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Grant Details

Grant Number: 5R01CA154647-02 Interpret this number
Primary Investigator: Lee, I-Min
Organization: Brigham And Women'S Hospital
Project Title: Objectively Measured Physical Activity and Mortality in Women
Fiscal Year: 2012
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Abstract

DESCRIPTION (provided by applicant): This proposal seeks funding to measure physical activity objectively using the Actigraph GT3X accelerometer, a device that can accurately measure movement accelerations in three planes, among 21,249 women in the Women's Health Study and to follow them over 4 years for mortality. Already available are data from annual questionnaires over 15 years on risk factors (including self-reported physical activity every 2-3 years) and medical history in women, as well as plasma biomarker and whole genome scan data from blood samples collected at baseline. Morbidity follow-up is well over 90% and mortality follow-up is virtually 100%. In 2008, the federal government released its first-ever Physical Activity Guidelines for Americans, recommending the types and amounts of physical activity believed to offer substantial health benefits. The basis for these guidelines comes almost exclusively from observational epidemiologic studies of clinical endpoints, with physical activity assessed by self-report. Supporting such studies are data from randomized controlled trials of supervised exercise and cardiovascular risk factors, providing plausible biologic underpinnings for the lower risks of chronic diseases with physical activity. However, national surveys using self-reported physical activity show 47-50% of American adults meet physical activity recommendations, but national surveys measuring physical activity objectively using accelerometers indicate that <5% do so. Additionally, recent data suggest that sedentary behavior (e.g., time sitting) may be an independent risk factor, separate from physical activity, for chronic diseases. Sedentary behavior is imprecisely measured using self- reports, but can be accurately determined using accelerometers. Thus, the present proposal seeks to clarify the relations between physical activity, as well as sedentary behavior, and mortality by objectively measuring physical activity and sedentary behavior. Women will be asked to wear the Actigraph accelerometer for 1 week. Women will be recruited on a rolling basis over 2 years. Data from the accelerometers will classify women according to the time spent in light, moderate, and vigorous intensity physical activity (or combinations thereof), and sedentary behavior. At the end of the study, we will use the National Death Index to ascertain decedents. We will have sufficient statistical power to determine associations between physical activity, or sedentary behavior, and all-cause mortality. We also will be able to compare self-reported and accelerometer-measured physical activity, providing useful data on measurement error correction for other epidemiologic studies which may not have the resources to objectively measure physical activity. Finally, this study will be of tremendous advantage for future grant applications to cost- efficiently address the associations of objectively measured physical activity with other clinical endpoints which will accumulate in sufficient numbers over time, such as incident cardiovascular disease, cancer, and type 2 diabetes, all major causes of morbidity and mortality, as well as to examine physical activity-gene interactions. 1 PUBLIC HEALTH RELEVANCE: The federal government in 2008 recommended the types and amounts of physical activity believed to offer substantial health benefits, based primarily on observational epidemiologic studies of clinical endpoints, with physical activity assessed via self-report. However, there appears to be a large disparity between self-reported physical activity and objectively measured physical activity: national surveys using self-reports show 47-50% of American adults meet physical activity recommendations, but national surveys measuring physical activity objectively using accelerometers indicate that <5% do so. The present study seeks to clarify knowledge on the association of physical activity with health by objectively measuring physical activity using accelerometers among 21,249 women, and following them over 4 years for mortality. 1

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Publications

Do moderate-intensity and vigorous-intensity physical activities reduce mortality rates to the same extent?
Authors: Shiroma EJ, Sesso HD, Moorthy MV, Buring JE, Lee IM
Source: J Am Heart Assoc, 2014 Oct 17;3(5), p. e000802.
EPub date: 2014 Oct 17.
PMID: 25326527
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Duration and breaks in sedentary behaviour: accelerometer data from 1566 community-dwelling older men (British Regional Heart Study).
Authors: Jefferis BJ, Sartini C, Shiroma E, Whincup PH, Wannamethee SG, Lee IM
Source: Br J Sports Med, 2014 Sep 17;null, p. null.
EPub date: 2014 Sep 17.
PMID: 25232029
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Definition, Measurement, and Health Risks Associated with Sedentary Behavior.
Authors: Gibbs BB, Hergenroeder AL, Katzmarzyk PT, Lee IM, Jakicic JM
Source: Med Sci Sports Exerc, 2014 Sep 12;null, p. null.
EPub date: 2014 Sep 12.
PMID: 25222816
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Trajectories of Objectively Measured Physical Activity in Free-Living Older Men.
Authors: Jefferis BJ, Sartini C, Ash S, Lennon LT, Wannamethee SG, Lee IM, Whincup PH
Source: Med Sci Sports Exerc, 2014 Jul 1;null, p. null.
EPub date: 2014 Jul 1.
PMID: 24988411
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Adherence to physical activity guidelines in older adults, using objectively measured physical activity in a population-based study.
Authors: Jefferis BJ, Sartini C, Lee IM, Choi M, Amuzu A, Gutierrez C, Casas JP, Ash S, Lennnon LT, Wannamethee SG, Whincup PH
Source: BMC Public Health, 2014 Apr 19;14, p. 382.
EPub date: 2014 Apr 19.
PMID: 24745369
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Adiposity and insufficient MVPA predict cardiometabolic abnormalities in adults.
Authors: Peterson MD, Al Snih S, Stoddard J, McClain J, Lee IM
Source: Med Sci Sports Exerc, 2014 Jun;46(6), p. 1133-9.
PMID: 24389519
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Patterns of accelerometer-assessed sedentary behavior in older women.
Authors: Shiroma EJ, Freedson PS, Trost SG, Lee IM
Source: JAMA, 2013 Dec 18;310(23), p. 2562-3.
PMID: 24346993
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Using accelerometers to measure physical activity in large-scale epidemiological studies: issues and challenges.
Authors: Lee IM, Shiroma EJ
Source: Br J Sports Med, 2014 Feb;48(3), p. 197-201.
EPub date: 2013 Dec 2.
PMID: 24297837
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Years of life gained due to leisure-time physical activity in the U.S.
Authors: Janssen I, Carson V, Lee IM, Katzmarzyk PT, Blair SN
Source: Am J Prev Med, 2013 Jan;44(1), p. 23-9.
PMID: 23253646
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Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy.
Authors: Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT, Lancet Physical Activity Series Working Group
Source: Lancet, 2012 Jul 21;380(9838), p. 219-29.
PMID: 22818936
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