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Grant Details

Grant Number: 5R01CA092585-07 Interpret this number
Primary Investigator: Shu, Xiao-Ou
Organization: Vanderbilt University
Project Title: Soyfood, Gene Polymorphisms and Endometrial Cancer Risk
Fiscal Year: 2010
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Abstract

The Shanghai Endometrial Cancer Study (R01 CA92585) is thus far the largest population-based study of endometrial cancer, involving 1204 cases and 1212 controls. Over the past 6 years we have produced many significant, novel research findings from this study, particularly those related to soy food intake, tea consumption, genetic polymorphisms in the estrogen pathway, and gene-diet interactions in relation to the risk of endometrial cancer. In this renewal application, we propose to evaluate a new set of hypotheses related to the role of genetic variations in inflammation pathway genes in the developm ent of endometrial cancer. These genes were chosen because of the recently recognized critical role that inflammation and because of laboratory evidence indicating their interaction with estrogens and diet in the developm ent and progression of endometrial cancer. To reduce type I errors and enhance the statistical power of the study for gene-disease association studies, as well as gene-gene and gene-diet interactions, w e propose to recruit an additional 400 cases and 400 controls as part of this renewal proposal which will be used to validate all promising associations identified in the funding cycle and during the initial funding cycle. The proposed study, with its strong methodology and novel hypotheses, has great potential for discovering genetic markers and gene-d iet interactions that will be valuable for the prevention of endometrial cancer, one of the most common gynecological malignancies in the United States and many other parts of the world.

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Publications

Association of genetic polymorphisms in cell-cycle control genes and susceptibility to endometrial cancer among Chinese women.
Authors: Cai H, Xiang YB, Qu S, Long J, Cai Q, Gao J, Zheng W, Shu XO
Source: Am J Epidemiol, 2011 Jun 1;173(11), p. 1263-71.
EPub date: 2011 Mar 31.
PMID: 21454826
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Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.
Authors: Xu HL, Xu WH, Cai Q, Feng M, Long J, Zheng W, Xiang YB, Shu XO
Source: Cancer Epidemiol Biomarkers Prev, 2009 Jul;18(7), p. 2114-22.
EPub date: 2009 Jun 16.
PMID: 19531679
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No association between matrix metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and endometrial cancer risk.
Authors: Beeghly-Fadiel A, Xiang YB, Deming SL, Long JR, Xu WH, Cai Q, Zheng W, Shu XO
Source: Cancer Epidemiol Biomarkers Prev, 2009 Jun;18(6), p. 1925-8.
EPub date: 2009 May 12.
PMID: 19435861
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Association of thymidylate synthase gene with endometrial cancer risk in a Chinese population.
Authors: Xu WH, Long JR, Zheng W, Ruan ZX, Cai Q, Cheng JR, Zhao GM, Xiang YB, Shu XO
Source: Cancer Epidemiol Biomarkers Prev, 2009 Feb;18(2), p. 579-84.
EPub date: 2009 Feb 3.
PMID: 19190136
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Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium.
Authors: Setiawan VW, Doherty JA, Shu XO, Akbari MR, Chen C, De Vivo I, Demichele A, Garcia-Closas M, Goodman MT, Haiman CA, Hankinson SE, Henderson BE, Horn-Ross PL, Lacey JV Jr, Le Marchand L, Levine DA, Liang X, Lissowska J, Lurie G, McGrath M, Narod SA, Rebbeck TR, Ursin G, Weiss NS, Xiang YB, Yang HP, Zheng W, Olson SH
Source: Cancer Epidemiol Biomarkers Prev, 2009 Jan;18(1), p. 242-7.
PMID: 19124504
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The Asp(327)Asn polymorphism in the sex hormone-binding globulin gene modifies the association of soy food and tea intake with endometrial cancer risk.
Authors: Xu WH, Zheng W, Cai Q, Cheng JR, Cai H, Xiang YB, Shu XO
Source: Nutr Cancer, 2008;60(6), p. 736-43.
PMID: 19005973
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The modifying effect of C-reactive protein gene polymorphisms on the association between central obesity and endometrial cancer risk.
Authors: Wen W, Cai Q, Xiang YB, Xu WH, Ruan ZX, Cheng J, Zheng W, Shu XO
Source: Cancer, 2008 Jun;112(11), p. 2409-16.
PMID: 18383516
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UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk.
Authors: Deming SL, Zheng W, Xu WH, Cai Q, Ruan Z, Xiang YB, Shu XO
Source: Cancer Epidemiol Biomarkers Prev, 2008 Mar;17(3), p. 563-70.
PMID: 18349273
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Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene.
Authors: Kataoka N, Cai Q, Xu WH, Xiang YB, Cai H, Zheng W, Shu XO
Source: Cancer, 2007 Apr 1;109(7), p. 1296-302.
PMID: 17315164
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