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Grant Details

Grant Number: 5R01CA129059-05 Interpret this number
Primary Investigator: Caan, Bette
Organization: Kaiser Foundation Research Institute
Project Title: Molecular Profiles and Lifestyle Factors in Breast Cancer Prognosis
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): In recent years, new technologies have allowed us to better characterize the heterogeneity of breast cancer and to identify a number of biological subtypes based on their molecular profiles. Consequently, molecular classification of tumors is increasingly being used to guide treatment selection and new treatment development, in evaluating prognosis, and in studies of etiology. One molecular classification, the "intrinsic subtype", which distinguishes among breast cancers based on either their cell type of origin (luminal A/B or basal) or whether the tumor is HER2-positive, has been used to identify biologically and clinically distinct subtypes of breast cancer. The primary goal of this proposal is to examine the effects of intrinsic subtypes and their relationship to breast cancer risk factors and short and long-term prognosis in two ongoing cohort studies of breast cancer survivors (N=4177) being conducted within the Kaiser Permanente of Northern California (KPNC) Medical Care program. The first study, the Life After Cancer Epidemiology (LACE) cohort, a population-based cohort of 2,288 women diagnosed with Stage I>1 cm, II, or IIIa breast cancer, was established in 2000- 2002 to examine behavioral factors and breast cancer prognosis. These data will be combined with 1890 additional cases of similar stage from the Pathways cohort, a study of short term breast cancer survivors which began in January 2006. Given the inconsistency observed to date in findings between energy related factors and prognosis and the suggestion that effects may vary by tumor characteristics such as hormone receptor status, a secondary goal of this proposal is to examine whether specific behaviors related to energy balance may be related to prognosis among breast cancer patients in general or primarily among women with certain intrinsic subtypes Since most studies have only reported on effects of energy related factors on short term prognosis, another secondary goal of this proposal is to continue to follow women in the LACE cohort up until 15 year post-diagnosis and to examine the relationship of energy related lifestyle factors with long-term prognosis. Data on weight, weight change, physical activity and diet were collected at multiple time points post diagnosis. Women are followed annually for recurrence and death by self report and verified by medical record and death certificates. During the proposed new funding period, archived tumor blocks will be retrieved and, using immunohistochemical assays (IHC), breast cancers will be classified into intrinsic subtypes. This study will achieve tremendous cost savings by examining the proposed questions within two existing cohort of cancer survivors for whom post diagnosis data on behavior are already available and by retrieving tumor specimens within a cohort where close to 90% the women belong to the KPNC, an HMO, where tumor specimens are readily accessible. Our proposal addresses a range of issues that are emerging priority areas in cancer survivorship research which will have both clinical and public health impact.

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Publications

Pre- to post-diagnosis weight change and associations with physical functional limitations in breast cancer survivors.
Authors: Young A, Weltzien E, Kwan M, Castillo A, Caan B, Kroenke CH
Source: J Cancer Surviv, 2014 Dec;8(4), p. 539-47.
EPub date: 2014 May 8.
PMID: 24806261
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Race and breast cancer survival by intrinsic subtype based on PAM50 gene expression.
Authors: Kroenke CH, Sweeney C, Kwan ML, Quesenberry CP, Weltzien EK, Habel LA, Castillo A, Bernard PS, Factor RE, Kushi LH, Caan BJ
Source: Breast Cancer Res Treat, 2014 Apr;144(3), p. 689-99.
EPub date: 2014 Mar 7.
PMID: 24604094
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Intrinsic subtypes from the PAM50 gene expression assay in a population-based breast cancer survivor cohort: prognostication of short- and long-term outcomes.
Authors: Caan BJ, Sweeney C, Habel LA, Kwan ML, Kroenke CH, Weltzien EK, Quesenberry CP Jr, Castillo A, Factor RE, Kushi LH, Bernard PS
Source: Cancer Epidemiol Biomarkers Prev, 2014 May;23(5), p. 725-34.
EPub date: 2014 Feb 12.
PMID: 24521998
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Intrinsic subtypes from PAM50 gene expression assay in a population-based breast cancer cohort: differences by age, race, and tumor characteristics.
Authors: Sweeney C, Bernard PS, Factor RE, Kwan ML, Habel LA, Quesenberry CP Jr, Shakespear K, Weltzien EK, Stijleman IJ, Davis CA, Ebbert MT, Castillo A, Kushi LH, Caan BJ
Source: Cancer Epidemiol Biomarkers Prev, 2014 May;23(5), p. 714-24.
EPub date: 2014 Feb 12.
PMID: 24521995
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Lifetime cigarette smoking and breast cancer prognosis in the After Breast Cancer Pooling Project.
Authors: Pierce JP, Patterson RE, Senger CM, Flatt SW, Caan BJ, Natarajan L, Nechuta SJ, Poole EM, Shu XO, Chen WY
Source: J Natl Cancer Inst, 2014 Jan;106(1), p. djt359.
EPub date: 2013 Dec 7.
PMID: 24317179
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Re: High- and low-fat dairy intake, recurrence, and mortality after breast cancer diagnosis. Response.
Authors: Kroenke CH, Caan BJ
Source: J Natl Cancer Inst, 2013 Nov 20;105(22), p. 1761-2.
EPub date: 2013 Oct 10.
PMID: 24115359
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Obesity and mortality after breast cancer by race/ethnicity: The California Breast Cancer Survivorship Consortium.
Authors: Kwan ML, John EM, Caan BJ, Lee VS, Bernstein L, Cheng I, Gomez SL, Henderson BE, Keegan TH, Kurian AW, Lu Y, Monroe KR, Roh JM, Shariff-Marco S, Sposto R, Vigen C, Wu AH
Source: Am J Epidemiol, 2014 Jan 1;179(1), p. 95-111.
EPub date: 2013 Oct 9.
PMID: 24107615
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The California Breast Cancer Survivorship Consortium (CBCSC): prognostic factors associated with racial/ethnic differences in breast cancer survival.
Authors: Wu AH, Gomez SL, Vigen C, Kwan ML, Keegan TH, Lu Y, Shariff-Marco S, Monroe KR, Kurian AW, Cheng I, Caan BJ, Lee VS, Roh JM, Sullivan-Halley J, Henderson BE, Bernstein L, John EM, Sposto R
Source: Cancer Causes Control, 2013 Oct;24(10), p. 1821-36.
EPub date: 2013 Jul 18.
PMID: 23864487
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Postdiagnosis cruciferous vegetable consumption and breast cancer outcomes: a report from the After Breast Cancer Pooling Project.
Authors: Nechuta S, Caan BJ, Chen WY, Kwan ML, Lu W, Cai H, Poole EM, Flatt SW, Zheng W, Pierce JP, Shu XO
Source: Cancer Epidemiol Biomarkers Prev, 2013 Aug;22(8), p. 1451-6.
EPub date: 2013 Jun 13.
PMID: 23765086
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Postdiagnosis supplement use and breast cancer prognosis in the After Breast Cancer Pooling Project.
Authors: Poole EM, Shu X, Caan BJ, Flatt SW, Holmes MD, Lu W, Kwan ML, Nechuta SJ, Pierce JP, Chen WY
Source: Breast Cancer Res Treat, 2013 Jun;139(2), p. 529-37.
EPub date: 2013 May 10.
PMID: 23660948
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High- and low-fat dairy intake, recurrence, and mortality after breast cancer diagnosis.
Authors: Kroenke CH, Kwan ML, Sweeney C, Castillo A, Caan BJ
Source: J Natl Cancer Inst, 2013 May 1;105(9), p. 616-23.
EPub date: 2013 Mar 14.
PMID: 23492346
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Postdiagnosis alcohol consumption and breast cancer prognosis in the after breast cancer pooling project.
Authors: Kwan ML, Chen WY, Flatt SW, Weltzien EK, Nechuta SJ, Poole EM, Holmes MD, Patterson RE, Shu XO, Pierce JP, Caan BJ
Source: Cancer Epidemiol Biomarkers Prev, 2013 Jan;22(1), p. 32-41.
EPub date: 2012 Nov 13.
PMID: 23150063
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Social networks, social support, and burden in relationships, and mortality after breast cancer diagnosis in the Life After Breast Cancer Epidemiology (LACE) study.
Authors: Kroenke CH, Quesenberry C, Kwan ML, Sweeney C, Castillo A, Caan BJ
Source: Breast Cancer Res Treat, 2013 Jan;137(1), p. 261-71.
EPub date: 2012 Nov 10.
PMID: 23143212
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Smoking and survival after breast cancer diagnosis: a prospective observational study and systematic review.
Authors: Braithwaite D, Izano M, Moore DH, Kwan ML, Tammemagi MC, Hiatt RA, Kerlikowske K, Kroenke CH, Sweeney C, Habel L, Castillo A, Weltzien E, Caan B
Source: Breast Cancer Res Treat, 2012 Nov;136(2), p. 521-33.
EPub date: 2012 Sep 29.
PMID: 23053660
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Weight change and survival after breast cancer in the after breast cancer pooling project.
Authors: Caan BJ, Kwan ML, Shu XO, Pierce JP, Patterson RE, Nechuta SJ, Poole EM, Kroenke CH, Weltzien EK, Flatt SW, Quesenberry CP Jr, Holmes MD, Chen WY
Source: Cancer Epidemiol Biomarkers Prev, 2012 Aug;21(8), p. 1260-71.
EPub date: 2012 Jun 13.
PMID: 22695738
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Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women.
Authors: Nechuta SJ, Caan BJ, Chen WY, Lu W, Chen Z, Kwan ML, Flatt SW, Zheng Y, Zheng W, Pierce JP, Shu XO
Source: Am J Clin Nutr, 2012 Jul;96(1), p. 123-32.
EPub date: 2012 May 30.
PMID: 22648714
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Prognostic impact of comorbidity among long-term breast cancer survivors: results from the LACE study.
Authors: Braithwaite D, Moore DH, Satariano WA, Kwan ML, Hiatt RA, Kroenke C, Caan BJ
Source: Cancer Epidemiol Biomarkers Prev, 2012 Jul;21(7), p. 1115-25.
EPub date: 2012 May 9.
PMID: 22573797
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Pre-diagnosis body mass index and survival after breast cancer in the After Breast Cancer Pooling Project.
Authors: Kwan ML, Chen WY, Kroenke CH, Weltzien EK, Beasley JM, Nechuta SJ, Poole EM, Lu W, Holmes MD, Quesenberry CP Jr, Pierce JP, Shu XO, Caan BJ
Source: Breast Cancer Res Treat, 2012 Apr;132(2), p. 729-39.
EPub date: 2011 Dec 21.
PMID: 22187127
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Antioxidant supplement use after breast cancer diagnosis and mortality in the Life After Cancer Epidemiology (LACE) cohort.
Authors: Greenlee H, Kwan ML, Kushi LH, Song J, Castillo A, Weltzien E, Quesenberry CP Jr, Caan BJ
Source: Cancer, 2012 Apr 15;118(8), p. 2048-58.
EPub date: 2011 Sep 27.
PMID: 21953120
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Meeting the physical activity guidelines and survival after breast cancer: findings from the after breast cancer pooling project.
Authors: Beasley JM, Kwan ML, Chen WY, Weltzien EK, Kroenke CH, Lu W, Nechuta SJ, Cadmus-Bertram L, Patterson RE, Sternfeld B, Shu XO, Pierce JP, Caan BJ
Source: Breast Cancer Res Treat, 2012 Jan;131(2), p. 637-43.
EPub date: 2011 Sep 21.
PMID: 21935600
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The After Breast Cancer Pooling Project: rationale, methodology, and breast cancer survivor characteristics.
Authors: Nechuta SJ, Caan BJ, Chen WY, Flatt SW, Lu W, Patterson RE, Poole EM, Kwan ML, Chen Z, Weltzien E, Pierce JP, Shu XO
Source: Cancer Causes Control, 2011 Sep;22(9), p. 1319-31.
EPub date: 2011 Jun 28.
PMID: 21710192
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Multivitamin use and breast cancer outcomes in women with early-stage breast cancer: the Life After Cancer Epidemiology study.
Authors: Kwan ML, Greenlee H, Lee VS, Castillo A, Gunderson EP, Habel LA, Kushi LH, Sweeney C, Tam EK, Caan BJ
Source: Breast Cancer Res Treat, 2011 Nov;130(1), p. 195-205.
EPub date: 2011 May 11.
PMID: 21559824
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Examining the influence of beta blockers and ACE inhibitors on the risk for breast cancer recurrence: results from the LACE cohort.
Authors: Ganz PA, Habel LA, Weltzien EK, Caan BJ, Cole SW
Source: Breast Cancer Res Treat, 2011 Sep;129(2), p. 549-56.
EPub date: 2011 Apr 11.
PMID: 21479924
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Alcohol consumption and breast cancer recurrence and survival among women with early-stage breast cancer: the life after cancer epidemiology study.
Authors: Kwan ML, Kushi LH, Weltzien E, Tam EK, Castillo A, Sweeney C, Caan BJ
Source: J Clin Oncol, 2010 Oct 10;28(29), p. 4410-6.
EPub date: 2010 Aug 30.
PMID: 20805458
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Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study.
Authors: Guha N, Kwan ML, Quesenberry CP Jr, Weltzien EK, Castillo AL, Caan BJ
Source: Breast Cancer Res Treat, 2009 Nov;118(2), p. 395-405.
EPub date: 2009 Feb 17.
PMID: 19221874
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Physical activity and risk of recurrence and mortality in breast cancer survivors: findings from the LACE study.
Authors: Sternfeld B, Weltzien E, Quesenberry CP Jr, Castillo AL, Kwan M, Slattery ML, Caan BJ
Source: Cancer Epidemiol Biomarkers Prev, 2009 Jan;18(1), p. 87-95.
PMID: 19124485
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Post-diagnosis statin use and breast cancer recurrence in a prospective cohort study of early stage breast cancer survivors.
Authors: Kwan ML, Habel LA, Flick ED, Quesenberry CP, Caan B
Source: Breast Cancer Res Treat, 2008 Jun;109(3), p. 573-9.
EPub date: 2007 Aug 3.
PMID: 17674197
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NSAIDs and breast cancer recurrence in a prospective cohort study.
Authors: Kwan ML, Habel LA, Slattery ML, Caan B
Source: Cancer Causes Control, 2007 Aug;18(6), p. 613-20.
EPub date: 2007 Apr 3.
PMID: 17404892
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