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Grant Details

Grant Number: 5R01CA111355-05 Interpret this number
Primary Investigator: Spector, Logan
Organization: University Of Minnesota
Project Title: Low Birth Weight & Other Risk Factors for Hepatoblastoma
Fiscal Year: 2009
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Abstract

DESCRIPTION (provided by applicant): Hepatoblastoma (HB) is a rare liver tumor, the incidence rate of which doubled between 1975 and 1999 in the U.S. Recent evidence suggests increased risk of HB in low (LBW: 1,500-2,500 grams), and especially very low (VLBW: <1,500 grams) birth weight infants. Small (< 100 cases) casecontrol studies have also suggested associations of HB with maternal smoking while pregnant,parental occupation, and a polymorphism in the myeloperoxidase (MPO) gene. We propose to conduct the largest and most comprehensive case-control study of hepatoblastoma to date. We will collect 600 cases of HB diagnosed at U.S, Children's Oncology Group institutions in 2000-2008,about 120 of whom should be LBW and VLBW. Controls (480 normal birth weight; 120 LBW; 120 VLBW) will be selected from United States birth registries and will be frequency matched on birth weight, sex, year of birth, and region of diagnosis. Exposure data will be collected through parental interview and buccal cells will be collected for DNA analysis; cases will also have their tumor tissue collected. Our primary aims are to: 1) Determine whether duration and intensity of treatment for prematurity increases risk of HB among LBW and VLBW infants, 2) Examine the role of parental occupation and maternal lifestyle while pregnant in the risk of HB, 3) Compare the frequency of candidate genetic susceptibility gene polymorphisms in cases and controls, 4) Compare the frequency of candidate genetic susceptibility gene polymorphisms in the mothers of cases and controls, 5) Describe the pattern of IGF-2 gene imprinting in HB cases in toto, by age, and by birthweight. We hypothesize that treatment for prematurity is the major risk factor among low birth weight children and that the other exogenous exposures are of minor etiologic importance. We further hypothesize that endogenous determinants of the ability to activate and detoxify toxins are risk factors among children with both normal and low birth weight.

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Publications

Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: a report from the Children's Oncology Group.
Authors: Turcotte LM, Georgieff MK, Ross JA, Feusner JH, Tomlinson GE, Malogolowkin MH, Krailo MD, Miller N, Fonstad R, Spector LG
Source: Pediatr Blood Cancer, 2014 Nov;61(11), p. 2018-23.
EPub date: 2014 Jul 15.
PMID: 25044669
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Congenital abnormalities and hepatoblastoma: a report from the Children's Oncology Group (COG) and the Utah Population Database (UPDB).
Authors: Venkatramani R, Spector LG, Georgieff M, Tomlinson G, Krailo M, Malogolowkin M, Kohlmann W, Curtin K, Fonstad RK, Schiffman JD
Source: Am J Med Genet A, 2014 Sep;164A(9), p. 2250-5.
EPub date: 2014 Jun 16.
PMID: 24934283
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Parental tobacco and alcohol use and risk of hepatoblastoma in offspring: a report from the children's oncology group.
Authors: Johnson KJ, Williams KS, Ross JA, Krailo MD, Tomlinson GE, Malogolowkin MH, Feusner JH, Spector LG
Source: Cancer Epidemiol Biomarkers Prev, 2013 Oct;22(10), p. 1837-43.
EPub date: 2013 Aug 15.
PMID: 23950215
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Predictors of mother and child DNA yields in buccal cell samples collected in pediatric cancer epidemiologic studies: a report from the Children's Oncology group.
Authors: Poynter JN, Ross JA, Hooten AJ, Langer E, Blommer C, Spector LG
Source: BMC Genet, 2013 Aug 12;14, p. 69.
EPub date: 2013 Aug 12.
PMID: 23937514
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Maternal pregnancy events and exposures and risk of hepatoblastoma: a Children's Oncology Group (COG) study.
Authors: Musselman JR, Georgieff MK, Ross JA, Tomlinson GE, Feusner J, Krailo M, Spector LG
Source: Cancer Epidemiol, 2013 Jun;37(3), p. 318-20.
EPub date: 2013 Jan 9.
PMID: 23312454
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Parental infertility, infertility treatment and hepatoblastoma: a report from the Children's Oncology Group.
Authors: Puumala SE, Ross JA, Feusner JH, Tomlinson GE, Malogolowkin MH, Krailo MD, Spector LG
Source: Hum Reprod, 2012 Jun;27(6), p. 1649-56.
EPub date: 2012 Apr 3.
PMID: 22473396
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Feasibility of nationwide birth registry control selection in the United States.
Authors: Spector LG, Ross JA, Puumala SE, Roesler M, Olshan AF, Bunin GR
Source: Am J Epidemiol, 2007 Oct 1;166(7), p. 852-6.
EPub date: 2007 Jul 10.
PMID: 17623744
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