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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA136859-04 Interpret this number
Primary Investigator: Rogers, Laura
Organization: Southern Illinois University Sch Of Med
Project Title: Enhancing Physical Activity After Breast Cancer Diagnosis: Randomized Trial
Fiscal Year: 2012
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Project Abstract Most breast cancer survivors do not engage in regular physical activity (PA). Our piloted PA behavior change intervention for breast cancer survivors significantly improved PA and health outcomes post-intervention. Testing in additional sites with longer follow-up is warranted to confirm program effectiveness short and longer term. Importantly, the pilot intervention resulted in changes in PA and social cognitive theory constructs, enhancing our potential for testing mechanisms mediating PA behavior change. Therefore, we propose a multi- center, randomized controlled trial enrolling 256 breast cancer survivors with the following study aims: Primary study aim: To examine intervention effectiveness, the primary study aim is to compare the effects of the BEAT Cancer PA behavior change intervention to usual care on short and longer term PA adherence among breast cancer survivors. We hypothesize that, compared with usual care, the intervention will result in a significant increase in PA adherence post-intervention that will be maintained 3 and 9 months post- intervention. Secondary study aim #1: To better understand the mechanisms of PA behavior change, secondary study aim #1 is to compare the effects of the BEAT Cancer PA behavior change intervention to usual care on social cognitive factors and examine if such changes mediate PA behavior change. We hypothesize that, compared with usual care, the intervention will result in significant improvements in social cognitive factors targeted by the intervention. We also hypothesize that social cognitive factors will mediate the intervention effect on PA with selected factors mediating the intervention effect on self-efficacy and the effect of self-efficacy on PA. Secondary study aim #2: Although the primary focus of this proposal is to achieve and understand PA behavior change, we also aim to compare the short and longer term health effects of the BEAT Cancer PA behavior change intervention when compared with usual care. We hypothesize that, compared with usual care, the intervention will result in significant improvements in fitness, muscle strength, waist-to-hip ratio, quality of life, fatigue, sleep quality, and joint dysfunction. Outcome measures obtained at baseline, 3 months (i.e., immediately post-intervention), 6 months, and 12 months will include accelerometer (PA and sleep), survey (social cognitive factors, quality of life, fatigue, perceived sleep, and joint dysfunction), submaximal treadmill test (fitness), dynamometer (muscle strength), and waist-to-hip ratio. The study aims will be analyzed with mixed-model analysis of variance (ANOVA) with the secondary study aim #1 also utilizing multivariate analysis of variance (MANOVA) and Freedman- Schatzkin difference-in-coefficients test of mediation. Identifying the effects and underlying mechanisms of PA behavior change interventions will facilitate translation to community settings for improving the health and well- being of breast cancer survivors.

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Lessons Learned In The Trenches: Facilitating Exercise Adherence Among Breast Cancer Survivors In A Group Setting
Authors: Rogers L.Q. , Vicari S. , Courneya K.S. .
Source: Cancer Nursing, 2010 Nov-Dec; 33(6), p. E10-7.
PMID: 20562618
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Physical Activity Type And Intensity Among Rural Breast Cancer Survivors: Patterns And Associations With Fatigue And Depressive Symptoms
Authors: Rogers L.Q. , Markwell S.J. , Courneya K.S. , McAuley E. , Verhulst S. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2011 Mar; 5(1), p. 54-61.
PMID: 21110134
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Reduced Barriers Mediated Physical Activity Maintenance Among Breast Cancer Survivors
Authors: Rogers L.Q. , Markwell S. , Hopkins-Price P. , Vicari S. , Courneya K.S. , Hoelzer K. , Verhulst S. .
Source: Journal Of Sport & Exercise Psychology, 2011 Apr; 33(2), p. 235-54.
PMID: 21558582
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Objective Monitoring Of Physical Activity After A Cancer Diagnosis: Challenges And Opportunities For Enhancing Cancer Control
Authors: Rogers L.Q. .
Source: Physical Therapy Reviews : Ptr, 2010-06-01 00:00:00.0; 15(3), p. 224-237.
PMID: 21603254
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Better Exercise Adherence After Treatment For Cancer (beat Cancer) Study: Rationale, Design, And Methods
Authors: Rogers L.Q. , McAuley E. , Anton P.M. , Courneya K.S. , Vicari S. , Hopkins-Price P. , Verhulst S. , Mocharnuk R. , Hoelzer K. .
Source: Contemporary Clinical Trials, 2012 Jan; 33(1), p. 124-37.
PMID: 21983625
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Diet Components Associated With Perceived Fatigue In Breast Cancer Survivors
Authors: Guest D.D. , Evans E.M. , Rogers L.Q. .
Source: European Journal Of Cancer Care, 2013 Jan; 22(1), p. 51-9.
PMID: 22672363
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Effects Of A Physical Activity Behavior Change Intervention On Inflammation And Related Health Outcomes In Breast Cancer Survivors: Pilot Randomized Trial
Authors: Rogers L.Q. , Fogleman A. , Trammell R. , Hopkins-Price P. , Vicari S. , Rao K. , Edson B. , Verhulst S. , Courneya K.S. , Hoelzer K. .
Source: Integrative Cancer Therapies, 2013 Jul; 12(4), p. 323-35.
PMID: 22831916
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Meeting Physical Activity Guidelines In Rural Breast Cancer Survivors
Authors: Olson E.A. , Mullen S.P. , Rogers L.Q. , Courneya K.S. , Verhulst S. , McAuley E. .
Source: American Journal Of Health Behavior, 2014 Nov; 38(6), p. 890-9.
PMID: 25341266
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Effects Of The Beat Cancer Physical Activity Behavior Change Intervention On Physical Activity, Aerobic Fitness, And Quality Of Life In Breast Cancer Survivors: A Multicenter Randomized Controlled Trial
Authors: Rogers L.Q. , Courneya K.S. , Anton P.M. , Hopkins-Price P. , Verhulst S. , Vicari S.K. , Robbs R.S. , Mocharnuk R. , McAuley E. .
Source: Breast Cancer Research And Treatment, 2015 Jan; 149(1), p. 109-19.
PMID: 25417174
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