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Grant Details

Grant Number: 5P50CA105632-09 Interpret this number
Primary Investigator: Paskett, Electra
Organization: Ohio State University
Project Title: Reducing Cervical Cancer in Appalachia
Fiscal Year: 2013
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Abstract

In response to RFA ES-02-009, a multi-disciplinary group of investigators from the Ohio State University and the University of Michigan have collaborated to propose a Center for Population Health and Health Disparities focusing on an important health issue in underserved populations,cancer. The Center will initially focus on the goal of understanding why high rates of cervical cancer incidence and mortality are observed in Appalachia Ohio, a mainly rural area in Southern and Eastern Ohio. This goal will be accomplished using community-based participatory research within the framework of the Social Determinants of Health model in three inter-related projects and four supporting cores. All studies will be conducted in 16 clinics which represent the general population of women aged 18 and older in the region. We will utilize the Center's internal and external advisory committees and community partners organized into a community advisory board and Consortium of communityorganizations to facilitate the accomplishment of project goals. Project 1 will recruit 1600 women to an observational study to investigate multi-level (social, environmental, behavioral, and biological) correlates of "risk-appropriate" Pap smear utilization, in Phase I. From this cohort of women, those who smoke (30%) will be eligible to participate in Project 2, which tests the effectiveness of a lay health educator (social) intervention to promote smoking cessation (behavioral) and validate cessation endpoints with saliva cotinine measurements (biological) in a quasi-experimental trial design; those women who are in need of & Pap test (48% of 1600) will be eligible to participate in Phase II of Project 1 which will test the effectiveness of a lay health educator (social) intervention to promote "risk-appropriate" Pap smear utilization (behavioral) and follow-up for abnormalities (biological) detected in a quasi-experimental trial design. Project 3 will examine the contribution of HPV (biological) to cervical abnormalities in Appalachia in relation to individual-level behaviors (e.g. smoking, sexual activity) within the social and environmental region of Appalachia in a case-control observational study among women who have Pap smears in these 16 clinics.The research will be supported by four cores: A) Administration - fiscal and Center oversight; B) Biostatistics and Data Resources - sample selection, data management, data analysis, and population data resources; C) Clinical Correlative Sciences - collect, obtain and process biomarker specimens; and D) Behavioral Assessment and Intervention - train interviewers and lay health educators, conduct interviews, design intervention material, and facilitate communication amongst sites. The Center includes a mechanism for pilot project solicitation, review and funding. This Center has institutional commitment in terms of personnel, funds and space, as well as, a commitment to focus on the problem of health disparities in the region. Finally, members of the team have worked together in the past in various settings that focus on the goals of the proposed Center and have an established relationship in Appalachian Ohio for the purpose of improving the health of the population. Future work of this Center will focus on moving this type of multi-level observational and interventional community-based research, into other areas where health disparities exist in relation to cancer withinour region.

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Publications

Disparities in receipt of advice to quit smoking from health care providers: 2010 National Health Interview Survey.
Authors: Danesh D, Paskett ED, Ferketich AK
Source: Prev Chronic Dis, 2014 Jul 31;11, p. E131.
EPub date: 2014 Jul 31.
PMID: 25078568
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Trust in physicians among rural Medicaid-enrolled smokers.
Authors: Nelms E, Wang L, Pennell M, Wewers ME, Seiber E, Adolph MD, Paskett ED, Ferketich AK
Source: J Rural Health, 2014 Spring;30(2), p. 214-20.
EPub date: 2013 Aug 13.
PMID: 24689546
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Provider-verified HPV vaccine coverage among a national sample of Hispanic adolescent females.
Authors: Reiter PL, Gupta K, Brewer NT, Gilkey MB, Katz ML, Paskett ED, Smith JS
Source: Cancer Epidemiol Biomarkers Prev, 2014 May;23(5), p. 742-54.
EPub date: 2014 Mar 14.
PMID: 24633142
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Improving symptom communication through personal digital assistants: the CHAT (Communicating Health Assisted by Technology) project.
Authors: Post DM, Shapiro CL, Cegala DJ, David P, Katz ML, Krok JL, Phillips GS, McAlearney AS, Lehman JS, Hicks W, Paskett ED
Source: J Natl Cancer Inst Monogr, 2013 Dec;2013(47), p. 153-61.
PMID: 24395985
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Parents' and sons' beliefs in sexual disinhibition after human papillomavirus vaccination.
Authors: Mayer MK, Reiter PL, Zucker RA, Brewer NT
Source: Sex Transm Dis, 2013 Oct;40(10), p. 822-8.
PMID: 24275737
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Acceptability of HPV vaccine for males and preferences for future education programs among Appalachian residents.
Authors: Reiter PL, Oldach BR, Randle KE, Katz ML
Source: Am J Mens Health, 2014 Mar;8(2), p. 167-74.
EPub date: 2013 Oct 1.
PMID: 24085197
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HPV prevalence among women from Appalachia: results from the CARE project.
Authors: Reiter PL, Katz ML, Ruffin MT, Hade EM, DeGraffenreid CR, Patel DA, Paskett ED, Unger ER
Source: PLoS One, 2013;8(8), p. e74276.
EPub date: 2013 Aug 30.
PMID: 24023700
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Validation of self-reported colorectal cancer screening behaviors among Appalachian residents.
Authors: Reiter PL, Katz ML, Oliveri JM, Young GS, Llanos AA, Paskett ED
Source: Public Health Nurs, 2013 Jul;30(4), p. 312-22.
EPub date: 2013 Apr 5.
PMID: 23808856
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Smoking behaviors and cessation interests among multiunit subsidized housing tenants, Columbus, Ohio, 2011.
Authors: Hood NE, Ferketich AK, Klein EG, Wewers ME, Pirie P
Source: Prev Chronic Dis, 2013 Jul 3;10, p. E108; quiz E108.
EPub date: 2013 Jul 3.
PMID: 23806803
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Longitudinal predictors of human papillomavirus vaccination among a national sample of adolescent males.
Authors: Reiter PL, McRee AL, Pepper JK, Gilkey MB, Galbraith KV, Brewer NT
Source: Am J Public Health, 2013 Aug;103(8), p. 1419-27.
EPub date: 2013 Jun 13.
PMID: 23763402
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Correlates of HPV vaccination among adolescent females from Appalachia and reasons why their parents do not intend to vaccinate.
Authors: Reiter PL, Katz ML, Paskett ED
Source: Vaccine, 2013 Jun 28;31(31), p. 3121-5.
EPub date: 2013 May 9.
PMID: 23664990
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Predictors of voluntary home-smoking restrictions and associations with an objective measure of in-home smoking among subsidized housing tenants.
Authors: Hood NE, Wewers ME, Ferketich AK, Klein EG, Pirie P
Source: Am J Health Promot, 2013 Nov-Dec;28(2), p. 97-104.
EPub date: 2013 Apr 26.
PMID: 23621755
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HPV vaccination among adolescent males: results from the National Immunization Survey-Teen.
Authors: Reiter PL, Gilkey MB, Brewer NT
Source: Vaccine, 2013 Jun 10;31(26), p. 2816-21.
EPub date: 2013 Apr 16.
PMID: 23602667
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Correlates of colorectal cancer screening among residents of Ohio Appalachia.
Authors: Paskett ED, Llanos AA, Young GS, Pennell ML, Lee CJ, Katz ML
Source: J Community Health, 2013 Aug;38(4), p. 609-18.
PMID: 23529450
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Health literacy among the Amish: measuring a complex concept among a unique population.
Authors: Katz ML, Ferketich AK, Paskett ED, Bloomfield CD
Source: J Community Health, 2013 Aug;38(4), p. 753-8.
PMID: 23529449
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Adolescent males' awareness of and willingness to try electronic cigarettes.
Authors: Pepper JK, Reiter PL, McRee AL, Cameron LD, Gilkey MB, Brewer NT
Source: J Adolesc Health, 2013 Feb;52(2), p. 144-50.
EPub date: 2012 Nov 30.
PMID: 23332477
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Correlates of comfort with alternative settings for HPV vaccine delivery.
Authors: McRee AL, Reiter PL, Pepper JK, Brewer NT
Source: Hum Vaccin Immunother, 2013 Feb;9(2), p. 306-13.
EPub date: 2013 Jan 4.
PMID: 23291948
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Oral cancer screening and dental care use among women from Ohio Appalachia.
Authors: Reiter PL, Wee AG, Lehman A, Paskett ED
Source: Rural Remote Health, 2012;12, p. 2184.
EPub date: 2012 Dec 17.
PMID: 23240899
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Assessing the burden of HPV-related cancers in Appalachia.
Authors: Reiter PL, Fisher JL, Hudson AG, Tucker TC, Plascak JJ, Paskett ED
Source: Hum Vaccin Immunother, 2013 Jan;9(1), p. 90-6.
EPub date: 2012 Nov 10.
PMID: 23143774
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Individual, social, and environmental factors associated with support for smoke-free housing policies among subsidized multiunit housing tenants.
Authors: Hood NE, Ferketich AK, Klein EG, Wewers ME, Pirie P
Source: Nicotine Tob Res, 2013 Jun;15(6), p. 1075-83.
EPub date: 2012 Nov 7.
PMID: 23136269
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HPV vaccination among adolescent females from Appalachia: implications for cervical cancer disparities.
Authors: Reiter PL, Katz ML, Paskett ED
Source: Cancer Epidemiol Biomarkers Prev, 2012 Dec;21(12), p. 2220-30.
EPub date: 2012 Nov 7.
PMID: 23136141
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Associations between self-reported in-home smoking behaviours and surface nicotine concentrations in multiunit subsidised housing.
Authors: Hood NE, Ferketich AK, Klein EG, Pirie P, Wewers ME
Source: Tob Control, 2014 Jan;23(1), p. 27-32.
EPub date: 2012 Oct 23.
PMID: 23092883
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The use of daily aspirin, nutritional supplements and alternative medications among Amish and non-Amish living in Ohio Appalachia.
Authors: Cuy˙n Carter GB, Katz ML, Ferketich AK, Clinton SK, Grainger EM, Paskett ED, Bloomfield CD
Source: Nutr Cancer, 2012;64(7), p. 911-8.
EPub date: 2012 Oct 4.
PMID: 23035923
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Perceived risk of cervical cancer in Appalachian women.
Authors: Kelly KM, Ferketich AK, Ruffin Iv MT, Tatum C, Paskett ED
Source: Am J Health Behav, 2012 Nov;36(6), p. 849-59.
PMID: 23026042
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Trends in HPV vaccine initiation among adolescent females in North Carolina, 2008-2010.
Authors: Moss JL, Gilkey MB, Reiter PL, Brewer NT
Source: Cancer Epidemiol Biomarkers Prev, 2012 Nov;21(11), p. 1913-22.
EPub date: 2012 Sep 20.
PMID: 23001239
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The HPV vaccine: a comparison of focus groups conducted in South Africa and Ohio Appalachia.
Authors: Francis SA, Katz ML
Source: Matern Child Health J, 2013 Sep;17(7), p. 1222-9.
PMID: 22930347
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Treatment adherence in a lay health adviser intervention to treat tobacco dependence.
Authors: Hood NE, Ferketich AK, Paskett ED, Wewers ME
Source: Health Educ Res, 2013 Feb;28(1), p. 72-82.
EPub date: 2012 Jul 28.
PMID: 22843347
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Human papillomavirus vaccine knowledge and hypothetical acceptance among women in Appalachia Ohio.
Authors: Ruffin MT 4th, Hade EM, Gorsline MR, DeGraffinreid CR, Katz ML, Kobrin SC, Paskett ED
Source: Vaccine, 2012 Aug 3;30(36), p. 5349-57.
EPub date: 2012 Jun 27.
PMID: 22749839
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Patterns of cellular and HPV 16 methylation as biomarkers for cervical neoplasia.
Authors: Patel DA, Rozek LS, Colacino JA, Van Zomeren-Dohm A, Ruffin MT, Unger ER, Dolinoy DC, Swan DC, Onyekwuluje J, DeGraffinreid CR, Paskett ED
Source: J Virol Methods, 2012 Sep;184(1-2), p. 84-92.
EPub date: 2012 Jun 1.
PMID: 22664184
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