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Grant Details

Grant Number: 5R01CA160104-02 Interpret this number
Primary Investigator: Craig, Benjamin
Organization: H. Lee Moffitt Cancer Ctr & Res Inst
Project Title: Hrqol Values for Cancer Survivors: Enhancing Promis Measures for Cer
Fiscal Year: 2012
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Abstract

DESCRIPTION (provided by applicant): Cancer is predicted to be the leading cause of death in 2010 and with 1.5 million newly diagnosed cases for this year alone, cancer survivors are becoming an increasingly large part of the US population. Patient- reported outcomes (PROs) instruments of health-related quality of life (HRQoL) can capture the experiences of cancer patients, and are increasingly used in clinical trials and other forms of comparative effectiveness research (CER) to characterize decision-relevant health outcomes. The NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Network has developed standardized, valid, and precise PROs measures for CER. While these tools provide domain-specific scores, scores alone do not express the value or importance of specific domains or summarize HRQoL across domains from the perspective of cancer patients. Thus, there is a need to facilitate CER by translating PROMIS PROs into decision-relevant health outcome values. In the proposed study, we will recruit members of the general public and cancer survivors (breast, prostate, colorectal) to complete a discrete choice experiment (DCE) to value PROMIS-29 outcomes. The PROMIS-29 instrument includes 7 HRQoL scales (physical function, pain interference, fatigue, depression, anxiety, sleep disturbance, and social role-participation) measured by 4 items/questions each, and a pain intensity scale measured by a single item. Specific aims of the project are (1) to value PROMIS-29 outcomes from a societal perspective, and (2) to value PROMIS-29 outcomes from a cancer survivor perspective. By aggregating HRQoL domains into decision-relevant values from a societal and cancer survivor perspective, CER can better differentiate treatment outcomes and enhance the translation of its findings to clinical practice. Since living with cancer may alter a person's values for HRQoL outcomes, discrepancies between cancer survivor and general public values must be understood and accounted for in CER, patient-centered decision- making, and public health resource allocation. Although the general public is considered the central stakeholder for CER and allocation of public resources, the values of experienced patients may better inform prospective patients of the burden associated with cancer therapies. Incorporating these values with PROs in CER can help NIH achieve its goal of improving the Nation's health and economic well-being by increasing the availability of decision-relevant information that can be applied at the patient and societal level.

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Publications

Demographic differences in health preferences in the United States.
Authors: Craig BM, Reeve BB, Cella D, Hays RD, Pickard AS, Revicki DA
Source: Med Care, 2014 Apr;52(4), p. 307-13.
PMID: 24374420
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Comparison of US panel vendors for online surveys.
Authors: Craig BM, Hays RD, Pickard AS, Cella D, Revicki DA, Reeve BB
Source: J Med Internet Res, 2013 Nov 29;15(11), p. e260.
EPub date: 2013 Nov 29.
PMID: 24292159
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Health problems are more common, but less severe when measured using newer EQ-5D versions.
Authors: Craig BM, Pickard AS, Lubetkin EI
Source: J Clin Epidemiol, 2014 Jan;67(1), p. 93-9.
EPub date: 2013 Sep 24.
PMID: 24075597
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Infertility evaluation and treatment among women in the United States.
Authors: Kessler LM, Craig BM, Plosker SM, Reed DR, Quinn GP
Source: Fertil Steril, 2013 Oct;100(4), p. 1025-32.
EPub date: 2013 Jul 10.
PMID: 23849845
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US valuation of the SF-6D.
Authors: Craig BM, Pickard AS, Stolk E, Brazier JE
Source: Med Decis Making, 2013 Aug;33(6), p. 793-803.
EPub date: 2013 Apr 29.
PMID: 23629865
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Starting a family: characteristics associated with men's reproductive preferences.
Authors: Kessler LM, Craig BM, Saigal C, Quinn GP
Source: Am J Mens Health, 2013 May;7(3), p. 198-205.
EPub date: 2012 Oct 29.
PMID: 23112251
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Proceedings of the Modeling Evidence in HPV Pre-Conference Workshop in Malmö, Sweden, May 9-10, 2009.
Authors: Craig BM, Brisson M, Chesson H, Giuliano AR, Jit M
Source: Clin Ther, 2010 Aug;32(8), p. 1546-64.
PMID: 20728767
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