Skip Navigation
National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5U01CA150387-04 Interpret this number
Primary Investigator: Wing, Rena
Organization: Miriam Hospital
Project Title: Increasing Sleep Duration: a Novel Approach to Weight Control
Fiscal Year: 2012
Back to top


Abstract

DESCRIPTION (provided by applicant): Simultaneous with the epidemic of obesity, there has been an epidemic of short sleep duration. Epidemiological studies have documented a link between short sleep duration and both obesity and obesity- related health problems including hypertension, diabetes, and mortality and basic laboratory studies have identified physiological mechanisms that may explain this association. However, to date, there have been no intervention studies examining the impact of changes in sleep duration on changes in body weight. The Center for Behavioral Intervention Development (CBID) proposed in this application seeks to translate the basic science on sleep duration into a novel intervention to reduce obesity and obesity-related co- morbidities. We propose a programmatic series of studies to develop a sleep + weight loss intervention. The target population for our studies will be young adults (age 25 - 45) where the association between sleep duration and obesity appears strongest, who are overweight or obese (BIVII 25 - 40), and who currently sleep less than six and a half hours per night. This series of studies will be used to examine the effects of increases in sleep duration alone and in combination with a weight loss program on eating and exercise behaviors (measured objectively), and ultimately on body weight. We will also examine the effects of increasing sleep duration on physiological, psychological and cognitive changes that may relate to the changes in eating and activity and adherence to weight control recommendations. The proposed CBID creates a new interdisciplinary team, including investigators in the areas of behavioral weight control, basic and clinical aspects of sleep, fMRI and neuropsychological assessment of cognitive function, eating and exercise behavior, and physiological changes associated with sleep and weight. RELEVANCE: Both obesity and short sleep duration are major health problems, with a variety of negative consequences. Given that short sleep may contribute to the problem of obesity, this proposal seeks to develop an intervention to increase sleep duration and to determine whether increasing sleep alone, or in combination with a weight loss program, can have positive effects on eating, exercise, and ultimately weight control. (End of Abstract)

Back to top


Publications

Pilot Pharmacologic Randomized Controlled Trial For Psychogenic Nonepileptic Seizures
Authors: LaFrance W.C. , Keitner G.I. , Papandonatos G.D. , Blum A.S. , Machan J.T. , Ryan C.E. , Miller I.W. .
Source: Neurology, 2010-09-28 00:00:00.0; 75(13), p. 1166-73.
PMID: 20739647
Related Citations

Sleep And Obesity In Children And Adolescents
Authors: Hart C.N. , Cairns A. , Jelalian E. .
Source: Pediatric Clinics Of North America, 2011 Jun; 58(3), p. 715-33.
PMID: 21600351
Related Citations

The Association Between Time In Bed And Obesity Risk In Young Adults
Authors: Hart C.N. , Larose J.G. , Fava J.L. , James B.L. , Wing R.R. .
Source: Behavioral Sleep Medicine, 2013; 11(5), p. 321-7.
PMID: 23286548
Related Citations

Sleep Duration And Weight Loss Among Overweight/obese Women Enrolled In A Behavioral Weight Loss Program
Authors: O'Brien E.M. , Fava J. , Subak L.L. , Stone K. , Hart C.N. , Demos K. , Wing R. .
Source: Nutrition & Diabetes, 2012; 2, p. e43.
PMID: 23446658
Related Citations

Enrollment And Retention Challenges In Early-phase Intervention Development Studies: The Obesity-related Behavioral Intervention Trials (orbit)
Authors: Boyington J.E. , Czajkowski S. .
Source: Preventing Chronic Disease, 2013; 10, .
PMID: 23469764
Related Citations

Time In Bed Is Associated With Decreased Physical Activity And Higher Bmi In Women Seeking Weight Loss Treatment
Authors: Hart C.N. , Fava J.L. , Subak L.L. , Stone K. , Vittinghoff E. , Demos K. , O'Brien E. , Cairns A. , Wing R. .
Source: Isrn Obesity, 2012; 2012, .
PMID: 24198999
Related Citations

Associations Of Self-reported And Actigraphy-assessed Sleep Characteristics With Body Mass Index And Waist Circumference In Adults: Moderation By Gender
Authors: Mezick E.J. , Wing R.R. , McCaffery J.M. .
Source: Sleep Medicine, 2014 Jan; 15(1), p. 64-70.
PMID: 24239499
Related Citations

Association Of Fish Oil Supplement Use With Preservation Of Brain Volume And Cognitive Function
Authors: Daiello L.A. , Gongvatana A. , Dunsiger S. , Cohen R.A. , Ott B.R. , Alzheimer's Disease Neuroimaging Initiative .
Source: Alzheimer's & Dementia : The Journal Of The Alzheimer's Association, 2015 Feb; 11(2), p. 226-35.
PMID: 24954371
Related Citations

Acute Changes In Sleep Duration On Eating Behaviors And Appetite-regulating Hormones In Overweight/obese Adults
Authors: Hart C.N. , Carskadon M.A. , Demos K.E. , Van Reen E. , Sharkey K.M. , Raynor H.A. , Considine R.V. , Jones R.N. , Wing R.R. .
Source: Behavioral Sleep Medicine, 2015; 13(5), p. 424-36.
PMID: 25105727
Related Citations

Failure To Replicate Depletion Of Self-control
Authors: Xu X. , Demos K.E. , Leahey T.M. , Hart C.N. , Trautvetter J. , Coward P. , Middleton K.R. , Wing R.R. .
Source: Plos One, 2014; 9(10), p. e109950.
PMID: 25333564
Related Citations

From Ideas To Efficacy: The Orbit Model For Developing Behavioral Treatments For Chronic Diseases
Authors: Czajkowski S.M. , Powell L.H. , Adler N. , Naar-King S. , Reynolds K.D. , Hunter C.M. , Laraia B. , Olster D.H. , Perna F.M. , Peterson J.C. , et al. .
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2015 Oct; 34(10), p. 971-82.
PMID: 25642841
Related Citations

Estimating Sleep From Multisensory Armband Measurements: Validity And Reliability In Teens
Authors: Roane B.M. , Van Reen E. , Hart C.N. , Wing R. , Carskadon M.A. .
Source: Journal Of Sleep Research, 2015 Dec; 24(6), p. 714-21.
PMID: 26126746
Related Citations

Discrepancies Between Self-reported Usual Sleep Duration And Objective Measures Of Total Sleep Time In Treatment-seeking Overweight And Obese Individuals
Authors: O'Brien E. , Hart C. , Wing R.R. .
Source: Behavioral Sleep Medicine, 2015-10-27 00:00:00.0; , p. 1-11.
PMID: 26503348
Related Citations

Successful Weight Loss Maintenance Associated With Morning Chronotype And Better Sleep Quality
Authors: Ross K.M. , Graham Thomas J. , Wing R.R. .
Source: Journal Of Behavioral Medicine, 2015-12-10 00:00:00.0; , .
PMID: 26660638
Related Citations