|Grant Number:||5R01CA039742-25 Interpret this number|
|Primary Investigator:||Folsom, Aaron|
|Organization:||University Of Minnesota|
|Project Title:||Epidemiology of Cancer in a Cohort of Older Women|
DESCRIPTION (provided by applicant): Because cancer is a leading cause of death in postmenopausal women, detailed epidemiological investigations are warranted to identify etiologic factors, including potentially modifiable risk factors, for cancer and to better understand health issues for cancer survivors. The Iowa Women's Health Study (IWHS) recruited a population-based cohort of 41,836 Iowa women, aged 55-69 years in 1986, to determine whether diet, body fat distribution, and other risk factors were related to cancer incidence. Exposure and lifestyle information was collected in a baseline mailed survey and five follow-up surveys in 1987, 1989, 1992, 1997, and 2004. Cancer incidence and mortality have been ascertained since 1986 by linkage with the Iowa Cancer Registry, a SEER site, and the National Death Index. The project has been extremely productive, with nearly 200 publications, and key findings related to body fat distribution, diet, and other risk factors for cancer. With the existing wealth of information on this large cohort of women, we propose in this 5-year renewal to extend follow-up for cancer incidence and mortality through 22 years. Further IWHS follow-up is expected to yield a total of at least 9,723 incident cancers and 15,756 deaths. We also propose linkage of the IWHS cohort to the Medicare database through 2004, to retrospectively identify, for women 65+, new exposures, new cancer-relevant endpoints, and outcomes after cancer. This linkage will allow us to test hypotheses in six broad areas: a) dietary risk factors for common cancers; b) non-dietary risk factors for common cancers; c) risk factors for uncommon cancers; d) cancer outcomes; e) risk factors for cancers not previously available from SEER; and f) the epidemiology of high risk or premalignant conditions. The proposed extension of IWHS will provide new information on the risk and outcomes of cancer in older women. The incremental cost needed to combine Medicare data with IWHS data is relatively small, yet the new opportunities afforded by this linkage are substantial. With this progressive approach, continued funding of the IWHS should prove to be of value in the control of this major public health problem.
Farm residence and lymphohematopoietic cancers in the Iowa Women's Health Study.
Authors: Jones RR, Yu CL, Nuckols JR, Cerhan JR, Airola M, Ross JA, Robien K, Ward MH
Source: Environ Res, 2014 Aug;133, p. 353-61.
EPub date: 2014 Jul 16.
A pooled analysis of waist circumference and mortality in 650,000 adults.
Authors: Cerhan JR, Moore SC, Jacobs EJ, Kitahara CM, Rosenberg PS, Adami HO, Ebbert JO, English DR, Gapstur SM, Giles GG, Horn-Ross PL, Park Y, Patel AV, Robien K, Weiderpass E, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Hartge P, Bernstein L, Berrington de Gonzalez A
Source: Mayo Clin Proc, 2014 Mar;89(3), p. 335-45.
Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's Health Study cohort.
Authors: Leal AD, Thompson CA, Wang AH, Vierkant RA, Habermann TM, Ross JA, Mesa RA, Virnig BA, Cerhan JR
Source: Int J Cancer, 2014 Apr 1;134(7), p. 1741-50.
EPub date: 2013 Oct 15.
Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer.
Authors: Uccella S, Mariani A, Wang AH, Vierkant RA, Cliby WA, Robien K, Anderson KE, Cerhan JR
Source: Br J Cancer, 2013 Oct 1;109(7), p. 1908-13.
EPub date: 2013 Sep 10.
Diet quality indexes and mortality in postmenopausal women: the Iowa Women's Health Study.
Authors: Mursu J, Steffen LM, Meyer KA, Duprez D, Jacobs DR Jr
Source: Am J Clin Nutr, 2013 Aug;98(2), p. 444-53.
Type I and II endometrial cancers: have they different risk factors?
Authors: Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB, Wolk A, Wentzensen N, Weiss NS, Webb PM, van den Brandt PA, van de Vijver K, Thompson PJ, Australian National Endometrial Cancer Study Group, Strom BL, Spurdle AB, Soslow RA, Shu XO, Schairer C, Sacerdote C, Rohan TE, Robien K, Risch HA, Ricceri F, Rebbeck TR, Rastogi R, Prescott J, Polidoro S, Park Y, Olson SH, Moysich KB, Miller AB, McCullough ML, Matsuno RK, Magliocco AM, Lurie G, Lu L, Lissowska J, Liang X, Lacey JV Jr, Kolonel LN, Henderson BE, Hankinson SE, Håkansson N, Goodman MT, Gaudet MM, Garcia-Closas M, Friedenreich CM, Freudenheim JL, Doherty J, De Vivo I, Courneya KS, Cook LS, Chen C, Cerhan JR, Cai H, Brinton LA, Bernstein L, Anderson KE, Anton-Culver H, Schouten LJ, Horn-Ross PL
Source: J Clin Oncol, 2013 Jul 10;31(20), p. 2607-18.
EPub date: 2013 Jun 3.
Duration of diabetes and pancreatic cancer in a case-control study in the Midwest and the Iowa Women's Health Study (IWHS) cohort.
Authors: Henry SA, Prizment AE, Anderson KE
Source: JOP, 2013 May 10;14(3), p. 243-9.
EPub date: 2013 May 10.
Reproductive, lifestyle, and anthropometric risk factors for cancer in elderly women.
Authors: Poynter JN, Inoue-Choi M, Ross JA, Jacobs DR Jr, Robien K
Source: Cancer Epidemiol Biomarkers Prev, 2013 Apr;22(4), p. 681-7.
EPub date: 2013 Feb 19.
Diabetes and risk of bladder cancer among postmenopausal women in the Iowa Women's Health Study.
Authors: Prizment AE, Anderson KE, Yuan JM, Folsom AR
Source: Cancer Causes Control, 2013 Mar;24(3), p. 603-8.
EPub date: 2013 Jan 8.
Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study.
Authors: Razzak AA, Oxentenko AS, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Potter JD, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ
Source: Nutr Cancer, 2012;64(7), p. 899-910.
Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium.
Authors: Setiawan VW, Pike MC, Karageorgi S, Deming SL, Anderson K, Bernstein L, Brinton LA, Cai H, Cerhan JR, Cozen W, Chen C, Doherty J, Freudenheim JL, Goodman MT, Hankinson SE, Lacey JV Jr, Liang X, Lissowska J, Lu L, Lurie G, Mack T, Matsuno RK, McCann S, Moysich KB, Olson SH, Rastogi R, Rebbeck TR, Risch H, Robien K, Schairer C, Shu XO, Spurdle AB, Strom BL, Thompson PJ, Ursin G, Webb PM, Weiss NS, Wentzensen N, Xiang YB, Yang HP, Yu H, Horn-Ross PL, De Vivo I, Australian National Endometrial Cancer Study Group
Source: Am J Epidemiol, 2012 Aug 15;176(4), p. 269-78.
EPub date: 2012 Jul 23.
Interaction of nitrate and folate on the risk of breast cancer among postmenopausal women.
Authors: Inoue-Choi M, Ward MH, Cerhan JR, Weyer PJ, Anderson KE, Robien K
Source: Nutr Cancer, 2012;64(5), p. 685-94.
EPub date: 2012 May 29.
Cigarette smoking and colorectal cancer risk by KRAS mutation status among older women.
Authors: Samadder NJ, Vierkant RA, Tillmans LS, Wang AH, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Potter JD, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ
Source: Am J Gastroenterol, 2012 May;107(5), p. 782-9.
EPub date: 2012 Feb 21.
Psoriasis is associated with a greater risk of incident venous thromboembolism: the Iowa Women's Health Study.
Authors: Lutsey PL, Prizment AE, Folsom AR
Source: J Thromb Haemost, 2012 Apr;10(4), p. 708-11.
Vitamin D intake and mental health-related quality of life in older women: the Iowa Women's Health Study.
Authors: Motsinger S, Lazovich D, MacLehose RF, Torkelson CJ, Robien K
Source: Maturitas, 2012 Mar;71(3), p. 267-73.
EPub date: 2011 Dec 29.
Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women.
Authors: Razzak AA, Oxentenko AS, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ
Source: Cancer Prev Res (Phila), 2011 Dec;4(12), p. 2035-43.
EPub date: 2011 Sep 7.
Risk factors for meningioma in postmenopausal women: results from the Iowa Women's Health Study.
Authors: Johnson DR, Olson JE, Vierkant RA, Hammack JE, Wang AH, Folsom AR, Virnig BA, Cerhan JR
Source: Neuro Oncol, 2011 Sep;13(9), p. 1011-9.
EPub date: 2011 Jul 12.
Association between psoriasis and incident cancer: the Iowa's Women's Health Study.
Authors: Prizment AE, Alonso A, Folsom AR, Ahmed RL, Virnig BA, Warshaw EM, Anderson KE
Source: Cancer Causes Control, 2011 Jul;22(7), p. 1003-10.
EPub date: 2011 May 7.
Dietary and supplemental intake of one-carbon nutrients and the risk of type I and type II endometrial cancer: a prospective cohort study.
Authors: Uccella S, Mariani A, Wang AH, Vierkant RA, Robien K, Anderson KE, Cerhan JR
Source: Ann Oncol, 2011 Sep;22(9), p. 2129-36.
EPub date: 2011 Feb 15.
Nutrients, food groups, dietary patterns, and risk of pancreatic cancer in postmenopausal women.
Authors: Inoue-Choi M, Flood A, Robien K, Anderson K
Source: Cancer Epidemiol Biomarkers Prev, 2011 Apr;20(4), p. 711-4.
EPub date: 2011 Jan 28.