Grant Details
| Grant Number: | 5P01CA151135-02 Interpret this number |
| Primary Investigator: | Ambrosone, Christine |
| Organization: | Roswell Park Cancer Institute Corp |
| Project Title: | Epidemiology of Breast Cancer Subtypes in African American Women: a Consortium |
| Fiscal Year: | 2012 |
Abstract
Women of African ancestry (AA) women are more likely than those with European ancestry (EA) to be diagnosed with breast cancer before age 45, and to have more aggressive tumors, characterized by high grade, with negative staining for estrogen and progesterone receptors and HER-2 (triple negative). They are also more likely to have basal-like breast tumors, an intrinsic breast cancer subtype with the poorest prognosis. The reasons for these disparities are unclear, and existing studies lack the statistical power to investigate risk factors for breast cancer subtypes among young women. In this Program Project, we will pool data and samples from the Carolina Breast Cancer Study (CBCS), the Black Women's Health Study (BWHS), the Women's Circle of Health Study (WCHS) and the Multi-ethnic Cohort (MEC) and continue to accrue cases for a final sample size of more than 5500 cases and 5500 controls. We will collect tissue blocks and classify cancers by their intrinsic subtypes, and investigate specific genetic, biologic and epidemiologic risk factors for subtypes in four highly interactive projects. The specific aims are to examine associations between age at diagnosis and breast cancer subtypes and 1) genetic loci identified in recent GWAS findings, using fine-mapping to identify potential causal alleles; 2) pregnancy history and lactation, and potential modification by genetic variants in related pathways; 3) body size, early life and adult physical activity, and gene/environment interactions; and 4) risk factors that may have been adaptive in Africa to endemic infectious disease (robust immune response) and intense sunlight (high skin pigmentation), but that in western society may result in hyper-inflammatory milieu and vitamin D deficiency, which may be related to early, aggressive breast cancer. Interactive aims will investigate relationships between subtypes and genetic and biologic factors, as well as epidemiologic characteristics. Cores that support all of the projects include the 1) Administrative Core; 2) Data Collection Core; 3) Biospecimen Core; and 4) Biostatistics and Data Management Core. By pooling our data, specimens, and importantly, expertise to investigate these synergist hypotheses, we will elucidate much of the etiology of aggressive, early onset breast cancers in AA women.
Publications
Fine-mapping of the 6q25 locus identifies a novel SNP associated with breast cancer risk in African-American women.
Authors: Ruiz-Narváez EA, Rosenberg L, Yao S, Rotimi CN, Cupples AL, Bandera EV, Ambrosone CB, Adams-Campbell LL, Palmer JR
Source: Carcinogenesis, 2013 Feb;34(2), p. 287-91.
EPub date: 2012 Oct 26.
PMID: 23104177
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA098663 | NCI NIH HHS - R01 CA100598 | NCI NIH HHS - P01 CA151135 |
| NCI NIH HHS - K22 CA138563 | NCI NIH HHS - R01 CA058420 |
MeSH Terms:
Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study.
Authors: Yao S, Zirpoli G, Bovbjerg DH, Jandorf L, Hong CC, Zhao H, Sucheston LE, Tang L, Roberts M, Ciupak G, Davis W, Hwang H, Johnson CS, Trump DL, McCann SE, Ademuyiwa F, Pawlish KS, Bandera EV, Ambrosone CB
Source: Breast Cancer Res, 2012 Apr 4;14(2), p. R58.
EPub date: 2012 Apr 4.
PMID: 22480149
Related Citations
Grant Numbers:
| NCI NIH HHS - P30 CA016056-32 | NCI NIH HHS - R01 CA100598 | NCCDPHP CDC HHS - DP07-703 |
| NCI NIH HHS - P01 CA151135 | NCI NIH HHS - N01-PC-95001-20 | NCI NIH HHS - K22 CA138563 |
| NCI NIH HHS - K07 CA148888 |
MeSH Terms:
