|Grant Number:||5P01CA028842-27 Interpret this number|
|Primary Investigator:||Correa, Pelayo|
|Project Title:||Etiological Studies of Gastric Carcinoma|
DESCRIPTION (provided by applicant): The overarching goal of this Program Project is to advance our understanding of gastric cancer causation utilizing the unique population laboratory identified in Colombia. This Program Project was based at Louisiana State University for 22 years but the activities at that institution were seriously disrupted by Hurricane Katrina in 2005. Since then, the base of operations was transferred to Vanderbilt University in Nashville, TN. This transfer has been highly beneficial for the research because the unique field work opportunities in Colombia are now exploited by an expanded team of scientists whose focus has been Helicobacter pylori infection. The field work in Colombia has continued its highly efficient and economical operation uninterrupted. Three projects and three cores are proposed. Project 1 proposes to continue the long-term follow up of cohorts of adults and children previously treated for Helicobacter pylori infections. It also proposes to study biomarkers of progression, especially DNA methylation, utilizing the tissue bank accumulated over the years. Project 2 addresses the issue of immune modulation by parasites of the response to H. pylori infection, in humans and experimental animals. Project 3 studies oxidative stress induced by Helicobacter isolated from low and high risk populations. Core A provides histopathology services for all projects. Core B deals with all administrative matters and data management. Core C coordinates all field work in Colombia.
Human and Helicobacter pylori coevolution shapes the risk of gastric disease.
Authors: Kodaman N, Pazos A, Schneider BG, Piazuelo MB, Mera R, Sobota RS, Sicinschi LA, Shaffer CL, Romero-Gallo J, de Sablet T, Harder RH, Bravo LE, Peek RM Jr, Wilson KT, Cover TL, Williams SM, Correa P
Source: Proc Natl Acad Sci U S A, 2014 Jan 28;111(4), p. 1455-60.
EPub date: 2014 Jan 13.
Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae.
Authors: Schneider BG, Piazuelo MB, Sicinschi LA, Mera R, Peng DF, Roa JC, Romero-Gallo J, Delgado AG, de Sablet T, Bravo LE, Wilson KT, El-Rifai W, Peek RM Jr, Correa P
Source: Epigenetics, 2013 Nov;8(11), p. 1153-61.
EPub date: 2013 Aug 22.
Gastric cancer: overview.
Authors: Correa P
Source: Gastroenterol Clin North Am, 2013 Jun;42(2), p. 211-7.
EPub date: 2013 Feb 21.
Gastric cancer prevention by demethylation.
Authors: Schneider BG, Peek RM Jr
Source: Cancer Prev Res (Phila), 2013 Apr;6(4), p. 253-6.
Gastric cancer: an infectious disease.
Authors: Piazuelo MB, Epplein M, Correa P
Source: Infect Dis Clin North Am, 2010 Dec;24(4), p. 853-69, vii.
Etiology of gastric cancer: what is new?
Authors: Correa P, Schneider BG
Source: Cancer Epidemiol Biomarkers Prev, 2005 Aug;14(8), p. 1865-8.
Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis.
Authors: Whary MT, Sundina N, Bravo LE, Correa P, Quinones F, Caro F, Fox JG
Source: Cancer Epidemiol Biomarkers Prev, 2005 Jun;14(6), p. 1464-9.
Role and limitations of epidemiology in establishing a causal association.
Authors: Franco EL, Correa P, Santella RM, Wu X, Goodman SN, Petersen GM
Source: Semin Cancer Biol, 2004 Dec;14(6), p. 413-26.
Virulence-associated genotypes of Helicobacter pylori: do they explain the African enigma?
Authors: Bravo LE, van Doom LJ, Realpe JL, Correa P
Source: Am J Gastroenterol, 2002 Nov;97(11), p. 2839-42.
KRAS mutations are not predictive for progression of preneoplastic gastric lesions.
Authors: Hunt JD, Mera R, Strimas A, Gillespie AT, Ruiz B, Correa P, Fontham ET
Source: Cancer Epidemiol Biomarkers Prev, 2001 Jan;10(1), p. 79-80.
Unsuccessful treatment results in survival of less virulent genotypes of Helicobacter pylori in Colombian patients.
Authors: Correa P, van Doorn LJ, Bravo JC, Ruiz B, Bravo LE, Realpe JL
Source: Am J Gastroenterol, 2000 Feb;95(2), p. 564-6.
Transmission of Helicobacter pylori among siblings.
Authors: Goodman KJ, Correa P
Source: Lancet, 2000 Jan 29;355(9201), p. 358-62.
KRAS mutations predict progression of preneoplastic gastric lesions.
Authors: Gong C, Mera R, Bravo JC, Ruiz B, Diaz-Escamilla R, Fontham ET, Correa P, Hunt JD
Source: Cancer Epidemiol Biomarkers Prev, 1999 Feb;8(2), p. 167-71.
Diffusion-limited reaction of free nitric oxide with erythrocytes.
Authors: Liu X, Miller MJ, Joshi MS, Sadowska-Krowicka H, Clark DA, Lancaster JR Jr
Source: J Biol Chem, 1998 Jul 24;273(30), p. 18709-13.
Helicobacter pylori infection in the Colombian Andes: a population-based study of transmission pathways.
Authors: Goodman KJ, Correa P, Tenganá Aux HJ, Ramírez H, DeLany JP, Guerrero Pepinosa O, López Quiñones M, Collazos Parra T
Source: Am J Epidemiol, 1996 Aug 1;144(3), p. 290-9.
Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants.
Authors: Mannick EE, Bravo LE, Zarama G, Realpe JL, Zhang XJ, Ruiz B, Fontham ET, Mera R, Miller MJ, Correa P
Source: Cancer Res, 1996 Jul 15;56(14), p. 3238-43.
Animal and public health implications of gastric colonization of cats by Helicobacter-like organisms.
Authors: Otto G, Hazell SH, Fox JG, Howlett CR, Murphy JC, O'Rourke JL, Lee A
Source: J Clin Microbiol, 1994 Apr;32(4), p. 1043-9.
p53 alteration in gastric precancerous lesions.
Authors: Shiao YH, Rugge M, Correa P, Lehmann HP, Scheer WD
Source: Am J Pathol, 1994 Mar;144(3), p. 511-7.
Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.
Authors: Correa P
Source: Cancer Res, 1992 Dec 15;52(24), p. 6735-40.
Immunohistochemical evidence of p53 overexpression in gastric epithelial dysplasia.
Authors: Rugge M, Shiao YH, Correa P, Baffa R, DiMario F
Source: Cancer Epidemiol Biomarkers Prev, 1992 Nov-Dec;1(7), p. 551-4.
Prospective study of Lewis antigen alterations in the gastric precancerous process.
Authors: Torrado J, Correa P, Ruiz B, Zavala D, Bara J
Source: Cancer Epidemiol Biomarkers Prev, 1992 Mar-Apr;1(3), p. 199-205.
Lewis antigen alterations in gastric cancer precursors.
Authors: Torrado J, Correa P, Ruiz B, Bernardi P, Zavala D, Bara J
Source: Gastroenterology, 1992 Feb;102(2), p. 424-30.
Urinary excretion of nitrate, N-nitrosoproline, 3-methyladenine, and 7-methylguanine in a Colombian population at high risk for stomach cancer.
Authors: Stillwell WG, Glogowski J, Xu HX, Wishnok JS, Zavala D, Montes G, Correa P, Tannenbaum SR
Source: Cancer Res, 1991 Jan 1;51(1), p. 190-4.
Clinical trials as etiologic research tools in Helicobacter-associated gastritis.
Authors: Correa P, Ruiz B, Hunter F
Source: Scand J Gastroenterol Suppl, 1991;181, p. 15-9.