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Grant Details

Grant Number: 5R01CA151993-04 Interpret this number
Primary Investigator: Ogino, Shuji
Organization: Dana-Farber Cancer Inst
Project Title: Epigenetic Events and Colorectal Cancer Epidemiology
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): As the first independent application led by a recipient of NCI K07 Award ("Molecular Epidemiology of Colorectal Cancer"), this proposal addresses hypotheses in epigenetics and epidemiology of colorectal cancer, in response to NIH Program Announcement PA- 09-234 ("Diet, Epigenetic Events, and Cancer Prevention"). Colorectal cancer is the second leading cause of cancer death in the United States. Abnormal DNA methylation patterns are a hallmark of most cancers including colorectal cancer. Furthermore, DNA methylation alterations (such as loss of imprinting) in non-cancerous cells may predispose to cancer development. Importantly, epigenetic changes, including DNA methylation alterations, are reversible and thus can be targets for therapy or chemoprevention. Accumulating evidence suggests that dietary factors (e.g., alcohol and one-carbon nutrients such as B vitamins) may affect cellular epigenetic status. Examining how dietary factors influence epigenetic alterations is important for better understanding of colorectal cancer development and progression, which can provide a scientific basis for dietary recommendations and help optimize preventive strategies. For that purpose, we will utilize the resources of two large prospective cohort studies, the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Both cohort studies provide dietary data over a 20-year period, DNA from blood cells, long-term survival data, and paraffin-embedded tissue of colorectal cancers. We anticipate over 4500 incident colorectal cancer cases up to 2012 in these cohorts, and among those, paraffin-embedded tissue materials will be available in over 3000 cases. We propose to examine the interrelationship between intake of dietary one-carbon nutrients and alcohol, colorectal cancer risk, cellular epigenetic changes, and clinical outcome. In addition, we will utilize data resulting from genome-wide expression profiling of 1000 colorectal cancers in the cohorts (which has been ongoing with separate funding supports) to discover genes potentially related to abnormal one-carbon metabolism as well as specific epigenomic aberrations in colorectal cancer. Thus, we are in a unique position to examine the relations between modifiable dietary factors, epigenetic and epigenomic aberrations, and genome-wide expression patterns in tumor cells. Through better understanding of epigenetic mechanisms of carcinogenesis, we can propose preventive measures for the incidence and mortality from colorectal cancer.

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Publications

Association Between Plasma Levels of Macrophage Inhibitory Cytokine-1 Before Diagnosis of Colorectal Cancer and Mortality.
Authors: Mehta RS, Chong DQ, Song M, Meyerhardt JA, Ng K, Nishihara R, Qian Z, Morikawa T, Wu K, Giovannucci EL, Fuchs CS, Ogino S, Chan AT
Source: Gastroenterology, 2015 May 27;null, p. null.
EPub date: 2015 May 27.
PMID: 26026393
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Mendelian Randomization Study of Body Mass Index and Colorectal Cancer Risk.
Authors: Thrift AP, Gong J, Peters U, Chang-Claude J, Rudolph A, Slattery ML, Chan AT, Locke AE, Kahali B, Justice AE, Pers TH, Gallinger S, Hayes RB, Baron JA, Caan BJ, Ogino S, Berndt SI, Chanock SJ, Casey G, Haile RW, Du M, Harrison TA, Thornquist M, Duggan DJ, Le Marchand L, Lindor NM, Seminara D, Song M, Wu K, Thibodeau SN, Cotterchio M, Win AK, Jenkins MA, Hopper JL, Ulrich CM, Potter JD, Newcomb PA, Hoffmeister M, Brenner H, White E, Hsu L, Campbell PT
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jul;24(7), p. 1024-31.
EPub date: 2015 May 14.
PMID: 25976416
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Proceedings of the second international molecular pathological epidemiology (MPE) meeting.
Authors: Ogino S, Campbell PT, Nishihara R, Phipps AI, Beck AH, Sherman ME, Chan AT, Troester MA, Bass AJ, Fitzgerald KC, Irizarry RA, Kelsey KT, Nan H, Peters U, Poole EM, Qian ZR, Tamimi RM, Tchetgen Tchetgen EJ, Tworoger SS, Zhang X, Giovannucci EL, van den Brandt PA, Rosner BA, Wang M, Chatterjee N, Begg CB
Source: Cancer Causes Control, 2015 Jul;26(7), p. 959-72.
EPub date: 2015 May 9.
PMID: 25956270
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Marine ?-3 polyunsaturated fatty acids and risk of colorectal cancer according to microsatellite instability.
Authors: Song M, Nishihara R, Wu K, Qian ZR, Kim SA, Sukawa Y, Mima K, Inamura K, Masuda A, Yang J, Fuchs CS, Giovannucci EL, Ogino S, Chan AT
Source: J Natl Cancer Inst, 2015 Apr;107(4), p. null.
EPub date: 2015 Mar 25.
PMID: 25810492
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Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.
Authors: Nan H, Hutter CM, Lin Y, Jacobs EJ, Ulrich CM, White E, Baron JA, Berndt SI, Brenner H, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Casey G, Chang-Claude J, Chanock SJ, Cotterchio M, Duggan D, Figueiredo JC, Fuchs CS, Giovannucci EL, Gong J, Haile RW, Harrison TA, Hayes RB, Hoffmeister M, Hopper JL, Hudson TJ, Jenkins MA, Jiao S, Lindor NM, Lemire M, Le Marchand L, Newcomb PA, Ogino S, Pflugeisen BM, Potter JD, Qu C, Rosse SA, Rudolph A, Schoen RE, Schumacher FR, Seminara D, Slattery ML, Thibodeau SN, Thomas F, Thornquist M, Warnick GS, Zanke BW, Gauderman WJ, Peters U, Hsu L, Chan AT, CCFR, GECCO
Source: JAMA, 2015 Mar 17;313(11), p. 1133-42.
PMID: 25781442
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Early life body fatness and risk of colorectal cancer in u.s. Women and men-results from two large cohort studies.
Authors: Zhang X, Wu K, Giovannucci EL, Ma J, Colditz GA, Fuchs CS, Willett WC, Stampfer MJ, Nimptsch K, Ogino S, Wei EK
Source: Cancer Epidemiol Biomarkers Prev, 2015 Apr;24(4), p. 690-7.
EPub date: 2015 Mar 16.
PMID: 25777804
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Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
Authors: Song M, Nishihara R, Wang M, Chan AT, Qian ZR, Inamura K, Zhang X, Ng K, Kim SA, Mima K, Sukawa Y, Nosho K, Fuchs CS, Giovannucci EL, Wu K, Ogino S
Source: Gut, 2015 Jan 15;null, p. null.
EPub date: 2015 Jan 15.
PMID: 25591978
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Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy.
Authors: Li TT, Ogino S, Qian ZR
Source: World J Gastroenterol, 2014 Dec 21;20(47), p. 17699-708.
PMID: 25548469
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Lifecourse epidemiology and molecular pathological epidemiology.
Authors: Nishi A, Kawachi I, Koenen KC, Wu K, Nishihara R, Ogino S
Source: Am J Prev Med, 2015 Jan;48(1), p. 116-9.
PMID: 25528613
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Derivation and validation of homocysteine score in u.s. Men and women.
Authors: Jung S, Je Y, Giovannucci EL, Rosner B, Ogino S, Cho E
Source: J Nutr, 2015 Jan;145(1), p. 96-104.
EPub date: 2014 Nov 12.
PMID: 25527664
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Post diagnosis diet quality and colorectal cancer survival in women.
Authors: Fung TT, Kashambwa R, Sato K, Chiuve SE, Fuchs CS, Wu K, Giovannucci E, Ogino S, Hu FB, Meyerhardt JA
Source: PLoS One, 2014;9(12), p. e115377.
EPub date: 2014 Dec 15.
PMID: 25506700
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Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region.
Authors: Nishihara R, Wang M, Qian ZR, Baba Y, Yamauchi M, Mima K, Sukawa Y, Kim SA, Inamura K, Zhang X, Wu K, Giovannucci EL, Chan AT, Fuchs CS, Ogino S, Schernhammer ES
Source: Am J Clin Nutr, 2014 Dec;100(6), p. 1479-88.
EPub date: 2014 Oct 8.
PMID: 25411283
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RNF43 is frequently mutated in colorectal and endometrial cancers.
Authors: Giannakis M, Hodis E, Jasmine Mu X, Yamauchi M, Rosenbluh J, Cibulskis K, Saksena G, Lawrence MS, Qian ZR, Nishihara R, Van Allen EM, Hahn WC, Gabriel SB, Lander ES, Getz G, Ogino S, Fuchs CS, Garraway LA
Source: Nat Genet, 2014 Dec;46(12), p. 1264-6.
EPub date: 2014 Oct 26.
PMID: 25344691
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Red meat intake, NAT2, and risk of colorectal cancer: a pooled analysis of 11 studies.
Authors: Ananthakrishnan AN, Du M, Berndt SI, Brenner H, Caan BJ, Casey G, Chang-Claude J, Duggan D, Fuchs CS, Gallinger S, Giovannucci EL, Harrison TA, Hayes RB, Hoffmeister M, Hopper JL, Hou L, Hsu L, Jenkins MA, Kraft P, Ma J, Nan H, Newcomb PA, Ogino S, Potter JD, Seminara D, Slattery ML, Thornquist M, White E, Wu K, Peters U, Chan AT
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jan;24(1), p. 198-205.
EPub date: 2014 Oct 23.
PMID: 25342387
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Prognostic significance and molecular features of signet-ring cell and mucinous components in colorectal carcinoma.
Authors: Inamura K, Yamauchi M, Nishihara R, Kim SA, Mima K, Sukawa Y, Li T, Yasunari M, Zhang X, Wu K, Meyerhardt JA, Fuchs CS, Harris CC, Qian ZR, Ogino S
Source: Ann Surg Oncol, 2015 Apr;22(4), p. 1226-35.
EPub date: 2014 Oct 18.
PMID: 25326395
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Challenges and opportunities in international molecular cancer prevention research: An ASPO Molecular Epidemiology and the Environment and International Cancer Prevention Interest Groups Report.
Authors: Epplein M, Bostick RM, Mu L, Ogino S, Braithwaite D, Kanetsky PA
Source: Cancer Epidemiol Biomarkers Prev, 2014 Nov;23(11), p. 2613-7.
EPub date: 2014 Oct 2.
PMID: 25277796
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Tumor LINE-1 methylation level and microsatellite instability in relation to colorectal cancer prognosis.
Authors: Inamura K, Yamauchi M, Nishihara R, Lochhead P, Qian ZR, Kuchiba A, Kim SA, Mima K, Sukawa Y, Jung S, Zhang X, Wu K, Cho E, Chan AT, Meyerhardt JA, Harris CC, Fuchs CS, Ogino S
Source: J Natl Cancer Inst, 2014 Sep;106(9), p. null.
EPub date: 2014 Sep 4.
PMID: 25190725
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IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.
Authors: Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y
Source: World J Gastroenterol, 2014 Aug 7;20(29), p. 10050-61.
PMID: 25110432
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SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features.
Authors: Li T, Liao X, Lochhead P, Morikawa T, Yamauchi M, Nishihara R, Inamura K, Kim SA, Mima K, Sukawa Y, Kuchiba A, Imamura Y, Baba Y, Shima K, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S, Qian ZR
Source: Ann Surg Oncol, 2014 Dec;21(13), p. 4164-73.
EPub date: 2014 Jul 15.
PMID: 25023548
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