|Grant Number:||1U24CA171524-01 Interpret this number|
|Primary Investigator:||Kushi, Lawrence|
|Organization:||Kaiser Foundation Research Institute|
|Project Title:||CRN4: Cancer Research Resources & Collaboration in Integrated Health Care Systems|
DESCRIPTION (provided by applicant): This application is for a competitive renewal and transformation of the HMO Cancer Research Network (CRN) into a research resource. The CRN, which has been continuously funded since 1999, provides infrastructure support to conduct cancer research in the setting of not-for-profit integrated health care delivery systems. The setting has advantages for conducting population sciences research that collectively result in a unique, unparalleled resource for conducting epidemiologic and health services research in cancer. These advantages include externally-funded research groups with investigators with expertise in conducting public-domain cancer research in these settings; defined populations with a combined membership of over 10 million individuals for whom health care is provided; clinical and administrative data systems that capture most aspects of care; development and implementation of common data models in the Virtual Data Warehouse (VDW) to facilitate collaborative and multi-institutional research; and access to clinicians and administrators to facilitate translation of research findings to practice. We plan to enhance the CRN in several areas, including: Establishing an Informatics Core focused on continual improvement of the VDW through implementation of distributed query tools to facilitate preparatory-to-research and collaborative research studies, and improvement of existing and implementation of new VDW domains of relevance to cancer research; identification and promotion of research in strategic areas for which the CRN is uniquely positioned (i.e., Prevention & Screening; Treatment & Outcomes; Biospecimens & Molecular Applications; Communications & Decision-Making; Health Care Quality & Cost; and Dissemination & Implementation); institutionalizing a CRN Scholars mentored career development program for junior investigators; continuation of a Developmental and Pilot Studies Program to support pilot studies and to enhance infrastructure; and implementation of an Outreach and External Collaborations Core to facilitate research collaborations. This continued infrastructure support will enable and facilitate researchers' continued access to large integrated delivery systems and motivate continued evolution as the nation's premier learning healthcare systems. PUBLIC HEALTH RELEVANCE: This application for the Cancer Research Network supports activities that enhance the ability to conduct impactful, relevant cancer research in integrated health care systems that provide health care to over 10 million members. Activities include data resource enhancement, career development of junior investigators, funding of promising pilot studies, and promotion of collaborations among research scientists.
Variation in Adenoma Detection Rate and the Lifetime Benefits and Cost of Colorectal Cancer Screening: A Microsimulation Model.
Authors: Meester RG, Doubeni CA, Lansdorp-Vogelaar I, Jensen CD, van der Meulen MP, Levin TR, Quinn VP, Schottinger JE, Zauber AG, Corley DA, van Ballegooijen M
Source: JAMA, 2015 Jun 16;313(23), p. 2349-58.
Where does it FIT?: The roles of fecal testing and colonoscopy in colorectal cancer screening.
Authors: Hillyer GC, Neugut AI
Source: Cancer, 2015 May 20;null, p. null.
EPub date: 2015 May 20.
Public health impact of achieving 80% colorectal cancer screening rates in the United States by 2018.
Authors: Meester RG, Doubeni CA, Zauber AG, Goede SL, Levin TR, Corley DA, Jemal A, Lansdorp-Vogelaar I
Source: Cancer, 2015 Mar 12;null, p. null.
EPub date: 2015 Mar 12.
Leveraging biospecimen resources for discovery or validation of markers for early cancer detection.
Authors: Schully SD, Carrick DM, Mechanic LE, Srivastava S, Anderson GL, Baron JA, Berg CD, Cullen J, Diamandis EP, Doria-Rose VP, Goddard KA, Hankinson SE, Kushi LH, Larson EB, McShane LM, Schilsky RL, Shak S, Skates SJ, Urban N, Kramer BS, Khoury MJ, Ransohoff DF
Source: J Natl Cancer Inst, 2015 Apr;107(4), p. null.
EPub date: 2015 Feb 16.
Effects of eliminating drug caps on racial differences in antidepressant use among dual enrollees with diabetes and depression.
Authors: Adams AS, Soumerai SB, Zhang F, Gilden D, Burns M, Huskamp HA, Trinacty C, Alegria M, LeCates RF, Griggs JJ, Ross-Degnan D, Madden JM
Source: Clin Ther, 2015 Mar 1;37(3), p. 597-609.
EPub date: 2015 Jan 22.
Adjusting for patient demographics has minimal effects on rates of adenoma detection in a large, community-based setting.
Authors: Jensen CD, Doubeni CA, Quinn VP, Levin TR, Zauber AG, Schottinger JE, Marks AR, Zhao WK, Lee JK, Ghai NR, Schneider JL, Fireman BH, Quesenberry CP, Corley DA
Source: Clin Gastroenterol Hepatol, 2015 Apr;13(4), p. 739-46.
EPub date: 2014 Oct 25.
Fecal-based colorectal cancer screening among the uninsured in northern Manhattan.
Authors: Hillyer GC, Schmitt KM, Freedberg DE, Kramer RA, Su Y, Rosenberg RM, Neugut AI
Source: Am J Prev Med, 2014 Aug;47(2), p. 182-7.
EPub date: 2014 Jun 17.
Non-initiation and early discontinuation of adjuvant trastuzumab in women with localized HER2-positive breast cancer.
Authors: Neugut AI, Hillyer GC, Kushi LH, Lamerato L, Leoce N, Ambrosone CB, Bovbjerg DH, Mandelblatt JS, Hershman DL
Source: Breast Cancer, 2014 Nov;21(6), p. 780-5.
EPub date: 2014 Jun 6.
Does KRAS testing in metastatic colorectal cancer impact overall survival? A comparative effectiveness study in a population-based sample.
Authors: Feigelson HS, Zeng C, Pawloski PA, Onitilo AA, Richards CS, Johnson MA, Kauffman TL, Webster J, Nyirenda C, Alexander GL, Hwang C, Cross D, McCarty CA, Davis RL, Schwarzkopf D, Williams AE, Honda S, Daida Y, Kushi LH, Delate T, Goddard KA, CERGEN Study Team
Source: PLoS One, 2014;9(5), p. e94977.
EPub date: 2014 May 1.
Adenoma detection rate and risk of colorectal cancer and death.
Authors: Corley DA, Jensen CD, Marks AR, Zhao WK, Lee JK, Doubeni CA, Zauber AG, de Boer J, Fireman BH, Schottinger JE, Quinn VP, Ghai NR, Levin TR, Quesenberry CP
Source: N Engl J Med, 2014 Apr 3;370(14), p. 1298-306.
Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis.
Authors: Lee JK, Liles EG, Bent S, Levin TR, Corley DA
Source: Ann Intern Med, 2014 Feb 4;160(3), p. 171.
Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer.
Authors: Hershman DL, Shao T, Kushi LH, Buono D, Tsai WY, Fehrenbacher L, Kwan M, Gomez SL, Neugut AI
Source: Breast Cancer Res Treat, 2011 Apr;126(2), p. 529-37.
EPub date: 2010 Aug 28.