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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA114205-06 Interpret this number
Primary Investigator: Michaud, Dominique
Organization: U Of L Imperial Col Of Sci/Technlgy/Med
Project Title: Allergies, Genetic Susceptibility and Adult Glioma Risk
Fiscal Year: 2011
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Abstract

Gliomas are the most common primary malignant brain tumors in adults and are often highly fatal. Little is known about the etiology of these tumors. Recent studies suggest that individuals with allergies may have a lower risk of glioma. Studies have also reported associations with detoxification genes, especially GSTT1 and GSTP1. However, most epidemiologic studies reporting these associations have been case- control studies, which are particularly prone to biases, given the high fatality of gliomas. To examine hypotheses related to allergies and genetic susceptibility, we propose to draw on five established prospective cohorts: the Health Professionals Follow-Up study, the Nurses' Health Study I, the Nurses' Health Study II, the Physicians' Health Study, and the Women's Health Study. Specifically, we propose to examine IgE levels (total, food and respiratory specific) in blood specimens, SNPs (both alleles and haplotypes) of genes strongly related to allergies or asthma (IL-4, IL-4Ralpha, IL-13, FceRI-p, IL-10, CTLA- 4), and known functional variants of two detoxification genes (GSTP1 and GSTT1) in relation to the risk of gliomas. In these five cohorts, blood samples were collected from participants prior to disease diagnosis. For the genetic polymorphism analyses, we will have 341 incident glioma cases with 3 matched controls, using a nested case-control design. In addition, we propose to obtain tissue blocks from all incident glioma cases to classify the different types of gliomas using molecular markers (TP53 mutations, EGFR amplification, chromosome loss of 1p and 10p). Use of molecular markers to identify subtypes of gliomas may enhance our ability to uncover etiologic risk factors. This will be the largest prospective study of gliomas to date, and with its considerable strengths, holds the promise of contributing substantially to our understanding of the relation between allergies, genetic susceptibility and adult glioma risk. Improving our understanding of the etiology of gliomas will provide opportunities for treatment options or prevention of this deadly cancer.

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Publications

Mannose-binding lectin 2 gene and risk of adult glioma.
Authors: Michaud D.S. , Siddiq A. , Cox D.G. , Backes D.M. , Calboli F.C. , Sughrue M.E. , Gaziano J.M. , Ma J. , Stampfer M. , Tworoger S.S. , et al. .
Source: PloS one, 2013; 8(4), p. e61117.
EPub date: 2013-04-18.
PMID: 23637788
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Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma.
Authors: Backes D.M. , Siddiq A. , Cox D.G. , Calboli F.C. , Gaziano J.M. , Ma J. , Stampfer M. , Hunter D.J. , Camargo C.A. , Michaud D.S. .
Source: Journal of neuro-oncology, 2013 Jun; 113(2), p. 229-38.
EPub date: 2013-03-25.
PMID: 23525950
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Genome-wide association study of glioma and meta-analysis.
Authors: Rajaraman P. , Melin B.S. , Wang Z. , McKean-Cowdin R. , Michaud D.S. , Wang S.S. , Bondy M. , Houlston R. , Jenkins R.B. , Wrensch M. , et al. .
Source: Human genetics, 2012 Dec; 131(12), p. 1877-88.
EPub date: 2012-08-11.
PMID: 22886559
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Prediagnostic plasma IgE levels and risk of adult glioma in four prospective cohort studies.
Authors: Calboli F.C. , Cox D.G. , Buring J.E. , Gaziano J.M. , Ma J. , Stampfer M. , Willett W.C. , Tworoger S.S. , Hunter D.J. , Camargo C.A. , et al. .
Source: Journal of the National Cancer Institute, 2011-11-02; 103(21), p. 1588-95.
EPub date: 2011-10-18.
PMID: 22010181
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Anthropometric measures, physical activity, and risk of glioma and meningioma in a large prospective cohort study.
Authors: Michaud D.S. , Bové G. , Gallo V. , Schlehofer B. , Tjønneland A. , Olsen A. , Overvad K. , Dahm C.C. , Teucher B. , Boeing H. , et al. .
Source: Cancer prevention research (Philadelphia, Pa.), 2011 Sep; 4(9), p. 1385-92.
EPub date: 2011-06-17.
PMID: 21685234
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Coffee, tea, caffeine intake, and risk of adult glioma in three prospective cohort studies.
Authors: Holick C.N. , Smith S.G. , Giovannucci E. , Michaud D.S. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010 Jan; 19(1), p. 39-47.
PMID: 20056621
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Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study.
Authors: Michaud D.S. , Liu Y. , Meyer M. , Giovannucci E. , Joshipura K. .
Source: The Lancet. Oncology, 2008 Jun; 9(6), p. 550-8.
EPub date: 2008-05-05.
PMID: 18462995
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Atopy and risk of brain tumors: a meta-analysis.
Authors: Linos E. , Raine T. , Alonso A. , Michaud D. .
Source: Journal of the National Cancer Institute, 2007-10-17; 99(20), p. 1544-50.
EPub date: 2007-10-09.
PMID: 17925535
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