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Grant Details

Grant Number: 7R01CA100555-05 Interpret this number
Primary Investigator: Chiu, Brian
Organization: University Of Chicago
Project Title: Lymphoma Defined Cytogenetically for Epidemiologic Study
Fiscal Year: 2009
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Abstract

DESCRIPTION (provided by applicant): It is important that analytic epidemiologic studies of non-Hodgkin's lymphoma (NHL) focus on risk factors according to NHL subtypes because: 1) NHL comprises a heterogeneous group of malignancies that vary in etiology; and 2) the patterns of change in NHL incidence vary across different subtypes. At this time, NHL cannot be subdivided into standard pathologic categories for epidemiologic studies. We propose to define NHL according to rearrangements of the BCL2, BCL6, and C-MYC genes because cytogenetic studies have shown that recurring chromosomal abnormalities leading to the deregulation of these genes are important in the pathogenesis of certain NHL subtypes. The central innovative hypothesis is that risk factors differ for discrete subsets of NHL defined by genetic abnormalities, The rationale is that cases with specific, nonrandom chromosomal abnormalities may be more closely related etiologically than NHL cases as a whole. The specific aims are to investigate whether the associations with cigarette smoking, farming and pesticide exposure, family history of hematopoietic cancer, and dietary intake of animal fat differs for BCL2 rearrangement-positive NHL, BCL6 rearrangement-positive NHL and C-MYC rearrangement-positive NHL. We estimate that 540 tumor blocks will be available (and of which, 530 will yield chromosomal information) from NHL cases in two existing population-based, case-control studies conducted in Nebraska, and there will be data on 1967 controls for comparison. Fluorescence in-situ hybridization (FISH) technique will be used to determine the rearrangements of the BCL2, BCL6, and C-MYC genes. Subtypes of NHL will be defined by the presence or absence of the specific genetic abnormalities. Logistic regression model will be used to calculate the odds ratios for rearrangement defined subsets of NHL associated with exposures. Polytomous logistic regression will be used to compare associations across discrete subsets of NHL defined by rearrangements. The results will be significant because they could provide new insights about the etiology of lymphomagenesis. Because the study population is well-characterized and extensive data on exposures have been collected, the current proposal is extremely cost-effective to address the etiology of NHL, one of the most common malignancies in this country. The long-term objective is to improve understanding of the disease process which may ultimately lead to appropriate preventive measures in the general population.

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Publications

Pre-diagnosis cigarette smoking and overall survival in non-Hodgkin lymphoma.
Authors: Ollberding NJ, Evens AM, Aschebrook-Kilfoy B, Caces DB, Weisenburger DD, Smith SM, Chiu BC
Source: Br J Haematol, 2013 Nov;163(3), p. 352-6.
EPub date: 2013 Aug 2.
PMID: 23909494
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Dietary intake of fruits and vegetables and overall survival in non-Hodgkin lymphoma.
Authors: Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Smith SM, Weisenburger DD, Chiu BC
Source: Leuk Lymphoma, 2013 Dec;54(12), p. 2613-9.
EPub date: 2013 Apr 30.
PMID: 23488609
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An upward trend in the age-specific incidence patterns for mantle cell lymphoma in the USA.
Authors: Aschebrook-Kilfoy B, Caces DB, Ollberding NJ, Smith SM, Chiu BC
Source: Leuk Lymphoma, 2013 Aug;54(8), p. 1677-83.
EPub date: 2013 Feb 7.
PMID: 23350889
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Phytanic acid and the risk of non-Hodgkin lymphoma.
Authors: Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Wright ME, Weisenburger DD, Smith SM, Chiu BC
Source: Carcinogenesis, 2013 Jan;34(1), p. 170-5.
EPub date: 2012 Oct 5.
PMID: 23042099
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Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma.
Authors: Aschebrook-Kilfoy B, Ward MH, Dave BJ, Smith SM, Weisenburger DD, Chiu BC
Source: Leuk Lymphoma, 2013 May;54(5), p. 945-50.
EPub date: 2012 Oct 24.
PMID: 23013327
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Meat intake and risk of non-Hodgkin lymphoma.
Authors: Aschebrook-Kilfoy B, Ollberding NJ, Kolar C, Lawson TA, Smith SM, Weisenburger DD, Chiu BC
Source: Cancer Causes Control, 2012 Oct;23(10), p. 1681-92.
EPub date: 2012 Aug 14.
PMID: 22890783
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Dietary intake of fruit and vegetables and risk of non-Hodgkin lymphoma.
Authors: Chiu BC, Kwon S, Evens AM, Surawicz T, Smith SM, Weisenburger DD
Source: Cancer Causes Control, 2011 Aug;22(8), p. 1183-95.
EPub date: 2011 Jun 22.
PMID: 21695384
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Pesticides, chromosomal aberrations, and non-Hodgkin's lymphoma.
Authors: Chiu BC, Blair A
Source: J Agromedicine, 2009;14(2), p. 250-5.
PMID: 19437285
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The utility of t(14;18) in understanding risk factors for non-Hodgkin lymphoma.
Authors: Chiu BC, Lan Q, Dave BJ, Blair A, Zahm SH, Weisenburger DD
Source: J Natl Cancer Inst Monogr, 2008;null(39), p. 69-73.
PMID: 18648007
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Dietary factors and risk of t(14;18)-defined subgroups of non-Hodgkin lymphoma.
Authors: Chiu BC, Dave BJ, Ward MH, Fought AJ, Hou L, Jain S, Gapstur S, Evens AM, Zahm SH, Blair A, Weisenburger DD
Source: Cancer Causes Control, 2008 Oct;19(8), p. 859-67.
EPub date: 2008 Apr 2.
PMID: 18386141
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