|Grant Number:||1UM1CA176726-01 Interpret this number|
|Primary Investigator:||Willett, Walter|
|Organization:||Harvard School Of Public Health|
|Project Title:||Life Course Cancer Epidemiology Cohort in Women|
DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Nurses' Health Study II, a cancer epidemiology cohort of 116,430 women enrolled at ages 25 to 42 years in 1989. The cohort is currently supported as an R0I. Consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The NHSII biorepository includes plasma, red blood cells, white blood cells, and first morning urine samples from 29,611 women; for two thirds of these women we have timed follicular and luteal premenopausal samples. Over 16,000 provided a 2nd blood/urine sample in 2008-11 when the majorities were postmenopausal, and we have cheek cell DNA from an additional 29,859 women. We have collected archival tissue blocks for incident breast and ovarian cancers and melanoma (approximately 70% of requested have been obtained). We have created tissue microarrays for breast cancers that are already being used extensively. Prediagnostic mammograms have been collected for breast cancer cases and controls, as well as pathology material from previous biopsies of benign lesions. The follow-up of the NHSII cohort, conducted every two years, has been high and accounts for 93% of potential person-time. We have nearly complete ascertainment of deaths using the National Death Index and other methods. The NHSII cohort is unique in many ways, as the only large cohort of women enrolled before menopause, with information on smoking, weight, medication use, and medical diagnoses updated every 2 years and information on diet and physical activity updated every four years. Further, we have collected detailed on in utero and infant exposures (from participants' mothers), diet during high school, and other valuable exposure information. This cohort has been highly productive; over 150 papers have been published during the last five years, and the rate of publication is increasingly rapidly. This cohort is a member of the NCI Cohort Consortium, has participated in many collaborative studies, and has an active resource-sharing component. Enhancements of the cohort infrastructure involve assessment of breast tumor DNA methylation and RNA expression and the gut microbiome, and development of software to account for measurement error.
Adolescent dietary vitamin D and sun exposure in relation to benign breast disease.
Authors: Boeke CE, Tamimi RM, Berkey CS, Colditz GA, Giovannucci E, Malspeis S, Willett WC, Frazier AL
Source: Cancer Causes Control, 2015 Jun 18;null, p. null.
EPub date: 2015 Jun 18.
Genome-wide significant risk associations for mucinous ovarian carcinoma.
Authors: Ovarian Cancer Association Consortium, Australian Cancer Study, Australian Ovarian Cancer Study Group
Source: Nat Genet, 2015 Jun 15;null, p. null.
EPub date: 2015 Jun 15.
Oral Contraceptive Use and Colorectal Cancer in the Nurses' Health Study I and II.
Authors: Charlton BM, Wu K, Zhang X, Giovannucci EL, Fuchs CS, Missmer SA, Rosner B, Hankinson SE, Willett WC, Michels KB
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jun 10;null, p. null.
EPub date: 2015 Jun 10.
Caffeine, coffee and tea intake and urinary estrogens and estrogen metabolites in premenopausal women.
Authors: Sisti JS, Hankinson SE, Caporaso NE, Gu F, Tamimi RM, Rosner B, Xu X, Zeigler R, Eliassen AH
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jun 10;null, p. null.
EPub date: 2015 Jun 10.
Infertility, fertility treatment, and risk of hypertension.
Authors: Farland LV, Grodstein F, Srouji SS, Forman JP, Rich-Edwards J, Chavarro JE, Missmer SA
Source: Fertil Steril, 2015 Jun 11;null, p. null.
EPub date: 2015 Jun 11.
Job strain and changes in the body mass index among working women: a prospective study.
Authors: Fujishiro K, Lawson CC, Hibert EL, Chavarro JE, Rich-Edwards JW
Source: Int J Obes (Lond), 2015 May 19;null, p. null.
EPub date: 2015 May 19.
Premenopausal plasma carotenoids, fluorescent oxidation products, and subsequent breast cancer risk in the nurses' health studies.
Authors: Sisti JS, Lindström S, Kraft P, Tamimi RM, Rosner BA, Wu T, Willett WC, Eliassen AH
Source: Breast Cancer Res Treat, 2015 Jun;151(2), p. 415-25.
EPub date: 2015 Apr 28.
Adolescent and Early Adulthood Dietary Carbohydrate Quantity and Quality in Relation to Breast Cancer Risk.
Authors: Farvid MS, Eliassen AH, Cho E, Chen WY, Willett WC
Source: Cancer Epidemiol Biomarkers Prev, 2015 Mar 24;null, p. null.
EPub date: 2015 Mar 24.
Long-term risk of type 2 diabetes mellitus in relation to BMI and weight change among women with a history of gestational diabetes mellitus: a prospective cohort study.
Authors: Bao W, Yeung E, Tobias DK, Hu FB, Vaag AA, Chavarro JE, Mills JL, Grunnet LG, Bowers K, Ley SH, Kiely M, Olsen SF, Zhang C
Source: Diabetologia, 2015 Jun;58(6), p. 1212-9.
EPub date: 2015 Mar 22.
Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics.
Authors: Bertrand KA, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Norman AD, Visscher DW, Couch FJ, Shepherd J, Chen YY, Fan B, Wu FF, Ma L, Beck AH, Cummings SR, Kerlikowske K, Vachon CM
Source: Cancer Epidemiol Biomarkers Prev, 2015 May;24(5), p. 798-809.
EPub date: 2015 Feb 25.
Asthma history, job type and job changes among US nurses.
Authors: Dumas O, Varraso R, Zock JP, Henneberger PK, Speizer FE, Wiley AS, Le Moual N, Camargo CA Jr
Source: Occup Environ Med, 2015 Jul;72(7), p. 482-8.
EPub date: 2015 Feb 24.
Antihypertensive medication use and incident breast cancer in women.
Authors: Devore EE, Kim S, Ramin CA, Wegrzyn LR, Massa J, Holmes MD, Michels KB, Tamimi RM, Forman JP, Schernhammer ES
Source: Breast Cancer Res Treat, 2015 Feb;150(1), p. 219-29.
EPub date: 2015 Feb 21.
Investigation of dietary factors and endometrial cancer risk using a nutrient-wide association study approach in the EPIC and Nurses' Health Study (NHS) and NHSII.
Authors: Merritt MA, Tzoulaki I, Tworoger SS, De Vivo I, Hankinson SE, Fernandes J, Tsilidis KK, Weiderpass E, Tjønneland A, Petersen KE, Dahm CC, Overvad K, Dossus L, Boutron-Ruault MC, Fagherazzi G, Fortner RT, Kaaks R, Aleksandrova K, Boeing H, Trichopoulou A, Bamia C, Trichopoulos D, Palli D, Grioni S, Tumino R, Sacerdote C, Mattiello A, Bueno-de-Mesquita HB, Onland-Moret NC, Peeters PH, Gram IT, Skeie G, Quirós JR, Duell EJ, Sánchez MJ, Salmerón D, Barricarte A, Chamosa S, Ericson U, Sonestedt E, Nilsson LM, Idahl A, Khaw KT, Wareham N, Travis RC, Rinaldi S, Romieu I, Patel CJ, Riboli E, Gunter MJ
Source: Cancer Epidemiol Biomarkers Prev, 2015 Feb;24(2), p. 466-71.
Dietary phosphatidylcholine intake and type 2 diabetes in men and women.
Authors: Li Y, Wang DD, Chiuve SE, Manson JE, Willett WC, Hu FB, Qi L
Source: Diabetes Care, 2015 Feb;38(2), p. e13-4.
History of infertility and risk of type 2 diabetes mellitus: a prospective cohort study.
Authors: Tobias DK, Gaskins AJ, Missmer SA, Hu FB, Manson JE, Buck Louis GM, Zhang C, Chavarro JE
Source: Diabetologia, 2015 Apr;58(4), p. 707-15.
EPub date: 2015 Jan 18.
Urinary melatonin concentration and the risk of breast cancer in Nurses' Health Study II.
Authors: Brown SB, Hankinson SE, Eliassen AH, Reeves KW, Qian J, Arcaro KF, Wegrzyn LR, Willett WC, Schernhammer ES
Source: Am J Epidemiol, 2015 Feb 1;181(3), p. 155-62.
EPub date: 2015 Jan 13.
Teenage acne and cancer risk in US women: A prospective cohort study.
Authors: Zhang M, Qureshi AA, Fortner RT, Hankinson SE, Wei Q, Wang LE, Eliassen AH, Willett WC, Hunter DJ, Han J
Source: Cancer, 2015 May 15;121(10), p. 1681-7.
EPub date: 2015 Jan 8.
Healthy lifestyle in the primordial prevention of cardiovascular disease among young women.
Authors: Chomistek AK, Chiuve SE, Eliassen AH, Mukamal KJ, Willett WC, Rimm EB
Source: J Am Coll Cardiol, 2015 Jan 6;65(1), p. 43-51.
Measures of obesity and risk of Crohn's disease and ulcerative colitis.
Authors: Khalili H, Ananthakrishnan AN, Konijeti GG, Higuchi LM, Fuchs CS, Richter JM, Chan AT
Source: Inflamm Bowel Dis, 2015 Feb;21(2), p. 361-8.
Premenopausal plasma 25-hydroxyvitamin D, mammographic density, and risk of breast cancer.
Authors: Bertrand KA, Rosner B, Eliassen AH, Hankinson SE, Rexrode KM, Willett W, Tamimi RM
Source: Breast Cancer Res Treat, 2015 Jan;149(2), p. 479-87.
EPub date: 2014 Dec 28.
Rice consumption and risk of cardiovascular disease: results from a pooled analysis of 3 U.S. cohorts.
Authors: Muraki I, Wu H, Imamura F, Laden F, Rimm EB, Hu FB, Willett WC, Sun Q
Source: Am J Clin Nutr, 2015 Jan;101(1), p. 164-72.
EPub date: 2014 Nov 12.
Autism spectrum disorder and particulate matter air pollution before, during, and after pregnancy: a nested case-control analysis within the Nurses' Health Study II Cohort.
Authors: Raz R, Roberts AL, Lyall K, Hart JE, Just AC, Laden F, Weisskopf MG
Source: Environ Health Perspect, 2015 Mar;123(3), p. 264-70.
EPub date: 2014 Dec 18.
Migraine and breast cancer risk: a prospective cohort study and meta-analysis.
Authors: Winter AC, Rice MS, Fortner RT, Eliassen AH, Kurth T, Tamimi RM
Source: J Natl Cancer Inst, 2015 Jan;107(1), p. 381.
EPub date: 2014 Dec 12.
Within-person reproducibility of red blood cell mercury over a 10- to 15-year period among women in the Nurses' Health Study II.
Authors: Kioumourtzoglou MA, Roberts AL, Nielsen F, Tworoger SS, Grandjean P, Weisskopf MG
Source: J Expo Sci Environ Epidemiol, 2014 Dec 10;null, p. null.
EPub date: 2014 Dec 10.
Prospective study of alcohol consumption and self-reported hearing loss in women.
Authors: Curhan SG, Eavey R, Wang M, Stampfer MJ, Curhan GC
Source: Alcohol, 2015 Feb;49(1), p. 71-7.
EPub date: 2014 Oct 31.