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Grant Details

Grant Number: 5R01CA092447-11 Interpret this number
Primary Investigator: Blot, William
Organization: Vanderbilt University
Project Title: Southern Community Cohort Study
Fiscal Year: 2012
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Abstract

DESCRIPTION (provided by applicant): The second five-year renewal of the Southern Community Cohort Study (SCCS) is proposed in this grant application. Progress during the initial nine years of the study has been exceptional. We achieved a final cohort size of approximately 86,000 adults aged 40-79, two-thirds of whom are African American, with detailed baseline data assembled for all and biological specimens in frozen storage for nearly 90%. The cohort is now under follow-up for cancer mortality and incidence and other health outcomes. Historically, large-scale recruitment of African Americans, a group disproportionately burdened by cancer, into health research studies has been challenging. However, we uniquely overcame many known barriers to inclusion by developing partnerships with a network of southern Community Health Centers (CHCs), institutions that provide basic health services primarily to America's poor and uninsured. The SCCS thus differs from all other cohort studies in racial composition and socioeconomic disadvantage, and tracks a population possibly at higher cancer risk than any American population segment studied to date. Our specific aims for the renewal are (1) to continue passive follow-up of the cohort via linkages with various national and state registries to identify deaths, incident cancers and other health outcomes, (2) to continue active follow-up of the cohort via re-contact with participants to directly update exposure and health information, and (3) to conduct multiple new cohort and nested case-control analyses utilizing the baseline and follow-up data and stored DNA and blood specimens for evaluation of lifestyle, genetic and other risk or protective factors affecting the incidence of and disparities in the major cancers (lung, breast, prostate, and colon/rectum). We will evaluate hypotheses that the SCCS is uniquely or especially well positioned to address, many for the first time among African Americans, including the roles of obesity, vitamin D, specific infections (Chlamydia pneumoniae, Trichomonas vaginalis, Helicobacter pylori, and xenotropic murine leukemia virus-related virus), several nutrition-related pathways (one carbon metabolism, n-6 and n-3 polyunsaturated fatty acids and other dietary factors), cigarette mentholation, and use of the commonly prescribed glycemic control medication metformin, in relation to cancer risk and cancer disparities.

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Publications

Incidence and predictors of end stage renal disease among low-income blacks and whites.
Authors: Lipworth L, Mumma MT, Cavanaugh KL, Edwards TL, Ikizler TA, Tarone RE, McLaughlin JK, Blot WJ
Source: PLoS One, 2012;7(10), p. e48407.
EPub date: 2012 Oct 24.
PMID: 23110237
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Race-specific impact of atrial fibrillation risk factors in blacks and whites in the southern community cohort study.
Authors: Lipworth L, Okafor H, Mumma MT, Edwards TL, Roden DM, Blot WJ, Darbar D
Source: Am J Cardiol, 2012 Dec 1;110(11), p. 1637-42.
EPub date: 2012 Aug 23.
PMID: 22922000
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Obesity and all-cause mortality among black adults and white adults.
Authors: Cohen SS, Signorello LB, Cope EL, McLaughlin JK, Hargreaves MK, Zheng W, Blot WJ
Source: Am J Epidemiol, 2012 Sep 1;176(5), p. 431-42.
EPub date: 2012 Jul 20.
PMID: 22822174
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Differences in the association between serum leptin levels and body mass index in black and white women: a report from the Southern Community Cohort Study.
Authors: Cohen SS, Fowke JH, Cai Q, Buchowski MS, Signorello LB, Hargreaves MK, Zheng W, Blot WJ, Matthews CE
Source: Ann Nutr Metab, 2012;60(2), p. 90-7.
EPub date: 2012 Feb 18.
PMID: 22353927
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Relationship between smoking and obesity among women.
Authors: Patel K, Hargreaves MK, Liu J, Schlundt D, Sanderson M, Matthews CE, Dewey CM, Kenerson D, Buchowski MS, Blot WJ
Source: Am J Health Behav, 2011 Sep;35(5), p. 627-36.
PMID: 22040623
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Serum adiponectin in relation to body mass index and other correlates in black and white women.
Authors: Cohen SS, Gammon MD, Signorello LB, North KE, Lange EM, Fowke JH, Hargreaves MK, Cai Q, Zheng W, Blot WJ, Matthews CE
Source: Ann Epidemiol, 2011 Feb;21(2), p. 86-94.
EPub date: 2010 Dec 15.
PMID: 21109453
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Adult weight gain and diabetes among African American and white adults in southeastern US communities.
Authors: Cohen SS, Signorello LB, Blot WJ
Source: Prev Med, 2009 Dec;49(6), p. 476-81.
EPub date: 2009 Oct 27.
PMID: 19874842
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Racial differences in the association between body mass index and serum IGF1, IGF2, and IGFBP3.
Authors: Fowke JH, Matthews CE, Yu H, Cai Q, Cohen S, Buchowski MS, Zheng W, Blot WJ
Source: Endocr Relat Cancer, 2010 Mar;17(1), p. 51-60.
EPub date: 2010 Jan 29.
PMID: 19786462
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Parity and breastfeeding in relation to obesity among black and white women in the southern community cohort study.
Authors: Cohen SS, Larson CO, Matthews CE, Buchowski MS, Signorello LB, Hargreaves MK, Blot WJ
Source: J Womens Health (Larchmt), 2009 Sep;18(9), p. 1323-32.
PMID: 19743905
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Estimating nutrient intake from a food frequency questionnaire: incorporating the elements of race and geographic region.
Authors: Signorello LB, Munro HM, Buchowski MS, Schlundt DG, Cohen SS, Hargreaves MK, Blot WJ
Source: Am J Epidemiol, 2009 Jul 1;170(1), p. 104-11.
EPub date: 2009 May 18.
PMID: 19451177
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Seasonal changes in amount and patterns of physical activity in women.
Authors: Buchowski MS, Choi L, Majchrzak KM, Acra S, Mathews CE, Chen KY
Source: J Phys Act Health, 2009 Mar;6(2), p. 252-61.
PMID: 19420404
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Correlates of high serum C-reactive protein levels in a socioeconomically disadvantaged population.
Authors: Zhang X, Shu XO, Signorello LB, Hargreaves MK, Cai Q, Linton MF, Fazio S, Zheng W, Blot WJ
Source: Dis Markers, 2008;24(6), p. 351-9.
PMID: 18688084
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Mammography use in the Southern Community Cohort Study (United States).
Authors: Cui Y, Peterson NB, Hargreaves M, Wen W, Patel K, Drake J, Munro HM, Signorello LB, Blot WJ
Source: J Health Care Poor Underserved, 2007 Nov;18(4 Suppl), p. 102-17.
PMID: 18065854
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Comparing diabetes prevalence between African Americans and Whites of similar socioeconomic status.
Authors: Signorello LB, Schlundt DG, Cohen SS, Steinwandel MD, Buchowski MS, McLaughlin JK, Hargreaves MK, Blot WJ
Source: Am J Public Health, 2007 Dec;97(12), p. 2260-7.
EPub date: 2007 Oct 30.
PMID: 17971557
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Obesity and recent mammography use among black and white women in the Southern Community Cohort Study (United States).
Authors: Cohen SS, Signorello LB, Gammon MD, Blot WJ
Source: Cancer Causes Control, 2007 Sep;18(7), p. 765-73.
EPub date: 2007 Jun 14.
PMID: 17569015
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Separate estimates of portion size were not essential for energy and nutrient estimation: results from the Southern Community Cohort food-frequency questionnaire pilot study.
Authors: Schlundt DG, Buchowski MS, Hargreaves MK, Hankin JH, Signorello LB, Blot WJ
Source: Public Health Nutr, 2007 Mar;10(3), p. 245-51.
PMID: 17288621
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Effects of obesity and height on prostate-specific antigen (PSA) and percentage of free PSA levels among African-American and Caucasian men.
Authors: Fowke JH, Signorello LB, Chang SS, Matthews CE, Buchowski MS, Cookson MS, Ukoli FM, Blot WJ
Source: Cancer, 2006 Nov 15;107(10), p. 2361-7.
PMID: 17031814
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Development of a culturally sensitive food frequency questionnaire for use in the Southern Community Cohort Study.
Authors: Buchowski MS, Schlundt DG, Hargreaves MK, Hankin JH, Signorello LB, Blot WJ
Source: Cell Mol Biol (Noisy-le-grand), 2003 Dec;49(8), p. 1295-304.
PMID: 14984001
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Contextual factors influencing the eating behaviours of African American women: a focus group investigation.
Authors: Hargreaves MK, Schlundt DG, Buchowski MS
Source: Ethn Health, 2002 Aug;7(3), p. 133-47.
PMID: 12523941
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