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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA098661-10 Interpret this number
Primary Investigator: Zeleniuch-Jacquotte, Anne
Organization: New York University School Of Medicine
Project Title: Vitamin D, Related Genes and Breast Cancer Risk
Fiscal Year: 2013
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DESCRIPTION (provided by investigator): A large body of experimental data indicates that vitamin D inhibits cellular proliferation and induces differentiation and apoptosis, suggesting a protective effect against cancer. The enzymes coding for the formation and degradation of 1,25(OH)2D, the active metabolite of vitamin D, are present in both normal and cancer breast cells, as is the vitamin D receptor, a key mediator in the vitamin D pathway. Ecological and case- control studies support a protective role of vitamin D against breast cancer; however, prospective data are sparse. Moreover, few studies have measured circulating 25(OH)D which is considered the best indicator of vitamin D status because it captures both the absorption of vitamin D in the intestine and its production in the skin. We propose to conduct a comprehensive study of the vitamin D pathway in relation to breast cancer risk. Because vitamin D impacts cell proliferation, the main mechanism by which estrogens increase breast cancer risk, we will also assess whether vitamin D modifies the association of circulating estradiol with breast cancer risk in postmenopausal women. The study will be a case-control study nested within two cohorts, the NYU Women's Health Study and the Mammary Screening Cohort in Sweden. These two cohorts have a similar design and collected biological samples prospectively. A total of 1,995 incident cases is expected to be observed within these two cohorts. One (or two for cases d 52 years of age) control(s) will be selected for each case, matching the case on cohort, race/ethnicity, menopausal status, age at, and date of, blood donation. In addition to baseline measurements, we will assess 25(OH)D at repeat points in time in about 50 percent of the matched sets (2 samples in 25 percent and 3 samples in 25 percent). We will also assess genetic variation in vitamin D-related genes (CYP27A1, CYP24A1, DBP, VDR, and RXRA) and evaluate the joint effects of circulating 25(OH)D and variants in these genes on breast cancer risk. Circulating levels of estradiol will be measured in postmenopausal matched sets.

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Reliability Of Serum Assays Of Iron Status In Postmenopausal Women
Authors: Zeleniuch-Jacquotte A. , Zhang Q. , Dai J. , Shore R.E. , Arslan A.A. , Koenig K.L. , Karkoszka J. , Afanasyeva Y. , Frenkel K. , Toniolo P. , et al. .
Source: Annals Of Epidemiology, 2007 May; 17(5), p. 354-8.
PMID: 17027294
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Reproducibility Of Serum Pituitary Hormones In Women
Authors: Arslan A.A. , Gu Y. , Zeleniuch-Jacquotte A. , Koenig K.L. , Liu M. , Velikokhatnaya L. , Shore R.E. , Toniolo P. , Linkov F. , Lokshin A.E. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 Aug; 17(8), p. 1880-3.
PMID: 18708375
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Reproducibility Of Serum Cytokines And Growth Factors
Authors: Gu Y. , Zeleniuch-Jacquotte A. , Linkov F. , Koenig K.L. , Liu M. , Velikokhatnaya L. , Shore R.E. , Marrangoni A. , Toniolo P. , Lokshin A.E. , et al. .
Source: Cytokine, 2009 Jan; 45(1), p. 44-9.
PMID: 19058974
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Reliability Of Tumor Markers, Chemokines, And Metastasis-related Molecules In Serum
Authors: Linkov F. , Gu Y. , Arslan A.A. , Liu M. , Shore R.E. , Velikokhatnaya L. , Koenig K.L. , Toniolo P. , Marrangoni A. , Yurkovetsky Z. , et al. .
Source: European Cytokine Network, 2009 Mar; 20(1), p. 21-6.
PMID: 19318317
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Circulating Cytokines And Risk Of B-cell Non-hodgkin Lymphoma: A Prospective Study
Authors: Gu Y. , Shore R.E. , Arslan A.A. , Koenig K.L. , Liu M. , Ibrahim S. , Lokshin A.E. , Zeleniuch-Jacquotte A. .
Source: Cancer Causes & Control : Ccc, 2010 Aug; 21(8), p. 1323-33.
PMID: 20373009
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