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Grant Details

Grant Number: 5R01CA082729-11 Interpret this number
Primary Investigator: Shu, Xiao-Ou
Organization: Vanderbilt University
Project Title: Cohort Study of Cancer-Inhibitory Dietary Factors in Men
Fiscal Year: 2011
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Abstract

DESCRIPTION (provided by applicant): While it has long been recognized that dietary factors play an important role in the etiology of cancer, information regarding the preventive potential of specific dietary compounds is scarce. The Shanghai Men's Health Study (SMHS) is a population-based cohort study of 61,582 Chinese men between 40 and 74 who lived in urban Shanghai at enrollment. Because intake levels of many suspected cancer-inhibitory dietary factors are high and diverse in Shanghai, the SMHS offers unique opportunities to fill such knowledge gaps. Detailed information on dietary and other lifestyle factors was collected at baseline and is being updated in a follow-up survey. Biological samples were collected from 89% of cohort members. The cohort has been followed for cancer occurrence and deaths via linkage with the population-based Shanghai Cancer Registry and the Shanghai Vital Statistics Unit, as well as through visits to all living cohort members every 2 years. We propose in this renewal application to extend the follow-up of this cohort for 5 more years and to evaluate dietary hypotheses for the lung, stomach, and colorectal (CRC). The primary focus of the study is to determine whether regular tea consumption and high intake of folate, soy foods, allium vegetables, and crucifers are associated with a reduced risk of cancer. We also propose to conduct a nested case-control study to evaluate whether the levels of blood folate, urinary phytoestrogens (CRC only) and isothiocyanate are inversely associated with the risk of cancers of colorectum, lung, and stomach. These biomarkers are aggregate measures of level of intake, absorption, and metabolism and will provide added insight in elucidating the relationship of dietary factors with cancer risk. Blood level C-reactive protein and H.pylori antibodies will also be evaluated in the nested case-control study for CRC and stomach cancer. Finally, we propose to re-survey all living cohort-members to update information on usual dietary intake and other lifestyle factors to refine exposure assessments and to characterize and evaluate how temporal changes in exposures may influence cancer risk. Because of its size, setting, and unique exposure patterns and biological specimens, the SMHS provides an exceptional opportunity to address dietary hypotheses for cancer that cannot be adequately investigated in any other existing cohort study. The results from this study may guide new strategies in the primary prevention of common cancers in both Western and Asian men.

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Publications

Burden of total and cause-specific mortality related to tobacco smoking among adults aged ? 45 years in Asia: a pooled analysis of 21 cohorts.
Authors: Zheng W, McLerran DF, Rolland BA, Fu Z, Boffetta P, He J, Gupta PC, Ramadas K, Tsugane S, Irie F, Tamakoshi A, Gao YT, Koh WP, Shu XO, Ozasa K, Nishino Y, Tsuji I, Tanaka H, Chen CJ, Yuan JM, Ahn YO, Yoo KY, Ahsan H, Pan WH, Qiao YL, Gu D, Pednekar MS, Sauvaget C, Sawada N, Sairenchi T, Yang G, Wang R, Xiang YB, Ohishi W, Kakizaki M, Watanabe T, Oze I, You SL, Sugawara Y, Butler LM, Kim DH, Park SK, Parvez F, Chuang SY, Fan JH, Shen CY, Chen Y, Grant EJ, Lee JE, Sinha R, Matsuo K, Thornquist M, Inoue M, Feng Z, Kang D, Potter JD
Source: PLoS Med, 2014 Apr;11(4), p. e1001631.
EPub date: 2014 Apr 22.
PMID: 24756146
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Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men.
Authors: Epplein M, Zheng W, Li H, Peek RM Jr, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Xiang YB, Shu XO
Source: Nutr Cancer, 2014;66(4), p. 550-7.
EPub date: 2014 Mar 25.
PMID: 24666234
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An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
Authors: Klein AP, Lindström S, Mendelsohn JB, Steplowski E, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Lacroix A, Li D, Mandelson MT, Olson SH, Petersen GM, Risch HA, Stolzenberg-Solomon RZ, Zheng W, Amundadottir L, Albanes D, Allen NE, Bamlet WR, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, Duell EJ, Elena J, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hassan M, Hutchinson A, Hunter DJ, Kooperberg C, Kurtz RC, Liu S, Overvad K, Palli D, Patel AV, Rabe KG, Shu XO, Slimani N, Tobias GS, Trichopoulos D, Van Den Eeden SK, Vineis P, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hoover RN, Hartge P, Kraft P
Source: PLoS One, 2013;8(9), p. e72311.
EPub date: 2013 Sep 13.
PMID: 24058443
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Circulating cytokines and gastric cancer risk.
Authors: Epplein M, Xiang YB, Cai Q, Peek RM Jr, Li H, Correa P, Gao J, Wu J, Michel A, Pawlita M, Zheng W, Shu XO
Source: Cancer Causes Control, 2013 Dec;24(12), p. 2245-50.
EPub date: 2013 Sep 20.
PMID: 24052422
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Effects of polymorphisms in translesion DNA synthesis genes on lung cancer risk and prognosis in Chinese men.
Authors: Xu HL, Gao XR, Zhang W, Cheng JR, Tan YT, Zheng W, Shu XO, Xiang YB
Source: Cancer Epidemiol, 2013 Dec;37(6), p. 917-22.
EPub date: 2013 Sep 5.
PMID: 24012694
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Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population.
Authors: Kweon SS, Shu XO, Xiang Y, Cai H, Yang G, Ji BT, Li H, Gao YT, Zheng W, Epplein M
Source: J Nutr, 2013 Nov;143(11), p. 1736-42.
EPub date: 2013 Aug 28.
PMID: 23986366
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Associations of Tai Chi, walking, and jogging with mortality in Chinese men.
Authors: Wang N, Zhang X, Xiang YB, Li H, Yang G, Gao J, Zheng W, Shu XO
Source: Am J Epidemiol, 2013 Sep 1;178(5), p. 791-6.
EPub date: 2013 Jun 27.
PMID: 23813700
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Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis.
Authors: Wu QJ, Xie L, Zheng W, Vogtmann E, Li HL, Yang G, Ji BT, Gao YT, Shu XO, Xiang YB
Source: Ann Oncol, 2013 Jul;24(7), p. 1918-24.
EPub date: 2013 Apr 3.
PMID: 23553059
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Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
Authors: Wu C, Kraft P, Stolzenberg-Solomon R, Steplowski E, Brotzman M, Xu M, Mudgal P, Amundadottir L, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, Kooperberg C, Petersen GM, Zheng W, Albanes D, Boutron-Ruault MC, Buring JE, Canzian F, Cao G, Duell EJ, Elena JW, Gaziano JM, Giovannucci EL, Hallmans G, Hutchinson A, Hunter DJ, Jenab M, Jiang G, Khaw KT, LaCroix A, Li Z, Mendelsohn JB, Panico S, Patel AV, Qian ZR, Riboli E, Sesso H, Shen H, Shu XO, Tjonneland A, Tobias GS, Trichopoulos D, Virtamo J, Visvanathan K, Wactawski-Wende J, Wang C, Yu K, Zeleniuch-Jacquotte A, Chanock S, Hoover R, Hartge P, Fuchs CS, Lin D, Wolpin BM
Source: Gut, 2014 Jan;63(1), p. 152-60.
EPub date: 2012 Nov 24.
PMID: 23180869
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Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men.
Authors: Epplein M, Zheng W, Xiang YB, Peek RM Jr, Li H, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Shu XO
Source: Cancer Epidemiol Biomarkers Prev, 2012 Dec;21(12), p. 2185-92.
EPub date: 2012 Oct 3.
PMID: 23035179
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Dietary glycemic load, glycemic index, and carbohydrates on the risk of primary liver cancer among Chinese women and men.
Authors: Vogtmann E, Li HL, Shu XO, Chow WH, Ji BT, Cai H, Gao J, Zhang W, Gao YT, Zheng W, Xiang YB
Source: Ann Oncol, 2013 Jan;24(1), p. 238-44.
EPub date: 2012 Aug 16.
PMID: 22898034
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Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
Authors: Li D, Duell EJ, Yu K, Risch HA, Olson SH, Kooperberg C, Wolpin BM, Jiao L, Dong X, Wheeler B, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross M, Hartge P, Hoover RN, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Mandelson MT, Petersen G, Zheng W, Agalliu I, Albanes D, Boutron-Ruault MC, Bracci PM, Buring JE, Canzian F, Chang K, Chanock SJ, Cotterchio M, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hoffman Bolton JA, Hunter DJ, Hutchinson A, Jacobs KB, Jenab M, Khaw KT, Kraft P, Krogh V, Kurtz RC, McWilliams RR, Mendelsohn JB, Patel AV, Rabe KG, Riboli E, Shu XO, Tjønneland A, Tobias GS, Trichopoulos D, Virtamo J, Visvanathan K, Watters J, Yu H, Zeleniuch-Jacquotte A, Amundadottir L, Stolzenberg-Solomon RZ
Source: Carcinogenesis, 2012 Jul;33(7), p. 1384-90.
EPub date: 2012 Apr 20.
PMID: 22523087
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Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies.
Authors: Abnet CC, Wang Z, Song X, Hu N, Zhou FY, Freedman ND, Li XM, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Liao LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Chung CC, Wang C, Wheeler W, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF Jr, Tucker MA, Chow WH, Zhao XK, Li JM, Li AL, Sun LD, Wei W, Li JL, Zhang P, Li HL, Cui WY, Wang WP, Liu ZC, Yang X, Fu WJ, Cui JL, Lin HL, Zhu WL, Liu M, Chen X, Chen J, Guo L, Han JJ, Zhou SL, Huang J, Wu Y, Yuan C, Huang J, Ji AF, Kul JW, Fan ZM, Wang JP, Zhang DY, Zhang LQ, Zhang W, Chen YF, Ren JL, Li XM, Dong JC, Xing GL, Guo ZG, Yang JX, Mao YM, Yuan Y, Guo ET, Zhang W, Hou ZC, Liu J, Li Y, Tang S, Chang J, Peng XQ, Han M, Yin WL, Liu YL, Hu YL, Liu Y, Yang LQ, Zhu FG, Yang XF, Feng XS, Wang Z, Li Y, Gao SG, Liu HL, Yuan L, Jin Y, Zhang YR, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Zhang GF, Yue WB, Feng CW, Qige Q, Zhao JT, Yang WJ, Lei GY, Chen LQ, Li EM, Xu LY, Wu ZY, Bao ZQ, Chen JL, Li XC, Zhuang X, Zhou YF, Zuo XB, Dong ZM, Wang LW, Fan XP, Wang J, Zhou Q, Ma GS, Zhang QX, Liu H, Jian XY, Lian SY, Wang JS, Chang FB, Lu CD, Miao JJ, Chen ZG, Wang R, Guo M, Fan ZL, Tao P, Liu TJ, Wei JC, Kong QP, Fan L, Wang XZ, Gao FS, Wang TY, Xie D, Wang L, Chen SQ, Yang WC, Hong JY, Wang L, Qiu SL, Goldstein AM, Yuan ZQ, Chanock SJ, Zhang XJ, Taylor PR, Wang LD
Source: Hum Mol Genet, 2012 May 1;21(9), p. 2132-41.
EPub date: 2012 Feb 8.
PMID: 22323360
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Marital status and mortality among middle age and elderly men and women in urban Shanghai.
Authors: Va P, Yang WS, Nechuta S, Chow WH, Cai H, Yang G, Gao S, Gao YT, Zheng W, Shu XO, Xiang YB
Source: PLoS One, 2011;6(11), p. e26600.
EPub date: 2011 Nov 2.
PMID: 22073174
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Liver enzymes, type 2 diabetes, and metabolic syndrome in middle-aged, urban Chinese men.
Authors: Villegas R, Xiang YB, Elasy T, Cai Q, Xu W, Li H, Fazio S, Linton MF, Raiford D, Zheng W, Shu XO
Source: Metab Syndr Relat Disord, 2011 Aug;9(4), p. 305-11.
EPub date: 2011 Apr 15.
PMID: 21495862
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Lifestyle determinants of C-reactive protein in middle-aged, urban Chinese men.
Authors: Villegas R, Xiang YB, Cai H, Elasy T, Cai Q, Zhang X, Fazio S, Linton MF, Li H, Xu WH, Yang G, Zheng W, Shu XO
Source: Nutr Metab Cardiovasc Dis, 2012 Mar;22(3), p. 223-30.
EPub date: 2010 Nov 25.
PMID: 21111583
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Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium.
Authors: Wolpin BM, Kraft P, Xu M, Steplowski E, Olsson ML, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, LaCroix A, Petersen G, Stolzenberg-Solomon RZ, Zheng W, Albanes D, Allen NE, Amundadottir L, Austin MA, Boutron-Ruault MC, Buring JE, Canzian F, Chanock SJ, Gaziano JM, Giovannucci EL, Hallmans G, Hankinson SE, Hoover RN, Hunter DJ, Hutchinson A, Jacobs KB, Kooperberg C, Mendelsohn JB, Michaud DS, Overvad K, Patel AV, Sanchéz MJ, Sansbury L, Shu XO, Slimani N, Tobias GS, Trichopoulos D, Vineis P, Visvanathan K, Virtamo J, Wactawski-Wende J, Watters J, Yu K, Zeleniuch-Jacquotte A, Hartge P, Fuchs CS
Source: Cancer Epidemiol Biomarkers Prev, 2010 Dec;19(12), p. 3140-9.
EPub date: 2010 Oct 22.
PMID: 20971884
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A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
Authors: Abnet CC, Freedman ND, Hu N, Wang Z, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Dong LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Wang C, Wheeler W, Gail MH, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF Jr, Tucker MA, Chow WH, Goldstein AM, Chanock SJ, Taylor PR
Source: Nat Genet, 2010 Sep;42(9), p. 764-7.
EPub date: 2010 Aug 22.
PMID: 20729852
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Fruit and vegetable consumption and risk of distal gastric cancer in the Shanghai Women's and Men's Health studies.
Authors: Epplein M, Shu XO, Xiang YB, Chow WH, Yang G, Li HL, Ji BT, Cai H, Gao YT, Zheng W
Source: Am J Epidemiol, 2010 Aug 15;172(4), p. 397-406.
EPub date: 2010 Jul 20.
PMID: 20647333
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Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Helzlsouer KJ, VDPP Steering Committee
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 4-9.
EPub date: 2010 Jun 18.
PMID: 20562193
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Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Abnet CC, Chen Y, Chow WH, Gao YT, Helzlsouer KJ, Le Marchand L, McCullough ML, Shikany JM, Virtamo J, Weinstein SJ, Xiang YB, Yu K, Zheng W, Albanes D, Arslan AA, Campbell DS, Campbell PT, Hayes RB, Horst RL, Kolonel LN, Nomura AM, Purdue MP, Snyder K, Shu XO
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 94-106.
EPub date: 2010 Jun 18.
PMID: 20562192
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Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: McCullough ML, Weinstein SJ, Freedman DM, Helzlsouer K, Flanders WD, Koenig K, Kolonel L, Laden F, Le Marchand L, Purdue M, Snyder K, Stevens VL, Stolzenberg-Solomon R, Virtamo J, Yang G, Yu K, Zheng W, Albanes D, Ashby J, Bertrand K, Cai H, Chen Y, Gallicchio L, Giovannucci E, Jacobs EJ, Hankinson SE, Hartge P, Hartmuller V, Harvey C, Hayes RB, Horst RL, Shu XO
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 21-35.
EPub date: 2010 Jun 18.
PMID: 20562191
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Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Gallicchio L, Helzlsouer KJ, Chow WH, Freedman DM, Hankinson SE, Hartge P, Hartmuller V, Harvey C, Hayes RB, Horst RL, Koenig KL, Kolonel LN, Laden F, McCullough ML, Parisi D, Purdue MP, Shu XO, Snyder K, Stolzenberg-Solomon RZ, Tworoger SS, Varanasi A, Virtamo J, Wilkens LR, Xiang YB, Yu K, Zeleniuch-Jacquotte A, Zheng W, Abnet CC, Albanes D, Bertrand K, Weinstein SJ
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 10-20.
EPub date: 2010 Jun 18.
PMID: 20562188
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Circulating 25-hydroxyvitamin D and risk of kidney cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Gallicchio L, Moore LE, Stevens VL, Ahn J, Albanes D, Hartmuller V, Setiawan VW, Helzlsouer KJ, Yang G, Xiang YB, Shu XO, Snyder K, Weinstein SJ, Yu K, Zeleniuch-Jacquotte A, Zheng W, Cai Q, Campbell DS, Chen Y, Chow WH, Horst RL, Kolonel LN, McCullough ML, Purdue MP, Koenig KL
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 47-57.
EPub date: 2010 Jun 18.
PMID: 20562187
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Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Stolzenberg-Solomon RZ, Jacobs EJ, Arslan AA, Qi D, Patel AV, Helzlsouer KJ, Weinstein SJ, McCullough ML, Purdue MP, Shu XO, Snyder K, Virtamo J, Wilkins LR, Yu K, Zeleniuch-Jacquotte A, Zheng W, Albanes D, Cai Q, Harvey C, Hayes R, Clipp S, Horst RL, Irish L, Koenig K, Le Marchand L, Kolonel LN
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 81-93.
EPub date: 2010 Jun 18.
PMID: 20562185
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Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
Authors: Arslan AA, Helzlsouer KJ, Kooperberg C, Shu XO, Steplowski E, Bueno-de-Mesquita HB, Fuchs CS, Gross MD, Jacobs EJ, Lacroix AZ, Petersen GM, Stolzenberg-Solomon RZ, Zheng W, Albanes D, Amundadottir L, Bamlet WR, Barricarte A, Bingham SA, Boeing H, Boutron-Ruault MC, Buring JE, Chanock SJ, Clipp S, Gaziano JM, Giovannucci EL, Hankinson SE, Hartge P, Hoover RN, Hunter DJ, Hutchinson A, Jacobs KB, Kraft P, Lynch SM, Manjer J, Manson JE, McTiernan A, McWilliams RR, Mendelsohn JB, Michaud DS, Palli D, Rohan TE, Slimani N, Thomas G, Tjønneland A, Tobias GS, Trichopoulos D, Virtamo J, Wolpin BM, Yu K, Zeleniuch-Jacquotte A, Patel AV, Pancreatic Cancer Cohort Consortium (PanScan)
Source: Arch Intern Med, 2010 May 10;170(9), p. 791-802.
PMID: 20458087
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Validity of a physical activity questionnaire in Shanghai.
Authors: Peters TM, Shu XO, Moore SC, Xiang YB, Yang G, Ekelund U, Liu DK, Tan YT, Ji BT, Schatzkin AS, Zheng W, Chow WH, Matthews CE, Leitzmann MF
Source: Med Sci Sports Exerc, 2010 Dec;42(12), p. 2222-30.
PMID: 20404770
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Dietary patterns and blood pressure among middle-aged and elderly Chinese men in Shanghai.
Authors: Lee SA, Cai H, Yang G, Xu WH, Zheng W, Li H, Gao YT, Xiang YB, Shu XO
Source: Br J Nutr, 2010 Jul;104(2), p. 265-75.
EPub date: 2010 Mar 1.
PMID: 20187997
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Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men.
Authors: Villegas R, Xiang YB, Cai Q, Fazio S, Linton M, Li H, Elasy T, Zheng W, Shu XO
Source: Metab Syndr Relat Disord, 2010 Jun;8(3), p. 263-70.
PMID: 20158446
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