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Grant Details

Grant Number: 1UM1CA176726-01 Interpret this number
Primary Investigator: Willett, Walter
Organization: Harvard University (Sch Of Public Hlth)
Project Title: Life Course Cancer Epidemiology Cohort in Women
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Nurses' Health Study II, a cancer epidemiology cohort of 116,430 women enrolled at ages 25 to 42 years in 1989. The cohort is currently supported as an R0I. Consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The NHSII biorepository includes plasma, red blood cells, white blood cells, and first morning urine samples from 29,611 women; for two thirds of these women we have timed follicular and luteal premenopausal samples. Over 16,000 provided a 2nd blood/urine sample in 2008-11 when the majorities were postmenopausal, and we have cheek cell DNA from an additional 29,859 women. We have collected archival tissue blocks for incident breast and ovarian cancers and melanoma (approximately 70% of requested have been obtained). We have created tissue microarrays for breast cancers that are already being used extensively. Prediagnostic mammograms have been collected for breast cancer cases and controls, as well as pathology material from previous biopsies of benign lesions. The follow-up of the NHSII cohort, conducted every two years, has been high and accounts for 93% of potential person-time. We have nearly complete ascertainment of deaths using the National Death Index and other methods. The NHSII cohort is unique in many ways, as the only large cohort of women enrolled before menopause, with information on smoking, weight, medication use, and medical diagnoses updated every 2 years and information on diet and physical activity updated every four years. Further, we have collected detailed on in utero and infant exposures (from participants' mothers), diet during high school, and other valuable exposure information. This cohort has been highly productive; over 150 papers have been published during the last five years, and the rate of publication is increasingly rapidly. This cohort is a member of the NCI Cohort Consortium, has participated in many collaborative studies, and has an active resource-sharing component. Enhancements of the cohort infrastructure involve assessment of breast tumor DNA methylation and RNA expression and the gut microbiome, and development of software to account for measurement error.

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Publications

Polymorphisms of MUC16 (CA125) and MUC1 (CA15.3) in relation to ovarian cancer risk and survival.
Authors: Williams KA, Terry KL, Tworoger SS, Vitonis AF, Titus LJ, Cramer DW
Source: PLoS One, 2014;9(2), p. e88334.
EPub date: 2014 Feb 13.
PMID: 24551091
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Muscle-strengthening and conditioning activities and risk of type 2 diabetes: a prospective study in two cohorts of US women.
Authors: Gr°ntved A, Pan A, Mekary RA, Stampfer M, Willett WC, Manson JE, Hu FB
Source: PLoS Med, 2014 Jan;11(1), p. e1001587.
EPub date: 2014 Jan 14.
PMID: 24453948
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Premenopausal Plasma Ferritin Levels, HFE Polymorphisms, and Risk of Breast Cancer in the Nurses' Health Study II.
Authors: Graff RE, Cho E, Lindstr÷m S, Kraft P, Willett WC, Eliassen AH
Source: Cancer Epidemiol Biomarkers Prev, 2014 Mar;23(3), p. 516-24.
EPub date: 2014 Jan 17.
PMID: 24443403
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Body-mass index and mortality among adults with incident type 2 diabetes.
Authors: Tobias DK, Pan A, Jackson CL, O'Reilly EJ, Ding EL, Willett WC, Manson JE, Hu FB
Source: N Engl J Med, 2014 Jan 16;370(3), p. 233-44.
PMID: 24428469
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Analgesic use and patterns of estrogen metabolism in premenopausal women.
Authors: Fortner RT, Oh H, Daugherty SE, Xu X, Hankinson SE, Ziegler RG, Eliassen AH
Source: Horm Cancer, 2014 Apr;5(2), p. 104-12.
EPub date: 2014 Jan 10.
PMID: 24407556
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Air pollution exposures during adulthood and risk of endometriosis in the Nurses' Health Study II.
Authors: Mahalingaiah S, Hart JE, Laden F, Aschengrau A, Missmer SA
Source: Environ Health Perspect, 2014 Jan;122(1), p. 58-64.
EPub date: 2013 Nov 8.
PMID: 24225723
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Genome-wide association study identifies multiple loci associated with bladder cancer risk.
Authors: Figueroa JD, Ye Y, Siddiq A, Garcia-Closas M, Chatterjee N, Prokunina-Olsson L, Cortessis VK, Kooperberg C, Cussenot O, Benhamou S, Prescott J, Porru S, Dinney CP, Malats N, Baris D, Purdue M, Jacobs EJ, Albanes D, Wang Z, Deng X, Chung CC, Tang W, Bas Bueno-de-Mesquita H, Trichopoulos D, Ljungberg B, Clavel-Chapelon F, Weiderpass E, Krogh V, Dorronsoro M, Travis R, Tj°nneland A, Brenan P, Chang-Claude J, Riboli E, Conti D, Gago-Dominguez M, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Hohensee C, Rodabough R, Cancel-Tassin G, Roupret M, Comperat E, Chen C, De Vivo I, Giovannucci E, Hunter DJ, Kraft P, Lindstrom S, Carta A, Pavanello S, Arici C, Mastrangelo G, Kamat AM, Lerner SP, Barton Grossman H, Lin J, Gu J, Pu X, Hutchinson A, Burdette L, Wheeler W, Kogevinas M, Tardˇn A, Serra C, Carrato A, GarcÝa-Closas R, Lloreta J, Schwenn M, Karagas MR, Johnson A, Schned A, Armenti KR, Hosain GM, Andriole G Jr, Grubb R 3rd, Black A, Ryan Diver W, Gapstur SM, Weinstein SJ, Virtamo J, Haiman CA, Landi MT, Caporaso N, Fraumeni JF Jr, Vineis P, Wu X, Silverman DT, Chanock S, Rothman N
Source: Hum Mol Genet, 2014 Mar 1;23(5), p. 1387-98.
EPub date: 2013 Oct 24.
PMID: 24163127
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Prenatal diethylstilbestrol exposure and risk of uterine leiomyomata in the Nurses' Health Study II.
Authors: Mahalingaiah S, Hart JE, Wise LA, Terry KL, Boynton-Jarrett R, Missmer SA
Source: Am J Epidemiol, 2014 Jan 15;179(2), p. 186-91.
EPub date: 2013 Oct 18.
PMID: 24142917
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Reproductive factors and risk of premenopausal breast cancer by age at diagnosis: are there differences before and after age 40?
Authors: Warner ET, Colditz GA, Palmer JR, Partridge AH, Rosner BA, Tamimi RM
Source: Breast Cancer Res Treat, 2013 Nov;142(1), p. 165-75.
EPub date: 2013 Oct 18.
PMID: 24136668
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Tanning bed use is not associated with internal cancer risk: evidence from a large cohort study.
Authors: Zhang M, Song F, Hunter DJ, Qureshi AA, Han J
Source: Cancer Epidemiol Biomarkers Prev, 2013 Dec;22(12), p. 2425-9.
EPub date: 2013 Oct 15.
PMID: 24130225
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A genome-wide association study of severe teenage acne in European Americans.
Authors: Zhang M, Qureshi AA, Hunter DJ, Han J
Source: Hum Genet, 2014 Mar;133(3), p. 259-64.
EPub date: 2013 Oct 11.
PMID: 24114350
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Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies.
Authors: Muraki I, Imamura F, Manson JE, Hu FB, Willett WC, van Dam RM, Sun Q
Source: BMJ, 2013 Aug 28;347, p. f5001.
EPub date: 2013 Aug 28.
PMID: 23990623
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Associations between dietary acrylamide intake and plasma sex hormone levels.
Authors: Hogervorst JG, Fortner RT, Mucci LA, Tworoger SS, Eliassen AH, Hankinson SE, Wilson KM
Source: Cancer Epidemiol Biomarkers Prev, 2013 Nov;22(11), p. 2024-36.
EPub date: 2013 Aug 27.
PMID: 23983241
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Chronotype and breast cancer risk in a cohort of US nurses.
Authors: Ramin C, Devore EE, Pierre-Paul J, Duffy JF, Hankinson SE, Schernhammer ES
Source: Chronobiol Int, 2013 Nov;30(9), p. 1181-6.
EPub date: 2013 Aug 20.
PMID: 23961712
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Sexual orientation differences in teen pregnancy and hormonal contraceptive use: an examination across 2 generations.
Authors: Charlton BM, Corliss HL, Missmer SA, Rosario M, Spiegelman D, Austin SB
Source: Am J Obstet Gynecol, 2013 Sep;209(3), p. 204.e1-8.
EPub date: 2013 Jun 22.
PMID: 23796650
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Early life factors and risk of inflammatory bowel disease in adulthood.
Authors: Khalili H, Ananthakrishnan AN, Higuchi LM, Richter JM, Fuchs CS, Chan AT
Source: Inflamm Bowel Dis, 2013 Mar;19(3), p. 542-7.
PMID: 23429446
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