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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA116174-05 Interpret this number
Primary Investigator: Egan, Kathleen
Organization: H. Lee Moffitt Cancer Ctr & Res Inst
Project Title: Southeast Region Case-Control Study of Adult Glioma
Fiscal Year: 2011
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Abstract

DESCRIPTION (provided by applicant): Tumors arising from non-neural or glial tissue of the brain ('gliomas') constitute one of the most lethal human cancers. Few case-control studies of glioma have been undertaken, and the etiology of the tumor is largely unknown. However, the descriptive epidemiology of the disease, including an unexplained excess of glioma n the southeastern US, is consistent with an environmental component in the disease. Strong candidate risk factors, based on experimental evidence, include exposure to N-nitroso compounds (NOCs) in processed meats, and tobacco products, and consumption of alcohol. To shed light on the contribution of diet, genes and other potential risk factors to adult glioma, we are proposing a clinic-based, multi-institutional case- control study. Adults with a new diagnosis of glioma will be recruited from 5 treatment referral centers in the southeastern US. Subjects will be enrolled directly from clinics, generally within days or weeks of diagnosis. In the 5-year project, an estimated 1,200 persons with incident glioma and age- and gender-matched community controls will be enrolled in the study. Information on diet will be collected using a validated food frequency questionnaire, supplemented with a questionnaire developed by Sinha and colleagues at NCI designed specifically to measure NOCs and other meat carcinogens in the diet. In a structured interview, data will also be gathered on atopic immunity, and other exposures linked in past studies to glioma risk. To explore the contribution of genetic susceptibility, oral DNA samples will be collected from cases and controls, and whole genome amplification undertaken to augment the DNA for planned and future genotyping. Both candidate SNPs and haplotypes will be examined in a set of 31 proposed susceptibility genes involved in NOC metabolism, DNA repair and access of carcinogens to the CNS. With the large numbers available for analysis, the study will have power to investigate interactions of alcohol consumption and NOC exposure with the susceptibility genes in these pathways. The proposed study will be the largest US case-control study of glioma. Based in a high incidence region, the study may identify novel environmental risk factors and offer new insights on prevention and treatment for a leading fatal cancer in the US.

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Publications

Cancer Susceptibility Variants And The Risk Of Adult Glioma In A Us Case-control Study
Authors: Egan,K.M. , Thompson,R.C. , Nabors,L.B. , Olson,J.J. , Brat,D.J. , Larocca,R.V. , Brem,S. , Moots,P.L. , Madden,M.H. , Browning,J.E. , et al. .
Source: Journal Of Neuro-oncology, 2011 Sep; 104(2), p. 535-42.
PMID: 21203894
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A Functional Polymorphism In The Pre-mir-146a Gene Is Associated With Risk And Prognosis In Adult Glioma
Authors: Permuth-Wey,J. , Thompson,R.C. , Burton Nabors,L. , Olson,J.J. , Browning,J.E. , Madden,M.H. , Ann Chen,Y. , Egan,K.M. .
Source: Journal Of Neuro-oncology, 2011 Dec; 105(3), p. 639-46.
PMID: 21744077
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Ssbp2 Variants Are Associated With Survival In Glioblastoma Patients
Authors: Xiao,Y. , Decker,P.A. , Rice,T. , McCoy,L.S. , Smirnov,I. , Patoka,J.S. , Hansen,H.M. , Wiemels,J.L. , Tihan,T. , Prados,M.D. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2012-06-01 00:00:00.0; 18(11), p. 3154-62.
PMID: 22472174
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Telomerase Reverse Transcriptase Locus Polymorphisms And Cancer Risk: A Field Synopsis And Meta-analysis
Authors: Mocellin,S. , Verdi,D. , Pooley,K.A. , Landi,M.T. , Egan,K.M. , Baird,D.M. , Prescott,J. , De Vivo,I. , Nitti,D. .
Source: Journal Of The National Cancer Institute, 2012-06-06 00:00:00.0; 104(11), p. 840-54.
PMID: 22523397
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Rare Tp53 Genetic Variant Associated With Glioma Risk And Outcome
Authors: Egan K.M. , Nabors L.B. , Olson J.J. , Monteiro A.N. , Browning J.E. , Madden M.H. , Thompson R.C. .
Source: Journal Of Medical Genetics, 2012 Jul; 49(7), p. 420-1.
PMID: 22706378
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An Exploratory Analysis Of Common Genetic Variants In The Vitamin D Pathway Including Genome-wide Associated Variants In Relation To Glioma Risk And Outcome
Authors: Anic G.M. , Thompson R.C. , Nabors L.B. , Burton Nabors L. , Olson J.J. , Browning J.E. , Madden M.H. , Murtagh F.R. , Reed Murtagh F. , Forsyth P.A. , et al. .
Source: Cancer Causes & Control : Ccc, 2012 Sep; 23(9), p. 1443-9.
PMID: 22740028
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Swi/snf Gene Variants And Glioma Risk And Outcome
Authors: Amankwah E.K. , Thompson R.C. , Nabors L.B. , Olson J.J. , Browning J.E. , Madden M.H. , Egan K.M. .
Source: Cancer Epidemiology, 2013 Apr; 37(2), p. 162-5.
PMID: 23276717
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Anthropometric Factors In Relation To Risk Of Glioma
Authors: Little R.B. , Madden M.H. , Thompson R.C. , Olson J.J. , Larocca R.V. , Pan E. , Browning J.E. , Egan K.M. , Nabors L.B. .
Source: Cancer Causes & Control : Ccc, 2013 May; 24(5), p. 1025-31.
PMID: 23456313
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Prediagnostic Body Weight And Survival In High Grade Glioma
Authors: Siegel E.M. , Nabors L.B. , Thompson R.C. , Olson J.J. , Browning J.E. , Madden M.H. , Han G. , Egan K.M. .
Source: Journal Of Neuro-oncology, 2013 Aug; 114(1), p. 79-84.
PMID: 23666204
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Early Life Exposures And The Risk Of Adult Glioma
Authors: Anic G.M. , Madden M.H. , Sincich K. , Thompson R.C. , Nabors L.B. , Olson J.J. , LaRocca R.V. , Browning J.E. , Pan E. , Egan K.M. .
Source: European Journal Of Epidemiology, 2013 Sep; 28(9), p. 753-8.
PMID: 23681776
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Toenail Iron, Genetic Determinants Of Iron Status, And The Risk Of Glioma
Authors: Anic G.M. , Madden M.H. , Thompson R.C. , Nabors L.B. , Olson J.J. , Larocca R.V. , Browning J.E. , Brockman J.D. , Forsyth P.A. , Egan K.M. .
Source: Cancer Causes & Control : Ccc, 2013 Dec; 24(12), p. 2051-8.
PMID: 23996192
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Circadian Pathway Genes In Relation To Glioma Risk And Outcome
Authors: Madden M.H. , Anic G.M. , Thompson R.C. , Nabors L.B. , Olson J.J. , Browning J.E. , Monteiro A.N. , Egan K.M. .
Source: Cancer Causes & Control : Ccc, 2014 Jan; 25(1), p. 25-32.
PMID: 24135790
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Reproductive Factors And Risk Of Primary Brain Tumors In Women
Authors: Anic G.M. , Madden M.H. , Nabors L.B. , Olson J.J. , LaRocca R.V. , Thompson Z.J. , Pamnani S.J. , Forsyth P.A. , Thompson R.C. , Egan K.M. .
Source: Journal Of Neuro-oncology, 2014 Jun; 118(2), p. 297-304.
PMID: 24700240
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Brain Tumor Risk According To Germ-line Variation In The Mllt10 Locus
Authors: Egan K.M. , Baskin R. , Nabors L.B. , Thompson R.C. , Olson J.J. , Browning J.E. , Madden M.H. , Monteiro A.N. .
Source: European Journal Of Human Genetics : Ejhg, 2015 Jan; 23(1), p. 132-4.
PMID: 24755950
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Rare And Uncommon Genetic Variants May Hold Key To The 'missing Heritability' In Glioma
Authors: Egan K.M. , Wrensch M.R. , Jenkins R.B. .
Source: Cns Oncology, 2012 Nov; 1(2), p. 109-12.
PMID: 25057857
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Functional Analysis Of The 11q23.3 Glioma Susceptibility Locus Implicates Phldb1 And Ddx6 In Glioma Susceptibility
Authors: Baskin R. , Woods N.T. , Mendoza-Fandiņo G. , Forsyth P. , Egan K.M. , Monteiro A.N. .
Source: Scientific Reports, 2015; 5, p. 17367.
PMID: 26610392
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