|Grant Number:||5R01CA114205-06 Interpret this number|
|Primary Investigator:||Michaud, Dominique|
|Organization:||U Of L Imperial Col Of Sci/Technlgy/Med|
|Project Title:||Allergies, Genetic Susceptibility and Adult Glioma Risk|
Gliomas are the most common primary malignant brain tumors in adults and are often highly fatal. Little is known about the etiology of these tumors. Recent studies suggest that individuals with allergies may have a lower risk of glioma. Studies have also reported associations with detoxification genes, especially GSTT1 and GSTP1. However, most epidemiologic studies reporting these associations have been case- control studies, which are particularly prone to biases, given the high fatality of gliomas. To examine hypotheses related to allergies and genetic susceptibility, we propose to draw on five established prospective cohorts: the Health Professionals Follow-Up study, the Nurses' Health Study I, the Nurses' Health Study II, the Physicians' Health Study, and the Women's Health Study. Specifically, we propose to examine IgE levels (total, food and respiratory specific) in blood specimens, SNPs (both alleles and haplotypes) of genes strongly related to allergies or asthma (IL-4, IL-4Ralpha, IL-13, FceRI-p, IL-10, CTLA- 4), and known functional variants of two detoxification genes (GSTP1 and GSTT1) in relation to the risk of gliomas. In these five cohorts, blood samples were collected from participants prior to disease diagnosis. For the genetic polymorphism analyses, we will have 341 incident glioma cases with 3 matched controls, using a nested case-control design. In addition, we propose to obtain tissue blocks from all incident glioma cases to classify the different types of gliomas using molecular markers (TP53 mutations, EGFR amplification, chromosome loss of 1p and 10p). Use of molecular markers to identify subtypes of gliomas may enhance our ability to uncover etiologic risk factors. This will be the largest prospective study of gliomas to date, and with its considerable strengths, holds the promise of contributing substantially to our understanding of the relation between allergies, genetic susceptibility and adult glioma risk. Improving our understanding of the etiology of gliomas will provide opportunities for treatment options or prevention of this deadly cancer.
Mannose-binding lectin 2 gene and risk of adult glioma.
Authors: Michaud DS, Siddiq A, Cox DG, Backes DM, Calboli FC, Sughrue ME, Gaziano JM, Ma J, Stampfer M, Tworoger SS, Hunter DJ, Camargo CA Jr, Parsa AT
Source: PLoS One, 2013;8(4), p. e61117.
EPub date: 2013 Apr 18.
Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma.
Authors: Backes DM, Siddiq A, Cox DG, Calboli FC, Gaziano JM, Ma J, Stampfer M, Hunter DJ, Camargo CA, Michaud DS
Source: J Neurooncol, 2013 Jun;113(2), p. 229-38.
EPub date: 2013 Mar 25.
Genome-wide association study of glioma and meta-analysis.
Authors: Rajaraman P, Melin BS, Wang Z, McKean-Cowdin R, Michaud DS, Wang SS, Bondy M, Houlston R, Jenkins RB, Wrensch M, Yeager M, Ahlbom A, Albanes D, Andersson U, Freeman LE, Buring JE, Butler MA, Braganza M, Carreon T, Feychting M, Fleming SJ, Gapstur SM, Gaziano JM, Giles GG, Hallmans G, Henriksson R, Hoffman-Bolton J, Inskip PD, Johansen C, Kitahara CM, Lathrop M, Liu C, Le Marchand L, Linet MS, Lonn S, Peters U, Purdue MP, Rothman N, Ruder AM, Sanson M, Sesso HD, Severi G, Shu XO, Simon M, Stampfer M, Stevens VL, Visvanathan K, White E, Wolk A, Zeleniuch-Jacquotte A, Zheng W, Decker P, Enciso-Mora V, Fridley B, Gao YT, Kosel M, Lachance DH, Lau C, Rice T, Swerdlow A, Wiemels JL, Wiencke JK, Shete S, Xiang YB, Xiao Y, Hoover RN, Fraumeni JF Jr, Chatterjee N, Hartge P, Chanock SJ
Source: Hum Genet, 2012 Dec;131(12), p. 1877-88.
EPub date: 2012 Aug 11.
Prediagnostic plasma IgE levels and risk of adult glioma in four prospective cohort studies.
Authors: Calboli FC, Cox DG, Buring JE, Gaziano JM, Ma J, Stampfer M, Willett WC, Tworoger SS, Hunter DJ, Camargo CA Jr, Michaud DS
Source: J Natl Cancer Inst, 2011 Nov 2;103(21), p. 1588-95.
EPub date: 2011 Oct 18.
Coffee, tea, caffeine intake, and risk of adult glioma in three prospective cohort studies.
Authors: Holick CN, Smith SG, Giovannucci E, Michaud DS
Source: Cancer Epidemiol Biomarkers Prev, 2010 Jan;19(1), p. 39-47.
Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study.
Authors: Michaud DS, Liu Y, Meyer M, Giovannucci E, Joshipura K
Source: Lancet Oncol, 2008 Jun;9(6), p. 550-8.
EPub date: 2008 May 5.
Atopy and risk of brain tumors: a meta-analysis.
Authors: Linos E, Raine T, Alonso A, Michaud D
Source: J Natl Cancer Inst, 2007 Oct 17;99(20), p. 1544-50.
EPub date: 2007 Oct 9.