|Grant Number:||1UM1CA167552-01 Interpret this number|
|Primary Investigator:||Willett, Walter|
|Organization:||Harvard School Of Public Health|
|Project Title:||Cancer Epidemiology Cohort in Male Health Professionals|
DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Health Professional's Follow-up Study, a cancer epidemiology cohort of 51,529 men enrolled in 1986 when they were 40 to 75 years of age. The cohort is currently supported as part of a Program Project; consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The cohort includes a biorespository with DNA samples from 35,000 participants, plasma from 18,000, nails from 33,000, and tumor tissue from approximately 70% of incident colon, prostate, and other important cancers. In this cohort, smoking, weight, medication use, and medical diagnoses have been updated every 2 years and information on diet and physical activity has been updated every four years. Much other valuable exposure information is collected. Follow-up of the cohort has been approximately 94% complete at each of the 2-year follow-up cycles and ascertainment of deaths is at least 98% complete. This cohort has been highly productive; 341 papers have been published during the current funding cycle or are in press. Novel findings include the identification of modifiable risk factors that account for one third of aggressive prostate cancer; strong evidence based on plasma levels, germ line DNA, and gene expression in tumor tissue that vitamin D is importantly involved in risk of death from prostate cancer; and roles of specific diet factors and physical activity after the diagnosis f colorectal and prostate cancer in survival. This cohort has also contributed to 19 cancer-related consortia during this funding period and has an active data sharing component. The HPFS is unique as the largest cancer cohort in men with many repeated measures of exposure over more than two decades, which provides a powerful view of realistic latent periods for carcinogenesis and the opportunity to examine both pre-and post-diagnosis determinants of survival from cancer. Because of the massive, detailed data and biological samples already in hand, the nearly complete ascertainment of incident cancers with high rates of tissue acquisition, and the entry of the younger members of the cohort into the age of maximal cancer incidence, this cohort will be even more fruitful scientifically during the next five years.
SMO Expression in Colorectal Cancer: Associations with Clinical, Pathological, and Molecular Features.
Authors: Li T, Liao X, Lochhead P, Morikawa T, Yamauchi M, Nishihara R, Inamura K, Kim SA, Mima K, Sukawa Y, Kuchiba A, Imamura Y, Baba Y, Shima K, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S, Qian ZR
Source: Ann Surg Oncol, 2014 Jul 15;null, p. null.
EPub date: 2014 Jul 15.
Predicted 25(OH)D Score and Colorectal Cancer Risk According to Vitamin D Receptor Expression.
Authors: Jung S, Qian ZR, Yamauchi M, Bertrand KA, Fitzgerald KC, Inamura K, Kim SA, Mima K, Sukawa Y, Zhang X, Wang M, Smith-Warner SA, Wu K, Fuchs CS, Chan AT, Giovannucci EL, Ng K, Cho E, Ogino S, Nishihara R
Source: Cancer Epidemiol Biomarkers Prev, 2014 Aug;23(8), p. 1628-37.
EPub date: 2014 Jun 11.
Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.
Authors: Imamura Y, Lochhead P, Yamauchi M, Kuchiba A, Qian ZR, Liao X, Nishihara R, Jung S, Wu K, Nosho K, Wang YE, Peng S, Bass AJ, Haigis KM, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S
Source: Mol Cancer, 2014 May 31;13, p. 135.
EPub date: 2014 May 31.
Relation between time spent outdoors and exfoliation glaucoma or exfoliation glaucoma suspect.
Authors: Kang JH, Wiggs JL, Pasquale LR
Source: Am J Ophthalmol, 2014 Sep;158(3), p. 605-614.e1.
EPub date: 2014 May 20.
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Authors: Zhang B, Jia WH, Matsuda K, Kweon SS, Matsuo K, Xiang YB, Shin A, Jee SH, Kim DH, Cai Q, Long J, Shi J, Wen W, Yang G, Zhang Y, Li C, Li B, Guo Y, Ren Z, Ji BT, Pan ZZ, Takahashi A, Shin MH, Matsuda F, Gao YT, Oh JH, Kim S, Ahn YO, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Chan AT, Chang-Claude J, Slattery ML, Colorectal Transdisciplinary (CORECT) Study, Gruber SB, Schumacher FR, Stenzel SL, Colon Cancer Family Registry (CCFR), Casey G, Kim HR, Jeong JY, Park JW, Li HL, Hosono S, Cho SH, Kubo M, Shu XO, Zeng YX, Zheng W
Source: Nat Genet, 2014 Jun;46(6), p. 533-42.
EPub date: 2014 May 18.
Urinary PGE-M levels are associated with risk of colorectal adenomas and chemopreventive response to anti-inflammatory drugs.
Authors: Bezawada N, Song M, Wu K, Mehta RS, Milne GL, Ogino S, Fuchs CS, Giovannucci EL, Chan AT
Source: Cancer Prev Res (Phila), 2014 Jul;7(7), p. 758-65.
EPub date: 2014 May 13.
Plasma homocysteine, dietary B vitamins, betaine, and choline and risk of peripheral artery disease.
Authors: Bertoia ML, Pai JK, Cooke JP, Joosten MM, Mittleman MA, Rimm EB, Mukamal KJ
Source: Atherosclerosis, 2014 Jul;235(1), p. 94-101.
EPub date: 2014 Apr 28.
Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).
Authors: Fink SP, Yamauchi M, Nishihara R, Jung S, Kuchiba A, Wu K, Cho E, Giovannucci E, Fuchs CS, Ogino S, Markowitz SD, Chan AT
Source: Sci Transl Med, 2014 Apr 23;6(233), p. 233re2.
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
Authors: Figueiredo JC, Hsu L, Hutter CM, Lin Y, Campbell PT, Baron JA, Berndt SI, Jiao S, Casey G, Fortini B, Chan AT, Cotterchio M, Lemire M, Gallinger S, Harrison TA, Le Marchand L, Newcomb PA, Slattery ML, Caan BJ, Carlson CS, Zanke BW, Rosse SA, Brenner H, Giovannucci EL, Wu K, Chang-Claude J, Chanock SJ, Curtis KR, Duggan D, Gong J, Haile RW, Hayes RB, Hoffmeister M, Hopper JL, Jenkins MA, Kolonel LN, Qu C, Rudolph A, Schoen RE, Schumacher FR, Seminara D, Stelling DL, Thibodeau SN, Thornquist M, Warnick GS, Henderson BE, Ulrich CM, Gauderman WJ, Potter JD, White E, Peters U, CCFR, GECCO
Source: PLoS Genet, 2014 Apr;10(4), p. e1004228.
EPub date: 2014 Apr 17.
Plasma antioxidants, genetic variation in SOD2, CAT, GPX1, GPX4, and prostate cancer survival.
Authors: Van Blarigan EL, Ma J, Kenfield SA, Stampfer MJ, Sesso HD, Giovannucci EL, Witte JS, Erdman JW Jr, Chan JM, Penney KL
Source: Cancer Epidemiol Biomarkers Prev, 2014 Jun;23(6), p. 1037-46.
EPub date: 2014 Apr 7.
Dietary intake of fish, ?-3 and ?-6 fatty acids and risk of colorectal cancer: A prospective study in U.S. men and women.
Authors: Song M, Chan AT, Fuchs CS, Ogino S, Hu FB, Mozaffarian D, Ma J, Willett WC, Giovannucci EL, Wu K
Source: Int J Cancer, 2014 Apr 7;null, p. null.
EPub date: 2014 Apr 7.
A prospective study of folate, vitamin B?, and vitamin B?? intake in relation to exfoliation glaucoma or suspected exfoliation glaucoma.
Authors: Kang JH, Loomis SJ, Wiggs JL, Willett WC, Pasquale LR
Source: JAMA Ophthalmol, 2014 May;132(5), p. 549-59.
Measures of Adiposity Are Associated With Increased Risk of Peptic Ulcer.
Authors: Boylan MR, Khalili H, Huang ES, Chan AT
Source: Clin Gastroenterol Hepatol, 2014 Mar 26;null, p. null.
EPub date: 2014 Mar 26.
Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma.
Authors: Kang JH, Loomis SJ, Yaspan BL, Bailey JC, Weinreb RN, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Gaasterland D, Gaasterland T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Forman JP, Buys ES, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Wiggs JL, Pasquale LR
Source: Eye (Lond), 2014 Jun;28(6), p. 662-71.
EPub date: 2014 Mar 7.
Benchmarks for Operative Outcomes of Robotic and Open Radical Prostatectomy: Results from the Health Professionals Follow-up Study.
Authors: Alemozaffar M, Sanda M, Yecies D, Mucci LA, Stampfer MJ, Kenfield SA
Source: Eur Urol, 2014 Feb 11;null, p. null.
EPub date: 2014 Feb 11.
Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss.
Authors: Loomis SJ, Kang JH, Weinreb RN, Yaspan BL, Cooke Bailey JN, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Pasquale LR, Wiggs JL
Source: Ophthalmology, 2014 Feb;121(2), p. 508-16.
EPub date: 2013 Oct 25.
A prospective study of macrophage inhibitory cytokine-1 (MIC-1/GDF15) and risk of colorectal cancer.
Authors: Mehta RS, Song M, Bezawada N, Wu K, Garcia-Albeniz X, Morikawa T, Fuchs CS, Ogino S, Giovannucci EL, Chan AT
Source: J Natl Cancer Inst, 2014 Apr;106(4), p. dju016.
EPub date: 2014 Feb 24.
Estimating the heritability of colorectal cancer.
Authors: Jiao S, Peters U, Berndt S, Brenner H, Butterbach K, Caan BJ, Carlson CS, Chan AT, Chang-Claude J, Chanock S, Curtis KR, Duggan D, Gong J, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M, Kolonel LN, Le Marchand L, Potter JD, Rudolph A, Schoen RE, Seminara D, Slattery ML, White E, Hsu L
Source: Hum Mol Genet, 2014 Jul 15;23(14), p. 3898-905.
EPub date: 2014 Feb 21.
Dietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era.
Authors: Zu K, Mucci L, Rosner BA, Clinton SK, Loda M, Stampfer MJ, Giovannucci E
Source: J Natl Cancer Inst, 2014 Feb;106(2), p. djt430.
EPub date: 2014 Jan 24.
Body-mass index and mortality among adults with incident type 2 diabetes.
Authors: Tobias DK, Pan A, Jackson CL, O'Reilly EJ, Ding EL, Willett WC, Manson JE, Hu FB
Source: N Engl J Med, 2014 Jan 16;370(3), p. 233-44.
Regular aspirin use and risk of multiple myeloma: a prospective analysis in the health professionals follow-up study and nurses' health study.
Authors: Birmann BM, Giovannucci EL, Rosner BA, Colditz GA
Source: Cancer Prev Res (Phila), 2014 Jan;7(1), p. 33-41.
EPub date: 2013 Nov 26.
Association of nut consumption with total and cause-specific mortality.
Authors: Bao Y, Han J, Hu FB, Giovannucci EL, Stampfer MJ, Willett WC, Fuchs CS
Source: N Engl J Med, 2013 Nov 21;369(21), p. 2001-11.
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
Authors: Figueroa JD, Ye Y, Siddiq A, Garcia-Closas M, Chatterjee N, Prokunina-Olsson L, Cortessis VK, Kooperberg C, Cussenot O, Benhamou S, Prescott J, Porru S, Dinney CP, Malats N, Baris D, Purdue M, Jacobs EJ, Albanes D, Wang Z, Deng X, Chung CC, Tang W, Bas Bueno-de-Mesquita H, Trichopoulos D, Ljungberg B, Clavel-Chapelon F, Weiderpass E, Krogh V, Dorronsoro M, Travis R, Tjřnneland A, Brenan P, Chang-Claude J, Riboli E, Conti D, Gago-Dominguez M, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Hohensee C, Rodabough R, Cancel-Tassin G, Roupret M, Comperat E, Chen C, De Vivo I, Giovannucci E, Hunter DJ, Kraft P, Lindstrom S, Carta A, Pavanello S, Arici C, Mastrangelo G, Kamat AM, Lerner SP, Barton Grossman H, Lin J, Gu J, Pu X, Hutchinson A, Burdette L, Wheeler W, Kogevinas M, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Schwenn M, Karagas MR, Johnson A, Schned A, Armenti KR, Hosain GM, Andriole G Jr, Grubb R 3rd, Black A, Ryan Diver W, Gapstur SM, Weinstein SJ, Virtamo J, Haiman CA, Landi MT, Caporaso N, Fraumeni JF Jr, Vineis P, Wu X, Silverman DT, Chanock S, Rothman N
Source: Hum Mol Genet, 2014 Mar 1;23(5), p. 1387-98.
EPub date: 2013 Oct 24.
Prediagnostic body mass index and pancreatic cancer survival.
Authors: Yuan C, Bao Y, Wu C, Kraft P, Ogino S, Ng K, Qian ZR, Rubinson DA, Stampfer MJ, Giovannucci EL, Wolpin BM
Source: J Clin Oncol, 2013 Nov 20;31(33), p. 4229-34.
EPub date: 2013 Oct 21.
Longitudinal and secular trends in dietary supplement use: Nurses' Health Study and Health Professionals Follow-Up Study, 1986-2006.
Authors: Kim HJ, Giovannucci E, Rosner B, Willett WC, Cho E
Source: J Acad Nutr Diet, 2014 Mar;114(3), p. 436-43.
EPub date: 2013 Oct 9.
Long-term colorectal-cancer incidence and mortality after lower endoscopy.
Authors: Nishihara R, Wu K, Lochhead P, Morikawa T, Liao X, Qian ZR, Inamura K, Kim SA, Kuchiba A, Yamauchi M, Imamura Y, Willett WC, Rosner BA, Fuchs CS, Giovannucci E, Ogino S, Chan AT
Source: N Engl J Med, 2013 Sep 19;369(12), p. 1095-105.
Methylmercury exposure and incident diabetes in U.S. men and women in two prospective cohorts.
Authors: Mozaffarian D, Shi P, Morris JS, Grandjean P, Siscovick DS, Spiegelman D, Hu FB
Source: Diabetes Care, 2013 Nov;36(11), p. 3578-84.
EPub date: 2013 Sep 11.