Skip Navigation
Grant Details

Grant Number: 5R03CA133914-02 Interpret this number
Primary Investigator: Han, Jiali
Organization: Brigham And Women'S Hospital
Project Title: Prospective Study of Telomere Length and Melanoma Risk
Fiscal Year: 2009
Back to top


Abstract

DESCRIPTION (provided by applicant): Abstract: Prospective study of telomere length and melanoma risk Telomere length in peripheral blood leukocytes (PBLs) has emerged as a potential biomarker of aging and of risk of age-related diseases such as cancers. Telomere length is determined in part by inherited genetic factors. In addition to causing DNA damage, UVB irradiation shortens telomeres. In skin tissue, telomere disruption triggers multiple DNA damage responses. We propose to examine telomere length and genetic variants in telomere-related genes in relation to the risk of cutaneous malignant melanoma (hereafter called melanoma). We will include 586 incident cases of melanoma and 586 matched controls who provided blood samples pre-diagnostically from three large well- characterized cohorts, the Women's Health Initiative Observational Study, the Nurses Health Study, and Nurses Health Study II. In addition, we will assess the interactions between telomere length and genetic variants in telomere-related genes and tendency to burn/tan on melanoma risk. This application will take advantage of the research opportunities nested within the existing well-characterized cohort, including cohort characteristics, quality of design, high follow-up rate, and large sample size. Our study will also take advantage of the previously confirmed cases of melanoma, stored blood and DNA samples, as well as previously collected information on host risk factors. To date, no one has evaluated how telomere length or genetic variation in telomere-related genes may influence melanoma risk. In this study, we will examine whether the risk of melanoma is higher in women with shorter telomeres and is influenced by variation in genes related to telomere stability and maintenance. Establishing the relationship between telomere length in pre-diagnostically collected peripheral blood leukocytes and melanoma risk will be important for several reasons. It would provide corroboration for the hypothesis that biological processes related to aging are important determinants of melanoma risk and may provide an assay to be used part of an assessment of melanoma risk. This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. Project Narrative: We propose a prospective evaluation of telomere length and the genetic variants in telomere-related genes in relation to the risk of cutaneous malignant melanoma. Establishing the relationship between telomere length in pre-diagnostically collected peripheral blood leukocytes and melanoma risk will be important for several reasons. It would provide corroboration for the hypothesis that biological processes related to aging are important determinants of melanoma risk and may provide an assay to be used part of an assessment of melanoma risk. This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies.

Back to top


Publications

Genetic predisposition to higher body mass index or type 2 diabetes and leukocyte telomere length in the Nurses' Health Study.
Authors: Du M, Prescott J, Cornelis MC, Hankinson SE, Giovannucci E, Kraft P, De Vivo I
Source: PLoS One, 2013;8(2), p. e52240.
EPub date: 2013 Feb 12.
PMID: 23424613
Related Citations

Back to top


Paternal age at birth is associated with offspring leukocyte telomere length in the nurses' health study.
Authors: Prescott J, Du M, Wong JY, Han J, De Vivo I
Source: Hum Reprod, 2012 Dec;27(12), p. 3622-31.
EPub date: 2012 Aug 30.
PMID: 22940768
Related Citations

Back to top


Shorter telomeres associate with a reduced risk of melanoma development.
Authors: Nan H, Du M, De Vivo I, Manson JE, Liu S, McTiernan A, Curb JD, Lessin LS, Bonner MR, Guo Q, Qureshi AA, Hunter DJ, Han J
Source: Cancer Res, 2011 Nov 1;71(21), p. 6758-63.
EPub date: 2011 Oct 25.
PMID: 22028319
Related Citations

Back to top


Associations between rotating night shifts, sleep duration, and telomere length in women.
Authors: Liang G, Schernhammer E, Qi L, Gao X, De Vivo I, Han J
Source: PLoS One, 2011;6(8), p. e23462.
EPub date: 2011 Aug 10.
PMID: 21853136
Related Citations

Back to top


Genome-wide association study of relative telomere length.
Authors: Prescott J, Kraft P, Chasman DI, Savage SA, Mirabello L, Berndt SI, Weissfeld JL, Han J, Hayes RB, Chanock SJ, Hunter DJ, De Vivo I
Source: PLoS One, 2011 May 10;6(5), p. e19635.
EPub date: 2011 May 10.
PMID: 21573004
Related Citations

Back to top


No association between telomere length in peripheral blood leukocytes and the risk of nonmelanoma skin cancer.
Authors: Liang G, Qureshi AA, Guo Q, De Vivo I, Han J
Source: Cancer Epidemiol Biomarkers Prev, 2011 May;20(5), p. 1043-5.
EPub date: 2011 Feb 25.
PMID: 21357377
Related Citations

Back to top


Genetic variants in telomere-maintaining genes and skin cancer risk.
Authors: Nan H, Qureshi AA, Prescott J, De Vivo I, Han J
Source: Hum Genet, 2011 Mar;129(3), p. 247-53.
EPub date: 2010 Nov 30.
PMID: 21116649
Related Citations

Back to top


A prospective study of telomere length and the risk of skin cancer.
Authors: Han J, Qureshi AA, Prescott J, Guo Q, Ye L, Hunter DJ, De Vivo I
Source: J Invest Dermatol, 2009 Feb;129(2), p. 415-21.
EPub date: 2008 Jul 31.
PMID: 18668136
Related Citations

Back to top