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Grant Details

Grant Number: 1UM1CA167552-01 Interpret this number
Primary Investigator: Willett, Walter
Organization: Harvard School Of Public Health
Project Title: Cancer Epidemiology Cohort in Male Health Professionals
Fiscal Year: 2012
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Abstract

DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Health Professional's Follow-up Study, a cancer epidemiology cohort of 51,529 men enrolled in 1986 when they were 40 to 75 years of age. The cohort is currently supported as part of a Program Project; consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The cohort includes a biorespository with DNA samples from 35,000 participants, plasma from 18,000, nails from 33,000, and tumor tissue from approximately 70% of incident colon, prostate, and other important cancers. In this cohort, smoking, weight, medication use, and medical diagnoses have been updated every 2 years and information on diet and physical activity has been updated every four years. Much other valuable exposure information is collected. Follow-up of the cohort has been approximately 94% complete at each of the 2-year follow-up cycles and ascertainment of deaths is at least 98% complete. This cohort has been highly productive; 341 papers have been published during the current funding cycle or are in press. Novel findings include the identification of modifiable risk factors that account for one third of aggressive prostate cancer; strong evidence based on plasma levels, germ line DNA, and gene expression in tumor tissue that vitamin D is importantly involved in risk of death from prostate cancer; and roles of specific diet factors and physical activity after the diagnosis f colorectal and prostate cancer in survival. This cohort has also contributed to 19 cancer-related consortia during this funding period and has an active data sharing component. The HPFS is unique as the largest cancer cohort in men with many repeated measures of exposure over more than two decades, which provides a powerful view of realistic latent periods for carcinogenesis and the opportunity to examine both pre-and post-diagnosis determinants of survival from cancer. Because of the massive, detailed data and biological samples already in hand, the nearly complete ascertainment of incident cancers with high rates of tissue acquisition, and the entry of the younger members of the cohort into the age of maximal cancer incidence, this cohort will be even more fruitful scientifically during the next five years.

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Publications

Physical activity and prostate tumor vessel morphology: data from the Health Professionals Follow-up Study.
Authors: Van Blarigan EL, Gerstenberger JP, Kenfield SA, Giovannucci EL, Stampfer M, Jones LW, Clinton SK, Chan JM, Mucci LA
Source: Cancer Prev Res (Phila), 2015 Aug 14;null, p. null.
EPub date: 2015 Aug 14.
PMID: 26276753
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Intake of meat mutagens and risk of prostate cancer in a cohort of U.S. health professionals.
Authors: Rohrmann S, Nimptsch K, Sinha R, Willett WC, Giovannucci EL, Platz EA, Wu K
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jul 29;null, p. null.
EPub date: 2015 Jul 29.
PMID: 26224797
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Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: The Liver Cancer Pooling Project.
Authors: Petrick JL, Freedman ND, Graubard BI, Sahasrabuddhe VV, Lai GY, Alavanja MC, Beane-Freeman LE, Boggs DA, Buring JE, Chan AT, Chong DQ, Fuchs CS, Gapstur SM, Gaziano JM, Giovannucci EL, Hollenbeck AR, King LY, Koshiol J, Lee IM, Linet MS, Palmer JR, Poynter JN, Purdue MP, Robien K, Schairer C, Sesso HD, Sigurdson AJ, Zeleniuch-Jacquotte A, Wactawski-Wende J, Campbell PT, McGlynn KA
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jun 30;null, p. null.
EPub date: 2015 Jun 30.
PMID: 26126626
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Measuring PI3K Activation: Clinicopathologic, Immunohistochemical, and RNA Expression Analysis in Prostate Cancer.
Authors: Martin NE, Gerke T, Sinnott JA, Stack EC, Andren O, Andersson SO, Johansson JE, Fiorentino M, Finn S, Fedele G, Stampfer M, Kantoff PW, Mucci LA, Loda M
Source: Mol Cancer Res, 2015 Jun 29;null, p. null.
EPub date: 2015 Jun 29.
PMID: 26124442
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Proportion of colon cancer attributable to lifestyle in a cohort of US women.
Authors: Erdrich J, Zhang X, Giovannucci E, Willett W
Source: Cancer Causes Control, 2015 Sep;26(9), p. 1271-9.
EPub date: 2015 Jun 20.
PMID: 26092381
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Circulating Very-Long-Chain Saturated Fatty Acids and Incident Coronary Heart Disease in US Men and Women.
Authors: Malik VS, Chiuve SE, Campos H, Rimm EB, Mozaffarian D, Hu FB, Sun Q
Source: Circulation, 2015 Jul 28;132(4), p. 260-8.
EPub date: 2015 Jun 5.
PMID: 26048094
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Fat intake after prostate cancer diagnosis and mortality in the Physicians' Health Study.
Authors: Van Blarigan EL, Kenfield SA, Yang M, Sesso HD, Ma J, Stampfer MJ, Chan JM, Chavarro JE
Source: Cancer Causes Control, 2015 Aug;26(8), p. 1117-26.
EPub date: 2015 Jun 6.
PMID: 26047644
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Association Between Plasma Levels of Macrophage Inhibitory Cytokine-1 Before Diagnosis of Colorectal Cancer and Mortality.
Authors: Mehta RS, Chong DQ, Song M, Meyerhardt JA, Ng K, Nishihara R, Qian Z, Morikawa T, Wu K, Giovannucci EL, Fuchs CS, Ogino S, Chan AT
Source: Gastroenterology, 2015 Sep;149(3), p. 614-22.
EPub date: 2015 May 27.
PMID: 26026393
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Mendelian randomization study of height and risk of colorectal cancer.
Authors: Thrift AP, Gong J, Peters U, Chang-Claude J, Rudolph A, Slattery ML, Chan AT, Esko T, Wood AR, Yang J, Vedantam S, Gustafsson S, Pers TH, GIANT Consortium, Baron JA, Bezieau S, Küry S, Ogino S, Berndt SI, Casey G, Haile RW, Du M, Harrison TA, Thornquist M, Duggan DJ, Le Marchand L, Lemire M, Lindor NM, Seminara D, Song M, Thibodeau SN, Cotterchio M, Win AK, Jenkins MA, Hopper JL, Ulrich CM, Potter JD, Newcomb PA, Schoen RE, Hoffmeister M, Brenner H, White E, Hsu L, Campbell PT
Source: Int J Epidemiol, 2015 Apr;44(2), p. 662-72.
EPub date: 2015 May 20.
PMID: 25997436
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Prediagnostic Obesity and Physical Inactivity Are Associated with Shorter Telomere Length in Prostate Stromal Cells.
Authors: Joshu CE, Peskoe SB, Heaphy CM, Kenfield SA, Van Blarigan EL, Mucci LA, Giovannucci EL, Stampfer MJ, Yoon G, Lee TK, Hicks JL, De Marzo AM, Meeker AK, Platz EA
Source: Cancer Prev Res (Phila), 2015 Aug;8(8), p. 737-42.
EPub date: 2015 May 19.
PMID: 25990087
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Mendelian Randomization Study of Body Mass Index and Colorectal Cancer Risk.
Authors: Thrift AP, Gong J, Peters U, Chang-Claude J, Rudolph A, Slattery ML, Chan AT, Locke AE, Kahali B, Justice AE, Pers TH, Gallinger S, Hayes RB, Baron JA, Caan BJ, Ogino S, Berndt SI, Chanock SJ, Casey G, Haile RW, Du M, Harrison TA, Thornquist M, Duggan DJ, Le Marchand L, Lindor NM, Seminara D, Song M, Wu K, Thibodeau SN, Cotterchio M, Win AK, Jenkins MA, Hopper JL, Ulrich CM, Potter JD, Newcomb PA, Hoffmeister M, Brenner H, White E, Hsu L, Campbell PT
Source: Cancer Epidemiol Biomarkers Prev, 2015 Jul;24(7), p. 1024-31.
EPub date: 2015 May 14.
PMID: 25976416
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Adulthood Weight Change and Risk of Colorectal Cancer in the Nurses' Health Study and Health Professionals Follow-up Study.
Authors: Song M, Hu FB, Spiegelman D, Chan AT, Wu K, Ogino S, Fuchs CS, Willett WC, Giovannucci EL
Source: Cancer Prev Res (Phila), 2015 Jul;8(7), p. 620-7.
EPub date: 2015 Apr 30.
PMID: 25930050
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