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Grant Details

Grant Number: 5R01CA083115-10 Interpret this number
Primary Investigator: Elder, David
Organization: University Of Pennsylvania
Project Title: Genetic Epidemiology of Melanoma
Fiscal Year: 2010
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Abstract

DESCRIPTION (provided by applicant): During the present funding cycle (09/01/01 to 08/31/06) we, GenoMEL, characterized the major effects of the known high penetrance melanoma susceptibility genes (cyclin dependent kinase [CDK] inhibitor 2A [CDKN2A] and CDK4) and increased understanding of interactions with lower penetrance genes, in particular MC1R. We also collected extensive data relating to geographic, environmental and phenotypic interactions. GenoMEL (www.genomel.org) was created in 1997; it brought together on an informal basis for exchange and promotion of melanoma science numerous international research groups interested in understanding the genetics of familial melanoma. In September 2001, funding was obtained from the NCI (this R01 CA83115) that served to underpin the fledgling, cooperative group. A successful application to the European Union for a Network of Excellence (NoE) "Framework 6" grant has ensured the viability of a considerably enlarged consortium by funding its administration and core data collection; as a result we have grown in effectiveness and size, with the recruitment of new participant groups in Utah, Toronto, Tel Aviv, Latvia, Poland, Slovenia and Queensland. This application for competitive renewal of the R01 will utilize the support of the members of GenoMEL and the European-based infrastructure established by the NoE funds to efficiently extend our exploration of the biological basis of susceptibility to melanoma and its application to risk assessment. This application will also support a large scale screening for identification of new high penetrance melanoma susceptibility genes. This application has two overarching objectives: Aim 1 is to determine the precise contribution of the CDKN2A locus to familial aggregation of melanoma and other cancers, and to develop tools which will enable clinicians to translate this information for use in counseling the population. We hypothesize that the prevalence and penetrance of CDKN2A mutations will vary strongly by region, by population, by population incidence, by the number and type of cancers in close relatives, and by covariates such as ethnicity, skin type, nevus phenotypes and sun exposure. Further, we hypothesize that specific classes of CDKN2A mutations differentially affect risk of melanoma, pancreatic and other cancers, as well as important intermediate phenotypes such as nevus count. We also hypothesize that current estimates of these parameters require validation because of concerns with respect to the effect of ascertainment; Aim 2 is to identify novel high-penetrance melanoma susceptibility genes. We hypothesize that other high penetrance melanoma susceptibility genes exist and that these encode members of the p16/CDK4/pRb and p14/MDM2/p53 pathways that have been previously implicated in melanoma susceptibility. Identification of additional high penetrance genes is important because our research to date has shown that 50% of families with 3+ cases of melanoma do not have mutations in CDKN2A and CDK4.

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Publications

An inherited variant in the gene coding for vitamin D-binding protein and survival from cutaneous melanoma: a BioGenoMEL study.
Authors: Davies JR, Field S, Randerson-Moor J, Harland M, Kumar R, Anic GM, Nagore E, Hansson J, Höiom V, Jönsson G, Gruis NA, Park JY, Guan J, Sivaramakrishna Rachakonda P, Wendt J, Pjanova D, Puig S, Schadendorf D, Okamoto I, Olsson H, Affleck P, García-Casado Z, Puig-Butille JA, Stratigos AJ, Kodela E, Donina S, Sucker A, Hosen I, Egan KM, Barrett JH, van Doorn R, Bishop DT, Newton-Bishop J
Source: Pigment Cell Melanoma Res, 2014 Mar;27(2), p. 234-43.
EPub date: 2013 Dec 11.
PMID: 24219834
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Surveillance of second-degree relatives from melanoma families with a CDKN2A germline mutation.
Authors: van der Rhee JI, Boonk SE, Putter H, Cannegieter SC, Flinterman LE, Hes FJ, de Snoo FA, Mooi WJ, Gruis NA, Vasen HF, Kukutsch NA, Bergman W
Source: Cancer Epidemiol Biomarkers Prev, 2013 Oct;22(10), p. 1771-7.
EPub date: 2013 Jul 29.
PMID: 23897584
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Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population.
Authors: Puig-Butillé JA, Carrera C, Kumar R, Garcia-Casado Z, Badenas C, Aguilera P, Malvehy J, Nagore E, Puig S
Source: Br J Dermatol, 2013 Oct;169(4), p. 804-11.
PMID: 23647022
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Dermoscopic patterns of melanoma metastases: interobserver consistency and accuracy for metastasis recognition.
Authors: Costa J, Ortiz-Ibañez K, Salerni G, Borges V, Carrera C, Puig S, Malvehy J
Source: Br J Dermatol, 2013 Jul;169(1), p. 91-9.
PMID: 23495915
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A variant in FTO shows association with melanoma risk not due to BMI.
Authors: Iles MM, Law MH, Stacey SN, Han J, Fang S, Pfeiffer R, Harland M, Macgregor S, Taylor JC, Aben KK, Akslen LA, Avril MF, Azizi E, Bakker B, Benediktsdottir KR, Bergman W, Scarrà GB, Brown KM, Calista D, Chaudru V, Fargnoli MC, Cust AE, Demenais F, de Waal AC, D?bniak T, Elder DE, Friedman E, Galan P, Ghiorzo P, Gillanders EM, Goldstein AM, Gruis NA, Hansson J, Helsing P, Ho?evar M, Höiom V, Hopper JL, Ingvar C, Janssen M, Jenkins MA, Kanetsky PA, Kiemeney LA, Lang J, Lathrop GM, Leachman S, Lee JE, Lubi?ski J, Mackie RM, Mann GJ, Martin NG, Mayordomo JI, Molven A, Mulder S, Nagore E, Novakovi? S, Okamoto I, Olafsson JH, Olsson H, Pehamberger H, Peris K, Grasa MP, Planelles D, Puig S, Puig-Butille JA, Randerson-Moor J, Requena C, Rivoltini L, Rodolfo M, Santinami M, Sigurgeirsson B, Snowden H, Song F, Sulem P, Thorisdottir K, Tuominen R, Van Belle P, van der Stoep N, van Rossum MM, Wei Q, Wendt J, Zelenika D, Zhang M, Landi MT, Thorleifsson G, Bishop DT, Amos CI, Hayward NK, Stefansson K, Bishop JA, Barrett JH, GenoMEL Consortium, Q-MEGA and AMFS Investigators
Source: Nat Genet, 2013 Apr;45(4), p. 428-32, 432e1.
EPub date: 2013 Mar 3.
PMID: 23455637
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Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants.
Authors: Puntervoll HE, Yang XR, Vetti HH, Bachmann IM, Avril MF, Benfodda M, Catricalà C, Dalle S, Duval-Modeste AB, Ghiorzo P, Grammatico P, Harland M, Hayward NK, Hu HH, Jouary T, Martin-Denavit T, Ozola A, Palmer JM, Pastorino L, Pjanova D, Soufir N, Steine SJ, Stratigos AJ, Thomas L, Tinat J, Tsao H, Veinalde R, Tucker MA, Bressac-de Paillerets B, Newton-Bishop JA, Goldstein AM, Akslen LA, Molven A
Source: J Med Genet, 2013 Apr;50(4), p. 264-70.
EPub date: 2013 Feb 5.
PMID: 23384855
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Genetic alterations in RAS-regulated pathway in acral lentiginous melanoma.
Authors: Puig-Butillé JA, Badenas C, Ogbah Z, Carrera C, Aguilera P, Malvehy J, Puig S
Source: Exp Dermatol, 2013 Feb;22(2), p. 148-50.
PMID: 23362874
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Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.
Authors: Qian J, Liu H, Wei S, Liu Z, Li Y, Wang LE, Chen WV, Amos CI, Lee JE, GenoMEL investigators, Iles MM, Law MH, Q-MEGA AMFS investigators, Cust AE, Barrett JH, Montgomery GW, Taylor J, Bishop JA, Macgregor S, Bishop DT, Mann GJ, Hayward NK, Wei Q
Source: Pigment Cell Melanoma Res, 2013 May;26(3), p. 392-401.
EPub date: 2013 Mar 27.
PMID: 23360169
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Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk.
Authors: Liu H, Wang LE, Liu Z, Chen WV, Amos CI, Lee JE, Q-MEGA and AMFS Investigators, GenoMEL Investigators, Iles MM, Law MH, Barrett JH, Montgomery GW, Taylor JC, MacGregor S, Cust AE, Newton Bishop JA, Hayward NK, Bishop DT, Mann GJ, Affleck P, Wei Q
Source: Carcinogenesis, 2013 Apr;34(4), p. 885-92.
EPub date: 2013 Jan 4.
PMID: 23291271
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Clinicopathologic features of V600E and V600K melanoma--letter.
Authors: Jewell R, Chambers P, Harland M, Laye J, Conway C, Mitra A, Elliott F, Cook MG, Boon A, Newton-Bishop J
Source: Clin Cancer Res, 2012 Dec 15;18(24), p. 6792; author's reply p. 6793.
EPub date: 2012 Nov 20.
PMID: 23169438
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Genetic counseling in melanoma.
Authors: Badenas C, Aguilera P, Puig-Butillé JA, Carrera C, Malvehy J, Puig S
Source: Dermatol Ther, 2012 Sep-Oct;25(5), p. 397-402.
PMID: 23046018
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Melanocortin 1 receptor (MC1R) variants in high melanoma risk patients are associated with specific dermoscopic ABCD features.
Authors: Quint KD, van der Rhee JI, Gruis NA, Ter Huurne JA, Wolterbeek R, van der Stoep N, Bergman W, Kukutsch NA
Source: Acta Derm Venereol, 2012 Nov;92(6), p. 587-92.
PMID: 22965007
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Benefits of oral Polypodium Leucotomos extract in MM high-risk patients.
Authors: Aguilera P, Carrera C, Puig-Butille JA, Badenas C, Lecha M, González S, Malvehy J, Puig S
Source: J Eur Acad Dermatol Venereol, 2013 Sep;27(9), p. 1095-100.
EPub date: 2012 Jul 31.
PMID: 22849563
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Dermoscopy: an aid to the detection of amelanotic cutaneous melanoma metastases.
Authors: Jaimes N, Halpern JA, Puig S, Malvehy J, Myskowski PL, Braun RP, Marghoob AA
Source: Dermatol Surg, 2012 Sep;38(9), p. 1437-44.
EPub date: 2012 May 15.
PMID: 22587541
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Characterization of 1152 lesions excised over 10 years using total-body photography and digital dermatoscopy in the surveillance of patients at high risk for melanoma.
Authors: Salerni G, Carrera C, Lovatto L, Martí-Laborda RM, Isern G, Palou J, Alós L, Puig S, Malvehy J
Source: J Am Acad Dermatol, 2012 Nov;67(5), p. 836-45.
EPub date: 2012 Apr 20.
PMID: 22521205
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Dermoscopic criteria and melanocytic lesions.
Authors: Roldán-Marín R, Puig S, Malvehy J
Source: G Ital Dermatol Venereol, 2012 Apr;147(2), p. 149-59.
PMID: 22481578
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Dermoscopic criteria and basal cell carcinoma.
Authors: Puig S, Cecilia N, Malvehy J
Source: G Ital Dermatol Venereol, 2012 Apr;147(2), p. 135-40.
PMID: 22481576
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Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study.
Authors: Davies JR, Randerson-Moor J, Kukalizch K, Harland M, Kumar R, Madhusudan S, Nagore E, Hansson J, Höiom V, Ghiorzo P, Gruis NA, Kanetsky PA, Wendt J, Pjanova D, Puig S, Saiag P, Schadendorf D, Soufir N, Okamoto I, Affleck P, García-Casado Z, Ogbah Z, Ozola A, Queirolo P, Sucker A, Barrett JH, van Doorn R, Bishop DT, Newton-Bishop J
Source: Pigment Cell Melanoma Res, 2012 May;25(3), p. 384-94.
EPub date: 2012 Mar 16.
PMID: 22325793
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