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Grant Details

Grant Number: 5R01CA105181-05 Interpret this number
Primary Investigator: Koutsky, Laura
Organization: University Of Washington
Project Title: Natural History of HPV Infections in Men
Fiscal Year: 2009
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Abstract

DESCRIPTION (provided by applicant): Promising results from prophylactic HPV vaccine trials support using these vaccines in cervical cancer prevention programs in the-future. Since vaccine coverage rarely if ever reaches 100%, population-level effectiveness of a prophylactic vaccine designed to prevent a sexually transmitted infection, such as an HPV vaccine, depends not only on the efficacy of the vaccine, but also on the incidence and duration of infection in both men and women. Although much has been learned about the epidemiology of human papillomavirus (HPV) infections in women, little is known about the incidence, determinants, and natural history of HPV infections in men. Research in men has been hampered, in part, by an inability to obtain adequate genital samples for HPV DNA testing. As discussed in this proposal, we developed a sensitive and acceptable method for sample collection and now propose to use this method in a prospective natural history study with the following aims. Among young men, (1) determine the incidence of infection with any type of HPV, oncogenic HPV, specific HPV types including HPV 16 and HPV6/11, and HPV 16 variants; (2) define risk 'factors for incident HPV infection, including lifetime and recent number of sex partners, circumcision status, condom use, frequency of vaginal intercourse, and courtship behavior; and (3) describe the natural history of HPV infection in men as measured by duration and levels of HPV DNA, HPV type-specific seroconversion, duration of antibodies, and development of genital warts. Our long-term goal is development of cost-effective approaches to the prevention of HPV-related cancers.

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Publications

Characterization of three novel human papillomavirus types isolated from oral rinse samples of healthy individuals.
Authors: Martin E, Dang J, Bzhalava D, Stern J, Edelstein ZR, Koutsky LA, Kiviat NB, Feng Q
Source: J Clin Virol, 2014 Jan;59(1), p. 30-7.
EPub date: 2013 Nov 1.
PMID: 24268765
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Rates and determinants of oral human papillomavirus infection in young men.
Authors: Edelstein ZR, Schwartz SM, Hawes S, Hughes JP, Feng Q, Stern ME, O'Reilly S, Lee SK, Fu Xi L, Koutsky LA
Source: Sex Transm Dis, 2012 Nov;39(11), p. 860-7.
PMID: 23064535
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Disclosure of genital human papillomavirus infection to female sex partners by young men.
Authors: Arima Y, Winer RL, Kurth AE, Martin DP, Hughes JP, Stern ME, Feng Q, Kiviat NB, Koutsky LA
Source: Sex Transm Dis, 2012 Aug;39(8), p. 583-7.
PMID: 22797688
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Circumcision and acquisition of human papillomavirus infection in young men.
Authors: Vanbuskirk K, Winer RL, Hughes JP, Feng Q, Arima Y, Lee SK, Stern ME, O'Reilly SF, Koutsky LA
Source: Sex Transm Dis, 2011 Nov;38(11), p. 1074-81.
PMID: 21992987
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Serum antibody response following genital {alpha}9 human papillomavirus infection in young men.
Authors: Edelstein ZR, Carter JJ, Garg R, Winer RL, Feng Q, Galloway DA, Koutsky LA
Source: J Infect Dis, 2011 Jul 15;204(2), p. 209-16.
PMID: 21673030
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Development of genital warts after incident detection of human papillomavirus infection in young men.
Authors: Arima Y, Winer RL, Feng Q, Hughes JP, Lee SK, Stern ME, O'Reilly SF, Koutsky LA
Source: J Infect Dis, 2010 Oct 15;202(8), p. 1181-4.
PMID: 20812849
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Development and evaluation of a liquid bead microarray assay for genotyping genital human papillomaviruses.
Authors: Feng Q, Cherne S, Winer RL, Balasubramanian A, Lee SK, Hawes SE, Kiviat NB, Koutsky LA
Source: J Clin Microbiol, 2009 Mar;47(3), p. 547-53.
EPub date: 2009 Jan 14.
PMID: 19144800
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Genital human papillomavirus infection in men: incidence and risk factors in a cohort of university students.
Authors: Partridge JM, Hughes JP, Feng Q, Winer RL, Weaver BA, Xi LF, Stern ME, Lee SK, O'Reilly SF, Hawes SE, Kiviat NB, Koutsky LA
Source: J Infect Dis, 2007 Oct 15;196(8), p. 1128-36.
EPub date: 2007 Sep 13.
PMID: 17955430
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