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Grant Details

Grant Number: 3U01CA093326-05S1 Interpret this number
Primary Investigator: Sandler, Robert
Organization: Univ Of North Carolina Chapel Hill
Project Title: NC Colorectal Cancer Care Outcomes Research Study
Fiscal Year: 2008
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Abstract

The burden of suffering from colorectal cancer is substantial. Although there has been tremendous progress in understanding the biology of colorectal cancer, and important advances in treatment, there is a lack of knowledge about the effect of specific process measures on health and behavioral outcomes. The long-term objective of the proposed study is to establish a system to examine the relationship of processes of care to clinical and patient care outcomes. The specific aims of this research are: 1) To assess determinants of access to cancer care services according to patient, health care delivery system and physician characteristics. 2) To describe variations in cancer practice patterns in vulnerable populations. 3) To longitudinally assess a range of clinical and patient-oriented health outcomes. 4) To identify patient, provider, and health system factors influencing the dissemination of effective interventions. 5) To assess the contribution of lifestyle factors on prognosis and outcomes. 6) To examine comorbid illness, diagnostic workup, surgical management and details of staging to investigate racial disparity. The study will enroll a population-based cohort of 1000 newly diagnosed colorectal cancer patients from a 22-county area in central and eastern North Carolina. To evaluate racial disparities, the study will include equal numbers of blacks and whites. Cases will be identified using the rapid ascertainment mechanisms of the North Carolina Central Cancer Registry using methods from an ongoing population-based case-control study. Cases will be interviewed by telephone and mailed surveys. Staff from Medical Review of North Carolina, a non-profit quality improvement organization, will abstract hospital records and physician office charts. Special research projects will 1) evaluate the effect of functional health literacy on treatment and outcomes; 2) collect blood specimens and tumor blocks to create a biorepository for future analyses.

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Publications

Enrollment of patients with lung and colorectal cancers onto clinical trials.
Authors: Fouad MN, Lee JY, Catalano PJ, Vogt TM, Zafar SY, West DW, Simon C, Klabunde CN, Kahn KL, Weeks JC, Kiefe CI
Source: J Oncol Pract, 2013 Mar;9(2), p. e40-7.
PMID: 23814523
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Economic burden for informal caregivers of lung and colorectal cancer patients.
Authors: Van Houtven CH, Ramsey SD, Hornbrook MC, Atienza AA, van Ryn M
Source: Oncologist, 2010;15(8), p. 883-93.
EPub date: 2010 Jul 28.
PMID: 20667966
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Objective burden, resources, and other stressors among informal cancer caregivers: a hidden quality issue?
Authors: van Ryn M, Sanders S, Kahn K, van Houtven C, Griffin JM, Martin M, Atienza AA, Phelan S, Finstad D, Rowland J
Source: Psychooncology, 2011 Jan;20(1), p. 44-52.
PMID: 20201115
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Statistical strategies to improve the efficiency of molecular studies of colorectal cancer prognosis.
Authors: Qu P, Chu H, Ibrahim JG, Peacock J, Shen XJ, Tepper J, Sandler RS, Keku TO
Source: Br J Cancer, 2008 Dec 16;99(12), p. 2001-5.
EPub date: 2008 Nov 18.
PMID: 19018265
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The effect of hospital and surgeon volume on outcomes for rectal cancer surgery.
Authors: Salz T, Sandler RS
Source: Clin Gastroenterol Hepatol, 2008 Nov;6(11), p. 1185-93.
EPub date: 2008 Oct 1.
PMID: 18829393
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Understanding cancer patients' experience and outcomes: development and pilot study of the Cancer Care Outcomes Research and Surveillance patient survey.
Authors: Malin JL, Ko C, Ayanian JZ, Harrington D, Nerenz DR, Kahn KL, Ganther-Urmie J, Catalano PJ, Zaslavsky AM, Wallace RB, Guadagnoli E, Arora NK, Roudier MD, Ganz PA
Source: Support Care Cancer, 2006 Aug;14(8), p. 837-48.
EPub date: 2006 Feb 16.
PMID: 16482448
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Patient perspectives on research recruitment through cancer registries.
Authors: Beskow LM, Sandler RS, Millikan RC, Weinberger M
Source: Cancer Causes Control, 2005 Dec;16(10), p. 1171-5.
PMID: 16215867
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Understanding cancer treatment and outcomes: the Cancer Care Outcomes Research and Surveillance Consortium.
Authors: Ayanian JZ, Chrischilles EA, Fletcher RH, Fouad MN, Harrington DP, Kahn KL, Kiefe CI, Lipscomb J, Malin JL, Potosky AL, Provenzale DT, Sandler RS, van Ryn M, Wallace RB, Weeks JC, West DW
Source: J Clin Oncol, 2004 Aug 1;22(15), p. 2992-6.
PMID: 15284250
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