|Grant Number:||5U54CA155496-02 Interpret this number|
|Primary Investigator:||Colditz, Graham|
|Project Title:||A Multilevel Approach to Energy Balance and Cancer Across the Lifecourse|
DESCRIPTION (provided by applicant): Drawing on the broad scientific expertise of faculty at Washington University in St. Louis and collaborators and consultants from other institutions, we propose to build on existing transdisciplinary approaches and create a center to address mechanisms of obesity and cancer, "from cell to society". We include projects that move beyond traditional risk factor-cancer associations to look at multilevel and multigenerational associations as well as the interaction of traditional cancer risk behaviors. We leverage the unique opportunity Missouri provides to study human populations given its diversity across race/ethnicity and socioeconomic status. We will delineate mechanisms by which preconception diet, nutrition & built environment polices impact inactivity and physical activity and energy balance to influence body weight and carcinogenesis across the life course. Specifically we aim to: 1. Investigate in a mouse model the effect of maternal high fat diet and changes in metabolic bioenergetics on prostate gland development and susceptibility to prostate cancer in male mouse offspring; 2. Study the role of physical activity and obesity in post-prostatectomy urinary and sexual function; 3. Develop models of obesity across the life course and generations incorporating biologic, clinical and social determinants of risk and mortality, which can be applied to different cancer outcomes, using non- Hodgkin Lymphoma as the initial platform; 4. Study policies relating to nutrition and built environment that impact energy balance and obesity; 5. Train postdoctoral fellows in a transdisciplinary environment to pursue careers in energetics and cancer and expose scholars from across our university to transdisciplinary work in obesity and cancer; 6. Foster scientific synergy via smaller-scale innovative transdisciplinary research that builds on the Center's theme and resources; and 7. Maximize efficiency and productivity of TREC-related studies and cores by building an outstanding transdisciplinary center supported by outstanding administrative, budgetary, and technology resources. To address these aims, we propose four research projects and five cores that form a cohesive, transdisciplinary center focused on research, training/career development, and dissemination.
Short-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women.
Authors: Rosner B, Eliassen AH, Toriola AT, Hankinson SE, Willett WC, Natarajan L, Colditz GA
Source: Breast Cancer Res Treat, 2015 Apr;150(3), p. 643-53.
EPub date: 2015 Mar 22.
Comparative effectiveness of anthracycline-containing chemotherapy in United States veterans age 80 and older with diffuse large B-cell lymphoma.
Authors: Carson KR, Riedell P, Lynch R, Nabhan C, Wildes TM, Liu W, Ganti A, Roop R, Sanfilippo KM, O'Brian K, Liu J, Bartlett NL, Cashen A, Wagner-Johnston N, Fehniger TA, Colditz GA
Source: J Geriatr Oncol, 2015 Jan 19;null, p. null.
EPub date: 2015 Jan 19.
Life years lost and lifetime health care expenditures associated with diabetes in the U.S., National Health Interview Survey, 1997-2000.
Authors: Leung MY, Pollack LM, Colditz GA, Chang SH
Source: Diabetes Care, 2015 Mar;38(3), p. 460-8.
EPub date: 2014 Dec 31.
A Framework for Training Transdisciplinary Scholars in Cancer Prevention and Control.
Authors: James AS, Gehlert S, Bowen DJ, Colditz GA
Source: J Cancer Educ, 2014 Dec 16;null, p. null.
EPub date: 2014 Dec 16.
Home and workplace built environment supports for physical activity.
Authors: Adlakha D, Hipp AJ, Marx C, Yang L, Tabak R, Dodson EA, Brownson RC
Source: Am J Prev Med, 2015 Jan;48(1), p. 104-7.
EPub date: 2014 Nov 6.
Occupational sitting and weight status in a diverse sample of employees in Midwest metropolitan cities, 2012-2013.
Authors: Yang L, Hipp JA, Marx CM, Brownson RC
Source: Prev Chronic Dis, 2014 Nov 20;11, p. E203.
EPub date: 2014 Nov 20.
Advancing Transdisciplinary Research: The Transdisciplinary Research on Energetics and Cancer Initiative.
Authors: Gehlert S, Hall K, Vogel A, Hohl S, Hartman S, Nebeling L, Redline S, Schmitz K, Thornquist M, Patterson R, Thompson B
Source: J Transl Med Epidemiol, 2014 Sep;2(2), p. 1032.
Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development.
Authors: Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO
Source: Cancer Res, 2014 Sep 15;74(18), p. 5322-35.
EPub date: 2014 Aug 1.
Introduction to the Special Issue.
Authors: Gehlert S, Hudson DL
Source: Race Soc Probl, 2013 Jun;5(2), p. 79-80.
Impact of body mass index on incidence of febrile neutropenia and treatment-related mortality in United States veterans with diffuse large B-cell lymphoma receiving rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone.
Authors: Ganti A, Liu W, Luo S, Sanfilippo KM, Roop R, Lynch R, Riedell P, O'Brian K, Colditz GA, Carson KR
Source: Br J Haematol, 2014 Dec;167(5), p. 699-702.
EPub date: 2014 Jul 15.
An active lifestyle for cancer prevention.
Authors: Yang L, Colditz GA
Source: J Natl Cancer Inst, 2014 Jul;106(7), p. null.
EPub date: 2014 Jun 16.
Perceived barriers to mammography among underserved women in a Breast Health Center Outreach Program.
Authors: Fayanju OM, Kraenzle S, Drake BF, Oka M, Goodman MS
Source: Am J Surg, 2014 Sep;208(3), p. 425-34.
EPub date: 2014 May 4.
A novel system dynamics model of female obesity and fertility.
Authors: Sabounchi NS, Hovmand PS, Osgood ND, Dyck RF, Jungheim ES
Source: Am J Public Health, 2014 Jul;104(7), p. 1240-6.
EPub date: 2014 May 15.
Breast cancer risk accumulation starts early: prevention must also.
Authors: Colditz GA, Bohlke K, Berkey CS
Source: Breast Cancer Res Treat, 2014 Jun;145(3), p. 567-79.
EPub date: 2014 May 13.
Racial disparities in healthy behaviors and cancer screening among breast cancer survivors and women without cancer: National Health Interview Survey 2005.
Authors: Yaghjyan L, Wolin K, Chang SH, Colditz G
Source: Cancer Causes Control, 2014 May;25(5), p. 605-14.
EPub date: 2014 Mar 18.
The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012.
Authors: Chang SH, Stoll CR, Song J, Varela JE, Eagon CJ, Colditz GA
Source: JAMA Surg, 2014 Mar;149(3), p. 275-87.
Maternal high-fat diet induces hyperproliferation and alters Pten/Akt signaling in prostates of offspring.
Authors: Benesh EC, Humphrey PA, Wang Q, Moley KH
Source: Sci Rep, 2013 Dec 10;3, p. 3466.
EPub date: 2013 Dec 10.
Implementation strategies: recommendations for specifying and reporting.
Authors: Proctor EK, Powell BJ, McMillen JC
Source: Implement Sci, 2013 Dec 1;8, p. 139.
EPub date: 2013 Dec 1.
Obesity, mortality, and life years lost associated with breast cancer in nonsmoking US Women, National Health Interview Survey, 1997-2000.
Authors: Chang SH, Pollack LM, Colditz GA
Source: Prev Chronic Dis, 2013 Nov 14;10, p. E186.
EPub date: 2013 Nov 14.
Obesity increases risk for pouch-related complications following restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA).
Authors: Klos CL, Safar B, Jamal N, Hunt SR, Wise PE, Birnbaum EH, Fleshman JW, Mutch MG, Dharmarajan S
Source: J Gastrointest Surg, 2014 Mar;18(3), p. 573-9.
EPub date: 2013 Oct 4.
Influence of body mass index on survival in veterans with multiple myeloma.
Authors: Beason TS, Chang SH, Sanfilippo KM, Luo S, Colditz GA, Vij R, Tomasson MH, Dipersio JF, Stockerl-Goldstein K, Ganti A, Wildes T, Carson KR
Source: Oncologist, 2013;18(10), p. 1074-9.
EPub date: 2013 Sep 18.
Impact of obesity on cancer survivorship and the potential relevance of race and ethnicity.
Authors: Schmitz KH, Neuhouser ML, Agurs-Collins T, Zanetti KA, Cadmus-Bertram L, Dean LT, Drake BF
Source: J Natl Cancer Inst, 2013 Sep 18;105(18), p. 1344-54.
EPub date: 2013 Aug 29.
A two-way street: bridging implementation science and cultural adaptations of mental health treatments.
Authors: Cabassa LJ, Baumann AA
Source: Implement Sci, 2013 Aug 19;8, p. 90.
EPub date: 2013 Aug 19.
Understanding the independent and joint associations of the home and workplace built environments on cardiorespiratory fitness and body mass index.
Authors: Hoehner CM, Allen P, Barlow CE, Marx CM, Brownson RC, Schootman M
Source: Am J Epidemiol, 2013 Oct 1;178(7), p. 1094-105.
EPub date: 2013 Aug 13.
Liver fatty acid-binding protein (L-Fabp) modifies intestinal fatty acid composition and adenoma formation in ApcMin/+ mice.
Authors: Dharmarajan S, Newberry EP, Montenegro G, Nalbantoglu I, Davis VR, Clanahan MJ, Blanc V, Xie Y, Luo J, Fleshman JW Jr, Kennedy S, Davidson NO
Source: Cancer Prev Res (Phila), 2013 Oct;6(10), p. 1026-37.
EPub date: 2013 Aug 6.
Designing for dissemination among public health researchers: findings from a national survey in the United States.
Authors: Brownson RC, Jacobs JA, Tabak RG, Hoehner CM, Stamatakis KA
Source: Am J Public Health, 2013 Sep;103(9), p. 1693-9.
EPub date: 2013 Jul 18.
Development and reliability testing of the Worksite and Energy Balance Survey.
Authors: Hoehner CM, Budd EL, Marx CM, Dodson EA, Brownson RC
Source: J Public Health Manag Pract, 2013 May-Jun;19(3 Suppl 1), p. S105-13.
Eight ways to stay healthy after cancer: an evidence-based message.
Authors: Wolin KY, Dart H, Colditz GA
Source: Cancer Causes Control, 2013 May;24(5), p. 827-37.
EPub date: 2013 Mar 12.
The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design.
Authors: Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD
Source: Cancer Causes Control, 2013 Apr;24(4), p. 695-704.
EPub date: 2013 Feb 3.
Implementation science and its application to population health.
Authors: Lobb R, Colditz GA
Source: Annu Rev Public Health, 2013;34, p. 235-51.
EPub date: 2013 Jan 7.
Advancing the application, quality and harmonization of implementation science measures.
Authors: Rabin BA, Purcell P, Naveed S, Moser RP, Henton MD, Proctor EK, Brownson RC, Glasgow RE
Source: Implement Sci, 2012 Dec 11;7, p. 119.
EPub date: 2012 Dec 11.
Physical activity and mammographic breast density: a systematic review.
Authors: Yaghjyan L, Colditz GA, Wolin K
Source: Breast Cancer Res Treat, 2012 Sep;135(2), p. 367-80.
EPub date: 2012 Jul 20.
Increased body mass index is associated with improved survival in United States veterans with diffuse large B-cell lymphoma.
Authors: Carson KR, Bartlett NL, McDonald JR, Luo S, Zeringue A, Liu J, Fu Q, Chang SH, Colditz GA
Source: J Clin Oncol, 2012 Sep 10;30(26), p. 3217-22.
EPub date: 2012 May 29.
A systematic review of body fat distribution and mortality in older people.
Authors: Chang SH, Beason TS, Hunleth JM, Colditz GA
Source: Maturitas, 2012 Jul;72(3), p. 175-91.
EPub date: 2012 May 16.
Applying what we know to accelerate cancer prevention.
Authors: Colditz GA, Wolin KY, Gehlert S
Source: Sci Transl Med, 2012 Mar 28;4(127), p. 127rv4.
Design and conduct of intervention-based research among cancer survivors.
Authors: Wolin KY, Colditz GA
Source: Cancer Epidemiol Biomarkers Prev, 2011 Oct;20(10), p. 2078-84.
Cancer disparities: unmet challenges in the elimination of disparities.
Authors: Gehlert S, Colditz GA
Source: Cancer Epidemiol Biomarkers Prev, 2011 Sep;20(9), p. 1809-14.
EPub date: 2011 Jul 22.