|Grant Number:||5U54CA155850-02 Interpret this number|
|Primary Investigator:||Schmitz, Kathryn|
|Organization:||University Of Pennsylvania|
|Project Title:||Penn TREC Survivor Center|
The overall goal of the Penn TREC Survivor Center is to improve the length and quality of cancer survivorship through establishing a sustainable transdisciplinary research, education, and outreach program that extends from 'bench to trench'. The proposed center will enhance knowledge of the causal associations of energy balance and breast cancer recurrence, from animal to human models, as well as exploring and integrating this knowledge with broad population impact at the policy level for control of obesity related adverse events among cancer survivors. Three projects are proposed. Project 1 will explore whether exercise and/or weight loss will alter breast cancer recurrence in mice and explore effects on biomarkers of mechanistic pathways hypothesized to explain these effects. Project 2 will translate project 1 biomarker findings into a human model. Intervention effects on clinical lymphedema outcomes will also be assessed in Project 2. Project 3 will assess whether exercise and/or weight loss is cost effective for breast cancer survivors with lymphedema. Organizationally, the administrative core will serve as the glue between the investigators, so that as the projects, training activities, and developmental pilots unfold, the transdisciplinary, translational nature of the center is preserved and extended. The developmental core will accelerate capacity to study effects of energetics on cancer recurrence by combining the unique strengths of our institution in obesity and cancer biology and extending the TREC initiative solidly into cancer survivorship. The education/training and outreach core will train scientists and clinicians regarding energy balance and cancer survivorship, serving the dual purpose of educating health care providers regarding the unique energy balance issues in survivors and spurring interest in research on this growing population across the spectrum from basic science to clinical applications. The Penn TREC Survivor Center will leverage the considerable strengths of Penn scientific investigators and physician scientists to accelerate capacity for research on energetics, cancer recurrence and persistent adverse treatment effects as well as disseminating those findings to improve clinical care and outcomes for cancer survivors.
Physical function as a prognostic biomarker among cancer survivors.
Authors: Brown JC, Harhay MO, Harhay MN
Source: Br J Cancer, 2015 Jan 6;112(1), p. 194-8.
EPub date: 2014 Nov 13.
Oncogene pathway activation in mammary tumors dictates FDG-PET uptake.
Authors: Alvarez JV, Belka GK, Pan TC, Chen CC, Blankemeyer E, Alavi A, Karp JS, Chodosh LA
Source: Cancer Res, 2014 Dec 15;74(24), p. 7583-98.
EPub date: 2014 Sep 19.
Association between lymphedema self-care adherence and lymphedema outcomes among women with breast cancer-related lymphedema.
Authors: Brown JC, Kumar A, Cheville AL, Tchou JC, Troxel AB, Harris SR, Schmitz KH
Source: Am J Phys Med Rehabil, 2015 Apr;94(4), p. 288-96.
Concomitant low-dose doxorubicin treatment and exercise.
Authors: Sturgeon K, Schadler K, Muthukumaran G, Ding D, Bajulaiye A, Thomas NJ, Ferrari V, Ryeom S, Libonati JR
Source: Am J Physiol Regul Integr Comp Physiol, 2014 Sep 15;307(6), p. R685-92.
EPub date: 2014 Jul 9.
Walking cadence and mortality among community-dwelling older adults.
Authors: Brown JC, Harhay MO, Harhay MN
Source: J Gen Intern Med, 2014 Sep;29(9), p. 1263-9.
EPub date: 2014 Jun 17.
Physical activity, daily walking, and lower limb lymphedema associate with physical function among uterine cancer survivors.
Authors: Brown JC, Lin LL, Segal S, Chu CS, Haggerty AE, Ko EM, Schmitz KH
Source: Support Care Cancer, 2014 Nov;22(11), p. 3017-25.
EPub date: 2014 Jun 7.
The prescription or proscription of exercise in colorectal cancer care.
Authors: Brown JC, Schmitz KH
Source: Med Sci Sports Exerc, 2014 Dec;46(12), p. 2202-9.
Cancer-related impairments influence physical activity in uterine cancer survivors.
Authors: Hammer SM, Brown JC, Segal S, Chu CS, Schmitz KH
Source: Med Sci Sports Exerc, 2014 Dec;46(12), p. 2195-201.
Effects of buffer size and shape on associations between the built environment and energy balance.
Authors: James P, Berrigan D, Hart JE, Hipp JA, Hoehner CM, Kerr J, Major JM, Oka M, Laden F
Source: Health Place, 2014 May;27, p. 162-70.
EPub date: 2014 Mar 7.
The effects of exercise on cardiovascular outcomes before, during, and after treatment for breast cancer.
Authors: Sturgeon KM, Ky B, Libonati JR, Schmitz KH
Source: Breast Cancer Res Treat, 2014 Jan;143(2), p. 219-26.
EPub date: 2013 Dec 14.
Aromatase inhibitor associated musculoskeletal symptoms are associated with reduced physical activity among breast cancer survivors.
Authors: Brown JC, Mao JJ, Stricker C, Hwang WT, Tan KS, Schmitz KH
Source: Breast J, 2014 Jan-Feb;20(1), p. 22-8.
EPub date: 2013 Oct 25.
Prescription and adherence to lymphedema self-care modalities among women with breast cancer-related lymphedema.
Authors: Brown JC, Cheville AL, Tchou JC, Harris SR, Schmitz KH
Source: Support Care Cancer, 2014 Jan;22(1), p. 135-43.
EPub date: 2013 Sep 7.
Impact of obesity on cancer survivorship and the potential relevance of race and ethnicity.
Authors: Schmitz KH, Neuhouser ML, Agurs-Collins T, Zanetti KA, Cadmus-Bertram L, Dean LT, Drake BF
Source: J Natl Cancer Inst, 2013 Sep 18;105(18), p. 1344-54.
EPub date: 2013 Aug 29.
Cancer, physical activity, and exercise.
Authors: Brown JC, Winters-Stone K, Lee A, Schmitz KH
Source: Compr Physiol, 2012 Oct;2(4), p. 2775-809.
Physical activity and lower limb lymphedema among uterine cancer survivors.
Authors: Brown JC, John GM, Segal S, Chu CS, Schmitz KH
Source: Med Sci Sports Exerc, 2013 Nov;45(11), p. 2091-7.
The effects of aerobic exercise on estrogen metabolism in healthy premenopausal women.
Authors: Smith AJ, Phipps WR, Thomas W, Schmitz KH, Kurzer MS
Source: Cancer Epidemiol Biomarkers Prev, 2013 May;22(5), p. 756-64.
The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design.
Authors: Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD
Source: Cancer Causes Control, 2013 Apr;24(4), p. 695-704.
EPub date: 2013 Feb 3.
Aerobic training reduces systemic oxidative stress in young women with elevated levels of F2-isoprostanes.
Authors: Arikawa AY, Thomas W, Gross M, Smith A, Phipps WR, Kurzer MS, Schmitz KH
Source: Contemp Clin Trials, 2013 Mar;34(2), p. 212-7.
EPub date: 2012 Nov 22.
The prevalence of lymphedema symptoms among survivors of long-term cancer with or at risk for lower limb lymphedema.
Authors: Brown JC, Chu CS, Cheville AL, Schmitz KH
Source: Am J Phys Med Rehabil, 2013 Mar;92(3), p. 223-31.
Lifestyle risk factors associated with arm swelling among women with breast cancer.
Authors: Showalter SL, Brown JC, Cheville AL, Fisher CS, Sataloff D, Schmitz KH
Source: Ann Surg Oncol, 2013 Mar;20(3), p. 842-9.
EPub date: 2012 Oct 3.
Safety of weightlifting among women with or at risk for breast cancer-related lymphedema: musculoskeletal injuries and health care use in a weightlifting rehabilitation trial.
Authors: Brown JC, Troxel AB, Schmitz KH
Source: Oncologist, 2012;17(8), p. 1120-8.
EPub date: 2012 Jul 2.
Exercise lowers estrogen and progesterone levels in premenopausal women at high risk of breast cancer.
Authors: Kossman DA, Williams NI, Domchek SM, Kurzer MS, Stopfer JE, Schmitz KH
Source: J Appl Physiol (1985), 2011 Dec;111(6), p. 1687-93.
EPub date: 2011 Sep 8.
Effects of aerobic exercise on premenopausal sex hormone levels: results of the WISER study, a randomized clinical trial in healthy, sedentary, eumenorrheic women.
Authors: Smith AJ, Phipps WR, Arikawa AY, O'Dougherty M, Kaufman B, Thomas W, Schmitz KH, Kurzer MS
Source: Cancer Epidemiol Biomarkers Prev, 2011 Jun;20(6), p. 1098-106.
EPub date: 2011 Apr 5.
No effect of exercise on insulin-like growth factor-I, insulin, and glucose in young women participating in a 16-week randomized controlled trial.
Authors: Arikawa AY, Kurzer MS, Thomas W, Schmitz KH
Source: Cancer Epidemiol Biomarkers Prev, 2010 Nov;19(11), p. 2987-90.
EPub date: 2010 Sep 10.
Women in Steady Exercise Research (WISER): study design and methods.
Authors: Arikawa AY, O'Dougherty M, Kaufman BC, Smith AJ, Thomas W, Warren M, Kurzer MS, Schmitz KH
Source: Contemp Clin Trials, 2010 Sep;31(5), p. 457-65.
EPub date: 2010 May 24.