||7R01CA132897-05 Interpret this number
||Northshore University Healthsystem
||Bayesian Models for Cancer Prognosis By Integrating Diverse Types of Data
A new strategy in cancer prognosis is to base the decision on integrated information from different sources,
including the traditional clinical and demographic information of patients, such as age, grade, and tumor size,
etc, and the recently emerged genetic information like expression of gene or protein markers. Implementation
of such a strategy requires efficient quantitative models that integrate the clinical measurements and genetic
measurements together for prognosis. The long-range goal of this application is to improve risk predication,
treatment selection, and subtype classification in cancer prevention, diagnosis, and prognosis. The short-term
objective is to improve prediction of treatment response for cancer patients by developing innovative statistical
models that integrate three different types of data, including two subtypes of informatics data, namely protein
pathway data and high-throughput protein expression data, and a third type, which is the standard clinical and
demographic data. We will accomplish the objective of this application by pursuing the following five specific
aims: 1) Develop Bayesian parametric models that integrate a known genetic pathway with high-throughput
protein expression measurements. 2) Develop Bayesian nonparametric model that integrate multiple genetic
pathways with protein expression measurements. 3) Develop Bayesian classification procedures based on the
Bayesian models proposed in previous two aims. 4) Integrate clinical and demographic measurements into the
Bayesian models and apply the Bayesian classification procedures using a comprehensive data set that
contains protein expression measurements and clinical measurements for more than 500 patients with
leukemia. 5) Validate statistical findings by performing biological experiments, which will be done by our
collaborating biologists. The proposed research is expected to provide quantitative prognostic tools for
oncologists based on integrated information. The impact of the proposed research will be significant because
models developed in this application can be applied to various cancer types and thus potentially improve the
prognosis for patients with different types of cancer.
A Nonparametric Bayesian Model for Local Clustering with Application to Proteomics.
Lee J, Müller P, Zhu Y, Ji Y
J Am Stat Assoc, 2013 Jan 1;108(503), p. null.
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