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Grant Details

Grant Number: 5R01CA039742-29 Interpret this number
Primary Investigator: Lazovich, Deann
Organization: University Of Minnesota
Project Title: Epidemiology of Cancer in a Cohort of Older Women
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): The Iowa Women's Health Study (IWHS) began in 1986 as a longitudinal cohort study to determine whether diet, body fat distribution, and other risk factors were related to cancer incidence among 41,836 post- menopausal women aged 55-69 years. Exposure and lifestyle information was collected in a baseline mailed survey in 1986, and five follow-up surveys in 1987, 1989, 1992, 1997 and 2004. Cancer incidence and mortality have been obtained by annual linkage with the Iowa Cancer Registry (a SEER cancer registry) and the National Death Index since 1986. The project has been extremely productive, with more than 260 research publications published to date. We propose, in this 5-year renewal, to continue to address important questions related to cancer in older women. The cohort is becoming especially informative with regard to less common cancers, and for lifestyle predictors of cancer occurrence and survival among the elderly. We also propose new linkages to sources of community-level data that will allow us to study how an individual's social and physical environment influences their cancer risk. These data sources include the Area Resource File (US Department of Health and Human Services), US Census Data, and data from the Rural Development Initiative Study based at Iowa State University. Our specific aims for the proposed funding period are to: 1) continue to follow the IWHS cohort, who are now 78-92 years old, through a total of 27 years (1986-2012), 2) expand our ongoing investigations of risk factors for incident cancers among women, 3) determine the factors associated with quality of life and mortality among female cancer survivors, and 4) determine the associations between community-level social and environmental characteristics and cancer outcomes and quality of life among elderly women. Continuation of funding for the IWHS is vital not only to completion of the research described in the specific aims, but is also key to supporting existing and several planned ancillary studies. The IWHS is also an active participant in several consortia of cohort studies. The combination of the extensive exposure and follow-up data already collected, linkage with community-level data that will be obtained at no cost, a productive research team, and the important research questions that are proposed make a 5-year continuation of the IWHS an extremely cost-effective means towards improving public health.

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Publications

Farm residence and lymphohematopoietic cancers in the Iowa Women's Health Study.
Authors: Jones RR, Yu CL, Nuckols JR, Cerhan JR, Airola M, Ross JA, Robien K, Ward MH
Source: Environ Res, 2014 Aug;133, p. 353-61.
EPub date: 2014 Jul 16.
PMID: 25038451
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Pooling prospective studies to investigate the etiology of second cancers.
Authors: Black A, Gibson TM, Shiels MS, Park Y, Robien K, Albanes D, Weinstein SJ, Freeman LE, Andreotti G, Purdue MP, Fraumeni JF, Hartge P, Tucker MA, Hoover RN, Cerhan JR, Zeleniuch-Jacquotte A, Curtis RE, Elena J, Sampson JN, Berrington de Gonzalez A, Morton LM
Source: Cancer Epidemiol Biomarkers Prev, 2014 Aug;23(8), p. 1598-608.
EPub date: 2014 May 15.
PMID: 24832874
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A pooled analysis of waist circumference and mortality in 650,000 adults.
Authors: Cerhan JR, Moore SC, Jacobs EJ, Kitahara CM, Rosenberg PS, Adami HO, Ebbert JO, English DR, Gapstur SM, Giles GG, Horn-Ross PL, Park Y, Patel AV, Robien K, Weiderpass E, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Hartge P, Bernstein L, Berrington de Gonzalez A
Source: Mayo Clin Proc, 2014 Mar;89(3), p. 335-45.
PMID: 24582192
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Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's Health Study cohort.
Authors: Leal AD, Thompson CA, Wang AH, Vierkant RA, Habermann TM, Ross JA, Mesa RA, Virnig BA, Cerhan JR
Source: Int J Cancer, 2014 Apr 1;134(7), p. 1741-50.
EPub date: 2013 Oct 15.
PMID: 24114627
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Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer.
Authors: Uccella S, Mariani A, Wang AH, Vierkant RA, Cliby WA, Robien K, Anderson KE, Cerhan JR
Source: Br J Cancer, 2013 Oct 1;109(7), p. 1908-13.
EPub date: 2013 Sep 10.
PMID: 24022184
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Diet quality indexes and mortality in postmenopausal women: the Iowa Women's Health Study.
Authors: Mursu J, Steffen LM, Meyer KA, Duprez D, Jacobs DR Jr
Source: Am J Clin Nutr, 2013 Aug;98(2), p. 444-53.
PMID: 23783291
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Type I and II endometrial cancers: have they different risk factors?
Authors: Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB, Wolk A, Wentzensen N, Weiss NS, Webb PM, van den Brandt PA, van de Vijver K, Thompson PJ, Australian National Endometrial Cancer Study Group, Strom BL, Spurdle AB, Soslow RA, Shu XO, Schairer C, Sacerdote C, Rohan TE, Robien K, Risch HA, Ricceri F, Rebbeck TR, Rastogi R, Prescott J, Polidoro S, Park Y, Olson SH, Moysich KB, Miller AB, McCullough ML, Matsuno RK, Magliocco AM, Lurie G, Lu L, Lissowska J, Liang X, Lacey JV Jr, Kolonel LN, Henderson BE, Hankinson SE, Håkansson N, Goodman MT, Gaudet MM, Garcia-Closas M, Friedenreich CM, Freudenheim JL, Doherty J, De Vivo I, Courneya KS, Cook LS, Chen C, Cerhan JR, Cai H, Brinton LA, Bernstein L, Anderson KE, Anton-Culver H, Schouten LJ, Horn-Ross PL
Source: J Clin Oncol, 2013 Jul 10;31(20), p. 2607-18.
EPub date: 2013 Jun 3.
PMID: 23733771
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Duration of diabetes and pancreatic cancer in a case-control study in the Midwest and the Iowa Women's Health Study (IWHS) cohort.
Authors: Henry SA, Prizment AE, Anderson KE
Source: JOP, 2013 May 10;14(3), p. 243-9.
EPub date: 2013 May 10.
PMID: 23669472
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Reproductive, lifestyle, and anthropometric risk factors for cancer in elderly women.
Authors: Poynter JN, Inoue-Choi M, Ross JA, Jacobs DR Jr, Robien K
Source: Cancer Epidemiol Biomarkers Prev, 2013 Apr;22(4), p. 681-7.
EPub date: 2013 Feb 19.
PMID: 23429062
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Diabetes and risk of bladder cancer among postmenopausal women in the Iowa Women's Health Study.
Authors: Prizment AE, Anderson KE, Yuan JM, Folsom AR
Source: Cancer Causes Control, 2013 Mar;24(3), p. 603-8.
EPub date: 2013 Jan 8.
PMID: 23296458
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Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study.
Authors: Razzak AA, Oxentenko AS, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Potter JD, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ
Source: Nutr Cancer, 2012;64(7), p. 899-910.
PMID: 23061900
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Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium.
Authors: Setiawan VW, Pike MC, Karageorgi S, Deming SL, Anderson K, Bernstein L, Brinton LA, Cai H, Cerhan JR, Cozen W, Chen C, Doherty J, Freudenheim JL, Goodman MT, Hankinson SE, Lacey JV Jr, Liang X, Lissowska J, Lu L, Lurie G, Mack T, Matsuno RK, McCann S, Moysich KB, Olson SH, Rastogi R, Rebbeck TR, Risch H, Robien K, Schairer C, Shu XO, Spurdle AB, Strom BL, Thompson PJ, Ursin G, Webb PM, Weiss NS, Wentzensen N, Xiang YB, Yang HP, Yu H, Horn-Ross PL, De Vivo I, Australian National Endometrial Cancer Study Group
Source: Am J Epidemiol, 2012 Aug 15;176(4), p. 269-78.
EPub date: 2012 Jul 23.
PMID: 22831825
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Interaction of nitrate and folate on the risk of breast cancer among postmenopausal women.
Authors: Inoue-Choi M, Ward MH, Cerhan JR, Weyer PJ, Anderson KE, Robien K
Source: Nutr Cancer, 2012;64(5), p. 685-94.
EPub date: 2012 May 29.
PMID: 22642949
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Cigarette smoking and colorectal cancer risk by KRAS mutation status among older women.
Authors: Samadder NJ, Vierkant RA, Tillmans LS, Wang AH, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Potter JD, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ
Source: Am J Gastroenterol, 2012 May;107(5), p. 782-9.
EPub date: 2012 Feb 21.
PMID: 22349355
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Psoriasis is associated with a greater risk of incident venous thromboembolism: the Iowa Women's Health Study.
Authors: Lutsey PL, Prizment AE, Folsom AR
Source: J Thromb Haemost, 2012 Apr;10(4), p. 708-11.
PMID: 22284895
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Vitamin D intake and mental health-related quality of life in older women: the Iowa Women's Health Study.
Authors: Motsinger S, Lazovich D, MacLehose RF, Torkelson CJ, Robien K
Source: Maturitas, 2012 Mar;71(3), p. 267-73.
EPub date: 2011 Dec 29.
PMID: 22209201
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Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women.
Authors: Razzak AA, Oxentenko AS, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ
Source: Cancer Prev Res (Phila), 2011 Dec;4(12), p. 2035-43.
EPub date: 2011 Sep 7.
PMID: 21900595
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Risk factors for meningioma in postmenopausal women: results from the Iowa Women's Health Study.
Authors: Johnson DR, Olson JE, Vierkant RA, Hammack JE, Wang AH, Folsom AR, Virnig BA, Cerhan JR
Source: Neuro Oncol, 2011 Sep;13(9), p. 1011-9.
EPub date: 2011 Jul 12.
PMID: 21750006
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Association between psoriasis and incident cancer: the Iowa's Women's Health Study.
Authors: Prizment AE, Alonso A, Folsom AR, Ahmed RL, Virnig BA, Warshaw EM, Anderson KE
Source: Cancer Causes Control, 2011 Jul;22(7), p. 1003-10.
EPub date: 2011 May 7.
PMID: 21553077
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