Skip Navigation
Grant Details

Grant Number: 1UM1CA173642-01 Interpret this number
Primary Investigator: Anderson, Garnet
Organization: Fred Hutchinson Cancer Research Center
Project Title: Women's Health Initiative Cancer Survivor Cohort
Fiscal Year: 2013
Back to top


Abstract

DESCRIPTION (provided by applicant): The Women's Health Initiative represents a large population-based sample of 161,000 postmenopausal US women. These women have been well-characterized in terms of demographics, diverse exposures, quality of life assessments and incidence of chronic diseases, including over 20,000 incident invasive cancers over a mean 12 years of follow-up. A biorepository maintains >5 million vials of serum, plasma and DNA, and over 93,000 women continue in active follow-up. WHI investigators seek to enhance opportunities for cancer survivorship studies, particularly those that recognize the import of molecular heterogeneity of tumors, by addressing two key limitations in the existing program. Specifically, we propose to; 1) collect information on cancer treatment, clinical outcomes (recurrence) and patient reported outcomes in women diagnosed with selected cancers (breast, colorectal, endometrial, lung, and ovarian cancers, lymphoma, leukemia, and melanoma, projected n=21,882) during WHI participation using Medicare linkages or direct medical record abstraction; and 2) collect paraffin-embedded tumor tissue from selected cancers (colorectal and ovarian cancers, melanoma, lymphoma, and breast and lung cancer subtypes, projected n=5,900). We will collect treatment and outcome data via linkage to Medicare datasets for cost efficiencies, whenever possible, and will pursue and evaluate methods to collect these data through access to other administrative databases. By enhancing the WHI database with cancer treatment and recurrence data, WHI will be a valuable resource to examine the effects of cancer diagnosis and treatment on overall health and quality of life in an aging cohort-one that represents the fastest growing population, bears the great cancer burden but has been under-represented in randomized trials. By supplementing the specimen repository with tumor specimens, the WHI Program will be able to support "up-to-date" phenotyping of cancers and contribute to our understanding of the molecular basis of cancer, its treatment and survival. We want to begin soon to ensure that a large and representative resource can be realized, because tumor tissue and records for cases diagnosed in the early period of the WHI will become increasingly difficult to obtain.

Back to top


Publications

Survivorship: screening for cancer and treatment effects, version 2.2014.
Authors: Denlinger CS, Ligibel JA, Are M, Baker KS, Demark-Wahnefried W, Dizon D, Friedman DL, Goldman M, Jones L, King A, Ku GH, Kvale E, Langbaum TS, Leonardi-Warren K, McCabe MS, Melisko M, Montoya JG, Mooney K, Morgan MA, Moslehi JJ, O'Connor T, Overholser L, Paskett ED, Peppercorn J, Raza M, Rodriguez MA, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian NR, Freedman-Cass DA
Source: J Natl Compr Canc Netw, 2014 Nov;12(11), p. 1526-31.
PMID: 25361799
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

MeSH Terms:
Neoplasms Survival Rate Humans
Early Detection of Cancer Survivors

Back to top


Survivorship: nutrition and weight management, Version 2.2014. Clinical practice guidelines in oncology.
Authors: Denlinger CS, Ligibel JA, Are M, Baker KS, Demark-Wahnefried W, Dizon D, Friedman DL, Goldman M, Jones L, King A, Ku GH, Kvale E, Langbaum TS, Leonardi-Warren K, McCabe MS, Melisko M, Montoya JG, Mooney K, Morgan MA, Moslehi JJ, O'Connor T, Overholser L, Paskett ED, Peppercorn J, Raza M, Rodriguez MA, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian NR, Freedman-Cass DA
Source: J Natl Compr Canc Netw, 2014 Oct;12(10), p. 1396-406.
PMID: 25313179
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

Back to top


Survivorship: healthy lifestyles, version 2.2014.
Authors: Denlinger CS, Ligibel JA, Are M, Baker KS, Demark-Wahnefried W, Dizon D, Friedman DL, Goldman M, Jones L, King A, Ku GH, Kvale E, Langbaum TS, Leonardi-Warren K, McCabe MS, Melisko M, Montoya JG, Mooney K, Morgan MA, Moslehi JJ, O'Connor T, Overholser L, Paskett ED, Peppercorn J, Raza M, Rodriguez MA, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian NR, Freedman-Cass DA, National comprehensive cancer network
Source: J Natl Compr Canc Netw, 2014 Sep;12(9), p. 1222-37.
PMID: 25190692
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

MeSH Terms:
Life Style Behavior Humans
Exercise Survivors

Back to top


Survivorship: immunizations and prevention of infections, version 2.2014.
Authors: Denlinger CS, Ligibel JA, Are M, Baker KS, Demark-Wahnefried W, Dizon D, Friedman DL, Goldman M, Jones L, King A, Ku GH, Kvale E, Langbaum TS, Leonardi-Warren K, McCabe MS, Melisko M, Montoya JG, Mooney K, Morgan MA, Moslehi JJ, O'Connor T, Overholser L, Paskett ED, Peppercorn J, Raza M, Rodriguez MA, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian NR, Freedman-Cass DA
Source: J Natl Compr Canc Netw, 2014 Aug;12(8), p. 1098-111.
PMID: 25099442
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

MeSH Terms:
Communicable Diseases Neoplasms Survival Rate
Humans Guidelines as Topic Vaccination
Survivors Immunization Risk Assessment

Back to top


Survivorship: cognitive function, version 1.2014.
Authors: Denlinger CS, Ligibel JA, Are M, Baker KS, Demark-Wahnefried W, Friedman DL, Goldman M, Jones L, King A, Ku GH, Kvale E, Langbaum TS, Leonardi-Warren K, McCabe MS, Melisko M, Montoya JG, Mooney K, Morgan MA, Moslehi JJ, O'Connor T, Overholser L, Paskett ED, Raza M, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian NR, Freedman-Cass DA, National Comprehensive Cancer Network
Source: J Natl Compr Canc Netw, 2014 Jul;12(7), p. 976-86.
PMID: 24994918
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

MeSH Terms:
Pain Management Fatigue Benzhydryl Compounds
Humans Occupational Therapy Methylphenidate
Quality of Life Sleep Disorders Central Nervous System Stimulants
Cognition Disorders Brain Neoplasms Wakefulness-Promoting Agents
Survival Rate Adaptation, Psychological Treatment Outcome

Back to top


Survivorship: fatigue, version 1.2014.
Authors: Denlinger CS, Ligibel JA, Are M, Baker KS, Demark-Wahnefried W, Friedman DL, Goldman M, Jones L, King A, Ku GH, Kvale E, Langbaum TS, Leonardi-Warren K, McCabe MS, Melisko M, Montoya JG, Mooney K, Morgan MA, Moslehi JJ, O'Connor T, Overholser L, Paskett ED, Raza M, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian N, Freedman-Cass D
Source: J Natl Compr Canc Netw, 2014 Jun;12(6), p. 876-87.
PMID: 24925198
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

MeSH Terms:
Patient Education as Topic Neoplasms Fatigue
Survival Rate Humans Motor Activity

Back to top


Survivorship: sleep disorders, version 1.2014.
Authors: Denlinger CS, Ligibel JA, Are M, Baker KS, Demark-Wahnefried W, Friedman DL, Goldman M, Jones L, King A, Ku GH, Kvale E, Langbaum TS, Leonardi-Warren K, McCabe MS, Melisko M, Montoya JG, Mooney K, Morgan MA, Moslehi JJ, O'Connor T, Overholser L, Paskett ED, Raza M, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian N, Freedman-Cass D, National Comprehensive Cancer Network
Source: J Natl Compr Canc Netw, 2014 May;12(5), p. 630-42.
PMID: 24812132
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

MeSH Terms:
Neoplasms Humans Sleep Disorders
Survivors

Back to top


Survivorship: pain version 1.2014.
Authors: Denlinger CS, Ligibel JA, Are M, Baker KS, Demark-Wahnefried W, Friedman DL, Goldman M, Jones L, King A, Ku GH, Kvale E, Langbaum TS, Leonardi-Warren K, McCabe MS, Melisko M, Montoya JG, Mooney K, Morgan MA, Moslehi JJ, O'Connor T, Overholser L, Paskett ED, Raza M, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian N, Freedman-Cass D, National Comprehensive Cancer Network
Source: J Natl Compr Canc Netw, 2014 Apr;12(4), p. 488-500.
PMID: 24717568
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

MeSH Terms:
Neoplasms Humans Chronic Pain
Survivors

Back to top


Survivorship: sexual dysfunction (male), version 1.2013.
Authors: Denlinger CS, Carlson RW, Are M, Baker KS, Davis E, Edge SB, Friedman DL, Goldman M, Jones L, King A, Kvale E, Langbaum TS, Ligibel JA, McCabe MS, McVary KT, Melisko M, Montoya JG, Mooney K, Morgan MA, O'Connor T, Paskett ED, Raza M, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian N, Freedman-Cass D, National comprehensive cancer network
Source: J Natl Compr Canc Netw, 2014 Mar 1;12(3), p. 356-63.
PMID: 24616541
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

MeSH Terms:
Neoplasms Humans Survivors
Erectile Dysfunction Male

Back to top


Survivorship: sexual dysfunction (female), version 1.2013.
Authors: Denlinger CS, Carlson RW, Are M, Baker KS, Davis E, Edge SB, Friedman DL, Goldman M, Jones L, King A, Kvale E, Langbaum TS, Ligibel JA, McCabe MS, McVary KT, Melisko M, Montoya JG, Mooney K, Morgan MA, O'Connor T, Paskett ED, Raza M, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian N, Freedman-Cass D, National compresensive cancer network
Source: J Natl Compr Canc Netw, 2014 Feb;12(2), p. 184-92.
PMID: 24586080
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

MeSH Terms:
Neoplasms Sexual Dysfunction, Physiological Humans
Survivors Female

Back to top


Survivorship: introduction and definition. Clinical practice guidelines in oncology.
Authors: Denlinger CS, Carlson RW, Are M, Baker KS, Davis E, Edge SB, Friedman DL, Goldman M, Jones L, King A, Kvale E, Langbaum TS, Ligibel JA, McCabe MS, McVary KT, Melisko M, Montoya JG, Mooney K, Morgan MA, O'Connor T, Paskett ED, Raza M, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian N, Freedman-Cass D
Source: J Natl Compr Canc Netw, 2014 Jan;12(1), p. 34-45.
PMID: 24453291
Related Citations

Grant Numbers:
NCI NIH HHS - UM1 CA173642

MeSH Terms:
Neoplasms Survival Rate Humans
Adult Guidelines as Topic Survivors

Back to top