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Grant Details

Grant Number: 1UM1CA164974-01A1 Interpret this number
Primary Investigator: Rosenberg, Lynn
Organization: Boston University Medical Campus
Project Title: A Follow-Up Study for Causes of Cancer in Black Women
Fiscal Year: 2012
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Abstract

DESCRIPTION (provided by applicant): The Black Women's Health Study (BWHS), the largest follow-up study for cancer in African American (AA) women, began in 1995 when 59,000 women (median age, 38) from across the U.S. enrolled. The BWHS has successfully followed participants with biennial questionnaires for data on incident disease and medical, reproductive, behavioral, psychosocial, and socioeconomic factors, linked addresses to U.S. census data, and are currently linking to air pollution data. Cancer diagnoses are validated by pathology data from hospitals and cancer registries. A DNA bio repository was established through collection of cheek cell samples from 26,800 participants. Despite initial slow accrual of cancers due to the young age of participants at entry, the BWHS has published extensively on risk factors for breast cancer; sufficient cases of lung cancer, colorectal cancer, and colon adenomas are now available. We propose to (1) continue follow-up/data collection; (2) establish a repository of 17,800 blood samples; (3) share data/samples in consortia projects. Continuation of the BWHS is highly desirable: 90% of participants are still cancer-free; follow-up has been successful and unbiased; the cohort has reached ages at which cancer incidence increases markedly; effects of exposures (e.g., severe obesity, racism) that are less common in other populations can be studied; the DNA has made valuable contributions to genetic cancer studies and is a major replication source for studies of breast cancer and related phenotypes in AA and other groups; the BWHS is a key contributor to consortia projects of rarer cancers in /\As; and the BWHS has been highly productive. Because levels of many blood markers are unfavorable among AAs and few studies of blood biomarkers in relation to cancer incidence have been carried out specifically in /\As, we propose to establish a repository of blood samples in the BWHS. A successful pilot study demonstrated the feasibility of our methods and participation was unbiased and similar to that in other large follow-up studies. The repository will increase by 60% the limited number of AA women with available blood samples being followed in U.S. cancer cohort studies. AA women continue to be disproportionately affected by many cancers. Continuation of the BWHS will permit continuation of its valuable contributions to understanding cancer etiology in this understudied group. A blood repository will greatly increase the value of the BWHS resource by permitting studies that help to fill the knowledge gap about the relation of biomarkers to cancer incidence and survival in AAs. The assessment of serious nonmalignant illnesses in the BWHS enhances the value of this resource at no cost to the study of cancer.

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Publications

Parity, lactation, and breast cancer subtypes in African American women: results from the AMBER Consortium.
Authors: Palmer JR, Viscidi E, Troester MA, Hong CC, Schedin P, Bethea TN, Bandera EV, Borges V, McKinnon C, Haiman CA, Lunetta K, Kolonel LN, Rosenberg L, Olshan AF, Ambrosone CB
Source: J Natl Cancer Inst, 2014 Oct;106(10), p. null.
EPub date: 2014 Sep 15.
PMID: 25224496
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Hypothesis about alternative use of redundant regulatory elements was validated by recent results.
Authors: Ruiz-NarvŠez EA
Source: Med Hypotheses, 2014 Oct;83(4), p. 513-4.
EPub date: 2014 Aug 20.
PMID: 25182521
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Birth weight and risk of type 2 diabetes in the black women's health study: does adult BMI play a mediating role?
Authors: Ruiz-NarvŠez EA, Palmer JR, Gerlovin H, Wise LA, Vimalananda VG, Rosenzweig JL, Rosenberg L
Source: Diabetes Care, 2014 Sep;37(9), p. 2572-8.
PMID: 25147255
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A prospective study of physical activity and breast cancer incidence in african-american women.
Authors: Rosenberg L, Palmer JR, Bethea TN, Ban Y, Kipping-Ruane K, Adams-Campbell LL
Source: Cancer Epidemiol Biomarkers Prev, 2014 Nov;23(11), p. 2522-31.
EPub date: 2014 Aug 7.
PMID: 25103823
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Prospective study of dietary fat and risk of uterine leiomyomata.
Authors: Wise LA, Radin RG, Kumanyika SK, Ruiz-NarvŠez EA, Palmer JR, Rosenberg L
Source: Am J Clin Nutr, 2014 May;99(5), p. 1105-16.
EPub date: 2014 Mar 5.
PMID: 24598152
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Racism, segregation, and risk of obesity in the Black Women's Health Study.
Authors: Cozier YC, Yu J, Coogan PF, Bethea TN, Rosenberg L, Palmer JR
Source: Am J Epidemiol, 2014 Apr 1;179(7), p. 875-83.
EPub date: 2014 Feb 27.
PMID: 24585257
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Depressive symptoms and the incidence of adult-onset asthma in African American women.
Authors: Coogan PF, Yu J, O'Connor GT, Brown TA, Palmer JR, Rosenberg L
Source: Ann Allergy Asthma Immunol, 2014 Apr;112(4), p. 333-8.e1.
EPub date: 2014 Jan 17.
PMID: 24440322
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Restaurant foods, sugar-sweetened soft drinks, and obesity risk among young African American women.
Authors: Boggs DA, Rosenberg L, Coogan PF, Makambi KH, Adams-Campbell LL, Palmer JR
Source: Ethn Dis, 2013 Autumn;23(4), p. 445-51.
PMID: 24392607
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A collaborative study of the etiology of breast cancer subtypes in African American women: the AMBER consortium.
Authors: Palmer JR, Ambrosone CB, Olshan AF
Source: Cancer Causes Control, 2014 Mar;25(3), p. 309-19.
EPub date: 2013 Dec 17.
PMID: 24343304
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Type 2 diabetes and the risk of colorectal adenomas: Black Women's Health Study.
Authors: Dash C, Palmer JR, Boggs DA, Rosenberg L, Adams-Campbell LL
Source: Am J Epidemiol, 2014 Jan 1;179(1), p. 112-9.
EPub date: 2013 Oct 2.
PMID: 24091887
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A prospective study of smoking and breast cancer risk among African-American women.
Authors: Rosenberg L, Boggs DA, Bethea TN, Wise LA, Adams-Campbell LL, Palmer JR
Source: Cancer Causes Control, 2013 Dec;24(12), p. 2207-15.
EPub date: 2013 Oct 2.
PMID: 24085586
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??Mortality among African American women with sarcoidosis: data from the Black Women's Health Study.
Authors: Tukey MH, Berman JS, Boggs Et Al DA
Source: Sarcoidosis Vasc Diffuse Lung Dis, 2013 Aug 1;30(2), p. 128-33.
EPub date: 2013 Aug 1.
PMID: 24071884
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Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
Authors: Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE, Fox CS
Source: PLoS Genet, 2013;9(8), p. e1003681.
EPub date: 2013 Aug 15.
PMID: 23966867
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Body size and time-to-pregnancy in black women.
Authors: Wise LA, Palmer JR, Rosenberg L
Source: Hum Reprod, 2013 Oct;28(10), p. 2856-64.
EPub date: 2013 Aug 19.
PMID: 23958939
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Physical activity and the incidence of obesity in young African-American women.
Authors: Rosenberg L, Kipping-Ruane KL, Boggs DA, Palmer JR
Source: Am J Prev Med, 2013 Sep;45(3), p. 262-8.
PMID: 23953351
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Long-term diet quality is associated with lower obesity risk in young African American women with normal BMI at baseline.
Authors: Boggs DA, Rosenberg L, RodrŪguez-Bernal CL, Palmer JR
Source: J Nutr, 2013 Oct;143(10), p. 1636-41.
EPub date: 2013 Jul 31.
PMID: 23902954
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