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Grant Details

Grant Number: 5R01CA115857-05 Interpret this number
Primary Investigator: Yang, Ping
Organization: Mayo Clinic Rochester
Project Title: Health and Qol Among Long-Term Lung Cancer Survivors
Fiscal Year: 2010
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Abstract

DESCRIPTION (provided by applicant): The overall likelihood of surviving primary lung cancer beyond five years is approximately 15%. Those who survive beyond five years after a cancer diagnosis have been referred to as long-term survivors. To date, there is limited information about the health status, health behavior, and quality of life (QoL) among long-term lung cancer (LTLC) survivors. This application will primarily focus on a descriptive study of clinical outcomes and general health. Predictors of a longer survival and better QoL among LTLC survivors will be investigated. We will use a conceptual framework developed by Wilson and Clean/7 as a guideline in analyzing health-related QoL. To accomplish our goal, we will utilize an established comprehensive lung cancer resource and expand the current patient cohort that has been followed for a minimum of five years to ten years post diagnosis. Since 2001, more than 120 patients each year in our clinical research program become LTLC survivors and are prospectively followed annually; and therefore, over 1000 survivors will be participants in this proposed study by the year 2010. In Specific Aim 1. We seek to gain a better understanding of the long-term outcomes of these LTLC survivors (including second primary cancers, overall and disease-free survival, and cause of death of deceased patients), their health behaviors, and their QoL. The characteristics of LTLC survivors in the following four major categories will be described: (1) lung cancer therapy including type of treatment, specific regimens, tumor responses, and side effects; (2) subsequent clinical events including new primary cancer(s) and other co-morbid conditions; (3) selected health behaviors including physical activity level, dietary patterns, and tobacco use; and (4) health-related quality of life in five domains: physical, mental, emotional, social, and spiritual well-being. In Specific Aim 2. We will evaluate the effects of factors described in Aim 1 on patients' long-term outcome and QoL. Statistical models will be established for defining predictors of QoL and survival time. By accomplishing this aim, we will gain further understanding about the QoL and health of LTLC survivors in multiple respects of their life, and identify significant contributing factors to improved QoL and prolonged survival. As an important exploratory step, Specific Aim 3 will be focused on identifying biological markers, and their roles in concert with other important prognostic factors identified from Aim 2, in predicting outcomes of lung cancer patients by two sets of case-case comparisons: stage I non small cell lung cancer (NSCLC) patients who died of lung cancer within two years versus those who become LTLC survivors; and stage III NSCLC patients who survived beyond five years after diagnosis versus those who died of lung cancer within two years. New knowledge gained from our proposed study may help lung cancer survivors, their healthcare providers, their caregivers, and the general public by providing evidence for establishing clinical recommendations to enhance their long-term survival and health-related QoL.

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Publications

Evidence that the lung Adenocarcinoma EML4-ALK fusion gene is not caused by exposure to secondhand tobacco smoke during childhood.
Authors: Ryan BM, Wang Y, Jen J, Yi ES, Olivo-Marston S, Yang P, Harris CC
Source: Cancer Epidemiol Biomarkers Prev, 2014 Jul;23(7), p. 1432-4.
EPub date: 2014 Apr 22.
PMID: 24755712
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Correlation of regional emphysema and lung cancer: a lung tissue research consortium-based study.
Authors: Hohberger LA, Schroeder DR, Bartholmai BJ, Yang P, Wendt CH, Bitterman PB, Larsson O, Limper AH
Source: J Thorac Oncol, 2014 May;9(5), p. 639-45.
PMID: 24662456
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Exposure to secondhand tobacco smoke and lung cancer by histological type: a pooled analysis of the International Lung Cancer Consortium (ILCCO).
Authors: Kim CH, Lee YC, Hung RJ, McNallan SR, Cote ML, Lim WY, Chang SC, Kim JH, Ugolini D, Chen Y, Liloglou T, Andrew AS, Onega T, Duell EJ, Field JK, Lazarus P, Le Marchand L, Neri M, Vineis P, Kiyohara C, Hong YC, Morgenstern H, Matsuo K, Tajima K, Christiani DC, McLaughlin JR, Bencko V, Holcatova I, Boffetta P, Brennan P, Fabianova E, Foretova L, Janout V, Lissowska J, Mates D, Rudnai P, Szeszenia-Dabrowska N, Mukeria A, Zaridze D, Seow A, Schwartz AG, Yang P, Zhang ZF
Source: Int J Cancer, 2014 Oct 15;135(8), p. 1918-30.
EPub date: 2014 Mar 25.
PMID: 24615328
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Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers.
Authors: Wu X, Wang L, Ye Y, Aakre JA, Pu X, Chang GC, Yang PC, Roth JA, Marks RS, Lippman SM, Chang JY, Lu C, Deschamps C, Su WC, Wang WC, Huang MS, Chang DW, Li Y, Pankratz VS, Minna JD, Hong WK, Hildebrandt MA, Hsiung CA, Yang P
Source: Cancer Res, 2013 Jul 1;73(13), p. 4028-38.
EPub date: 2013 May 23.
PMID: 23704207
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Spiritual well-being in lung cancer survivors.
Authors: Frost MH, Novotny PJ, Johnson ME, Clark MM, Sloan JA, Yang P
Source: Support Care Cancer, 2013 Jul;21(7), p. 1939-46.
EPub date: 2013 Feb 19.
PMID: 23420557
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Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients.
Authors: Li Y, Tang H, Sun Z, Bungum AO, Edell ES, Lingle WL, Stoddard SM, Zhang M, Jen J, Yang P, Wang L
Source: Lung Cancer, 2013 Apr;80(1), p. 91-8.
EPub date: 2013 Jan 26.
PMID: 23357462
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Physical activity level and quality of life in long term lung cancer survivors.
Authors: Solberg Nes L, Liu H, Patten CA, Rausch SM, Sloan JA, Garces YI, Cheville AL, Yang P, Clark MM
Source: Lung Cancer, 2012 Sep;77(3), p. 611-6.
EPub date: 2012 Jun 6.
PMID: 22681871
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SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors.
Authors: Rausch SM, Gonzalez BD, Clark MM, Patten C, Felten S, Liu H, Li Y, Sloan J, Yang P
Source: Lung Cancer, 2012 Jul;77(1), p. 217-23.
EPub date: 2012 Mar 29.
PMID: 22464751
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Effect of cigarette smoking on quality of life in small cell lung cancer patients.
Authors: Chen J, Qi Y, Wampfler JA, Jatoi A, Garces YI, Busta AJ, Mandrekar SJ, Yang P
Source: Eur J Cancer, 2012 Jul;48(11), p. 1593-601.
EPub date: 2012 Jan 12.
PMID: 22244802
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Worse disease-free survival in never-smokers with ALK+ lung adenocarcinoma.
Authors: Yang P, Kulig K, Boland JM, Erickson-Johnson MR, Oliveira AM, Wampfler J, Jatoi A, Deschamps C, Marks R, Fortner C, Stoddard S, Nichols F, Molina J, Aubry MC, Tang H, Yi ES
Source: J Thorac Oncol, 2012 Jan;7(1), p. 90-7.
PMID: 22134072
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Quality of life and symptom burden among long-term lung cancer survivors.
Authors: Yang P, Cheville AL, Wampfler JA, Garces YI, Jatoi A, Clark MM, Cassivi SD, Midthun DE, Marks RS, Aubry MC, Okuno SH, Williams BA, Nichols FC, Trastek VF, Sugimura H, Sarna L, Allen MS, Deschamps C, Sloan JA
Source: J Thorac Oncol, 2012 Jan;7(1), p. 64-70.
PMID: 22134070
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The purported effects of alcohol on appetite and weight in lung cancer patients.
Authors: Jatoi A, Qi Y, Wampfler JA, Busta AJ, Yang P, Mandrekar S
Source: Nutr Cancer, 2011 Nov;63(8), p. 1251-5.
EPub date: 2011 Oct 14.
PMID: 21999412
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Lung cancer in never smokers.
Authors: Yang P
Source: Semin Respir Crit Care Med, 2011 Feb;32(1), p. 10-21.
EPub date: 2011 Apr 15.
PMID: 21500120
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Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy.
Authors: Wu X, Ye Y, Rosell R, Amos CI, Stewart DJ, Hildebrandt MA, Roth JA, Minna JD, Gu J, Lin J, Buch SC, Nukui T, Ramirez Serrano JL, Taron M, Cassidy A, Lu C, Chang JY, Lippman SM, Hong WK, Spitz MR, Romkes M, Yang P
Source: J Natl Cancer Inst, 2011 May 18;103(10), p. 817-25.
EPub date: 2011 Apr 11.
PMID: 21483023
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Fatigue, dyspnea, and cough comprise a persistent symptom cluster up to five years after diagnosis with lung cancer.
Authors: Cheville AL, Novotny PJ, Sloan JA, Basford JR, Wampfler JA, Garces YI, Jatoi A, Yang P
Source: J Pain Symptom Manage, 2011 Aug;42(2), p. 202-12.
EPub date: 2011 Mar 12.
PMID: 21398090
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The value of a symptom cluster of fatigue, dyspnea, and cough in predicting clinical outcomes in lung cancer survivors.
Authors: Cheville AL, Novotny PJ, Sloan JA, Basford JR, Wampfler JA, Garces YI, Jatoi A, Yang P
Source: J Pain Symptom Manage, 2011 Aug;42(2), p. 213-21.
EPub date: 2011 Mar 12.
PMID: 21398089
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Effect of emphysema on lung cancer risk in smokers: a computed tomography-based assessment.
Authors: Li Y, Swensen SJ, Karabekmez LG, Marks RS, Stoddard SM, Jiang R, Worra JB, Zhang F, Midthun DE, de Andrade M, Song Y, Yang P
Source: Cancer Prev Res (Phila), 2011 Jan;4(1), p. 43-50.
EPub date: 2010 Nov 30.
PMID: 21119049
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Relationship between cytokine gene single nucleotide polymorphisms and symptom burden and quality of life in lung cancer survivors.
Authors: Rausch SM, Clark MM, Patten C, Liu H, Felten S, Li Y, Sloan J, Yang P
Source: Cancer, 2010 Sep 1;116(17), p. 4103-13.
PMID: 20564140
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Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.
Authors: Moyer AM, Sun Z, Batzler AJ, Li L, Schaid DJ, Yang P, Weinshilboum RM
Source: Cancer Epidemiol Biomarkers Prev, 2010 Mar;19(3), p. 811-21.
EPub date: 2010 Mar 3.
PMID: 20200426
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A pessimistic explanatory style is prognostic for poor lung cancer survival.
Authors: Novotny P, Colligan RC, Szydlo DW, Clark MM, Rausch S, Wampfler J, Sloan JA, Yang P
Source: J Thorac Oncol, 2010 Mar;5(3), p. 326-32.
PMID: 20139778
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A rigorous and comprehensive validation: common genetic variations and lung cancer.
Authors: Yang P, Li Y, Jiang R, Cunningham JM, Li Y, Zhang F, de Andrade M
Source: Cancer Epidemiol Biomarkers Prev, 2010 Jan;19(1), p. 240-4.
PMID: 20056643
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The cancer anorexia/weight loss syndrome: exploring associations with single nucleotide polymorphisms (SNPs) of inflammatory cytokines in patients with non-small cell lung cancer.
Authors: Jatoi A, Qi Y, Kendall G, Jiang R, McNallan S, Cunningham J, Mandrekar S, Yang P
Source: Support Care Cancer, 2010 Oct;18(10), p. 1299-304.
EPub date: 2009 Dec 15.
PMID: 20012999
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Prognostic factors for limited-stage small cell lung cancer: a study of 284 patients.
Authors: Chen J, Jiang R, Garces YI, Jatoi A, Stoddard SM, Sun Z, Marks RS, Liu Y, Yang P
Source: Lung Cancer, 2010 Feb;67(2), p. 221-6.
EPub date: 2009 Jun 3.
PMID: 19497635
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Epidemiology of lung cancer prognosis: quantity and quality of life.
Authors: Yang P
Source: Methods Mol Biol, 2009;471, p. 469-86.
PMID: 19109795
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Non-overlapping and non-cell-type-specific gene expression signatures predict lung cancer survival.
Authors: Sun Z, Wigle DA, Yang P
Source: J Clin Oncol, 2008 Feb 20;26(6), p. 877-83.
PMID: 18281660
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Motivational readiness for physical activity and quality of life in long-term lung cancer survivors.
Authors: Clark MM, Novotny PJ, Patten CA, Rausch SM, Garces YI, Jatoi A, Sloan JA, Yang P
Source: Lung Cancer, 2008 Jul;61(1), p. 117-22.
EPub date: 2008 Feb 19.
PMID: 18243406
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Does marital status impact survival and quality of life in patients with non-small cell lung cancer? Observations from the mayo clinic lung cancer cohort.
Authors: Jatoi A, Novotny P, Cassivi S, Clark MM, Midthun D, Patten CA, Sloan J, Yang P
Source: Oncologist, 2007 Dec;12(12), p. 1456-63.
PMID: 18165623
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