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Grant Details

Grant Number: 7P50CA084735-10 Interpret this number
Primary Investigator: Johnson, Carl
Organization: Claremont Graduate University
Project Title: Genes, Environment & Tobacco Use Across Cultures
Fiscal Year: 2008
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Abstract

The University of Southern California _ Pacific Rim Transdisciplinary Tobacco Use Research Center (USC-PR TTURC) will investigate the efficacy of tobacco and alcohol use prevention programs (1) across cultures, (2) within specific cultural contexts, and (3) dependent on individual-level variations for dispositional attributes. The previous USC TTURC projects focused on characterizing the role of culture in tobacco use behavior and prevention by investigating multiethnic and multicultural populations within the US and in China. The research indicated that cultural context and individual disposition have potentially important moderator effects on prevention prepares. The proposed USC-PR TTURC will extend this program of research with three projects and four cores. Project 1, Heritable and social-environment risks for substance use, will bridge the disciplines of psychology, sociology, and behavioral genetics to examine the genetic and social-environmental risk and protective factors for adolescent tobacco and alcohol use among adolescent twins in Southern California and Qingdao, China. Project 2, Effect moderation and mediation in prevention programs, will investigate specific social, behavioral, and programmatic characteristics that are associated with substance use outcomes following exposure to evidence-based prevention programs in the U.S. and Chinese youth. This investigation will determine not only the presence of main effects for variables in each domain but, significantly, the presence of interactive effects between children's personal and social characteristics and program characteristics in the prediction of prevention outcomes. Project 3, Genetic Variants and Tobacco Use in Chinese Adolescents, will investigate the hypothesis that genetic factors responsible for dispositional attributes, such as hostility and depression, may substantially influence both an individual's tobacco use progression and moderate the effectiveness of tobacco control intervention and prevention trials. The Measurement Core will assist TTURC projects by researching, developing, and validating measures to assess tobacco use and its psychosocial correlates. The Statistics Core will provide data management and statistical support for TTURC projects. The Career Development Core will provide a variety of training opportunities to support the development of the next generation of transdisciplinary scientists to advance our knowledge of the complex social, cultural, biological, and environmental determinants of tobacco use and alcohol comorbidity. The Administrative _ Scientific Liaison Core will provide the scientific and administrative leadership key to the efficient and productive operation of the Center. This transdisciplinary collab! oration will lead to a more complete understanding of the etiology of adolescent substance use across cultural contexts and across individuals, leading to the development of more effective prevention programs.

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Publications

The Qingdao Twin Registry: a status update.
Authors: Duan H, Ning F, Zhang D, Wang S, Zhang D, Tan Q, Tian X, Pang Z
Source: Twin Res Hum Genet, 2013 Feb;16(1), p. 79-85.
EPub date: 2012 Nov 27.
PMID: 23182450
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The role of cognitive attributions for smoking in subsequent smoking progression and regression among adolescents in China.
Authors: Guo Q, Unger JB, Palmer PH, Chou CP, Johnson CA
Source: Addict Behav, 2013 Jan;38(1), p. 1493-8.
EPub date: 2012 Aug 28.
PMID: 23017586
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Abnormal affective decision making revealed in adolescent binge drinkers using a functional magnetic resonance imaging study.
Authors: Xiao L, Bechara A, Gong Q, Huang X, Li X, Xue G, Wong S, Lu ZL, Palmer P, Wei Y, Jia Y, Johnson CA
Source: Psychol Addict Behav, 2013 Jun;27(2), p. 443-54.
EPub date: 2012 Apr 9.
PMID: 22486330
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Multiple peer group self-identification and adolescent tobacco use.
Authors: Fuqua JL, Gallaher PE, Unger JB, Trinidad DR, Sussman S, Ortega E, Johnson CA
Source: Subst Use Misuse, 2012 May;47(6), p. 757-66.
EPub date: 2012 Mar 29.
PMID: 22458850
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Do cognitive attributions for smoking predict subsequent smoking development?
Authors: Guo Q, Unger JB, Azen SP, MacKinnon DP, Johnson CA
Source: Addict Behav, 2012 Mar;37(3), p. 273-9.
EPub date: 2011 Nov 6.
PMID: 22112425
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Correlates of overweight status in Chinese youth: an East-West paradox.
Authors: Hsu YW, Johnson CA, Chou CP, Unger JB, Sun P, Xie B, Palmer PH, Gallaher PE, Spruijt-Metz D
Source: Am J Health Behav, 2011 Jul;35(4), p. 496-506.
PMID: 22040595
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Longitudinal effects of hostility, depression, and bullying on adolescent smoking initiation.
Authors: Weiss JW, Mouttapa M, Cen S, Johnson CA, Unger J
Source: J Adolesc Health, 2011 Jun;48(6), p. 591-6.
EPub date: 2010 Dec 18.
PMID: 21575819
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Preventing behavior problems among elementary schoolchildren: impact of a universal school-based program in China.
Authors: Hong L, Yufeng W, Agho K, Jacobs J
Source: J Sch Health, 2011 May;81(5), p. 273-80.
PMID: 21517867
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Overweight, body image, and depression in Asian and Hispanic adolescents.
Authors: Xie B, Unger JB, Gallaher P, Johnson CA, Wu Q, Chou CP
Source: Am J Health Behav, 2010 Jul-Aug;34(4), p. 476-88.
PMID: 20218759
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Understanding the effect of social capital on the depression of urban Chinese adolescents: an integrative framework.
Authors: Wu Q, Xie B, Chou CP, Palmer PH, Gallaher PE, Johnson CA
Source: Am J Community Psychol, 2010 Mar;45(1-2), p. 1-16.
PMID: 20066487
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Cognitive attributions for smoking among adolescents in China.
Authors: Guo Q, Unger JB, Azen SP, Li C, Spruijt-Metz D, Palmer PH, Chou CP, Lee L, Sun P, Johnson CA
Source: Addict Behav, 2010 Feb;35(2), p. 95-101.
EPub date: 2009 Sep 9.
PMID: 19800741
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Transdisciplinary Tobacco Use Research Centers: research achievements and future implications.
Authors: Baker TB, Cummings KM, Hatsukami DK, Johnson CA, Lerman C, Niaura R, O'Malley SS
Source: Nicotine Tob Res, 2009 Oct;11(10), p. 1231-44.
EPub date: 2009 Jul 24.
PMID: 19633277
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Affective decision-making predictive of Chinese adolescent drinking behaviors.
Authors: Xiao L, Bechara A, Grenard LJ, Stacy WA, Palmer P, Wei Y, Jia Y, Fu X, Johnson CA
Source: J Int Neuropsychol Soc, 2009 Jul;15(4), p. 547-57.
PMID: 19573273
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Monitoring the tobacco use epidemic IV. The vector: Tobacco industry data sources and recommendations for research and evaluation.
Authors: Cruz TB
Source: Prev Med, 2009 Jan;48(1 Suppl), p. S24-34.
EPub date: 2008 Oct 11.
PMID: 18976685
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A longitudinal analysis of stressful life events, smoking behaviors, and gender differences in a multicultural sample of adolescents.
Authors: Booker CL, Unger JB, Azen SP, Baezconde-Garbanati L, Lickel B, Johnson CA
Source: Subst Use Misuse, 2008;43(11), p. 1521-43.
PMID: 18752157
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Comorbidity between depression and smoking moderates the effect of a smoking prevention program among boys in China.
Authors: Sun P, Unger JB, Guo Q, Gong J, Ma H, Palmer PH, Chou CP, Li Y, Sussman S, Ritt-Olson A, Xiao L, Johnson CA
Source: Nicotine Tob Res, 2007 Nov;9 Suppl 4, p. S599-609.
PMID: 18067035
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Affective decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in 10th-grade Chinese adolescent smokers.
Authors: Xiao L, Bechara A, Cen S, Grenard JL, Stacy AW, Gallaher P, Wei Y, Jia Y, Anderson Johnson C
Source: Nicotine Tob Res, 2008 Jun;10(6), p. 1085-97.
PMID: 18584472
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Association between psychological factors and adolescent smoking in seven cities in China.
Authors: Weiss JW, Palmer PH, Chou CP, Mouttapa M, Johnson CA
Source: Int J Behav Med, 2008;15(2), p. 149-56.
PMID: 18569133
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Risk factors for adolescent smoking in urban and rural China: findings from the China seven cities study.
Authors: Ma H, Unger JB, Chou CP, Sun P, Palmer PH, Zhou Y, Yao J, Xie B, Gallaher PE, Guo Q, Wei Y, Chen B, Wang Z, Wang X, Duan H, Song Y, Gong J, Azen SP, Lee L, Johnson CA
Source: Addict Behav, 2008 Aug;33(8), p. 1081-5.
EPub date: 2008 Apr 8.
PMID: 18495363
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Novel monoamine oxidase A knock out mice with human-like spontaneous mutation.
Authors: Scott AL, Bortolato M, Chen K, Shih JC
Source: Neuroreport, 2008 May 7;19(7), p. 739-43.
PMID: 18418249
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Affective decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in 10th grade Chinese adolescent binge drinkers.
Authors: Johnson CA, Xiao L, Palmer P, Sun P, Wang Q, Wei Y, Jia Y, Grenard JL, Stacy AW, Bechara A
Source: Neuropsychologia, 2008 Jan 31;46(2), p. 714-26.
EPub date: 2007 Sep 29.
PMID: 17996909
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