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Grant Details

Grant Number: 5R21CA157219-03 Interpret this number
Primary Investigator: Li, Yi
Organization: University Of Michigan
Project Title: Integrated Analysis of High Throughput Cancer Genomic Data
Fiscal Year: 2012
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Abstract

Project Summary and Relevance The primary goal of this project is to develop a novel, integrated approach for the analysis of high-throughput cancer genomic data. We plan to develop new variable selection methods for 1) class discovery, that is we propose to determine subgroups of the specified cancer to better understand the underlying cancer biology and 2) predictive gene signatures, that is we propose to determine a subset of genes which are predictive for patients' clinical phenotypes, including survival and response to therapy. Specifically, we will develop a new method for variable selection in clustering. Clustering plays a critical role in the analysis of genomic cancer data. For example, based on the gene expression profiles, important cluster distinctions can be found among a set of tissue samples, which may reflect categories of diseases, mutation status, or different responses to a given therapy. Second, we will develop a new penalized-likelihood method for variable selection in regression which utilizes group information to select groups of correlated genes that share the same biological pathway. The developed methodology will be useful for identifying important gene signatures that may lead to more effective personalized treatment in any health studies where survival time or response to therapy is of interest.

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Publications

Ultrahigh dimensional time course feature selection.
Authors: Xu P, Zhu L, Li Y
Source: Biometrics, 2014 Jun;70(2), p. 356-65.
EPub date: 2014 Jan 19.
PMID: 24571586
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Discrete mixture modeling to address genetic heterogeneity in time-to-event regression.
Authors: Eng KH, Hanlon BM
Source: Bioinformatics, 2014 Jun 15;30(12), p. 1690-7.
EPub date: 2014 Feb 14.
PMID: 24532723
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The Dantzig Selector for Censored Linear Regression Models.
Authors: Li Y, Dicker L, Zhao SD
Source: Stat Sin, 2014 Jan 1;24(1), p. 251-2568.
PMID: 24478569
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