|Grant Number:||1UM1CA167552-01 Interpret this number|
|Primary Investigator:||Willett, Walter|
|Organization:||Harvard University (Sch Of Public Hlth)|
|Project Title:||Cancer Epidemiology Cohort in Male Health Professionals|
DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Health Professional's Follow-up Study, a cancer epidemiology cohort of 51,529 men enrolled in 1986 when they were 40 to 75 years of age. The cohort is currently supported as part of a Program Project; consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The cohort includes a biorespository with DNA samples from 35,000 participants, plasma from 18,000, nails from 33,000, and tumor tissue from approximately 70% of incident colon, prostate, and other important cancers. In this cohort, smoking, weight, medication use, and medical diagnoses have been updated every 2 years and information on diet and physical activity has been updated every four years. Much other valuable exposure information is collected. Follow-up of the cohort has been approximately 94% complete at each of the 2-year follow-up cycles and ascertainment of deaths is at least 98% complete. This cohort has been highly productive; 341 papers have been published during the current funding cycle or are in press. Novel findings include the identification of modifiable risk factors that account for one third of aggressive prostate cancer; strong evidence based on plasma levels, germ line DNA, and gene expression in tumor tissue that vitamin D is importantly involved in risk of death from prostate cancer; and roles of specific diet factors and physical activity after the diagnosis f colorectal and prostate cancer in survival. This cohort has also contributed to 19 cancer-related consortia during this funding period and has an active data sharing component. The HPFS is unique as the largest cancer cohort in men with many repeated measures of exposure over more than two decades, which provides a powerful view of realistic latent periods for carcinogenesis and the opportunity to examine both pre-and post-diagnosis determinants of survival from cancer. Because of the massive, detailed data and biological samples already in hand, the nearly complete ascertainment of incident cancers with high rates of tissue acquisition, and the entry of the younger members of the cohort into the age of maximal cancer incidence, this cohort will be even more fruitful scientifically during the next five years.
Dietary intake of fish, ?-3 and ?-6 fatty acids and risk of colorectal cancer: A prospective study in U.S. men and women.
Authors: Song M, Chan AT, Fuchs CS, Ogino S, Hu FB, Mozaffarian D, Ma J, Willett WC, Giovannucci EL, Wu K
Source: Int J Cancer, 2014 Apr 7;null, p. null.
EPub date: 2014 Apr 7.
Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss.
Authors: Loomis SJ, Kang JH, Weinreb RN, Yaspan BL, Cooke Bailey JN, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Pasquale LR, Wiggs JL
Source: Ophthalmology, 2014 Feb;121(2), p. 508-16.
EPub date: 2013 Oct 25.
Dietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era.
Authors: Zu K, Mucci L, Rosner BA, Clinton SK, Loda M, Stampfer MJ, Giovannucci E
Source: J Natl Cancer Inst, 2014 Feb;106(2), p. djt430.
EPub date: 2014 Jan 24.
Body-mass index and mortality among adults with incident type 2 diabetes.
Authors: Tobias DK, Pan A, Jackson CL, O'Reilly EJ, Ding EL, Willett WC, Manson JE, Hu FB
Source: N Engl J Med, 2014 Jan 16;370(3), p. 233-44.
Regular aspirin use and risk of multiple myeloma: a prospective analysis in the health professionals follow-up study and nurses' health study.
Authors: Birmann BM, Giovannucci EL, Rosner BA, Colditz GA
Source: Cancer Prev Res (Phila), 2014 Jan;7(1), p. 33-41.
EPub date: 2013 Nov 26.
Association of nut consumption with total and cause-specific mortality.
Authors: Bao Y, Han J, Hu FB, Giovannucci EL, Stampfer MJ, Willett WC, Fuchs CS
Source: N Engl J Med, 2013 Nov 21;369(21), p. 2001-11.
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
Authors: Figueroa JD, Ye Y, Siddiq A, Garcia-Closas M, Chatterjee N, Prokunina-Olsson L, Cortessis VK, Kooperberg C, Cussenot O, Benhamou S, Prescott J, Porru S, Dinney CP, Malats N, Baris D, Purdue M, Jacobs EJ, Albanes D, Wang Z, Deng X, Chung CC, Tang W, Bas Bueno-de-Mesquita H, Trichopoulos D, Ljungberg B, Clavel-Chapelon F, Weiderpass E, Krogh V, Dorronsoro M, Travis R, Tjřnneland A, Brenan P, Chang-Claude J, Riboli E, Conti D, Gago-Dominguez M, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Hohensee C, Rodabough R, Cancel-Tassin G, Roupret M, Comperat E, Chen C, De Vivo I, Giovannucci E, Hunter DJ, Kraft P, Lindstrom S, Carta A, Pavanello S, Arici C, Mastrangelo G, Kamat AM, Lerner SP, Barton Grossman H, Lin J, Gu J, Pu X, Hutchinson A, Burdette L, Wheeler W, Kogevinas M, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Schwenn M, Karagas MR, Johnson A, Schned A, Armenti KR, Hosain GM, Andriole G Jr, Grubb R 3rd, Black A, Ryan Diver W, Gapstur SM, Weinstein SJ, Virtamo J, Haiman CA, Landi MT, Caporaso N, Fraumeni JF Jr, Vineis P, Wu X, Silverman DT, Chanock S, Rothman N
Source: Hum Mol Genet, 2014 Mar 1;23(5), p. 1387-98.
EPub date: 2013 Oct 24.
Prediagnostic body mass index and pancreatic cancer survival.
Authors: Yuan C, Bao Y, Wu C, Kraft P, Ogino S, Ng K, Qian ZR, Rubinson DA, Stampfer MJ, Giovannucci EL, Wolpin BM
Source: J Clin Oncol, 2013 Nov 20;31(33), p. 4229-34.
EPub date: 2013 Oct 21.
Long-term colorectal-cancer incidence and mortality after lower endoscopy.
Authors: Nishihara R, Wu K, Lochhead P, Morikawa T, Liao X, Qian ZR, Inamura K, Kim SA, Kuchiba A, Yamauchi M, Imamura Y, Willett WC, Rosner BA, Fuchs CS, Giovannucci E, Ogino S, Chan AT
Source: N Engl J Med, 2013 Sep 19;369(12), p. 1095-105.
Methylmercury exposure and incident diabetes in U.S. men and women in two prospective cohorts.
Authors: Mozaffarian D, Shi P, Morris JS, Grandjean P, Siscovick DS, Spiegelman D, Hu FB
Source: Diabetes Care, 2013 Nov;36(11), p. 3578-84.
EPub date: 2013 Sep 11.
Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies.
Authors: Muraki I, Imamura F, Manson JE, Hu FB, Willett WC, van Dam RM, Sun Q
Source: BMJ, 2013 Aug 28;347, p. f5001.
EPub date: 2013 Aug 28.
Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.
Authors: Hiraki LT, Qu C, Hutter CM, Baron JA, Berndt SI, Bézieau S, Brenner H, Caan BJ, Casey G, Chang-Claude J, Chanock SJ, Conti DV, Duggan D, Fuchs CS, Gallinger S, Giovannucci EL, Harrison TA, Hayes RB, Hazra A, Henderson B, Hoffmeister M, Hopper JL, Hudson TJ, Jenkins MA, Küry S, Le Marchand L, Lemire M, Ma J, Manson JE, Nan H, Newcomb PA, Ng K, Potter JD, Schoen RE, Schumacher FR, Seminara D, Slattery ML, Wactawski-Wende J, White E, Wu K, Zanke BW, Kraft P, Peters U, Chan AT
Source: Cancer Epidemiol Biomarkers Prev, 2013 Nov;22(11), p. 2037-46.
EPub date: 2013 Aug 27.
Protein expression of PTEN, insulin-like growth factor I receptor (IGF-IR), and lethal prostate cancer: a prospective study.
Authors: Zu K, Martin NE, Fiorentino M, Flavin R, Lis RT, Sinnott JA, Finn S, Penney KL, Ma J, Fazli L, Gleave ME, Bismar TA, Stampfer MJ, Pollak MN, Loda M, Mucci LA, Giovannucci E
Source: Cancer Epidemiol Biomarkers Prev, 2013 Nov;22(11), p. 1984-93.
EPub date: 2013 Aug 27.
Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication.
Authors: Lochhead P, Kuchiba A, Imamura Y, Liao X, Yamauchi M, Nishihara R, Qian ZR, Morikawa T, Shen J, Meyerhardt JA, Fuchs CS, Ogino S
Source: J Natl Cancer Inst, 2013 Aug 7;105(15), p. 1151-6.
EPub date: 2013 Jul 22.
Plasma adiponectin and soluble leptin receptor and risk of colorectal cancer: a prospective study.
Authors: Song M, Zhang X, Wu K, Ogino S, Fuchs CS, Giovannucci EL, Chan AT
Source: Cancer Prev Res (Phila), 2013 Sep;6(9), p. 875-85.
EPub date: 2013 Jul 19.
Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States.
Authors: Pasquale LR, Loomis SJ, Weinreb RN, Kang JH, Yaspan BL, Bailey JC, Gaasterland D, Gaasterland T, Lee RK, Scott WK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Wiggs JL
Source: Mol Vis, 2013;19, p. 1471-81.
EPub date: 2013 Jul 12.
Aspirin use and risk of colorectal cancer according to BRAF mutation status.
Authors: Nishihara R, Lochhead P, Kuchiba A, Jung S, Yamauchi M, Liao X, Imamura Y, Qian ZR, Morikawa T, Wang M, Spiegelman D, Cho E, Giovannucci E, Fuchs CS, Chan AT, Ogino S
Source: JAMA, 2013 Jun 26;309(24), p. 2563-71.
Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology.
Authors: Ogino S, Lochhead P, Giovannucci E, Meyerhardt JA, Fuchs CS, Chan AT
Source: Oncogene, 2013 Jun 24;null, p. null.
EPub date: 2013 Jun 24.
A prospective study of duration of smoking cessation and colorectal cancer risk by epigenetics-related tumor classification.
Authors: Nishihara R, Morikawa T, Kuchiba A, Lochhead P, Yamauchi M, Liao X, Imamura Y, Nosho K, Shima K, Kawachi I, Qian ZR, Fuchs CS, Chan AT, Giovannucci E, Ogino S
Source: Am J Epidemiol, 2013 Jul 1;178(1), p. 84-100.
EPub date: 2013 Jun 20.
SBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases.
Authors: Jiao S, Hsu L, Bézieau S, Brenner H, Chan AT, Chang-Claude J, Le Marchand L, Lemire M, Newcomb PA, Slattery ML, Peters U
Source: Genet Epidemiol, 2013 Jul;37(5), p. 452-64.
EPub date: 2013 May 29.
Physical activity, tumor PTGS2 expression, and survival in patients with colorectal cancer.
Authors: Yamauchi M, Lochhead P, Imamura Y, Kuchiba A, Liao X, Qian ZR, Nishihara R, Morikawa T, Shima K, Wu K, Giovannucci E, Meyerhardt JA, Fuchs CS, Chan AT, Ogino S
Source: Cancer Epidemiol Biomarkers Prev, 2013 Jun;22(6), p. 1142-52.
EPub date: 2013 Apr 29.
A prospective study of plasma inflammatory markers and risk of colorectal cancer in men.
Authors: Song M, Wu K, Ogino S, Fuchs CS, Giovannucci EL, Chan AT
Source: Br J Cancer, 2013 May 14;108(9), p. 1891-8.
EPub date: 2013 Apr 16.
Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease.
Authors: Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, Giovannucci E
Source: Mod Pathol, 2013 Apr;26(4), p. 465-84.
EPub date: 2013 Jan 11.
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
Authors: Peters U, Jiao S, Schumacher FR, Hutter CM, Aragaki AK, Baron JA, Berndt SI, Bézieau S, Brenner H, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Casey G, Chan AT, Chang-Claude J, Chanock SJ, Chen LS, Coetzee GA, Coetzee SG, Conti DV, Curtis KR, Duggan D, Edwards T, Fuchs CS, Gallinger S, Giovannucci EL, Gogarten SM, Gruber SB, Haile RW, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M, Hopper JL, Hudson TJ, Hunter DJ, Jackson RD, Jee SH, Jenkins MA, Jia WH, Kolonel LN, Kooperberg C, Küry S, Lacroix AZ, Laurie CC, Laurie CA, Le Marchand L, Lemire M, Levine D, Lindor NM, Liu Y, Ma J, Makar KW, Matsuo K, Newcomb PA, Potter JD, Prentice RL, Qu C, Rohan T, Rosse SA, Schoen RE, Seminara D, Shrubsole M, Shu XO, Slattery ML, Taverna D, Thibodeau SN, Ulrich CM, White E, Xiang Y, Zanke BW, Zeng YX, Zhang B, Zheng W, Hsu L, Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium
Source: Gastroenterology, 2013 Apr;144(4), p. 799-807.e24.
EPub date: 2012 Dec 22.
Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.
Authors: Jia WH, Zhang B, Matsuo K, Shin A, Xiang YB, Jee SH, Kim DH, Ren Z, Cai Q, Long J, Shi J, Wen W, Yang G, Delahanty RJ, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Colon Cancer Family Registry (CCFR), Ji BT, Pan ZZ, Matsuda F, Gao YT, Oh JH, Ahn YO, Park EJ, Li HL, Park JW, Jo J, Jeong JY, Hosono S, Casey G, Peters U, Shu XO, Zeng YX, Zheng W
Source: Nat Genet, 2013 Feb;45(2), p. 191-6.
EPub date: 2012 Dec 23.