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Grant Details

Grant Number: 5R01CA116174-05 Interpret this number
Primary Investigator: Egan, Kathleen
Organization: H. Lee Moffitt Cancer Ctr & Res Inst
Project Title: Southeast Region Case-Control Study of Adult Glioma
Fiscal Year: 2011
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Abstract

DESCRIPTION (provided by applicant): Tumors arising from non-neural or glial tissue of the brain ('gliomas') constitute one of the most lethal human cancers. Few case-control studies of glioma have been undertaken, and the etiology of the tumor is largely unknown. However, the descriptive epidemiology of the disease, including an unexplained excess of glioma n the southeastern US, is consistent with an environmental component in the disease. Strong candidate risk factors, based on experimental evidence, include exposure to N-nitroso compounds (NOCs) in processed meats, and tobacco products, and consumption of alcohol. To shed light on the contribution of diet, genes and other potential risk factors to adult glioma, we are proposing a clinic-based, multi-institutional case- control study. Adults with a new diagnosis of glioma will be recruited from 5 treatment referral centers in the southeastern US. Subjects will be enrolled directly from clinics, generally within days or weeks of diagnosis. In the 5-year project, an estimated 1,200 persons with incident glioma and age- and gender-matched community controls will be enrolled in the study. Information on diet will be collected using a validated food frequency questionnaire, supplemented with a questionnaire developed by Sinha and colleagues at NCI designed specifically to measure NOCs and other meat carcinogens in the diet. In a structured interview, data will also be gathered on atopic immunity, and other exposures linked in past studies to glioma risk. To explore the contribution of genetic susceptibility, oral DNA samples will be collected from cases and controls, and whole genome amplification undertaken to augment the DNA for planned and future genotyping. Both candidate SNPs and haplotypes will be examined in a set of 31 proposed susceptibility genes involved in NOC metabolism, DNA repair and access of carcinogens to the CNS. With the large numbers available for analysis, the study will have power to investigate interactions of alcohol consumption and NOC exposure with the susceptibility genes in these pathways. The proposed study will be the largest US case-control study of glioma. Based in a high incidence region, the study may identify novel environmental risk factors and offer new insights on prevention and treatment for a leading fatal cancer in the US.

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Publications

Brain tumor risk according to germ-line variation in the MLLT10 locus.
Authors: Egan KM, Baskin R, Nabors LB, Thompson RC, Olson JJ, Browning JE, Madden MH, Monteiro AN
Source: Eur J Hum Genet, 2014 Apr 23;null, p. null.
EPub date: 2014 Apr 23.
PMID: 24755950
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Reproductive factors and risk of primary brain tumors in women.
Authors: Anic GM, Madden MH, Nabors LB, Olson JJ, LaRocca RV, Thompson ZJ, Pamnani SJ, Forsyth PA, Thompson RC, Egan KM
Source: J Neurooncol, 2014 Jun;118(2), p. 297-304.
EPub date: 2014 Apr 4.
PMID: 24700240
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Circadian pathway genes in relation to glioma risk and outcome.
Authors: Madden MH, Anic GM, Thompson RC, Nabors LB, Olson JJ, Browning JE, Monteiro AN, Egan KM
Source: Cancer Causes Control, 2014 Jan;25(1), p. 25-32.
EPub date: 2013 Oct 18.
PMID: 24135790
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Toenail iron, genetic determinants of iron status, and the risk of glioma.
Authors: Anic GM, Madden MH, Thompson RC, Nabors LB, Olson JJ, Larocca RV, Browning JE, Brockman JD, Forsyth PA, Egan KM
Source: Cancer Causes Control, 2013 Dec;24(12), p. 2051-8.
EPub date: 2013 Aug 31.
PMID: 23996192
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Early life exposures and the risk of adult glioma.
Authors: Anic GM, Madden MH, Sincich K, Thompson RC, Nabors LB, Olson JJ, LaRocca RV, Browning JE, Pan E, Egan KM
Source: Eur J Epidemiol, 2013 Sep;28(9), p. 753-8.
EPub date: 2013 May 17.
PMID: 23681776
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Prediagnostic body weight and survival in high grade glioma.
Authors: Siegel EM, Nabors LB, Thompson RC, Olson JJ, Browning JE, Madden MH, Han G, Egan KM
Source: J Neurooncol, 2013 Aug;114(1), p. 79-84.
EPub date: 2013 May 11.
PMID: 23666204
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Anthropometric factors in relation to risk of glioma.
Authors: Little RB, Madden MH, Thompson RC, Olson JJ, Larocca RV, Pan E, Browning JE, Egan KM, Nabors LB
Source: Cancer Causes Control, 2013 May;24(5), p. 1025-31.
EPub date: 2013 Mar 3.
PMID: 23456313
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SWI/SNF gene variants and glioma risk and outcome.
Authors: Amankwah EK, Thompson RC, Nabors LB, Olson JJ, Browning JE, Madden MH, Egan KM
Source: Cancer Epidemiol, 2013 Apr;37(2), p. 162-5.
EPub date: 2012 Dec 29.
PMID: 23276717
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An exploratory analysis of common genetic variants in the vitamin D pathway including genome-wide associated variants in relation to glioma risk and outcome.
Authors: Anic GM, Thompson RC, Nabors LB, Olson JJ, Browning JE, Madden MH, Murtagh FR, Forsyth PA, Egan KM
Source: Cancer Causes Control, 2012 Sep;23(9), p. 1443-9.
EPub date: 2012 Jun 28.
PMID: 22740028
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Rare TP53 genetic variant associated with glioma risk and outcome.
Authors: Egan KM, Nabors LB, Olson JJ, Monteiro AN, Browning JE, Madden MH, Thompson RC
Source: J Med Genet, 2012 Jul;49(7), p. 420-1.
EPub date: 2012 Jun 15.
PMID: 22706378
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Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis.
Authors: Mocellin S, Verdi D, Pooley KA, Landi MT, Egan KM, Baird DM, Prescott J, De Vivo I, Nitti D
Source: J Natl Cancer Inst, 2012 Jun 6;104(11), p. 840-54.
EPub date: 2012 Apr 20.
PMID: 22523397
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SSBP2 variants are associated with survival in glioblastoma patients.
Authors: Xiao Y, Decker PA, Rice T, McCoy LS, Smirnov I, Patoka JS, Hansen HM, Wiemels JL, Tihan T, Prados MD, Chang SM, Berger MS, Kosel ML, Fridley BL, Lachance DH, O'Neill BP, Buckner JC, Thompson RC, Nabors LB, Olson JJ, Brem S, Madden MH, Browning JE, Wiencke JK, Egan KM, Jenkins RB, Wrensch MR
Source: Clin Cancer Res, 2012 Jun 1;18(11), p. 3154-62.
EPub date: 2012 Apr 3.
PMID: 22472174
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A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma.
Authors: Permuth-Wey J, Thompson RC, Burton Nabors L, Olson JJ, Browning JE, Madden MH, Ann Chen Y, Egan KM
Source: J Neurooncol, 2011 Dec;105(3), p. 639-46.
EPub date: 2011 Jul 9.
PMID: 21744077
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Cancer susceptibility variants and the risk of adult glioma in a US case-control study.
Authors: Egan KM, Thompson RC, Nabors LB, Olson JJ, Brat DJ, Larocca RV, Brem S, Moots PL, Madden MH, Browning JE, Ann Chen Y
Source: J Neurooncol, 2011 Sep;104(2), p. 535-42.
EPub date: 2011 Jan 4.
PMID: 21203894
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