Skip Navigation
Grant Details

Grant Number: 5R01CA058420-20 Interpret this number
Primary Investigator: Rosenberg, Lynn
Organization: Boston University Medical Campus
Project Title: A Follow-Up Study for Causes of Illness in Black Women
Fiscal Year: 2013
Back to top


Abstract

DESCRIPTION (provided by applicant): We propose a 5-year continuation of the largest follow-up study of African-American women, the Black Women's Health Study (BWHS). We have followed 59,000 U.S. black women biennially since 1995, collected information on medical, reproductive, lifestyle, psychosocial, and socioeconomic factors, identified incident disease and deaths, and collected cheek cell samples from 26,800 participants. The overarching goal is to elucidate risk factors for cancers with disproportionately high incidence or mortality rates in black women, prominent among which are breast and colorectal cancer, and to elucidate causes of important nonmalignant conditions. Continued follow-up will increase the number of incident breast cancer cases to ~2,400, colorectal cancers to ~500, all-cause deaths to ~3,500, and cancer deaths to ~1,500. Compared with white women, black women have higher breast cancer mortality rates, colorectal cancer incidence and mortality rates, and all- cause and cancer mortality rates. Black women also experience more racism, tend to live in neighborhoods of lower socioeconomic status, have less access to healthy foods, and are more likely to have experienced poverty as children and as adults. Aims of this proposal address aspects of these exposures and outcomes that are of special relevance to black women. Novel aims include the assessment of the relation of experiences of racism to all-cause and cancer mortality; poor diet quality, including restaurant food consumption ("fast food"), to breast and colorectal cancer incidence and all-cause and cancer mortality; and life-course socioeconomic status to obesity and all-cause and cancer mortality. This proposal also addresses the genetic etiology of breast cancer. Under separate funding, we are assessing two genes, FGFR2 and TNRC9 (which have been associated with breast cancer risk in genome wide association studies of European-ancestry women) to identify SNPs associated with breast cancer risk in the BWHS. Here we propose a novel aim based on those findings, to assess effect modification -- by physical activity, obesity, and reproductive factors -- of associations found in the BWHS in order to identify groups of black women at high risk of breast cancer. Thus, the proposed continuation of the BWHS will provide crucial information for the effort to reduce black/white health disparities.

Back to top


Publications

Body size and time-to-pregnancy in black women.
Authors: Wise LA, Palmer JR, Rosenberg L
Source: Hum Reprod, 2013 Oct;28(10), p. 2856-64.
EPub date: 2013 Aug 19.
PMID: 23958939
Related Citations

Back to top


Is the observed association between dairy intake and fibroids in African Americans explained by genetic ancestry?
Authors: Wise LA, Palmer JR, Ruiz-Narvaez E, Reich DE, Rosenberg L
Source: Am J Epidemiol, 2013 Oct 1;178(7), p. 1114-9.
EPub date: 2013 Jul 3.
PMID: 23825169
Related Citations

Back to top


Whole grains, type 2 diabetes, coronary heart disease, and hypertension: links to the aleurone preferred over indigestible fiber.
Authors: Lillioja S, Neal AL, Tapsell L, Jacobs DR Jr
Source: Biofactors, 2013 May-Jun;39(3), p. 242-58.
EPub date: 2013 Jan 28.
PMID: 23355358
Related Citations

Back to top


Lifetime abuse victimization and risk of uterine leiomyomata in black women.
Authors: Wise LA, Palmer JR, Rosenberg L
Source: Am J Obstet Gynecol, 2013 Apr;208(4), p. 272.e1-272.e13.
EPub date: 2013 Jan 4.
PMID: 23295977
Related Citations

Back to top


A genome-wide association study of breast cancer in women of African ancestry.
Authors: Chen F, Chen GK, Stram DO, Millikan RC, Ambrosone CB, John EM, Bernstein L, Zheng W, Palmer JR, Hu JJ, Rebbeck TR, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Ruiz-Narvaez EA, Deming SL, Rodriguez-Gil JL, Demichele A, Chanock SJ, Blot W, Signorello L, Cai Q, Li G, Long J, Huo D, Zheng Y, Cox NJ, Olopade OI, Ogundiran TO, Adebamowo C, Nathanson KL, Domchek SM, Simon MS, Hennis A, Nemesure B, Wu SY, Leske MC, Ambs S, Hutter CM, Young A, Kooperberg C, Peters U, Rhie SK, Wan P, Sheng X, Pooler LC, Van Den Berg DJ, Le Marchand L, Kolonel LN, Henderson BE, Haiman CA
Source: Hum Genet, 2013 Jan;132(1), p. 39-48.
EPub date: 2012 Aug 25.
PMID: 22923054
Related Citations

Back to top


Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata.
Authors: Wise LA, Radin RG, Palmer JR, Kumanyika SK, Boggs DA, Rosenberg L
Source: Am J Clin Nutr, 2011 Dec;94(6), p. 1620-31.
EPub date: 2011 Nov 9.
PMID: 22071705
Related Citations

Back to top


Use of multivitamins, folic acid and herbal supplements among breast cancer survivors: the black women's health study.
Authors: Bright-Gbebry M, Makambi KH, Rohan JP, Llanos AA, Rosenberg L, Palmer JR, Adams-Campbell LL
Source: BMC Complement Altern Med, 2011 Apr 15;11, p. 30.
EPub date: 2011 Apr 15.
PMID: 21496245
Related Citations

Back to top


Longitudinal assessment of urban form and weight gain in African-American women.
Authors: Coogan PF, White LF, Evans SR, Adler TJ, Hathaway KM, Palmer JR, Rosenberg L
Source: Am J Prev Med, 2011 Apr;40(4), p. 411-8.
PMID: 21406274
Related Citations

Back to top


Coffee, tea, and alcohol intake in relation to risk of type 2 diabetes in African American women.
Authors: Boggs DA, Rosenberg L, Ruiz-Narvaez EA, Palmer JR
Source: Am J Clin Nutr, 2010 Oct;92(4), p. 960-6.
EPub date: 2010 Sep 8.
PMID: 20826625
Related Citations

Back to top


Sarcoidosis in black women in the United States: data from the Black Women's Health Study.
Authors: Cozier YC, Berman JS, Palmer JR, Boggs DA, Serlin DM, Rosenberg L
Source: Chest, 2011 Jan;139(1), p. 144-50.
EPub date: 2010 Jul 1.
PMID: 20595459
Related Citations

Back to top


Colonoscopy utilization in the Black Women's Health Study.
Authors: Adams-Campbell LL, Makambi K, Mouton CP, Palmer JR, Rosenberg L
Source: J Natl Med Assoc, 2010 Mar;102(3), p. 237-42.
PMID: 20355353
Related Citations

Back to top


Dietary glycemic index and load in relation to risk of uterine leiomyomata in the Black Women's Health Study.
Authors: Radin RG, Palmer JR, Rosenberg L, Kumanyika SK, Wise LA
Source: Am J Clin Nutr, 2010 May;91(5), p. 1281-8.
EPub date: 2010 Mar 3.
PMID: 20200259
Related Citations

Back to top


Validity of self-reported rheumatoid arthritis in a large cohort: results from the Black Women's Health Study.
Authors: Formica MK, McAlindon TE, Lash TL, Demissie S, Rosenberg L
Source: Arthritis Care Res (Hoboken), 2010 Feb;62(2), p. 235-41.
PMID: 20191523
Related Citations

Back to top


Socioeconomic status and incidence of type 2 diabetes: results from the Black Women's Health Study.
Authors: Krishnan S, Cozier YC, Rosenberg L, Palmer JR
Source: Am J Epidemiol, 2010 Mar 1;171(5), p. 564-70.
EPub date: 2010 Feb 4.
PMID: 20133518
Related Citations

Back to top


Prepregnancy body size, gestational weight gain, and risk of preterm birth in African-American women.
Authors: Wise LA, Palmer JR, Heffner LJ, Rosenberg L
Source: Epidemiology, 2010 Mar;21(2), p. 243-52.
PMID: 20124904
Related Citations

Back to top


Consumption of restaurant foods and incidence of type 2 diabetes in African American women.
Authors: Krishnan S, Coogan PF, Boggs DA, Rosenberg L, Palmer JR
Source: Am J Clin Nutr, 2010 Feb;91(2), p. 465-71.
EPub date: 2009 Dec 16.
PMID: 20016014
Related Citations

Back to top


Prepregnancy depressive symptoms and preterm birth in the Black Women's Health Study.
Authors: Phillips GS, Wise LA, Rich-Edwards JW, Stampfer MJ, Rosenberg L
Source: Ann Epidemiol, 2010 Jan;20(1), p. 8-15.
PMID: 20006271
Related Citations

Back to top


A prospective study of dairy intake and risk of uterine leiomyomata.
Authors: Wise LA, Radin RG, Palmer JR, Kumanyika SK, Rosenberg L
Source: Am J Epidemiol, 2010 Jan 15;171(2), p. 221-32.
EPub date: 2009 Dec 2.
PMID: 19955473
Related Citations

Back to top


Family history of cancer and risk of breast cancer in the Black Women's Health Study.
Authors: Palmer JR, Boggs DA, Adams-Campbell LL, Rosenberg L
Source: Cancer Causes Control, 2009 Nov;20(9), p. 1733-7.
PMID: 19760028
Related Citations

Back to top


Dietary patterns and breast cancer risk in women participating in the Black Women's Health Study.
Authors: Agurs-Collins T, Rosenberg L, Makambi K, Palmer JR, Adams-Campbell L
Source: Am J Clin Nutr, 2009 Sep;90(3), p. 621-8.
EPub date: 2009 Jul 8.
PMID: 19587089
Related Citations

Back to top


An assessment of the CES-D scale factor structure in black women: The Black Women's Health Study.
Authors: Makambi KH, Williams CD, Taylor TR, Rosenberg L, Adams-Campbell LL
Source: Psychiatry Res, 2009 Jul 30;168(2), p. 163-70.
EPub date: 2009 Jun 5.
PMID: 19501414
Related Citations