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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA109468-05 Interpret this number
Primary Investigator: Claus, Elizabeth
Organization: Yale University
Project Title: MENINGIOMA: Risk Factors and Quality of Life
Fiscal Year: 2010
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Abstract

DESCRIPTION (provided by applicant): No large-scale study within the United States has examined any aspect of the epidemiology of intracranial meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to conduct a population-based case/control study of meningioma within the states of Connecticut, Massachusetts, North Carolina, and Texas as well as the San Francisco Bay area under the mechanism of an integrated R01 (Note that identical applications are submitted for all five sites). Cases will be selected using rapid case ascertainment and will include all male and female individuals diagnosed with a histologically confirmed intra-cranial meningioma between the ages of 20 and 79 years from 7/1/2006 through 6/30/2010 in the above listed regions. Control subjects will be identified via random-digit dial methods and matched to the cases by sex, ethnicity, geographic location, and five-year age category. Study subjects will be administered a telephone questionnaire to collect information on the two primary categories of risk, exposure to ionizing radiation and hormones as well as additional risk factors such as family history of meningioma and other tumors, cell-phone utilization, and head trauma as well as questions on outcome and quality of life. Parraffin-embedded tumor tissue blocks will be obtained for case subjects to allow for 1) a uniform histological review, and 2) immunohistochemical testing for estrogen, progesterone, androgen and MIB-1 receptors. Blood or buccal specimens will be collected from all study subjects for testing of DNA polymorphisms in DNA repair and cell cycle genes. This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma.

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Publications

Exogenous Hormone Use And Meningioma Risk: What Do We Tell Our Patients?
Authors: Claus E.B. , Black P.M. , Bondy M.L. , Calvocoressi L. , Schildkraut J.M. , Wiemels J.L. , Wrensch M. .
Source: Cancer, 2007-08-01 00:00:00.0; 110(3), p. 471-6.
PMID: 17580362
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Specific Genes Expressed In Association With Progesterone Receptors In Meningioma
Authors: Claus E.B. , Park P.J. , Carroll R. , Chan J. , Black P.M. .
Source: Cancer Research, 2008-01-01 00:00:00.0; 68(1), p. 314-22.
PMID: 18172325
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Epidemiology And Etiology Of Meningioma
Authors: Wiemels J. , Wrensch M. , Claus E.B. .
Source: Journal Of Neuro-oncology, 2010 Sep; 99(3), p. 307-14.
PMID: 20821343
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Reduced Allergy And Immunoglobulin E Among Adults With Intracranial Meningioma Compared To Controls
Authors: Wiemels J.L. , Wrensch M. , Sison J.D. , Zhou M. , Bondy M. , Calvocoressi L. , Black P.M. , Yu H. , Schildkraut J.M. , Claus E.B. .
Source: International Journal Of Cancer, 2011-10-15 00:00:00.0; 129(8), p. 1932-9.
PMID: 21520030
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Treatment And Survival Of Patients With Nonmalignant Intracranial Meningioma: Results From The Surveillance, Epidemiology, And End Results Program Of The National Cancer Institute. Clinical Article
Authors: Cahill K.S. , Claus E.B. .
Source: Journal Of Neurosurgery, 2011 Aug; 115(2), p. 259-67.
PMID: 21529132
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Family And Personal Medical History And Risk Of Meningioma
Authors: Claus E.B. , Calvocoressi L. , Bondy M.L. , Schildkraut J.M. , Wiemels J.L. , Wrensch M. .
Source: Journal Of Neurosurgery, 2011 Dec; 115(6), p. 1072-7.
PMID: 21780859
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Cigarette Smoking And Risk Of Meningioma: The Effect Of Gender
Authors: Claus E.B. , Walsh K.M. , Calvocoressi L. , Bondy M.L. , Schildkraut J.M. , Wrensch M. , Wiemels J.L. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2012 Jun; 21(6), p. 943-50.
PMID: 22473761
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Dental X-rays And Risk Of Meningioma
Authors: Claus E.B. , Calvocoressi L. , Bondy M.L. , Schildkraut J.M. , Wiemels J.L. , Wrensch M. .
Source: Cancer, 2012-09-15 00:00:00.0; 118(18), p. 4530-7.
PMID: 22492363
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Exogenous Hormone Use, Reproductive Factors, And Risk Of Intracranial Meningioma In Females
Authors: Claus E.B. , Calvocoressi L. , Bondy M.L. , Wrensch M. , Wiemels J.L. , Schildkraut J.M. .
Source: Journal Of Neurosurgery, 2013 Mar; 118(3), p. 649-56.
PMID: 23101448
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Assessment Of Autoantibodies To Meningioma In A Population-based Study
Authors: Wiemels J.L. , Bracci P.M. , Wrensch M. , Schildkraut J. , Bondy M. , Pfefferle J. , Zhou M. , Sison J. , Calvocoressi L. , Claus E.B. .
Source: American Journal Of Epidemiology, 2013-01-01 00:00:00.0; 177(1), p. 75-83.
PMID: 23221727
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Dental X-rays And Risk Of Meningioma: Response To Drs. Calnon, Jorgensen, And White
Authors: Claus E.B. , Wiemels J. , Wrensch M. .
Source: Cancer, 2013-01-15 00:00:00.0; 119(2), p. 465-6.
PMID: 23254687
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Endogenous And Exogenous Hormone Exposure And The Risk Of Meningioma In Men
Authors: Schildkraut J.M. , Calvocoressi L. , Wang F. , Wrensch M. , Bondy M.L. , Wiemels J.L. , Claus E.B. .
Source: Journal Of Neurosurgery, 2014 Apr; 120(4), p. 820-6.
PMID: 24484233
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