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Grant Details

Grant Number: 5R01CA082729-11 Interpret this number
Primary Investigator: Shu, Xiao-Ou
Organization: Vanderbilt University
Project Title: Cohort Study of Cancer-Inhibitory Dietary Factors in Men
Fiscal Year: 2011
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Abstract

DESCRIPTION (provided by applicant): While it has long been recognized that dietary factors play an important role in the etiology of cancer, information regarding the preventive potential of specific dietary compounds is scarce. The Shanghai Men's Health Study (SMHS) is a population-based cohort study of 61,582 Chinese men between 40 and 74 who lived in urban Shanghai at enrollment. Because intake levels of many suspected cancer-inhibitory dietary factors are high and diverse in Shanghai, the SMHS offers unique opportunities to fill such knowledge gaps. Detailed information on dietary and other lifestyle factors was collected at baseline and is being updated in a follow-up survey. Biological samples were collected from 89% of cohort members. The cohort has been followed for cancer occurrence and deaths via linkage with the population-based Shanghai Cancer Registry and the Shanghai Vital Statistics Unit, as well as through visits to all living cohort members every 2 years. We propose in this renewal application to extend the follow-up of this cohort for 5 more years and to evaluate dietary hypotheses for the lung, stomach, and colorectal (CRC). The primary focus of the study is to determine whether regular tea consumption and high intake of folate, soy foods, allium vegetables, and crucifers are associated with a reduced risk of cancer. We also propose to conduct a nested case-control study to evaluate whether the levels of blood folate, urinary phytoestrogens (CRC only) and isothiocyanate are inversely associated with the risk of cancers of colorectum, lung, and stomach. These biomarkers are aggregate measures of level of intake, absorption, and metabolism and will provide added insight in elucidating the relationship of dietary factors with cancer risk. Blood level C-reactive protein and H.pylori antibodies will also be evaluated in the nested case-control study for CRC and stomach cancer. Finally, we propose to re-survey all living cohort-members to update information on usual dietary intake and other lifestyle factors to refine exposure assessments and to characterize and evaluate how temporal changes in exposures may influence cancer risk. Because of its size, setting, and unique exposure patterns and biological specimens, the SMHS provides an exceptional opportunity to address dietary hypotheses for cancer that cannot be adequately investigated in any other existing cohort study. The results from this study may guide new strategies in the primary prevention of common cancers in both Western and Asian men.

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Publications

Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
Authors: Wu C, Wang Z, Song X, Feng XS, Abnet CC, He J, Hu N, Zuo XB, Tan W, Zhan Q, Hu Z, He Z, Jia W, Zhou Y, Yu K, Shu XO, Yuan JM, Zheng W, Zhao XK, Gao SG, Yuan ZQ, Zhou FY, Fan ZM, Cui JL, Lin HL, Han XN, Li B, Chen X, Dawsey SM, Liao L, Lee MP, Ding T, Qiao YL, Liu Z, Liu Y, Yu D, Chang J, Wei L, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Han JJ, Zhou SL, Zhang P, Zhang DY, Yuan Y, Huang Y, Liu C, Zhai K, Qiao Y, Jin G, Guo C, Fu J, Miao X, Lu C, Yang H, Wang C, Wheeler WA, Gail M, Yeager M, Yuenger J, Guo ET, Li AL, Zhang W, Li XM, Sun LD, Ma BG, Li Y, Tang S, Peng XQ, Liu J, Hutchinson A, Jacobs K, Giffen C, Burdette L, Fraumeni JF Jr, Shen H, Ke Y, Zeng Y, Wu T, Kraft P, Chung CC, Tucker MA, Hou ZC, Liu YL, Hu YL, Liu Y, Wang L, Yuan G, Chen LS, Liu X, Ma T, Meng H, Sun L, Li XM, Li XM, Ku JW, Zhou YF, Yang LQ, Wang Z, Li Y, Qige Q, Yang WJ, Lei GY, Chen LQ, Li EM, Yuan L, Yue WB, Wang R, Wang LW, Fan XP, Zhu FH, Zhao WX, Mao YM, Zhang M, Xing GL, Li JL, Han M, Ren JL, Liu B, Ren SW, Kong QP, Li F, Sheyhidin I, Wei W, Zhang YR, Feng CW, Wang J, Yang YH, Hao HZ, Bao QD, Liu BC, Wu AQ, Xie D, Yang WC, Wang L, Zhao XH, Chen SQ, Hong JY, Zhang XJ, Freedman ND, Goldstein AM, Lin D, Taylor PR, Wang LD, Chanock SJ
Source: Nat Genet, 2014 Sep;46(9), p. 1001-6.
EPub date: 2014 Aug 17.
PMID: 25129146
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Burden of total and cause-specific mortality related to tobacco smoking among adults aged ? 45 years in Asia: a pooled analysis of 21 cohorts.
Authors: Zheng W, McLerran DF, Rolland BA, Fu Z, Boffetta P, He J, Gupta PC, Ramadas K, Tsugane S, Irie F, Tamakoshi A, Gao YT, Koh WP, Shu XO, Ozasa K, Nishino Y, Tsuji I, Tanaka H, Chen CJ, Yuan JM, Ahn YO, Yoo KY, Ahsan H, Pan WH, Qiao YL, Gu D, Pednekar MS, Sauvaget C, Sawada N, Sairenchi T, Yang G, Wang R, Xiang YB, Ohishi W, Kakizaki M, Watanabe T, Oze I, You SL, Sugawara Y, Butler LM, Kim DH, Park SK, Parvez F, Chuang SY, Fan JH, Shen CY, Chen Y, Grant EJ, Lee JE, Sinha R, Matsuo K, Thornquist M, Inoue M, Feng Z, Kang D, Potter JD
Source: PLoS Med, 2014 Apr;11(4), p. e1001631.
EPub date: 2014 Apr 22.
PMID: 24756146
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Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men.
Authors: Epplein M, Zheng W, Li H, Peek RM Jr, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Xiang YB, Shu XO
Source: Nutr Cancer, 2014;66(4), p. 550-7.
EPub date: 2014 Mar 25.
PMID: 24666234
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Prospective cohort studies of association between family history of liver cancer and risk of liver cancer.
Authors: Yang Y, Wu QJ, Xie L, Chow WH, Rothman N, Li HL, Gao YT, Zheng W, Shu XO, Xiang YB
Source: Int J Cancer, 2014 Oct 1;135(7), p. 1605-14.
EPub date: 2014 Mar 7.
PMID: 24535817
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An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
Authors: Klein AP, Lindstr÷m S, Mendelsohn JB, Steplowski E, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Lacroix A, Li D, Mandelson MT, Olson SH, Petersen GM, Risch HA, Stolzenberg-Solomon RZ, Zheng W, Amundadottir L, Albanes D, Allen NE, Bamlet WR, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, Duell EJ, Elena J, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hassan M, Hutchinson A, Hunter DJ, Kooperberg C, Kurtz RC, Liu S, Overvad K, Palli D, Patel AV, Rabe KG, Shu XO, Slimani N, Tobias GS, Trichopoulos D, Van Den Eeden SK, Vineis P, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hoover RN, Hartge P, Kraft P
Source: PLoS One, 2013;8(9), p. e72311.
EPub date: 2013 Sep 13.
PMID: 24058443
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Circulating cytokines and gastric cancer risk.
Authors: Epplein M, Xiang YB, Cai Q, Peek RM Jr, Li H, Correa P, Gao J, Wu J, Michel A, Pawlita M, Zheng W, Shu XO
Source: Cancer Causes Control, 2013 Dec;24(12), p. 2245-50.
EPub date: 2013 Sep 20.
PMID: 24052422
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Effects of polymorphisms in translesion DNA synthesis genes on lung cancer risk and prognosis in Chinese men.
Authors: Xu HL, Gao XR, Zhang W, Cheng JR, Tan YT, Zheng W, Shu XO, Xiang YB
Source: Cancer Epidemiol, 2013 Dec;37(6), p. 917-22.
EPub date: 2013 Sep 5.
PMID: 24012694
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Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population.
Authors: Kweon SS, Shu XO, Xiang Y, Cai H, Yang G, Ji BT, Li H, Gao YT, Zheng W, Epplein M
Source: J Nutr, 2013 Nov;143(11), p. 1736-42.
EPub date: 2013 Aug 28.
PMID: 23986366
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Associations of Tai Chi, walking, and jogging with mortality in Chinese men.
Authors: Wang N, Zhang X, Xiang YB, Li H, Yang G, Gao J, Zheng W, Shu XO
Source: Am J Epidemiol, 2013 Sep 1;178(5), p. 791-6.
EPub date: 2013 Jun 27.
PMID: 23813700
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Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis.
Authors: Wu QJ, Xie L, Zheng W, Vogtmann E, Li HL, Yang G, Ji BT, Gao YT, Shu XO, Xiang YB
Source: Ann Oncol, 2013 Jul;24(7), p. 1918-24.
EPub date: 2013 Apr 3.
PMID: 23553059
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Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
Authors: Wu C, Kraft P, Stolzenberg-Solomon R, Steplowski E, Brotzman M, Xu M, Mudgal P, Amundadottir L, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, Kooperberg C, Petersen GM, Zheng W, Albanes D, Boutron-Ruault MC, Buring JE, Canzian F, Cao G, Duell EJ, Elena JW, Gaziano JM, Giovannucci EL, Hallmans G, Hutchinson A, Hunter DJ, Jenab M, Jiang G, Khaw KT, LaCroix A, Li Z, Mendelsohn JB, Panico S, Patel AV, Qian ZR, Riboli E, Sesso H, Shen H, Shu XO, Tjonneland A, Tobias GS, Trichopoulos D, Virtamo J, Visvanathan K, Wactawski-Wende J, Wang C, Yu K, Zeleniuch-Jacquotte A, Chanock S, Hoover R, Hartge P, Fuchs CS, Lin D, Wolpin BM
Source: Gut, 2014 Jan;63(1), p. 152-60.
EPub date: 2012 Nov 24.
PMID: 23180869
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Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men.
Authors: Epplein M, Zheng W, Xiang YB, Peek RM Jr, Li H, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Shu XO
Source: Cancer Epidemiol Biomarkers Prev, 2012 Dec;21(12), p. 2185-92.
EPub date: 2012 Oct 3.
PMID: 23035179
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Dietary glycemic load, glycemic index, and carbohydrates on the risk of primary liver cancer among Chinese women and men.
Authors: Vogtmann E, Li HL, Shu XO, Chow WH, Ji BT, Cai H, Gao J, Zhang W, Gao YT, Zheng W, Xiang YB
Source: Ann Oncol, 2013 Jan;24(1), p. 238-44.
EPub date: 2012 Aug 16.
PMID: 22898034
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Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
Authors: Li D, Duell EJ, Yu K, Risch HA, Olson SH, Kooperberg C, Wolpin BM, Jiao L, Dong X, Wheeler B, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross M, Hartge P, Hoover RN, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Mandelson MT, Petersen G, Zheng W, Agalliu I, Albanes D, Boutron-Ruault MC, Bracci PM, Buring JE, Canzian F, Chang K, Chanock SJ, Cotterchio M, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hoffman Bolton JA, Hunter DJ, Hutchinson A, Jacobs KB, Jenab M, Khaw KT, Kraft P, Krogh V, Kurtz RC, McWilliams RR, Mendelsohn JB, Patel AV, Rabe KG, Riboli E, Shu XO, Tj°nneland A, Tobias GS, Trichopoulos D, Virtamo J, Visvanathan K, Watters J, Yu H, Zeleniuch-Jacquotte A, Amundadottir L, Stolzenberg-Solomon RZ
Source: Carcinogenesis, 2012 Jul;33(7), p. 1384-90.
EPub date: 2012 Apr 20.
PMID: 22523087
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Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies.
Authors: Abnet CC, Wang Z, Song X, Hu N, Zhou FY, Freedman ND, Li XM, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Liao LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Chung CC, Wang C, Wheeler W, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF Jr, Tucker MA, Chow WH, Zhao XK, Li JM, Li AL, Sun LD, Wei W, Li JL, Zhang P, Li HL, Cui WY, Wang WP, Liu ZC, Yang X, Fu WJ, Cui JL, Lin HL, Zhu WL, Liu M, Chen X, Chen J, Guo L, Han JJ, Zhou SL, Huang J, Wu Y, Yuan C, Huang J, Ji AF, Kul JW, Fan ZM, Wang JP, Zhang DY, Zhang LQ, Zhang W, Chen YF, Ren JL, Li XM, Dong JC, Xing GL, Guo ZG, Yang JX, Mao YM, Yuan Y, Guo ET, Zhang W, Hou ZC, Liu J, Li Y, Tang S, Chang J, Peng XQ, Han M, Yin WL, Liu YL, Hu YL, Liu Y, Yang LQ, Zhu FG, Yang XF, Feng XS, Wang Z, Li Y, Gao SG, Liu HL, Yuan L, Jin Y, Zhang YR, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Zhang GF, Yue WB, Feng CW, Qige Q, Zhao JT, Yang WJ, Lei GY, Chen LQ, Li EM, Xu LY, Wu ZY, Bao ZQ, Chen JL, Li XC, Zhuang X, Zhou YF, Zuo XB, Dong ZM, Wang LW, Fan XP, Wang J, Zhou Q, Ma GS, Zhang QX, Liu H, Jian XY, Lian SY, Wang JS, Chang FB, Lu CD, Miao JJ, Chen ZG, Wang R, Guo M, Fan ZL, Tao P, Liu TJ, Wei JC, Kong QP, Fan L, Wang XZ, Gao FS, Wang TY, Xie D, Wang L, Chen SQ, Yang WC, Hong JY, Wang L, Qiu SL, Goldstein AM, Yuan ZQ, Chanock SJ, Zhang XJ, Taylor PR, Wang LD
Source: Hum Mol Genet, 2012 May 1;21(9), p. 2132-41.
EPub date: 2012 Feb 8.
PMID: 22323360
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Marital status and mortality among middle age and elderly men and women in urban Shanghai.
Authors: Va P, Yang WS, Nechuta S, Chow WH, Cai H, Yang G, Gao S, Gao YT, Zheng W, Shu XO, Xiang YB
Source: PLoS One, 2011;6(11), p. e26600.
EPub date: 2011 Nov 2.
PMID: 22073174
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Liver enzymes, type 2 diabetes, and metabolic syndrome in middle-aged, urban Chinese men.
Authors: Villegas R, Xiang YB, Elasy T, Cai Q, Xu W, Li H, Fazio S, Linton MF, Raiford D, Zheng W, Shu XO
Source: Metab Syndr Relat Disord, 2011 Aug;9(4), p. 305-11.
EPub date: 2011 Apr 15.
PMID: 21495862
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Lifestyle determinants of C-reactive protein in middle-aged, urban Chinese men.
Authors: Villegas R, Xiang YB, Cai H, Elasy T, Cai Q, Zhang X, Fazio S, Linton MF, Li H, Xu WH, Yang G, Zheng W, Shu XO
Source: Nutr Metab Cardiovasc Dis, 2012 Mar;22(3), p. 223-30.
EPub date: 2010 Nov 25.
PMID: 21111583
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