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Grant Details

Grant Number: 5R01CA122364-04 Interpret this number
Primary Investigator: Yang, Gong
Organization: Vanderbilt University
Project Title: Inflammatory Biomarkers and Colorectal Cancer Risk
Fiscal Year: 2010
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Abstract

Colorectal cancer (CRC) is a major cause of cancer deaths in the United States and many other countries. Chronic inflammation has been suggested to play a major role in the pathogenesis of CRC. We propose in this application to conduct a nested case-control study within the Shanghai Women's Health Study, a large population-based prospective cohort study, to evaluate the association of CRC risk with measures of several key products of the inflammatory process and with related genetic markers of inflammation. Specifically, we will include 580 incident cases of CRC and their individually matched controls (1 to1 match for biochemical markers and 1 to 3 match for genetic markers). Urine samples collected at baseline will be measured for a major metabolite of prostaglandin E2 (PGE2) using a liquid chromatographic/mass spectrometric assay and F2-isoprostanes using the mass spectrometric method. Baseline blood samples will be measured for soluble tumor necrosis factor-a receptors, interleukin-6, and C-reactive protein. Genomic DNA will be assayed for polymorphisms in genes involved in PGE2 production (PTGS2, PTGES), metabolism (15-PGDH), and signaling (PTGER1-PTGER4). We will perform statistical analyses to evaluate the associations between these biochemical and genetic markers of inflammation and CRC risk and potential interactions of these markers. Given the large sample size, the prospective study design, the availability of comprehensive baseline survey data and biospecimens, as well as the excellent collaborative environment, we believe that this proposed study represents a unique opportunity to evaluate, vigorously and cost-efficiently, the relationship between various markers of inflammation and CRC. Overall, this study will contribute significantly to the understanding of the role of inflammation in the etiology of CRC and to the development of new strategies for the assessment of CRC risk.

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Publications

Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.
Authors: Zhang B, Jia WH, Matsuo K, Shin A, Xiang YB, Matsuda K, Jee SH, Kim DH, Cheah PY, Ren Z, Cai Q, Long J, Shi J, Wen W, Yang G, Ji BT, Pan ZZ, Matsuda F, Gao YT, Oh JH, Ahn YO, Kubo M, Thean LF, Park EJ, Li HL, Park JW, Jo J, Jeong JY, Hosono S, Nakamura Y, Shu XO, Zeng YX, Zheng W
Source: Int J Cancer, 2014 Jan 21;null, p. null.
EPub date: 2014 Jan 21.
PMID: 24448986
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Nonexercise physical activity and inflammatory and oxidative stress markers in women.
Authors: Wu SH, Shu XO, Chow WH, Xiang YB, Zhang X, Li HL, Cai Q, Milne G, Ji BT, Cai H, Rothman N, Gao YT, Zheng W, Yang G
Source: J Womens Health (Larchmt), 2014 Feb;23(2), p. 159-67.
EPub date: 2013 Oct 29.
PMID: 24168102
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Soy food consumption and lung cancer risk: a meta-analysis using a common measure across studies.
Authors: Wu SH, Liu Z
Source: Nutr Cancer, 2013;65(5), p. 625-32.
PMID: 23859029
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Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women.
Authors: Wu SH, Shu XO, Chow WH, Xiang YB, Zhang X, Cai Q, Li HL, Milne G, Wen W, Ji BT, Rothman N, Gao YT, Zheng W, Yang G
Source: Dis Markers, 2013;34(4), p. 279-93.
PMID: 23396296
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Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
Authors: Peters U, Jiao S, Schumacher FR, Hutter CM, Aragaki AK, Baron JA, Berndt SI, Bézieau S, Brenner H, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Casey G, Chan AT, Chang-Claude J, Chanock SJ, Chen LS, Coetzee GA, Coetzee SG, Conti DV, Curtis KR, Duggan D, Edwards T, Fuchs CS, Gallinger S, Giovannucci EL, Gogarten SM, Gruber SB, Haile RW, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M, Hopper JL, Hudson TJ, Hunter DJ, Jackson RD, Jee SH, Jenkins MA, Jia WH, Kolonel LN, Kooperberg C, Küry S, Lacroix AZ, Laurie CC, Laurie CA, Le Marchand L, Lemire M, Levine D, Lindor NM, Liu Y, Ma J, Makar KW, Matsuo K, Newcomb PA, Potter JD, Prentice RL, Qu C, Rohan T, Rosse SA, Schoen RE, Seminara D, Shrubsole M, Shu XO, Slattery ML, Taverna D, Thibodeau SN, Ulrich CM, White E, Xiang Y, Zanke BW, Zeng YX, Zhang B, Zheng W, Hsu L, Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium
Source: Gastroenterology, 2013 Apr;144(4), p. 799-807.e24.
EPub date: 2012 Dec 22.
PMID: 23266556
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Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.
Authors: Jia WH, Zhang B, Matsuo K, Shin A, Xiang YB, Jee SH, Kim DH, Ren Z, Cai Q, Long J, Shi J, Wen W, Yang G, Delahanty RJ, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Colon Cancer Family Registry (CCFR), Ji BT, Pan ZZ, Matsuda F, Gao YT, Oh JH, Ahn YO, Park EJ, Li HL, Park JW, Jo J, Jeong JY, Hosono S, Casey G, Peters U, Shu XO, Zeng YX, Zheng W
Source: Nat Genet, 2013 Feb;45(2), p. 191-6.
EPub date: 2012 Dec 23.
PMID: 23263487
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Body weight, fat distribution and colorectal cancer risk: a report from cohort studies of 134?255 Chinese men and women.
Authors: Li H, Yang G, Xiang YB, Gao J, Zhang X, Zheng W, Gao YT, Shu XO
Source: Int J Obes (Lond), 2012 Sep 18;null, p. null.
EPub date: 2012 Sep 18.
PMID: 22986684
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Soy food intake and circulating levels of inflammatory markers in Chinese women.
Authors: Wu SH, Shu XO, Chow WH, Xiang YB, Zhang X, Li HL, Cai Q, Ji BT, Cai H, Rothman N, Gao YT, Zheng W, Yang G
Source: J Acad Nutr Diet, 2012 Jul;112(7), p. 996-1004, 1004.e1-4.
PMID: 22889631
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Green tea consumption and colorectal cancer risk: a report from the Shanghai Men's Health Study.
Authors: Yang G, Zheng W, Xiang YB, Gao J, Li HL, Zhang X, Gao YT, Shu XO
Source: Carcinogenesis, 2011 Nov;32(11), p. 1684-8.
EPub date: 2011 Aug 19.
PMID: 21856996
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Dietary glycemic load and risk of colorectal cancer in Chinese women.
Authors: Li HL, Yang G, Shu XO, Xiang YB, Chow WH, Ji BT, Zhang X, Cai H, Gao J, Gao YT, Zheng W
Source: Am J Clin Nutr, 2011 Jan;93(1), p. 101-7.
EPub date: 2010 Oct 20.
PMID: 20962156
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Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk.
Authors: Yang G, Gao YT, Shu XO, Cai Q, Li GL, Li HL, Ji BT, Rothman N, Dyba M, Xiang YB, Chung FL, Chow WH, Zheng W
Source: Am J Clin Nutr, 2010 Mar;91(3), p. 704-11.
EPub date: 2009 Dec 30.
PMID: 20042523
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Prospective cohort study of soy food intake and colorectal cancer risk in women.
Authors: Yang G, Shu XO, Li H, Chow WH, Cai H, Zhang X, Gao YT, Zheng W
Source: Am J Clin Nutr, 2009 Feb;89(2), p. 577-83.
EPub date: 2008 Dec 10.
PMID: 19073792
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