Skip Navigation
Grant Details

Grant Number: 5P01CA033619-22 Interpret this number
Primary Investigator: Kolonel, Laurence
Organization: University Of Hawaii At Manoa
Project Title: Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study
Fiscal Year: 2010
Back to top


Abstract

DESCRIPTION (provided by applicant): This application is a competing renewal of P01 CA 33619 "Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study." The overall goal of the research is to conduct biomarker studies of cancer etiology, taking advantage of a recently established biorepository of blood, urine and buccal cells collected from more than 67,000 participants in this unique cohort. Specimens from substantial numbers of Japanese Americans, whites, African Americans, Latinos and Native Hawaiians have been stored in multiple aliquots at -186?C (blood) and -80?C (urine). A common theme of the research is the role of over-nutrition, obesity and/or chronic inflammation as underlying mechanisms for the effects of particular exposures on carcinogenesis. Four projects are proposed: 1) A study of nutritional and genetic risk factors for the main molecular subtypes of colorectal cancer; 2) A study of interrelated metabolic pathways that may explain the ethnic and geographic variation in the risk of postmenopausal breast cancer; 3) A study of the role of infection in prostate cancer risk; and 4) A study of inflammatory markers as mediators of nutritional exposures in the risk of non-Hodgkin lymphoma. These projects will be supported by three core components: 1) Administration; 2) Biospecimens; and 3) Data Management and Analysis. We expect a total of nearly 5300 cases with stored prediagnostic blood and urine samples for the four cancer sites. Incident cancer cases will be identified through the population-based SEER tumor registries of Hawaii and California and matched to randomly selected controls. Data analyses will use nested case-control and case-case designs, and will apply data reduction techniques. The research will be highly integrated because of the many common scientific aims, the use of common resources, and the overlap in biomarkers and statistical methods. Provisions have been made to foster interactions among the investigators, so as to promote the scientific aims and enhance research accomplishments. Strengths of the program include the long-standing collaborations among the investigators; the extensive experience of the laboratory collaborators; the large number, unique ethnic diversity, and high quality of the biorepository specimens; and the population-based design of the Multiethnic Cohort. This P01 should add substantially to knowledge of cancer etiology, as well as to an understanding of the basis for ethnic/racial disparities in cancer occurrence.

Back to top


Publications

Genetic variation in the inflammation and innate immunity pathways and colorectal cancer risk.
Authors: Wang H, Taverna D, Stram DO, Fortini BK, Cheng I, Wilkens LR, Burnett T, Makar KW, Lindor NM, Hopper JL, Gallinger S, Baron JA, Haile R, Kolonel LN, Henderson BE, Newcomb PA, Casey G, Duggan D, Ulrich CM, Le Marchand L
Source: Cancer Epidemiol Biomarkers Prev, 2013 Nov;22(11), p. 2094-101.
EPub date: 2013 Sep 17.
PMID: 24045924
Related Citations

Back to top


Type I and II endometrial cancers: have they different risk factors?
Authors: Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB, Wolk A, Wentzensen N, Weiss NS, Webb PM, van den Brandt PA, van de Vijver K, Thompson PJ, Australian National Endometrial Cancer Study Group, Strom BL, Spurdle AB, Soslow RA, Shu XO, Schairer C, Sacerdote C, Rohan TE, Robien K, Risch HA, Ricceri F, Rebbeck TR, Rastogi R, Prescott J, Polidoro S, Park Y, Olson SH, Moysich KB, Miller AB, McCullough ML, Matsuno RK, Magliocco AM, Lurie G, Lu L, Lissowska J, Liang X, Lacey JV Jr, Kolonel LN, Henderson BE, Hankinson SE, Hĺkansson N, Goodman MT, Gaudet MM, Garcia-Closas M, Friedenreich CM, Freudenheim JL, Doherty J, De Vivo I, Courneya KS, Cook LS, Chen C, Cerhan JR, Cai H, Brinton LA, Bernstein L, Anderson KE, Anton-Culver H, Schouten LJ, Horn-Ross PL
Source: J Clin Oncol, 2013 Jul 10;31(20), p. 2607-18.
EPub date: 2013 Jun 3.
PMID: 23733771
Related Citations

Back to top


C-reactive protein, lipid-soluble micronutrients, and survival in colorectal cancer patients.
Authors: Cooney RV, Chai W, Franke AA, Wilkens LR, Kolonel LN, Le Marchand L
Source: Cancer Epidemiol Biomarkers Prev, 2013 Jul;22(7), p. 1278-88.
EPub date: 2013 May 15.
PMID: 23677577
Related Citations

Back to top


Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies.
Authors: Eliassen AH, Hendrickson SJ, Brinton LA, Buring JE, Campos H, Dai Q, Dorgan JF, Franke AA, Gao YT, Goodman MT, Hallmans G, Helzlsouer KJ, Hoffman-Bolton J, Hultén K, Sesso HD, Sowell AL, Tamimi RM, Toniolo P, Wilkens LR, Winkvist A, Zeleniuch-Jacquotte A, Zheng W, Hankinson SE
Source: J Natl Cancer Inst, 2012 Dec 19;104(24), p. 1905-16.
EPub date: 2012 Dec 6.
PMID: 23221879
Related Citations

Back to top


Plasma matrix metalloproteinases and postmenopausal breast cancer risk: a nested case-control study in the Multiethnic Cohort study.
Authors: Kim Y, Ollberding NJ, Shvetsov YB, Franke AA, Wilkens LR, Maskarinec G, Hernandez BY, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT
Source: Breast Cancer Res Treat, 2012 Dec;136(3), p. 837-45.
EPub date: 2012 Oct 31.
PMID: 23112106
Related Citations

Back to top


Serum zinc and prostate cancer risk in a nested case-control study: The multiethnic cohort.
Authors: Park SY, Wilkens LR, Morris JS, Henderson BE, Kolonel LN
Source: Prostate, 2013 Feb 15;73(3), p. 261-6.
EPub date: 2012 Jul 31.
PMID: 22851289
Related Citations

Back to top


Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium.
Authors: Setiawan VW, Pike MC, Karageorgi S, Deming SL, Anderson K, Bernstein L, Brinton LA, Cai H, Cerhan JR, Cozen W, Chen C, Doherty J, Freudenheim JL, Goodman MT, Hankinson SE, Lacey JV Jr, Liang X, Lissowska J, Lu L, Lurie G, Mack T, Matsuno RK, McCann S, Moysich KB, Olson SH, Rastogi R, Rebbeck TR, Risch H, Robien K, Schairer C, Shu XO, Spurdle AB, Strom BL, Thompson PJ, Ursin G, Webb PM, Weiss NS, Wentzensen N, Xiang YB, Yang HP, Yu H, Horn-Ross PL, De Vivo I, Australian National Endometrial Cancer Study Group
Source: Am J Epidemiol, 2012 Aug 15;176(4), p. 269-78.
EPub date: 2012 Jul 23.
PMID: 22831825
Related Citations

Back to top


Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels with risk of malignant melanoma.
Authors: Park SL, Setiawan VW, Kanetsky PA, Zhang ZF, Wilkens LR, Kolonel LN, Le Marchand L
Source: Cancer Causes Control, 2011 Sep;22(9), p. 1267-75.
EPub date: 2011 Jun 23.
PMID: 21698457
Related Citations

Back to top


Plasma coenzyme Q10 levels and prostate cancer risk: the multiethnic cohort study.
Authors: Chai W, Cooney RV, Franke AA, Caberto CP, Wilkens LR, Le Marchand L, Goodman MT, Henderson BE, Kolonel LN
Source: Cancer Epidemiol Biomarkers Prev, 2011 Apr;20(4), p. 708-10.
EPub date: 2011 Feb 4.
PMID: 21297042
Related Citations

Back to top


Plasma coenzyme Q10 levels and postmenopausal breast cancer risk: the multiethnic cohort study.
Authors: Chai W, Cooney RV, Franke AA, Shvetsov YB, Caberto CP, Wilkens LR, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT
Source: Cancer Epidemiol Biomarkers Prev, 2010 Sep;19(9), p. 2351-6.
EPub date: 2010 Jul 28.
PMID: 20668119
Related Citations

Back to top


Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Helzlsouer KJ, VDPP Steering Committee
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 4-9.
EPub date: 2010 Jun 18.
PMID: 20562193
Related Citations

Back to top


Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Abnet CC, Chen Y, Chow WH, Gao YT, Helzlsouer KJ, Le Marchand L, McCullough ML, Shikany JM, Virtamo J, Weinstein SJ, Xiang YB, Yu K, Zheng W, Albanes D, Arslan AA, Campbell DS, Campbell PT, Hayes RB, Horst RL, Kolonel LN, Nomura AM, Purdue MP, Snyder K, Shu XO
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 94-106.
EPub date: 2010 Jun 18.
PMID: 20562192
Related Citations

Back to top


Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: McCullough ML, Weinstein SJ, Freedman DM, Helzlsouer K, Flanders WD, Koenig K, Kolonel L, Laden F, Le Marchand L, Purdue M, Snyder K, Stevens VL, Stolzenberg-Solomon R, Virtamo J, Yang G, Yu K, Zheng W, Albanes D, Ashby J, Bertrand K, Cai H, Chen Y, Gallicchio L, Giovannucci E, Jacobs EJ, Hankinson SE, Hartge P, Hartmuller V, Harvey C, Hayes RB, Horst RL, Shu XO
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 21-35.
EPub date: 2010 Jun 18.
PMID: 20562191
Related Citations

Back to top


Circulating 25-hydroxyvitamin D and risk of endometrial cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Zeleniuch-Jacquotte A, Gallicchio L, Hartmuller V, Helzlsouer KJ, McCullough ML, Setiawan VW, Shu XO, Weinstein SJ, Weiss JM, Arslan AA, De Vivo I, Gao YT, Hayes RB, Henderson BE, Horst RL, Koenig KL, Patel AV, Purdue MP, Snyder K, Steplowski E, Yu K, Zheng W, Hankinson SE
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 36-46.
EPub date: 2010 Jun 18.
PMID: 20562189
Related Citations

Back to top


Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Gallicchio L, Helzlsouer KJ, Chow WH, Freedman DM, Hankinson SE, Hartge P, Hartmuller V, Harvey C, Hayes RB, Horst RL, Koenig KL, Kolonel LN, Laden F, McCullough ML, Parisi D, Purdue MP, Shu XO, Snyder K, Stolzenberg-Solomon RZ, Tworoger SS, Varanasi A, Virtamo J, Wilkens LR, Xiang YB, Yu K, Zeleniuch-Jacquotte A, Zheng W, Abnet CC, Albanes D, Bertrand K, Weinstein SJ
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 10-20.
EPub date: 2010 Jun 18.
PMID: 20562188
Related Citations

Back to top


Circulating 25-hydroxyvitamin D and risk of kidney cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Gallicchio L, Moore LE, Stevens VL, Ahn J, Albanes D, Hartmuller V, Setiawan VW, Helzlsouer KJ, Yang G, Xiang YB, Shu XO, Snyder K, Weinstein SJ, Yu K, Zeleniuch-Jacquotte A, Zheng W, Cai Q, Campbell DS, Chen Y, Chow WH, Horst RL, Kolonel LN, McCullough ML, Purdue MP, Koenig KL
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 47-57.
EPub date: 2010 Jun 18.
PMID: 20562187
Related Citations

Back to top


Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Zheng W, Danforth KN, Tworoger SS, Goodman MT, Arslan AA, Patel AV, McCullough ML, Weinstein SJ, Kolonel LN, Purdue MP, Shu XO, Snyder K, Steplowski E, Visvanathan K, Yu K, Zeleniuch-Jacquotte A, Gao YT, Hankinson SE, Harvey C, Hayes RB, Henderson BE, Horst RL, Helzlsouer KJ
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 70-80.
EPub date: 2010 Jun 18.
PMID: 20562186
Related Citations

Back to top


Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Stolzenberg-Solomon RZ, Jacobs EJ, Arslan AA, Qi D, Patel AV, Helzlsouer KJ, Weinstein SJ, McCullough ML, Purdue MP, Shu XO, Snyder K, Virtamo J, Wilkins LR, Yu K, Zeleniuch-Jacquotte A, Zheng W, Albanes D, Cai Q, Harvey C, Hayes R, Clipp S, Horst RL, Irish L, Koenig K, Le Marchand L, Kolonel LN
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 81-93.
EPub date: 2010 Jun 18.
PMID: 20562185
Related Citations

Back to top


Circulating 25-hydroxyvitamin D and risk of non-hodgkin lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Purdue MP, Freedman DM, Gapstur SM, Helzlsouer KJ, Laden F, Lim U, Maskarinec G, Rothman N, Shu XO, Stevens VL, Zeleniuch-Jacquotte A, Albanes D, Bertrand K, Weinstein SJ, Yu K, Irish L, Horst RL, Hoffman-Bolton J, Giovannucci EL, Kolonel LN, Snyder K, Willett W, Arslan AA, Hayes RB, Zheng W, Xiang YB, Hartge P
Source: Am J Epidemiol, 2010 Jul 1;172(1), p. 58-69.
EPub date: 2010 Jun 18.
PMID: 20562184
Related Citations

Back to top


Plasma 25-hydroxyvitamin D and prostate cancer risk: the multiethnic cohort.
Authors: Park SY, Cooney RV, Wilkens LR, Murphy SP, Henderson BE, Kolonel LN
Source: Eur J Cancer, 2010 Mar;46(5), p. 932-6.
EPub date: 2010 Feb 8.
PMID: 20064705
Related Citations

Back to top


Plasma 25-hydroxyvitamin D levels and the risk of colorectal cancer: the multiethnic cohort study.
Authors: Woolcott CG, Wilkens LR, Nomura AM, Horst RL, Goodman MT, Murphy SP, Henderson BE, Kolonel LN, Le Marchand L
Source: Cancer Epidemiol Biomarkers Prev, 2010 Jan;19(1), p. 130-4.
PMID: 20056631
Related Citations

Back to top


Plasma sex hormone concentrations and breast cancer risk in an ethnically diverse population of postmenopausal women: the Multiethnic Cohort Study.
Authors: Woolcott CG, Shvetsov YB, Stanczyk FZ, Wilkens LR, White KK, Caberto C, Henderson BE, Le Marchand L, Kolonel LN, Goodman MT
Source: Endocr Relat Cancer, 2010 Mar;17(1), p. 125-34.
EPub date: 2010 Feb 18.
PMID: 19903744
Related Citations

Back to top


Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study.
Authors: Le Marchand L, White KK, Nomura AM, Wilkens LR, Selhub JS, Tiirikainen M, Goodman MT, Murphy SP, Henderson BE, Kolonel LN
Source: Cancer Epidemiol Biomarkers Prev, 2009 Aug;18(8), p. 2195-201.
PMID: 19661077
Related Citations

Back to top


Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study.
Authors: Epplein M, Shvetsov YB, Wilkens LR, Franke AA, Cooney RV, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT
Source: Breast Cancer Res, 2009;11(4), p. R49.
EPub date: 2009 Jul 20.
PMID: 19619335
Related Citations

Back to top


Nonsteroidal antiinflammatory drugs and risk of gastric adenocarcinoma: the multiethnic cohort study.
Authors: Epplein M, Nomura AM, Wilkens LR, Henderson BE, Kolonel LN
Source: Am J Epidemiol, 2009 Aug 15;170(4), p. 507-14.
EPub date: 2009 Jul 7.
PMID: 19584132
Related Citations

Back to top


Urinary phytoestrogen excretion and prostate cancer risk: a nested case-control study in the Multiethnic Cohort.
Authors: Park SY, Wilkens LR, Franke AA, Le Marchand L, Kakazu KK, Goodman MT, Murphy SP, Henderson BE, Kolonel LN
Source: Br J Cancer, 2009 Jul 7;101(1), p. 185-91.
EPub date: 2009 Jun 16.
PMID: 19536097
Related Citations