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Grant Details

Grant Number: 5R01CA120061-06 Interpret this number
Primary Investigator: Lukanova, Annekatrin
Organization: German Cancer Research Center
Project Title: Hormone Levels During Pregnancy and Maternal Ovarian Cancer
Fiscal Year: 2010
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Abstract

DESCRIPTION (provided by applicant): A pregnancy completed to term is the strongest known protective factor for ovarian cancer. Older age at the end of child-bearing confers greater protection than younger age and it was proposed that pregnancy may clear the ovaries from cells that have undergone malignant transformation - the wash-out hypothesis. Progesterone is the most likely hormone candidate to mediate the beneficial effect of pregnancy. In a case control study (1,827 cases, 3,654 controls), nested within two large cohorts in Finland and Sweden, we will explore the associations between progesterone and 17alpha-OH progesterone (marker of corpus luteum function and correlate of ovarian synthesis of progesterone) in stored specimens obtained during the first trimester of a last, full-term pregnancy and the subsequent risk of invasive or borderline ovarian cancer in the mother. Specific aims are the following: 1). To investigate prospectively the association of circulating progesterone and 17a-OH progesterone during the first trimester of a last full-term pregnancy with risk of epithelial ovarian cancer in the mother and to explore the effect of age at last full-term pregnancy on these associations. 2). To explore the above hormone-cancer associations according to the histological sub-type of both invasive and borderline epithelial ovarian malignancies. Additionally, the large Nordic cohorts offer the opportunity to address the role of two groups of hormones that have been associated with increased ovarian cancer risk. Two more specific aims are proposed: 3). To examine prospectively the association of IGF-I, IGFBP-3 and placental GH during early pregnancy with maternal risk of ovarian cancer overall, and in subgroups defined by the histological types of the tumors. 4). To examine prospectively the association of testosterone, androstenedione and SHBG during pregnancy with maternal risk of ovarian cancer overall, and in subgroups defined by the histological types of the tumors. The proposed study will be one of the largest studies on ovarian cancer conducted to date. It will gather important new data concerning the role of progesterone in the protection afforded by pregnancies, and the role of the IGF-system and androgens, on ovarian cancer risk. Observations from this study may lead to a better understanding of disease pathogenesis, and, ultimately to development of preventive interventions.

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Publications

Free ?-human chorionic gonadotropin, total human chorionic gonadotropin and maternal risk of breast cancer.
Authors: Toriola AT, Tolockiene E, Schock H, Surcel HM, Zeleniuch-Jacquotte A, Wadell G, Toniolo P, Lundin E, Grankvist K, Lukanova A
Source: Future Oncol, 2014 Feb;10(3), p. 377-84.
PMID: 24559445
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Determinants of maternal sex steroids during the first half of pregnancy.
Authors: Toriola AT, Vääräsmäki M, Lehtinen M, Zeleniuch-Jacquotte A, Lundin E, Rodgers KG, Lakso HA, Chen T, Schock H, Hallmans G, Pukkala E, Toniolo P, Grankvist K, Surcel HM, Lukanova A
Source: Obstet Gynecol, 2011 Nov;118(5), p. 1029-36.
PMID: 22015870
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Circulating insulin-like growth factor-I in pregnancy and maternal risk of breast cancer.
Authors: Toriola AT, Lundin E, Schock H, Grankvist K, Pukkala E, Chen T, Zeleniuch-Jacquotte A, Toniolo P, Lehtinen M, Surcel HM, Lukanova A
Source: Cancer Epidemiol Biomarkers Prev, 2011 Aug;20(8), p. 1798-801.
EPub date: 2011 Jun 15.
PMID: 21680537
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Circulating estrogens and progesterone during primiparous pregnancies and risk of maternal breast cancer.
Authors: Lukanova A, Surcel HM, Lundin E, Kaasila M, Lakso HA, Schock H, Husing A, Kaaks R, Koskela P, Grankvist K, Pukkala E, Zeleniuch-Jacquotte A, Lehtinen M, Toniolo P
Source: Int J Cancer, 2012 Feb 15;130(4), p. 910-20.
EPub date: 2011 May 9.
PMID: 21413009
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Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy.
Authors: Toriola AT, Surcel HM, Husing A, Grankvist K, Lakso HA, Schock H, Lundin E, Lehtinen M, Lukanova A
Source: Cancer Causes Control, 2011 Jun;22(6), p. 925-8.
EPub date: 2011 Mar 9.
PMID: 21387179
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Circulating sex steroids during pregnancy and maternal risk of non-epithelial ovarian cancer.
Authors: Chen T, Surcel HM, Lundin E, Kaasila M, Lakso HA, Schock H, Kaaks R, Koskela P, Grankvist K, Hallmans G, Pukkala E, Zeleniuch-Jacquotte A, Toniolo P, Lehtinen M, Lukanova A
Source: Cancer Epidemiol Biomarkers Prev, 2011 Feb;20(2), p. 324-36.
EPub date: 2010 Dec 21.
PMID: 21177423
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Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer.
Authors: Toniolo P, Grankvist K, Wulff M, Chen T, Johansson R, Schock H, Lenner P, Hallmans G, Lehtinen M, Kaaks R, Wadell G, Zeleniuch-Jacquotte A, Lundin E, Lukanova A
Source: Cancer Res, 2010 Sep 1;70(17), p. 6779-86.
EPub date: 2010 Aug 16.
PMID: 20713523
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Maternal hormones during early pregnancy: a cross-sectional study.
Authors: Chen T, Lundin E, Grankvist K, Zeleniuch-Jacquotte A, Wulff M, Afanasyeva Y, Schock H, Johansson R, Lenner P, Hallmans G, Wadell G, Toniolo P, Lukanova A
Source: Cancer Causes Control, 2010 May;21(5), p. 719-27.
EPub date: 2010 Jan 19.
PMID: 20084544
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IGF-I during primiparous pregnancy and maternal risk of breast cancer.
Authors: Chen T, Lukanova A, Grankvist K, Zeleniuch-Jacquotte A, Wulff M, Johansson R, Schock H, Lenner P, Hallmans G, Wadell G, Toniolo P, Lundin E
Source: Breast Cancer Res Treat, 2010 May;121(1), p. 169-75.
EPub date: 2009 Sep 2.
PMID: 19728079
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Human chorionic gonadotropin and alpha-fetoprotein concentrations in pregnancy and maternal risk of breast cancer: a nested case-control study.
Authors: Lukanova A, Andersson R, Wulff M, Zeleniuch-Jacquotte A, Grankvist K, Dossus L, Afanasyeva Y, Johansson R, Arslan AA, Lenner P, Wadell G, Hallmans G, Toniolo P, Lundin E
Source: Am J Epidemiol, 2008 Dec 1;168(11), p. 1284-91.
EPub date: 2008 Oct 20.
PMID: 18936438
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Effect of long-term storage on hormone measurements in samples from pregnant women: the experience of the Finnish Maternity Cohort.
Authors: Holl K, Lundin E, Kaasila M, Grankvist K, Afanasyeva Y, Hallmans G, Lehtinen M, Pukkala E, Surcel HM, Toniolo P, Zeleniuch-Jacquotte A, Koskela P, Lukanova A
Source: Acta Oncol, 2008;47(3), p. 406-12.
EPub date: 2007 Sep 24.
PMID: 17891670
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