Grant Details
| Grant Number: | 5R01CA118567-05 Interpret this number |
| Primary Investigator: | Spiegel, David |
| Organization: | Stanford University |
| Project Title: | Sleep, Circadian, Hormonal Dysregulation, and Breast Cancer Survival |
| Fiscal Year: | 2010 |
Abstract
DESCRIPTION (provided by applicant): Recent research provides evidence that disrupted circadian rhythms, including hormonal patterns and sleep, are associated with increased risk of breast cancer incidence and faster progression to mortality. We have observed that loss of normal diurnal cortisol rhythm associated with more awakenings during the night predicts early mortality with metastatic breast cancer. Other recent studies have shown that nighttime shift work is associated with higher breast cancer incidence, and in a murine model disrupting circadian cortisol cycles produced a doubling of implanted tumor growth. There is also recent evidence that abnormal clock genes are associated with cancer. However, it is not clear whether sleep disruption per se affects breast cancer progression, or whether such an effect is mediated by hormonal and immune dysregulation of this prevalent and hormone-mediated cancer. We propose to study sleep disruption as a prognostic factor in the progression of metastatic breast cancer. We will also examine sleep patterns in association with disrupted circadian rhythms of cortisol, CRF, ACTH, and melatonin as well as measures of immune function known to be salient to breast cancer progression. These are natural killer cell cytotoxicity and specific cytokines: tumor necrosis factor alpha and nuclear factor kappa B. We plan to recruit 117 women 55 and older with metastatic breast cancer and 63 age and SES-matched controls for a two-week at home sleep study using Actiwatch and one night of in-home EEG monitoring, followed by 32 hours of EEG sleep monitoring and continuous blood sampling in the General Clinical Research Center. This will provide full circadian hormone assessment associated with thorough assessment of sleep patterns. We will relate these measures to the subsequent course of breast cancer progression. Results of this study will provide specific evidence regarding how improved sleep management may affect the course of breast cancer.
Publications
Mind matters in cancer survival.
Authors: Spiegel D
Source: Psychooncology, 2012 Jun;21(6), p. 588-93.
EPub date: 2012 Mar 21.
PMID: 22438289
Related Citations
Grant Numbers:
| NCI NIH HHS - R01CA118567 |
MeSH Terms:
Mind matters in cancer survival.
Authors: Spiegel D
Source: JAMA, 2011 Feb 2;305(5), p. 502-3.
PMID: 21285429
Related Citations
Grant Numbers:
| NCI NIH HHS - 1 R01 CA118567 | NCCAM NIH HHS - 1 P30 AT00 5886 | NIMH NIH HHS - R01 MH47226 |
| NIA NIH HHS - P01 AG18784 |
MeSH Terms:
| Emotions | Terminal Care | Neoplasms |
| Psychophysiology | Patient Participation | Humans |
| Stress, Psychological | Prognosis | Survival |
| Social Support | Decision Making |
Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis.
Authors: Giese-Davis J, Collie K, Rancourt KM, Neri E, Kraemer HC, Spiegel D
Source: J Clin Oncol, 2011 Feb 1;29(4), p. 413-20.
EPub date: 2010 Dec 13.
PMID: 21149651
Related Citations
Grant Numbers:
| NCI NIH HHS - R01CA118567 | NIA NIH HHS - P01AG018784 | NIMH NIH HHS - 5R01MH047226 |
MeSH Terms:
Emotion modulation in PTSD: Clinical and neurobiological evidence for a dissociative subtype.
Authors: Lanius RA, Vermetten E, Loewenstein RJ, Brand B, Schmahl C, Bremner JD, Spiegel D
Source: Am J Psychiatry, 2010 Jun;167(6), p. 640-7.
EPub date: 2010 Apr 1.
PMID: 20360318
Related Citations
Grant Numbers:
| NIMH NIH HHS - R01 MH047226-15 | NIMH NIH HHS - R01 MH060556-04S1 | NCCAM NIH HHS - P30 AT005886-02 |
| NIMH NIH HHS - R21 MH080208-02 | NCI NIH HHS - R01 CA118567-05 | NCRR NIH HHS - S10 RR016917-01 |
| NIA NIH HHS - P01 AG018784-05S2 | NIMH NIH HHS - R01 MH056120-12 | NCCAM NIH HHS - RC1 AT005733-02 |
| NIMH NIH HHS - R01 MH056120-04 | NHLBI NIH HHS - R01 HL088726-04 | NCI NIH HHS - R01 CA061309-03S2 |
| NIMH NIH HHS - K24 MH076955-05 | NIMH NIH HHS - T32 MH067547-05 |
MeSH Terms:
| Magnetic Resonance Imaging | Cerebral Cortex | Humans |
| Gyrus Cinguli | Stress Disorders, Post-Traumatic | Dissociative Disorders |
| Chronic Disease | Amygdala | Affect |
| Neural Inhibition | Memory Disorders |
Hypnotizability, posttraumatic stress, and depressive symptoms in metastatic breast cancer.
Authors: Keuroghlian AS, Butler LD, Neri E, Spiegel D
Source: Int J Clin Exp Hypn, 2010 Jan;58(1), p. 39-52.
PMID: 20183737
Related Citations
Grant Numbers:
| NCI NIH HHS - 5 R01 CA 118567 | NIMH NIH HHS - R01 MH 47226 | NIA NIH HHS - 5P01 AG 018784 |
MeSH Terms:
| Questionnaires | Neoplasm Staging | Psychology |
| Humans | Adult | Stress Disorders, Post-Traumatic |
| Breast Neoplasms | Middle Aged | Depressive Disorder |
| Hypnosis | Female |
Use and misuse of the consolidated standards of reporting trials (CONSORT) guidelines to assess research findings: comment on Coyne, Stefanek, and Palmer (2007).
Authors: Kraemer HC, Kuchler T, Spiegel D
Source: Psychol Bull, 2009 Mar;135(2), p. 173-8; discussion 179-82.
PMID: 19254073
Related Citations
Grant Numbers:
| PHS HHS - 5 P01 18784 | NCI NIH HHS - 5 R01CA118567-02 |
MeSH Terms:
| Randomized Controlled Trials as Topic | Neoplasms | Psychotherapy |
| Humans | Breast Neoplasms | Guidelines as Topic |
| Research | Bias (Epidemiology) | Survival Analysis |
Vagal regulation, cortisol, and sleep disruption in women with metastatic breast cancer.
Authors: Palesh O, Zeitzer JM, Conrad A, Giese-Davis J, Mustian KM, Popek V, Nga K, Spiegel D
Source: J Clin Sleep Med, 2008 Oct 15;4(5), p. 441-9.
PMID: 18853702
Related Citations
Grant Numbers:
| NIA NIH HHS - AG18784 | NCI NIH HHS - CA118567 | NCI NIH HHS - 1 R01 CA118567-01A1 |
MeSH Terms:
Losing sleep over cancer.
Authors: Spiegel D
Source: J Clin Oncol, 2008 May 20;26(15), p. 2431-2.
PMID: 18487562
Related Citations
Grant Numbers:
| PHS HHS - 5 P01 18784 | NCI NIH HHS - 5 R01CA118567-02 |
MeSH Terms:
| Neoplasms | Circadian Rhythm | Humans |
| Sleep Disorders |
A longitudinal study of depression, pain, and stress as predictors of sleep disturbance among women with metastatic breast cancer.
Authors: Palesh OG, Collie K, Batiuchok D, Tilston J, Koopman C, Perlis ML, Butler LD, Carlson R, Spiegel D
Source: Biol Psychol, 2007 Apr;75(1), p. 37-44.
EPub date: 2006 Dec 12.
PMID: 17166646
Related Citations
Grant Numbers:
| NIMH NIH HHS - MH47226 | NIA NIH HHS - P01 AG018784-01A10001 | NIA NIH HHS - AG18784 |
| NIMH NIH HHS - R01 MH047226-10 | NCI NIH HHS - R01 CA118567-01A1 |
MeSH Terms:
