|Grant Number:||5P01CA033619-22 Interpret this number|
|Primary Investigator:||Kolonel, Laurence|
|Organization:||University Of Hawaii At Manoa|
|Project Title:||Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study|
DESCRIPTION (provided by applicant): This application is a competing renewal of P01 CA 33619 "Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study." The overall goal of the research is to conduct biomarker studies of cancer etiology, taking advantage of a recently established biorepository of blood, urine and buccal cells collected from more than 67,000 participants in this unique cohort. Specimens from substantial numbers of Japanese Americans, whites, African Americans, Latinos and Native Hawaiians have been stored in multiple aliquots at -186?C (blood) and -80?C (urine). A common theme of the research is the role of over-nutrition, obesity and/or chronic inflammation as underlying mechanisms for the effects of particular exposures on carcinogenesis. Four projects are proposed: 1) A study of nutritional and genetic risk factors for the main molecular subtypes of colorectal cancer; 2) A study of interrelated metabolic pathways that may explain the ethnic and geographic variation in the risk of postmenopausal breast cancer; 3) A study of the role of infection in prostate cancer risk; and 4) A study of inflammatory markers as mediators of nutritional exposures in the risk of non-Hodgkin lymphoma. These projects will be supported by three core components: 1) Administration; 2) Biospecimens; and 3) Data Management and Analysis. We expect a total of nearly 5300 cases with stored prediagnostic blood and urine samples for the four cancer sites. Incident cancer cases will be identified through the population-based SEER tumor registries of Hawaii and California and matched to randomly selected controls. Data analyses will use nested case-control and case-case designs, and will apply data reduction techniques. The research will be highly integrated because of the many common scientific aims, the use of common resources, and the overlap in biomarkers and statistical methods. Provisions have been made to foster interactions among the investigators, so as to promote the scientific aims and enhance research accomplishments. Strengths of the program include the long-standing collaborations among the investigators; the extensive experience of the laboratory collaborators; the large number, unique ethnic diversity, and high quality of the biorepository specimens; and the population-based design of the Multiethnic Cohort. This P01 should add substantially to knowledge of cancer etiology, as well as to an understanding of the basis for ethnic/racial disparities in cancer occurrence.
Genetic variation in the inflammation and innate immunity pathways and colorectal cancer risk.
Authors: Wang H, Taverna D, Stram DO, Fortini BK, Cheng I, Wilkens LR, Burnett T, Makar KW, Lindor NM, Hopper JL, Gallinger S, Baron JA, Haile R, Kolonel LN, Henderson BE, Newcomb PA, Casey G, Duggan D, Ulrich CM, Le Marchand L
Source: Cancer Epidemiol Biomarkers Prev, 2013 Nov;22(11), p. 2094-101.
EPub date: 2013 Sep 17.
Type I and II endometrial cancers: have they different risk factors?
Authors: Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB, Wolk A, Wentzensen N, Weiss NS, Webb PM, van den Brandt PA, van de Vijver K, Thompson PJ, Australian National Endometrial Cancer Study Group, Strom BL, Spurdle AB, Soslow RA, Shu XO, Schairer C, Sacerdote C, Rohan TE, Robien K, Risch HA, Ricceri F, Rebbeck TR, Rastogi R, Prescott J, Polidoro S, Park Y, Olson SH, Moysich KB, Miller AB, McCullough ML, Matsuno RK, Magliocco AM, Lurie G, Lu L, Lissowska J, Liang X, Lacey JV Jr, Kolonel LN, Henderson BE, Hankinson SE, Hĺkansson N, Goodman MT, Gaudet MM, Garcia-Closas M, Friedenreich CM, Freudenheim JL, Doherty J, De Vivo I, Courneya KS, Cook LS, Chen C, Cerhan JR, Cai H, Brinton LA, Bernstein L, Anderson KE, Anton-Culver H, Schouten LJ, Horn-Ross PL
Source: J Clin Oncol, 2013 Jul 10;31(20), p. 2607-18.
EPub date: 2013 Jun 3.
C-reactive protein, lipid-soluble micronutrients, and survival in colorectal cancer patients.
Authors: Cooney RV, Chai W, Franke AA, Wilkens LR, Kolonel LN, Le Marchand L
Source: Cancer Epidemiol Biomarkers Prev, 2013 Jul;22(7), p. 1278-88.
EPub date: 2013 May 15.
Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies.
Authors: Eliassen AH, Hendrickson SJ, Brinton LA, Buring JE, Campos H, Dai Q, Dorgan JF, Franke AA, Gao YT, Goodman MT, Hallmans G, Helzlsouer KJ, Hoffman-Bolton J, Hultén K, Sesso HD, Sowell AL, Tamimi RM, Toniolo P, Wilkens LR, Winkvist A, Zeleniuch-Jacquotte A, Zheng W, Hankinson SE
Source: J Natl Cancer Inst, 2012 Dec 19;104(24), p. 1905-16.
EPub date: 2012 Dec 6.
Plasma matrix metalloproteinases and postmenopausal breast cancer risk: a nested case-control study in the Multiethnic Cohort study.
Authors: Kim Y, Ollberding NJ, Shvetsov YB, Franke AA, Wilkens LR, Maskarinec G, Hernandez BY, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT
Source: Breast Cancer Res Treat, 2012 Dec;136(3), p. 837-45.
EPub date: 2012 Oct 31.
Serum zinc and prostate cancer risk in a nested case-control study: The multiethnic cohort.
Authors: Park SY, Wilkens LR, Morris JS, Henderson BE, Kolonel LN
Source: Prostate, 2013 Feb 15;73(3), p. 261-6.
EPub date: 2012 Jul 31.
Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium.
Authors: Setiawan VW, Pike MC, Karageorgi S, Deming SL, Anderson K, Bernstein L, Brinton LA, Cai H, Cerhan JR, Cozen W, Chen C, Doherty J, Freudenheim JL, Goodman MT, Hankinson SE, Lacey JV Jr, Liang X, Lissowska J, Lu L, Lurie G, Mack T, Matsuno RK, McCann S, Moysich KB, Olson SH, Rastogi R, Rebbeck TR, Risch H, Robien K, Schairer C, Shu XO, Spurdle AB, Strom BL, Thompson PJ, Ursin G, Webb PM, Weiss NS, Wentzensen N, Xiang YB, Yang HP, Yu H, Horn-Ross PL, De Vivo I, Australian National Endometrial Cancer Study Group
Source: Am J Epidemiol, 2012 Aug 15;176(4), p. 269-78.
EPub date: 2012 Jul 23.
Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels with risk of malignant melanoma.
Authors: Park SL, Setiawan VW, Kanetsky PA, Zhang ZF, Wilkens LR, Kolonel LN, Le Marchand L
Source: Cancer Causes Control, 2011 Sep;22(9), p. 1267-75.
EPub date: 2011 Jun 23.
Plasma coenzyme Q10 levels and prostate cancer risk: the multiethnic cohort study.
Authors: Chai W, Cooney RV, Franke AA, Caberto CP, Wilkens LR, Le Marchand L, Goodman MT, Henderson BE, Kolonel LN
Source: Cancer Epidemiol Biomarkers Prev, 2011 Apr;20(4), p. 708-10.
EPub date: 2011 Feb 4.
Plasma coenzyme Q10 levels and postmenopausal breast cancer risk: the multiethnic cohort study.
Authors: Chai W, Cooney RV, Franke AA, Shvetsov YB, Caberto CP, Wilkens LR, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT
Source: Cancer Epidemiol Biomarkers Prev, 2010 Sep;19(9), p. 2351-6.
EPub date: 2010 Jul 28.
Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Helzlsouer KJ, VDPP Steering Committee
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 4-9.
EPub date: 2010 Jun 18.
Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Abnet CC, Chen Y, Chow WH, Gao YT, Helzlsouer KJ, Le Marchand L, McCullough ML, Shikany JM, Virtamo J, Weinstein SJ, Xiang YB, Yu K, Zheng W, Albanes D, Arslan AA, Campbell DS, Campbell PT, Hayes RB, Horst RL, Kolonel LN, Nomura AM, Purdue MP, Snyder K, Shu XO
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 94-106.
EPub date: 2010 Jun 18.
Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: McCullough ML, Weinstein SJ, Freedman DM, Helzlsouer K, Flanders WD, Koenig K, Kolonel L, Laden F, Le Marchand L, Purdue M, Snyder K, Stevens VL, Stolzenberg-Solomon R, Virtamo J, Yang G, Yu K, Zheng W, Albanes D, Ashby J, Bertrand K, Cai H, Chen Y, Gallicchio L, Giovannucci E, Jacobs EJ, Hankinson SE, Hartge P, Hartmuller V, Harvey C, Hayes RB, Horst RL, Shu XO
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 21-35.
EPub date: 2010 Jun 18.