: an examination across 2 generations.
Authors: Charlton BM, Corliss HL, Missmer SA, Rosario M, Spiegelman D, Austin SB
Source: Am J Obstet Gynecol, 2013 Sep;209(3), p. 204.e1-8.
EPub date: 2013 Jun 22.
PMID: 23796650
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Early life factors and risk of inflammatory bowel disease in adulthood.
Authors: Khalili H, Ananthakrishnan AN, Higuchi LM, Richter JM, Fuchs CS, Chan AT
Source: Inflamm Bowel Dis, 2013 Mar;19(3), p. 542-7.
PMID: 23429446
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