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Grant Details

Grant Number: 5R01CA118567-05 Interpret this number
Primary Investigator: Spiegel, David
Organization: Stanford University
Project Title: Sleep, Circadian, Hormonal Dysregulation, and Breast Cancer Survival
Fiscal Year: 2010
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Abstract

DESCRIPTION (provided by applicant): Recent research provides evidence that disrupted circadian rhythms, including hormonal patterns and sleep, are associated with increased risk of breast cancer incidence and faster progression to mortality. We have observed that loss of normal diurnal cortisol rhythm associated with more awakenings during the night predicts early mortality with metastatic breast cancer. Other recent studies have shown that nighttime shift work is associated with higher breast cancer incidence, and in a murine model disrupting circadian cortisol cycles produced a doubling of implanted tumor growth. There is also recent evidence that abnormal clock genes are associated with cancer. However, it is not clear whether sleep disruption per se affects breast cancer progression, or whether such an effect is mediated by hormonal and immune dysregulation of this prevalent and hormone-mediated cancer. We propose to study sleep disruption as a prognostic factor in the progression of metastatic breast cancer. We will also examine sleep patterns in association with disrupted circadian rhythms of cortisol, CRF, ACTH, and melatonin as well as measures of immune function known to be salient to breast cancer progression. These are natural killer cell cytotoxicity and specific cytokines: tumor necrosis factor alpha and nuclear factor kappa B. We plan to recruit 117 women 55 and older with metastatic breast cancer and 63 age and SES-matched controls for a two-week at home sleep study using Actiwatch and one night of in-home EEG monitoring, followed by 32 hours of EEG sleep monitoring and continuous blood sampling in the General Clinical Research Center. This will provide full circadian hormone assessment associated with thorough assessment of sleep patterns. We will relate these measures to the subsequent course of breast cancer progression. Results of this study will provide specific evidence regarding how improved sleep management may affect the course of breast cancer.

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Publications

Correspondence of Plasma and Salivary Cortisol Patterns in Women with Breast Cancer.
Authors: Zeitzer JM, Nouriani B, Neri E, Spiegel D
Source: Neuroendocrinology, 2014 Sep 10;null, p. null.
EPub date: 2014 Sep 10.
PMID: 25228297
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Actigraphy-measured sleep disruption as a predictor of survival among women with advanced breast cancer.
Authors: Palesh O, Aldridge-Gerry A, Zeitzer JM, Koopman C, Neri E, Giese-Davis J, Jo B, Kraemer H, Nouriani B, Spiegel D
Source: Sleep, 2014 May 1;37(5), p. 837-42.
EPub date: 2014 May 1.
PMID: 24790261
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Posttraumatic growth and diurnal cortisol slope among women with metastatic breast cancer.
Authors: Diaz M, Aldridge-Gerry A, Spiegel D
Source: Psychoneuroendocrinology, 2014 Jun;44, p. 83-7.
EPub date: 2014 Mar 12.
PMID: 24767622
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Bedtime misalignment and progression of breast cancer.
Authors: Hahm BJ, Jo B, Dhabhar FS, Palesh O, Aldridge-Gerry A, Bajestan SN, Neri E, Nouriani B, Spiegel D, Zeitzer JM
Source: Chronobiol Int, 2014 Mar;31(2), p. 214-21.
EPub date: 2013 Oct 24.
PMID: 24156520
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Psychosocial correlates of sleep quality and architecture in women with metastatic breast cancer.
Authors: Aldridge-Gerry A, Zeitzer JM, Palesh OG, Jo B, Nouriani B, Neri E, Spiegel D
Source: Sleep Med, 2013 Nov;14(11), p. 1178-86.
EPub date: 2013 Sep 5.
PMID: 24074694
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Mind matters in cancer survival.
Authors: Spiegel D
Source: Psychooncology, 2012 Jun;21(6), p. 588-93.
EPub date: 2012 Mar 21.
PMID: 22438289
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Mind matters in cancer survival.
Authors: Spiegel D
Source: JAMA, 2011 Feb 2;305(5), p. 502-3.
PMID: 21285429
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Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis.
Authors: Giese-Davis J, Collie K, Rancourt KM, Neri E, Kraemer HC, Spiegel D
Source: J Clin Oncol, 2011 Feb 1;29(4), p. 413-20.
EPub date: 2010 Dec 13.
PMID: 21149651
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Emotion modulation in PTSD: Clinical and neurobiological evidence for a dissociative subtype.
Authors: Lanius RA, Vermetten E, Loewenstein RJ, Brand B, Schmahl C, Bremner JD, Spiegel D
Source: Am J Psychiatry, 2010 Jun;167(6), p. 640-7.
EPub date: 2010 Apr 1.
PMID: 20360318
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Hypnotizability, posttraumatic stress, and depressive symptoms in metastatic breast cancer.
Authors: Keuroghlian AS, Butler LD, Neri E, Spiegel D
Source: Int J Clin Exp Hypn, 2010 Jan;58(1), p. 39-52.
PMID: 20183737
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Use and misuse of the consolidated standards of reporting trials (CONSORT) guidelines to assess research findings: comment on Coyne, Stefanek, and Palmer (2007).
Authors: Kraemer HC, Kuchler T, Spiegel D
Source: Psychol Bull, 2009 Mar;135(2), p. 173-8; discussion 179-82.
PMID: 19254073
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Vagal regulation, cortisol, and sleep disruption in women with metastatic breast cancer.
Authors: Palesh O, Zeitzer JM, Conrad A, Giese-Davis J, Mustian KM, Popek V, Nga K, Spiegel D
Source: J Clin Sleep Med, 2008 Oct 15;4(5), p. 441-9.
PMID: 18853702
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Losing sleep over cancer.
Authors: Spiegel D
Source: J Clin Oncol, 2008 May 20;26(15), p. 2431-2.
PMID: 18487562
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A longitudinal study of depression, pain, and stress as predictors of sleep disturbance among women with metastatic breast cancer.
Authors: Palesh OG, Collie K, Batiuchok D, Tilston J, Koopman C, Perlis ML, Butler LD, Carlson R, Spiegel D
Source: Biol Psychol, 2007 Apr;75(1), p. 37-44.
EPub date: 2006 Dec 12.
PMID: 17166646
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