|Grant Number:||5U54CA155496-03 Interpret this number|
|Primary Investigator:||Colditz, Graham|
|Project Title:||A Multilevel Approach to Energy Balance and Cancer Across the Lifecourse|
DESCRIPTION (provided by applicant): Drawing on the broad scientific expertise of faculty at Washington University in St. Louis and collaborators and consultants from other institutions, we propose to build on existing transdisciplinary approaches and create a center to address mechanisms of obesity and cancer, "from cell to society". We include projects that move beyond traditional risk factor-cancer associations to look at multilevel and multigenerational associations as well as the interaction of traditional cancer risk behaviors. We leverage the unique opportunity Missouri provides to study human populations given its diversity across race/ethnicity and socioeconomic status. We will delineate mechanisms by which preconception diet, nutrition & built environment polices impact inactivity and physical activity and energy balance to influence body weight and carcinogenesis across the life course. Specifically we aim to: 1. Investigate in a mouse model the effect of maternal high fat diet and changes in metabolic bioenergetics on prostate gland development and susceptibility to prostate cancer in male mouse offspring; 2. Study the role of physical activity and obesity in post-prostatectomy urinary and sexual function; 3. Develop models of obesity across the life course and generations incorporating biologic, clinical and social determinants of risk and mortality, which can be applied to different cancer outcomes, using non- Hodgkin Lymphoma as the initial platform; 4. Study policies relating to nutrition and built environment that impact energy balance and obesity; 5. Train postdoctoral fellows in a transdisciplinary environment to pursue careers in energetics and cancer and expose scholars from across our university to transdisciplinary work in obesity and cancer; 6. Foster scientific synergy via smaller-scale innovative transdisciplinary research that builds on the Center's theme and resources; and 7. Maximize efficiency and productivity of TREC-related studies and cores by building an outstanding transdisciplinary center supported by outstanding administrative, budgetary, and technology resources. To address these aims, we propose four research projects and five cores that form a cohesive, transdisciplinary center focused on research, training/career development, and dissemination.
Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development.
Authors: Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO
Source: Cancer Res, 2014 Sep 15;74(18), p. 5322-35.
EPub date: 2014 Aug 1.
Introduction to the Special Issue.
Authors: Gehlert S, Hudson DL
Source: Race Soc Probl, 2013 Jun;5(2), p. 79-80.
Perceived barriers to mammography among underserved women in a Breast Health Center Outreach Program.
Authors: Fayanju OM, Kraenzle S, Drake BF, Oka M, Goodman MS
Source: Am J Surg, 2014 Sep;208(3), p. 425-34.
EPub date: 2014 May 4.
A novel system dynamics model of female obesity and fertility.
Authors: Sabounchi NS, Hovmand PS, Osgood ND, Dyck RF, Jungheim ES
Source: Am J Public Health, 2014 Jul;104(7), p. 1240-6.
EPub date: 2014 May 15.
Breast cancer risk accumulation starts early: prevention must also.
Authors: Colditz GA, Bohlke K, Berkey CS
Source: Breast Cancer Res Treat, 2014 Jun;145(3), p. 567-79.
EPub date: 2014 May 13.
Racial disparities in healthy behaviors and cancer screening among breast cancer survivors and women without cancer: National Health Interview Survey 2005.
Authors: Yaghjyan L, Wolin K, Chang SH, Colditz G
Source: Cancer Causes Control, 2014 May;25(5), p. 605-14.
EPub date: 2014 Mar 18.
The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012.
Authors: Chang SH, Stoll CR, Song J, Varela JE, Eagon CJ, Colditz GA
Source: JAMA Surg, 2014 Mar;149(3), p. 275-87.
Maternal high-fat diet induces hyperproliferation and alters Pten/Akt signaling in prostates of offspring.
Authors: Benesh EC, Humphrey PA, Wang Q, Moley KH
Source: Sci Rep, 2013 Dec 10;3, p. 3466.
EPub date: 2013 Dec 10.
Implementation strategies: recommendations for specifying and reporting.
Authors: Proctor EK, Powell BJ, McMillen JC
Source: Implement Sci, 2013 Dec 1;8, p. 139.
EPub date: 2013 Dec 1.
Obesity, mortality, and life years lost associated with breast cancer in nonsmoking US Women, National Health Interview Survey, 1997-2000.
Authors: Chang SH, Pollack LM, Colditz GA
Source: Prev Chronic Dis, 2013 Nov 14;10, p. E186.
EPub date: 2013 Nov 14.
Obesity increases risk for pouch-related complications following restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA).
Authors: Klos CL, Safar B, Jamal N, Hunt SR, Wise PE, Birnbaum EH, Fleshman JW, Mutch MG, Dharmarajan S
Source: J Gastrointest Surg, 2014 Mar;18(3), p. 573-9.
EPub date: 2013 Oct 4.
Influence of body mass index on survival in veterans with multiple myeloma.
Authors: Beason TS, Chang SH, Sanfilippo KM, Luo S, Colditz GA, Vij R, Tomasson MH, Dipersio JF, Stockerl-Goldstein K, Ganti A, Wildes T, Carson KR
Source: Oncologist, 2013;18(10), p. 1074-9.
EPub date: 2013 Sep 18.
Impact of obesity on cancer survivorship and the potential relevance of race and ethnicity.
Authors: Schmitz KH, Neuhouser ML, Agurs-Collins T, Zanetti KA, Cadmus-Bertram L, Dean LT, Drake BF
Source: J Natl Cancer Inst, 2013 Sep 18;105(18), p. 1344-54.
EPub date: 2013 Aug 29.
A two-way street: bridging implementation science and cultural adaptations of mental health treatments.
Authors: Cabassa LJ, Baumann AA
Source: Implement Sci, 2013 Aug 19;8, p. 90.
EPub date: 2013 Aug 19.
Understanding the independent and joint associations of the home and workplace built environments on cardiorespiratory fitness and body mass index.
Authors: Hoehner CM, Allen P, Barlow CE, Marx CM, Brownson RC, Schootman M
Source: Am J Epidemiol, 2013 Oct 1;178(7), p. 1094-105.
EPub date: 2013 Aug 13.
Liver fatty acid-binding protein (L-Fabp) modifies intestinal fatty acid composition and adenoma formation in ApcMin/+ mice.
Authors: Dharmarajan S, Newberry EP, Montenegro G, Nalbantoglu I, Davis VR, Clanahan MJ, Blanc V, Xie Y, Luo J, Fleshman JW Jr, Kennedy S, Davidson NO
Source: Cancer Prev Res (Phila), 2013 Oct;6(10), p. 1026-37.
EPub date: 2013 Aug 6.
Designing for dissemination among public health researchers: findings from a national survey in the United States.
Authors: Brownson RC, Jacobs JA, Tabak RG, Hoehner CM, Stamatakis KA
Source: Am J Public Health, 2013 Sep;103(9), p. 1693-9.
EPub date: 2013 Jul 18.
Development and reliability testing of the Worksite and Energy Balance Survey.
Authors: Hoehner CM, Budd EL, Marx CM, Dodson EA, Brownson RC
Source: J Public Health Manag Pract, 2013 May-Jun;19(3 Suppl 1), p. S105-13.
Eight ways to stay healthy after cancer: an evidence-based message.
Authors: Wolin KY, Dart H, Colditz GA
Source: Cancer Causes Control, 2013 May;24(5), p. 827-37.
EPub date: 2013 Mar 12.