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Grant Details

Grant Number: 1R01CA172058-01 Interpret this number
Primary Investigator: Messer, Karen
Organization: University Of California San Diego
Project Title: Population Studies of Cigarette Smoking, Other Tobacco Use, and Lung Cancer
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): Despite strong reductions in smoking prevalence, cigarette smoking remains the leading preventable cause of death in the US, and lung cancer is the leading cause of smoking-attributable deaths. Prior to 2009, marketing, manufacture and sale of tobacco products was not under the purview of the Food and Drug Administration (FDA). The 2009 Family Smoking Prevention and Control Act gave the FDA authority over tobacco products, under a new regulatory standard of protection of the public health. FDA actions regarding tobacco must take into account population level impacts of proposed regulation on the public health, considering users and non-users of tobacco alike. In response to changes in both smoking patterns and tobacco regulation, new, non-cigarette tobacco products have been introduced which are marketed as substitutes for or complements to cigarettes. At the population level, these products have the potential to improve public health by reducing cigarette consumption, or to decrease public health by reducing smoking cessation and encouraging smoking initiation. There is thus an urgent need for quantitative population-level estimates of cigarette smoking behavior, including cessation rates, consumption levels, and initiation rates. These estimates must be detailed enough to incorporate important predictors of cigarette smoking which might be impacted either by FDA regulation or by marketing and use of new tobacco products. There is also an urgent need to quantify the effect of changes in cigarette smoking behaviors on lung cancer mortality, also at the population level. This proposal is for secondary data analysis of the publicly available, federally-sponsored surveys of tobacco use, including the Tobacco Use Supplement to the Current Population survey; the National Health Interview Surveys (NHIS) and their Mortality Linked Files; and the National Survey on Drug Use and Health. The large sample sizes and representative nature of these surveys enable detailed estimates of smoking behavior at the state and regional level, by gender, age, and within race/ethnic groups. The specific aims of the grant are : 1) to quantify US population rates of smoking cessation, including success rates per quit attempt; 2) to identify important associations between use of other tobacco products and cigarette smoking behavior; and 3) to quantify the population impact of cigarette consumption level and quitting history on subsequent lung cancer mortality, within birth cohorts. The UCSD team has a successful history of conducting and analyzing national and state population surveys of tobacco use. The team has broad experience in tobacco control studies, in epidemiology and statistics, and in behavioral intervention trials, including smoking cessation trials. The study team is thus well poised to conduct population-level tobacco control studies relevant to new regulatory issues surrounding tobacco.

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Publications

Cigarette smoking cessation attempts among current US smokers who also use smokeless tobacco.
Authors: Messer K, Vijayaraghavan M, White MM, Shi Y, Chang C, Conway KP, Hartman A, Schroeder MJ, Compton WM, Pierce JP
Source: Addict Behav, 2015 Jul 4;51, p. 113-119.
EPub date: 2015 Jul 4.
PMID: 26253939
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Measurement of multiple nicotine dependence domains among cigarette, non-cigarette and poly-tobacco users: Insights from item response theory.
Authors: Strong DR, Messer K, Hartman SJ, Conway KP, Hoffman AC, Pharris-Ciurej N, White M, Green VR, Compton WM, Pierce J
Source: Drug Alcohol Depend, 2015 Jul 1;152, p. 185-93.
EPub date: 2015 Apr 27.
PMID: 26005043
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Predictive Validity of the Expanded Susceptibility to Smoke Index.
Authors: Strong DR, Hartman SJ, Nodora J, Messer K, James L, White M, Portnoy DB, Choiniere CJ, Vullo GC, Pierce J
Source: Nicotine Tob Res, 2015 Jul;17(7), p. 862-9.
EPub date: 2014 Dec 6.
PMID: 25481915
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Trends in use of little cigars or cigarillos and cigarettes among U.S. smokers, 2002-2011.
Authors: Messer K, White MM, Strong DR, Wang B, Shi Y, Conway KP, Pierce JP
Source: Nicotine Tob Res, 2015 May;17(5), p. 515-23.
EPub date: 2014 Sep 19.
PMID: 25239955
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Curiosity predicts smoking experimentation independent of susceptibility in a US national sample.
Authors: Nodora J, Hartman SJ, Strong DR, Messer K, Vera LE, White MM, Portnoy DB, Choiniere CJ, Vullo GC, Pierce JP
Source: Addict Behav, 2014 Dec;39(12), p. 1695-700.
EPub date: 2014 Jun 18.
PMID: 25117844
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Differential use of other tobacco products among current and former cigarette smokers by income level.
Authors: Vijayaraghavan M, Pierce JP, White M, Messer K
Source: Addict Behav, 2014 Oct;39(10), p. 1452-8.
EPub date: 2014 Jun 4.
PMID: 24930053
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Receptivity to cigarette and tobacco control messages and adolescent smoking initiation.
Authors: Emory KT, Messer K, Vera L, Ojeda N, Elder JP, Usita P, Pierce JP
Source: Tob Control, 2015 May;24(3), p. 281-4.
EPub date: 2014 Feb 6.
PMID: 24503771
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The effectiveness of cigarette price and smoke-free homes on low-income smokers in the United States.
Authors: Vijayaraghavan M, Messer K, White MM, Pierce JP
Source: Am J Public Health, 2013 Dec;103(12), p. 2276-83.
EPub date: 2013 Oct 17.
PMID: 24134354
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