Skip Navigation
Grant Details

Grant Number: 7R01CA100598-05 Interpret this number
Primary Investigator: Ambrosone, Christine
Organization: Roswell Park Cancer Institute Corp
Project Title: Race & Risk Factors for Early/Aggressive Breast Cancer
Fiscal Year: 2008
Back to top


Abstract

DESCRIPTION (provided by applicant): Breast cancer in African-American women occurs at an earlier age than in Caucasian women and is more likely to have aggressive features associated with poorer prognosis, regardless of age at diagnosis. The mechanisms underlying these differences are as yet unknown. Although factors related to socioeconomic status (SES) are likely to play a role in racial differences in stage at diagnosis and disease-free survival, SES factors are unlikely to fully explain the earlier age at diagnosis or the more aggressive nature of breast cancer in African-American women. Most recognized risk factors for breast cancer involve reproductive or hormonal characteristics. Importantly, there are notable differences between African-Americans and Caucasians in distribution of polymorphisms in genes that govern steroid biosynthesis and metabolism, in endogenous hormone profiles, and in menstrual and childbearing histories. These risk factor differences could impact breast cancer in African-American and Caucasian women, although the potential role of SES factors cannot be discounted. To our knowledge, there have been no studies specifically designed and with adequate power to address these questions. Building upon a funded case-control study of bio-behavioral risk factors for breast cancer in African-American women, we propose to investigate determinants of early age at onset and high grade, ER negative disease among African-Americans and Caucasians and to evaluate the proportion of disparities in aggressive disease that can be accounted for by differential distribution of genetic and hormonally-related risk factors in both racial groups. We intend to enroll 1200 Caucasian cases and 1200 controls and to enroll an additional 800 African-American women. We will over-enroll women under age 50 so that we will have equal proportions of younger and older women in both racial groups. Combined with data from the ongoing study, the proposed study will include 1200 African-American women with breast cancer and 1200 controls and an equal number of Caucasians. We hypothesize that factors associated with higher exposures to circulating estrogens, as well as the timing of those exposures, including early age at menarche, early and multiple pregnancies, energy balance and body size, as well as polymorphisms that result in higher active hormone levels will be associated with early age at diagnosis and high-grade, ER negative breast cancer, and that these factors will be more prevalent among African-American than Caucasian women. We will also examine the role of socio-economic factors, including screening behaviors and access to care, in the higher prevalence of high-grade, ER- tumors among African-American women. Results from this study will provide much-needed answers as to why African-American women are more likely than Caucasians to be diagnosed with more aggressive disease at an earlier age.

Back to top


Publications

A case-control analysis of oral contraceptive use and breast cancer subtypes in the African American Breast Cancer Epidemiology and Risk Consortium.
Authors: Bethea TN, Rosenberg L, Hong CC, Troester MA, Lunetta KL, Bandera EV, Schedin P, Kolonel LN, Olshan AF, Ambrosone CB, Palmer JR
Source: Breast Cancer Res, 2015 Feb 21;17, p. 22.
EPub date: 2015 Feb 21.
PMID: 25849024
Related Citations

Back to top


Obesity, body fat distribution, and risk of breast cancer subtypes in African American women participating in the AMBER Consortium.
Authors: Bandera EV, Chandran U, Hong CC, Troester MA, Bethea TN, Adams-Campbell LL, Haiman CA, Park SY, Olshan AF, Ambrosone CB, Palmer JR, Rosenberg L
Source: Breast Cancer Res Treat, 2015 Apr;150(3), p. 655-66.
EPub date: 2015 Mar 26.
PMID: 25809092
Related Citations

Back to top


Diagnosis and surgical delays in African American and white women with early-stage breast cancer.
Authors: George P, Chandwani S, Gabel M, Ambrosone CB, Rhoads G, Bandera EV, Demissie K
Source: J Womens Health (Larchmt), 2015 Mar;24(3), p. 209-17.
EPub date: 2015 Feb 4.
PMID: 25650628
Related Citations

Back to top


Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.
Authors: Gong Z, Yao S, Zirpoli G, David Cheng TY, Roberts M, Khoury T, Ciupak G, Davis W, Pawlish K, Jandorf L, Bovbjerg DH, Bandera EV, Ambrosone CB
Source: Int J Cancer, 2015 Aug 1;137(3), p. 666-77.
EPub date: 2015 Jan 29.
PMID: 25598430
Related Citations

Back to top


Intake of energy-dense foods, fast foods, sugary drinks, and breast cancer risk in African American and European American women.
Authors: Chandran U, McCann SE, Zirpoli G, Gong Z, Lin Y, Hong CC, Ciupak G, Pawlish K, Ambrosone CB, Bandera EV
Source: Nutr Cancer, 2014;66(7), p. 1187-99.
EPub date: 2014 Sep 29.
PMID: 25265504
Related Citations

Back to top


Effect of travel distance and time to radiotherapy on likelihood of receiving mastectomy.
Authors: Goyal S, Chandwani S, Haffty BG, Demissie K
Source: Ann Surg Oncol, 2015 Apr;22(4), p. 1095-101.
EPub date: 2014 Sep 23.
PMID: 25245129
Related Citations

Back to top


Variants of estrogen-related genes and breast cancer risk in European and African American women.
Authors: Quan L, Hong CC, Zirpoli G, Roberts MR, Khoury T, Sucheston-Campbell LE, Bovbjerg DH, Jandorf L, Pawlish K, Ciupak G, Davis W, Bandera EV, Ambrosone CB, Yao S
Source: Endocr Relat Cancer, 2014;21(6), p. 853-64.
EPub date: 2014 Sep 16.
PMID: 25228414
Related Citations

Back to top


Parity, lactation, and breast cancer subtypes in African American women: results from the AMBER Consortium.
Authors: Palmer JR, Viscidi E, Troester MA, Hong CC, Schedin P, Bethea TN, Bandera EV, Borges V, McKinnon C, Haiman CA, Lunetta K, Kolonel LN, Rosenberg L, Olshan AF, Ambrosone CB
Source: J Natl Cancer Inst, 2014 Oct;106(10), p. null.
EPub date: 2014 Sep 15.
PMID: 25224496
Related Citations

Back to top


Role of preoperative magnetic resonance imaging in the surgical management of early-stage breast cancer.
Authors: Chandwani S, George PA, Azu M, Bandera EV, Ambrosone CB, Rhoads GG, Demissie K
Source: Ann Surg Oncol, 2014 Oct;21(11), p. 3473-80.
EPub date: 2014 Jun 10.
PMID: 24912611
Related Citations

Back to top


Non-initiation and early discontinuation of adjuvant trastuzumab in women with localized HER2-positive breast cancer.
Authors: Neugut AI, Hillyer GC, Kushi LH, Lamerato L, Leoce N, Ambrosone CB, Bovbjerg DH, Mandelblatt JS, Hershman DL
Source: Breast Cancer, 2014 Nov;21(6), p. 780-5.
EPub date: 2014 Jun 6.
PMID: 24902664
Related Citations

Back to top


A comprehensive examination of breast cancer risk loci in African American women.
Authors: Feng Y, Stram DO, Rhie SK, Millikan RC, Ambrosone CB, John EM, Bernstein L, Zheng W, Olshan AF, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Deming SL, Rodriguez-Gil JL, Palmer JR, Olopade OI, Huo D, Adebamowo CA, Ogundiran T, Chen GK, Stram A, Park K, Rand KA, Chanock SJ, Le Marchand L, Kolonel LN, Conti DV, Easton D, Henderson BE, Haiman CA
Source: Hum Mol Genet, 2014 Oct 15;23(20), p. 5518-26.
EPub date: 2014 May 22.
PMID: 24852375
Related Citations

Back to top


Associations between estrogen receptor-negative breast cancer and timing of reproductive events differ between African American and European American women.
Authors: Ambrosone CB, Zirpoli GR, Bovbjerg DH, Shankar J, Hong CC, McCann SE, Ruszczyk M, Khoury T, Yao S, Ciupak GL, Jandorf L, Pawlish KS, Bandera EV
Source: Cancer Epidemiol Biomarkers Prev, 2014 Jun;23(6), p. 1115-20.
EPub date: 2014 Apr 9.
PMID: 24718280
Related Citations

Back to top


Parity and breastfeeding among African-American women: differential effects on breast cancer risk by estrogen receptor status in the Women's Circle of Health Study.
Authors: Ambrosone CB, Zirpoli G, Ruszczyk M, Shankar J, Hong CC, McIlwain D, Roberts M, Yao S, McCann SE, Ciupak G, Hwang H, Khoury T, Jandorf L, Bovbjerg DH, Pawlish K, Bandera EV
Source: Cancer Causes Control, 2014 Feb;25(2), p. 259-65.
EPub date: 2013 Nov 19.
PMID: 24249438
Related Citations

Back to top


Body fatness and breast cancer risk in women of African ancestry.
Authors: Bandera EV, Chandran U, Zirpoli G, Gong Z, McCann SE, Hong CC, Ciupak G, Pawlish K, Ambrosone CB
Source: BMC Cancer, 2013 Oct 14;13, p. 475.
EPub date: 2013 Oct 14.
PMID: 24118876
Related Citations

Back to top


Body size in early life and breast cancer risk in African American and European American women.
Authors: Bandera EV, Chandran U, Zirpoli G, Ciupak G, Bovbjerg DH, Jandorf L, Pawlish K, Freudenheim JL, Ambrosone CB
Source: Cancer Causes Control, 2013 Dec;24(12), p. 2231-43.
EPub date: 2013 Oct 10.
PMID: 24113797
Related Citations

Back to top


Racial disparities in red meat and poultry intake and breast cancer risk.
Authors: Chandran U, Zirpoli G, Ciupak G, McCann SE, Gong Z, Pawlish K, Lin Y, Demissie K, Ambrosone CB, Bandera EV
Source: Cancer Causes Control, 2013 Dec;24(12), p. 2217-29.
EPub date: 2013 Oct 5.
PMID: 24091794
Related Citations

Back to top


Genetic variants in microRNAs and breast cancer risk in African American and European American women.
Authors: Yao S, Graham K, Shen J, Campbell LE, Singh P, Zirpoli G, Roberts M, Ciupak G, Davis W, Hwang H, Khoury T, Bovbjerg DH, Jandorf L, Pawlish KS, Bandera EV, Liu S, Ambrosone CB, Zhao H
Source: Breast Cancer Res Treat, 2013 Oct;141(3), p. 447-59.
EPub date: 2013 Sep 24.
PMID: 24062209
Related Citations

Back to top


Does alcohol increase breast cancer risk in African-American women? Findings from a case-control study.
Authors: Chandran U, Zirpoli G, Ciupak G, McCann SE, Gong Z, Pawlish K, Lin Y, Demissie K, Ambrosone CB, Bandera EV
Source: Br J Cancer, 2013 Oct 1;109(7), p. 1945-53.
EPub date: 2013 Sep 5.
PMID: 24008665
Related Citations