Skip Navigation
Grant Details

Grant Number: 7R01CA100555-05 Interpret this number
Primary Investigator: Chiu, Brian
Organization: University Of Chicago
Project Title: Lymphoma Defined Cytogenetically for Epidemiologic Study
Fiscal Year: 2009
Back to top


Abstract

DESCRIPTION (provided by applicant): It is important that analytic epidemiologic studies of non-Hodgkin's lymphoma (NHL) focus on risk factors according to NHL subtypes because: 1) NHL comprises a heterogeneous group of malignancies that vary in etiology; and 2) the patterns of change in NHL incidence vary across different subtypes. At this time, NHL cannot be subdivided into standard pathologic categories for epidemiologic studies. We propose to define NHL according to rearrangements of the BCL2, BCL6, and C-MYC genes because cytogenetic studies have shown that recurring chromosomal abnormalities leading to the deregulation of these genes are important in the pathogenesis of certain NHL subtypes. The central innovative hypothesis is that risk factors differ for discrete subsets of NHL defined by genetic abnormalities, The rationale is that cases with specific, nonrandom chromosomal abnormalities may be more closely related etiologically than NHL cases as a whole. The specific aims are to investigate whether the associations with cigarette smoking, farming and pesticide exposure, family history of hematopoietic cancer, and dietary intake of animal fat differs for BCL2 rearrangement-positive NHL, BCL6 rearrangement-positive NHL and C-MYC rearrangement-positive NHL. We estimate that 540 tumor blocks will be available (and of which, 530 will yield chromosomal information) from NHL cases in two existing population-based, case-control studies conducted in Nebraska, and there will be data on 1967 controls for comparison. Fluorescence in-situ hybridization (FISH) technique will be used to determine the rearrangements of the BCL2, BCL6, and C-MYC genes. Subtypes of NHL will be defined by the presence or absence of the specific genetic abnormalities. Logistic regression model will be used to calculate the odds ratios for rearrangement defined subsets of NHL associated with exposures. Polytomous logistic regression will be used to compare associations across discrete subsets of NHL defined by rearrangements. The results will be significant because they could provide new insights about the etiology of lymphomagenesis. Because the study population is well-characterized and extensive data on exposures have been collected, the current proposal is extremely cost-effective to address the etiology of NHL, one of the most common malignancies in this country. The long-term objective is to improve understanding of the disease process which may ultimately lead to appropriate preventive measures in the general population.

Back to top


Publications

Etiologic heterogeneity among non-Hodgkin lymphoma subtypes: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Morton LM, Slager SL, Cerhan JR, Wang SS, Vajdic CM, Skibola CF, Bracci PM, de Sanjosé S, Smedby KE, Chiu BC, Zhang Y, Mbulaiteye SM, Monnereau A, Turner JJ, Clavel J, Adami HO, Chang ET, Glimelius B, Hjalgrim H, Melbye M, Crosignani P, di Lollo S, Miligi L, Nanni O, Ramazzotti V, Rodella S, Costantini AS, Stagnaro E, Tumino R, Vindigni C, Vineis P, Becker N, Benavente Y, Boffetta P, Brennan P, Cocco P, Foretova L, Maynadié M, Nieters A, Staines A, Colt JS, Cozen W, Davis S, de Roos AJ, Hartge P, Rothman N, Severson RK, Holly EA, Call TG, Feldman AL, Habermann TM, Liebow M, Blair A, Cantor KP, Kane EV, Lightfoot T, Roman E, Smith A, Brooks-Wilson A, Connors JM, Gascoyne RD, Spinelli JJ, Armstrong BK, Kricker A, Holford TR, Lan Q, Zheng T, Orsi L, Dal Maso L, Franceschi S, La Vecchia C, Negri E, Serraino D, Bernstein L, Levine A, Friedberg JW, Kelly JL, Berndt SI, Birmann BM, Clarke CA, Flowers CR, Foran JM, Kadin ME, Paltiel O, Weisenburger DD, Linet MS, Sampson JN
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 130-44.
PMID: 25174034
Related Citations

Back to top


Medical history, lifestyle, family history, and occupational risk factors for adult acute lymphocytic leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Skibola CF, Slager SL, Berndt SI, Lightfoot T, Sampson JN, Morton LM, Weisenburger DD
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 125-9.
PMID: 25174033
Related Citations

Back to top


Medical history, lifestyle, and occupational risk factors for hairy cell leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Monnereau A, Slager SL, Hughes AM, Smith A, Glimelius B, Habermann TM, Berndt SI, Staines A, Norman AD, Cerhan JR, Sampson JN, Morton LM, Clavel J
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 115-24.
PMID: 25174032
Related Citations

Back to top


Medical history, lifestyle, family history, and occupational risk factors for sporadic Burkitt lymphoma/leukemia: the Interlymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Mbulaiteye SM, Morton LM, Sampson JN, Chang ET, Costas L, de Sanjosé S, Lightfoot T, Kelly J, Friedberg JW, Cozen W, Marcos-Gragera R, Slager SL, Birmann BM, Weisenburger DD
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 106-14.
PMID: 25174031
Related Citations

Back to top


Medical history, lifestyle, family history, and occupational risk factors for mycosis fungoides and Sézary syndrome: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Aschebrook-Kilfoy B, Cocco P, La Vecchia C, Chang ET, Vajdic CM, Kadin ME, Spinelli JJ, Morton LM, Kane EV, Sampson JN, Kasten C, Feldman AL, Wang SS, Zhang Y
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 98-105.
PMID: 25174030
Related Citations

Back to top


Medical history, lifestyle, family history, and occupational risk factors for lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Vajdic CM, Landgren O, McMaster ML, Slager SL, Brooks-Wilson A, Smith A, Staines A, Dogan A, Ansell SM, Sampson JN, Morton LM, Linet MS
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 87-97.
PMID: 25174029
Related Citations

Back to top


Medical history, lifestyle, family history, and occupational risk factors for mantle cell lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Smedby KE, Sampson JN, Turner JJ, Slager SL, Maynadié M, Roman E, Habermann TM, Flowers CR, Berndt SI, Bracci PM, Hjalgrim H, Weisenburger DD, Morton LM
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 76-86.
PMID: 25174028
Related Citations

Back to top


Medical history, lifestyle, family history, and occupational risk factors for peripheral T-cell lymphomas: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Wang SS, Flowers CR, Kadin ME, Chang ET, Hughes AM, Ansell SM, Feldman AL, Lightfoot T, Boffetta P, Melbye M, Lan Q, Sampson JN, Morton LM, Zhang Y, Weisenburger DD
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 66-75.
PMID: 25174027
Related Citations

Back to top


Medical history, lifestyle, family history, and occupational risk factors for marginal zone lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Bracci PM, Benavente Y, Turner JJ, Paltiel O, Slager SL, Vajdic CM, Norman AD, Cerhan JR, Chiu BC, Becker N, Cocco P, Dogan A, Nieters A, Holly EA, Kane EV, Smedby KE, Maynadié M, Spinelli JJ, Roman E, Glimelius B, Wang SS, Sampson JN, Morton LM, de Sanjosé S
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 52-65.
PMID: 25174026
Related Citations

Back to top


Medical history, lifestyle, family history, and occupational risk factors for chronic lymphocytic leukemia/small lymphocytic lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Slager SL, Benavente Y, Blair A, Vermeulen R, Cerhan JR, Costantini AS, Monnereau A, Nieters A, Clavel J, Call TG, Maynadié M, Lan Q, Clarke CA, Lightfoot T, Norman AD, Sampson JN, Casabonne D, Cocco P, de Sanjosé S
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 41-51.
PMID: 25174025
Related Citations

Back to top


Medical history, lifestyle, family history, and occupational risk factors for follicular lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Linet MS, Vajdic CM, Morton LM, de Roos AJ, Skibola CF, Boffetta P, Cerhan JR, Flowers CR, de Sanjosé S, Monnereau A, Cocco P, Kelly JL, Smith AG, Weisenburger DD, Clarke CA, Blair A, Bernstein L, Zheng T, Miligi L, Clavel J, Benavente Y, Chiu BC
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 26-40.
PMID: 25174024
Related Citations

Back to top


Medical history, lifestyle, family history, and occupational risk factors for diffuse large B-cell lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Cerhan JR, Kricker A, Paltiel O, Flowers CR, Wang SS, Monnereau A, Blair A, Dal Maso L, Kane EV, Nieters A, Foran JM, Miligi L, Clavel J, Bernstein L, Rothman N, Slager SL, Sampson JN, Morton LM, Skibola CF
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 15-25.
PMID: 25174023
Related Citations

Back to top


Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project.
Authors: Morton LM, Sampson JN, Cerhan JR, Turner JJ, Vajdic CM, Wang SS, Smedby KE, de Sanjosé S, Monnereau A, Benavente Y, Bracci PM, Chiu BC, Skibola CF, Zhang Y, Mbulaiteye SM, Spriggs M, Robinson D, Norman AD, Kane EV, Spinelli JJ, Kelly JL, La Vecchia C, Dal Maso L, Maynadié M, Kadin ME, Cocco P, Costantini AS, Clarke CA, Roman E, Miligi L, Colt JS, Berndt SI, Mannetje A, de Roos AJ, Kricker A, Nieters A, Franceschi S, Melbye M, Boffetta P, Clavel J, Linet MS, Weisenburger DD, Slager SL
Source: J Natl Cancer Inst Monogr, 2014 Aug;2014(48), p. 1-14.
PMID: 25174022
Related Citations

Back to top


Pre-diagnosis cigarette smoking and overall survival in non-Hodgkin lymphoma.
Authors: Ollberding NJ, Evens AM, Aschebrook-Kilfoy B, Caces DB, Weisenburger DD, Smith SM, Chiu BC
Source: Br J Haematol, 2013 Nov;163(3), p. 352-6.
EPub date: 2013 Aug 2.
PMID: 23909494
Related Citations

Back to top


Dietary patterns and the risk of non-Hodgkin lymphoma.
Authors: Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Smith SM, Weisenburger DD, Chiu BC
Source: Public Health Nutr, 2014 Jul;17(7), p. 1531-7.
EPub date: 2013 May 9.
PMID: 23659580
Related Citations

Back to top


Dietary intake of fruits and vegetables and overall survival in non-Hodgkin lymphoma.
Authors: Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Smith SM, Weisenburger DD, Chiu BC
Source: Leuk Lymphoma, 2013 Dec;54(12), p. 2613-9.
EPub date: 2013 Apr 30.
PMID: 23488609
Related Citations

Back to top


An upward trend in the age-specific incidence patterns for mantle cell lymphoma in the USA.
Authors: Aschebrook-Kilfoy B, Caces DB, Ollberding NJ, Smith SM, Chiu BC
Source: Leuk Lymphoma, 2013 Aug;54(8), p. 1677-83.
EPub date: 2013 Feb 7.
PMID: 23350889
Related Citations

Back to top


Phytanic acid and the risk of non-Hodgkin lymphoma.
Authors: Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Wright ME, Weisenburger DD, Smith SM, Chiu BC
Source: Carcinogenesis, 2013 Jan;34(1), p. 170-5.
EPub date: 2012 Oct 5.
PMID: 23042099
Related Citations

Back to top


Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma.
Authors: Aschebrook-Kilfoy B, Ward MH, Dave BJ, Smith SM, Weisenburger DD, Chiu BC
Source: Leuk Lymphoma, 2013 May;54(5), p. 945-50.
EPub date: 2012 Oct 24.
PMID: 23013327
Related Citations

Back to top


Meat intake and risk of non-Hodgkin lymphoma.
Authors: Aschebrook-Kilfoy B, Ollberding NJ, Kolar C, Lawson TA, Smith SM, Weisenburger DD, Chiu BC
Source: Cancer Causes Control, 2012 Oct;23(10), p. 1681-92.
EPub date: 2012 Aug 14.
PMID: 22890783
Related Citations

Back to top


Dietary intake of fruit and vegetables and risk of non-Hodgkin lymphoma.
Authors: Chiu BC, Kwon S, Evens AM, Surawicz T, Smith SM, Weisenburger DD
Source: Cancer Causes Control, 2011 Aug;22(8), p. 1183-95.
EPub date: 2011 Jun 22.
PMID: 21695384
Related Citations

Back to top


Pesticides, chromosomal aberrations, and non-Hodgkin's lymphoma.
Authors: Chiu BC, Blair A
Source: J Agromedicine, 2009;14(2), p. 250-5.
PMID: 19437285
Related Citations

Back to top


The utility of t(14;18) in understanding risk factors for non-Hodgkin lymphoma.
Authors: Chiu BC, Lan Q, Dave BJ, Blair A, Zahm SH, Weisenburger DD
Source: J Natl Cancer Inst Monogr, 2008;null(39), p. 69-73.
PMID: 18648007
Related Citations

Back to top


Dietary factors and risk of t(14;18)-defined subgroups of non-Hodgkin lymphoma.
Authors: Chiu BC, Dave BJ, Ward MH, Fought AJ, Hou L, Jain S, Gapstur S, Evens AM, Zahm SH, Blair A, Weisenburger DD
Source: Cancer Causes Control, 2008 Oct;19(8), p. 859-67.
EPub date: 2008 Apr 2.
PMID: 18386141
Related Citations

Back to top