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Grant Details

Grant Number: 5P01CA151135-02 Interpret this number
Primary Investigator: Ambrosone, Christine
Organization: Roswell Park Cancer Institute Corp
Project Title: Epidemiology of Breast Cancer Subtypes in African American Women: a Consortium
Fiscal Year: 2012
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Abstract

Women of African ancestry (AA) women are more likely than those with European ancestry (EA) to be diagnosed with breast cancer before age 45, and to have more aggressive tumors, characterized by high grade, with negative staining for estrogen and progesterone receptors and HER-2 (triple negative). They are also more likely to have basal-like breast tumors, an intrinsic breast cancer subtype with the poorest prognosis. The reasons for these disparities are unclear, and existing studies lack the statistical power to investigate risk factors for breast cancer subtypes among young women. In this Program Project, we will pool data and samples from the Carolina Breast Cancer Study (CBCS), the Black Women's Health Study (BWHS), the Women's Circle of Health Study (WCHS) and the Multi-ethnic Cohort (MEC) and continue to accrue cases for a final sample size of more than 5500 cases and 5500 controls. We will collect tissue blocks and classify cancers by their intrinsic subtypes, and investigate specific genetic, biologic and epidemiologic risk factors for subtypes in four highly interactive projects. The specific aims are to examine associations between age at diagnosis and breast cancer subtypes and 1) genetic loci identified in recent GWAS findings, using fine-mapping to identify potential causal alleles; 2) pregnancy history and lactation, and potential modification by genetic variants in related pathways; 3) body size, early life and adult physical activity, and gene/environment interactions; and 4) risk factors that may have been adaptive in Africa to endemic infectious disease (robust immune response) and intense sunlight (high skin pigmentation), but that in western society may result in hyper-inflammatory milieu and vitamin D deficiency, which may be related to early, aggressive breast cancer. Interactive aims will investigate relationships between subtypes and genetic and biologic factors, as well as epidemiologic characteristics. Cores that support all of the projects include the 1) Administrative Core; 2) Data Collection Core; 3) Biospecimen Core; and 4) Biostatistics and Data Management Core. By pooling our data, specimens, and importantly, expertise to investigate these synergist hypotheses, we will elucidate much of the etiology of aggressive, early onset breast cancers in AA women.

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Publications

Associations between estrogen receptor-negative breast cancer and timing of reproductive events differ between African American and European American women.
Authors: Ambrosone CB, Zirpoli GR, Bovbjerg DH, Shankar J, Hong CC, McCann SE, Ruszczyk M, Khoury T, Yao S, Ciupak GL, Jandorf L, Pawlish KS, Bandera EV
Source: Cancer Epidemiol Biomarkers Prev, 2014 Jun;23(6), p. 1115-20.
EPub date: 2014 Apr 9.
PMID: 24718280
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A collaborative study of the etiology of breast cancer subtypes in African American women: the AMBER consortium.
Authors: Palmer JR, Ambrosone CB, Olshan AF
Source: Cancer Causes Control, 2014 Mar;25(3), p. 309-19.
EPub date: 2013 Dec 17.
PMID: 24343304
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Parity and breastfeeding among African-American women: differential effects on breast cancer risk by estrogen receptor status in the Women's Circle of Health Study.
Authors: Ambrosone CB, Zirpoli G, Ruszczyk M, Shankar J, Hong CC, McIlwain D, Roberts M, Yao S, McCann SE, Ciupak G, Hwang H, Khoury T, Jandorf L, Bovbjerg DH, Pawlish K, Bandera EV
Source: Cancer Causes Control, 2014 Feb;25(2), p. 259-65.
EPub date: 2013 Nov 19.
PMID: 24249438
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Body fatness and breast cancer risk in women of African ancestry.
Authors: Bandera EV, Chandran U, Zirpoli G, Gong Z, McCann SE, Hong CC, Ciupak G, Pawlish K, Ambrosone CB
Source: BMC Cancer, 2013 Oct 14;13, p. 475.
EPub date: 2013 Oct 14.
PMID: 24118876
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Body size in early life and breast cancer risk in African American and European American women.
Authors: Bandera EV, Chandran U, Zirpoli G, Ciupak G, Bovbjerg DH, Jandorf L, Pawlish K, Freudenheim JL, Ambrosone CB
Source: Cancer Causes Control, 2013 Dec;24(12), p. 2231-43.
EPub date: 2013 Oct 10.
PMID: 24113797
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Racial disparities in red meat and poultry intake and breast cancer risk.
Authors: Chandran U, Zirpoli G, Ciupak G, McCann SE, Gong Z, Pawlish K, Lin Y, Demissie K, Ambrosone CB, Bandera EV
Source: Cancer Causes Control, 2013 Dec;24(12), p. 2217-29.
EPub date: 2013 Oct 5.
PMID: 24091794
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Does alcohol increase breast cancer risk in African-American women? Findings from a case-control study.
Authors: Chandran U, Zirpoli G, Ciupak G, McCann SE, Gong Z, Pawlish K, Lin Y, Demissie K, Ambrosone CB, Bandera EV
Source: Br J Cancer, 2013 Oct 1;109(7), p. 1945-53.
EPub date: 2013 Sep 5.
PMID: 24008665
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Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women.
Authors: Gong Z, Ambrosone CB, McCann SE, Zirpoli G, Chandran U, Hong CC, Bovbjerg DH, Jandorf L, Ciupak G, Pawlish K, Lu Q, Hwang H, Khoury T, Wiam B, Bandera EV
Source: Int J Cancer, 2014 Mar 15;134(6), p. 1422-35.
EPub date: 2013 Sep 30.
PMID: 23996837
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Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry.
Authors: Quan L, Gong Z, Yao S, Bandera EV, Zirpoli G, Hwang H, Roberts M, Ciupak G, Davis W, Sucheston L, Pawlish K, Bovbjerg DH, Jandorf L, Cabasag C, Coignet JG, Ambrosone CB, Hong CC
Source: Int J Cancer, 2014 Mar 15;134(6), p. 1408-21.
EPub date: 2013 Oct 8.
PMID: 23996684
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Innate immunity pathways and breast cancer Risk in African American and European-American women in the Women's Circle of Health Study (WCHS).
Authors: Gong Z, Quan L, Yao S, Zirpoli G, Bandera EV, Roberts M, Coignet JG, Cabasag C, Sucheston L, Hwang H, Ciupak G, Davis W, Pawlish K, Jandorf L, Bovbjerg DH, Ambrosone CB, Hong CC
Source: PLoS One, 2013;8(8), p. e72619.
EPub date: 2013 Aug 21.
PMID: 23991131
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Rethinking sources of representative controls for the conduct of case-control studies in minority populations.
Authors: Bandera EV, Chandran U, Zirpoli G, McCann SE, Ciupak G, Ambrosone CB
Source: BMC Med Res Methodol, 2013 May 31;13, p. 71.
EPub date: 2013 May 31.
PMID: 23721229
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Fine-mapping of the 6q25 locus identifies a novel SNP associated with breast cancer risk in African-American women.
Authors: Ruiz-NarvŠez EA, Rosenberg L, Yao S, Rotimi CN, Cupples AL, Bandera EV, Ambrosone CB, Adams-Campbell LL, Palmer JR
Source: Carcinogenesis, 2013 Feb;34(2), p. 287-91.
EPub date: 2012 Oct 26.
PMID: 23104177
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Mammographic density and breast cancer risk in White and African American Women.
Authors: Razzaghi H, Troester MA, Gierach GL, Olshan AF, Yankaskas BC, Millikan RC
Source: Breast Cancer Res Treat, 2012 Sep;135(2), p. 571-80.
EPub date: 2012 Aug 3.
PMID: 22864770
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Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study.
Authors: Yao S, Zirpoli G, Bovbjerg DH, Jandorf L, Hong CC, Zhao H, Sucheston LE, Tang L, Roberts M, Ciupak G, Davis W, Hwang H, Johnson CS, Trump DL, McCann SE, Ademuyiwa F, Pawlish KS, Bandera EV, Ambrosone CB
Source: Breast Cancer Res, 2012 Apr 4;14(2), p. R58.
EPub date: 2012 Apr 4.
PMID: 22480149
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